Page last updated: 2024-10-31

modafinil and Pregnancy

modafinil has been researched along with Pregnancy in 16 studies

Modafinil: A benzhydryl acetamide compound, central nervous system stimulant, and CYP3A4 inducing agent that is used in the treatment of NARCOLEPSY and SLEEP WAKE DISORDERS.
modafinil : A racemate comprising equimolar amounts of armodafinil and (S)-modafinil. A central nervous system stimulant, it is used for the treatment of sleeping disorders such as narcolepsy, obstructive sleep apnoea, and shift-work sleep disorder. The optical enantiomers of modafinil have similar pharmacological actions in animals.
2-[(diphenylmethyl)sulfinyl]acetamide : A sulfoxide that is dimethylsulfoxide in which two hydrogens attached to one of the methyl groups are replaced by phenyl groups, while one hydrogen attached to the other methyl group is replaced by a carbamoyl (aminocarbonyl) group.

Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

Research Excerpts

ExcerptRelevanceReference
"Modafinil (MOD) is a dopamine (DA) reuptake blocker prescribed to treat sleep disorders; however, in recent years it has been used for the treatment of ADHD with positive results."1.56Modafinil reduces choice impulsivity while increasing motor activity in preadolescent rats treated prenatally with alcohol. ( Heyer-Osorno, R; Juárez, J, 2020)
" Hyperactivity increased with a dose-response effect of modafinil in the PS group; meanwhile, this behavior increased only with the dose of 60 mg/kg in the PA group."1.51Differential effect of modafinil on impulsivity, attention and motor activity in preadolescent rats prenatally treated with alcohol. ( Gomez-Ordoñez, D; Juárez, J, 2019)
"Patients with narcolepsy with cataplexy reported 59 pregnancies versus 164 in the control group."1.48Narcolepsy with cataplexy and pregnancy: a case-control study. ( Calvo-Ferrandiz, E; Peraita-Adrados, R, 2018)
"Modafinil is a psychostimulant drug prescribed for treatment of narcolepsy."1.48Prenatal exposure to modafinil alters behavioural response to methamphetamine in adult male mice. ( Amchova, P; Machalova, A; Pistovcakova, J; Ruda-Kucerova, J; Sulcova, A, 2018)
"Modafinil is a psychostimulant drug prescribed mainly for treatment of narcolepsy but is used as a "smart drug" by wide populations to increase wakefulness, concentration and overall mental performance."1.48Prenatal exposure to modafinil alters locomotor behaviour and leucocyte phagocytosis in mice. ( Amchova, P; Machalova, A; Pistovcakova, J; Ruda-Kucerova, J; Sulcova, A, 2018)
"We present a case of a 27-year-old woman in whom idiopathic hypersomnolence was diagnosed in adolescence with adequate symptomatic control on daily dosage of 250 mg of modafinil."1.48Evaluating Transfer of Modafinil Into Human Milk During Lactation: A Case Report. ( Aurora, N; Aurora, S; Baker, T; Datta, P; Hale, TW; Rewers-Felkins, K, 2018)
"Sleep deprivation is known to be a stressor, affecting multiple body functions such as the cognition."1.39Modafinil ameliorates cognitive deficits induced by maternal separation and sleep deprivation. ( Alvarenga, T; Andersen, ML; Garcia, VA; Hirotsu, C; Kapczinski, F; Matos, G; Pires, GN; Schröder, N; Tufik, S, 2013)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (6.25)29.6817
2010's9 (56.25)24.3611
2020's6 (37.50)2.80

Authors

AuthorsStudies
Bang Madsen, K1
Robakis, TK1
Liu, X1
Momen, N1
Larsson, H1
Dreier, JW1
Kildegaard, H1
Groth, JB1
Newcorn, JH1
Hove Thomsen, P1
Munk-Olsen, T1
Bergink, V1
Gomez-Ordoñez, D1
Juárez, J2
Damkier, P1
Broe, A1
Heyer-Osorno, R1
Cesta, CE1
Engeland, A1
Karlsson, P1
Kieler, H1
Reutfors, J1
Furu, K1
Ghaffari, N1
Robertson, PA1
Kaplan, S1
Braverman, DL1
Frishman, I1
Bartov, N1
Calvo-Ferrandiz, E1
Peraita-Adrados, R1
Ruda-Kucerova, J2
Pistovcakova, J2
Amchova, P2
Sulcova, A2
Machalova, A2
Aurora, S1
Aurora, N1
Datta, P1
Rewers-Felkins, K1
Baker, T1
Hale, TW1
Garcia, VA1
Hirotsu, C1
Matos, G1
Alvarenga, T1
Pires, GN1
Kapczinski, F1
Schröder, N1
Tufik, S1
Andersen, ML1
Warrer, P1
Aagaard, L1
Hansen, EH1
Andrade, C1
Hoque, R1
Chesson, AL1
Soltanifar, S1
Russell, R1

Other Studies

16 other studies available for modafinil and Pregnancy

ArticleYear
In utero exposure to ADHD medication and long-term offspring outcomes.
    Molecular psychiatry, 2023, Volume: 28, Issue:4

    Topics: Adult; Amphetamines; Attention Deficit Disorder with Hyperactivity; Child, Preschool; Clonidine; Coh

2023
Differential effect of modafinil on impulsivity, attention and motor activity in preadolescent rats prenatally treated with alcohol.
    Brain research, 2019, 11-01, Volume: 1722

    Topics: Animals; Attention; Behavior, Animal; Central Nervous System Stimulants; Ethanol; Female; Impulsive

2019
First-Trimester Pregnancy Exposure to Modafinil and Risk of Congenital Malformations.
    JAMA, 2020, Jan-28, Volume: 323, Issue:4

    Topics: Abnormalities, Drug-Induced; Adult; Central Nervous System Stimulants; Denmark; Female; Humans; Logi

2020
Modafinil reduces choice impulsivity while increasing motor activity in preadolescent rats treated prenatally with alcohol.
    Pharmacology, biochemistry, and behavior, 2020, Volume: 194

    Topics: Animals; Attention; Behavior, Animal; Central Nervous System Stimulants; Dopaminergic Neurons; Ethan

2020
Incidence of Malformations After Early Pregnancy Exposure to Modafinil in Sweden and Norway.
    JAMA, 2020, 09-01, Volume: 324, Issue:9

    Topics: Abnormalities, Drug-Induced; Adult; Central Nervous System Stimulants; Cohort Studies; Female; Human

2020
Caution in Prescribing Modafinil and Armodafinil to Individuals Who Could Become Pregnant.
    JAMA internal medicine, 2021, 02-01, Volume: 181, Issue:2

    Topics: Central Nervous System Stimulants; Female; Humans; Modafinil; Pregnancy; Wakefulness

2021
Pregnancy and Fetal Outcomes Following Exposure to Modafinil and Armodafinil During Pregnancy.
    JAMA internal medicine, 2021, 02-01, Volume: 181, Issue:2

    Topics: Abnormalities, Drug-Induced; Female; Humans; Modafinil; Narcolepsy; Pregnancy; Registries; United St

2021
Narcolepsy with cataplexy and pregnancy: a case-control study.
    Journal of sleep research, 2018, Volume: 27, Issue:2

    Topics: Adult; Breast Feeding; Case-Control Studies; Cataplexy; Central Nervous System Stimulants; Cesarean

2018
Prenatal exposure to modafinil alters behavioural response to methamphetamine in adult male mice.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2018, Volume: 67

    Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Benzhydryl Compounds; Central Nervous

2018
Prenatal exposure to modafinil alters locomotor behaviour and leucocyte phagocytosis in mice.
    Psychiatria Danubina, 2018, Volume: 30, Issue:3

    Topics: Age Factors; Animals; Disease Models, Animal; Female; Gestational Age; Leukocytes; Locomotion; Lumin

2018
Evaluating Transfer of Modafinil Into Human Milk During Lactation: A Case Report.
    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2018, 12-15, Volume: 14, Issue:12

    Topics: Adult; Chromatography, Liquid; Disorders of Excessive Somnolence; Dose-Response Relationship, Drug;

2018
Modafinil ameliorates cognitive deficits induced by maternal separation and sleep deprivation.
    Behavioural brain research, 2013, Sep-15, Volume: 253

    Topics: Analysis of Variance; Animals; Anxiety, Separation; Benzhydryl Compounds; Central Nervous System Sti

2013
Comparison of pregnancy and lactation labeling for attention-deficit hyperactivity disorder drugs marketed in Australia, the USA, Denmark, and the UK.
    Drug safety, 2014, Volume: 37, Issue:10

    Topics: Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Australia; Benzhydryl Comp

2014
A primer on confidence intervals in psychopharmacology.
    The Journal of clinical psychiatry, 2015, Volume: 76, Issue:2

    Topics: Abnormalities, Drug-Induced; Antidepressive Agents; Benzhydryl Compounds; Confidence Intervals; Curr

2015
Conception, pregnancy, delivery, and breastfeeding in a narcoleptic patient with cataplexy.
    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2008, Dec-15, Volume: 4, Issue:6

    Topics: Adult; Benzhydryl Compounds; Breast Feeding; Cataplexy; Central Nervous System Stimulants; Contraind

2008
Neuraxial anaesthesia for caesarean section in a patient with narcolepsy and cataplexy.
    International journal of obstetric anesthesia, 2010, Volume: 19, Issue:4

    Topics: Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Antidepressive Agents, Second-Generation; Benz

2010