modafinil has been researched along with Pain, Postoperative in 3 studies
Modafinil: A benzhydryl acetamide compound, central nervous system stimulant, and CYP3A4 inducing agent that is used in the treatment of NARCOLEPSY and SLEEP WAKE DISORDERS.
modafinil : A racemate comprising equimolar amounts of armodafinil and (S)-modafinil. A central nervous system stimulant, it is used for the treatment of sleeping disorders such as narcolepsy, obstructive sleep apnoea, and shift-work sleep disorder. The optical enantiomers of modafinil have similar pharmacological actions in animals.
2-[(diphenylmethyl)sulfinyl]acetamide : A sulfoxide that is dimethylsulfoxide in which two hydrogens attached to one of the methyl groups are replaced by phenyl groups, while one hydrogen attached to the other methyl group is replaced by a carbamoyl (aminocarbonyl) group.
Pain, Postoperative: Pain during the period after surgery.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Modafinil significantly reduces fatigue and improves feelings of alertness and energy in postoperative patients." | 5.11 | Modafinil improves recovery after general anesthesia. ( Dunn, JB; Goldberg, ME; Hojat, M; Khaleghi, B; Larijani, GE; Marr, AT, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Morimoto, Y | 1 |
| Nogami, Y | 1 |
| Harada, K | 1 |
| Shiramoto, H | 1 |
| Moguchi, T | 1 |
| Larijani, GE | 1 |
| Goldberg, ME | 1 |
| Hojat, M | 1 |
| Khaleghi, B | 1 |
| Dunn, JB | 1 |
| Marr, AT | 1 |
| Janeiro, M | 1 |
| Camblor, E | 1 |
| Fernández, R | 1 |
| Núñez, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized, Double Blind, Placebo Controlled Evaluation of Modafinil vs Placebo for the Treatment of General Anesthesia Related Delayed Emergence in Patients With the Diagnosis of Obstructive Sleep Apnea[NCT02494102] | Phase 4 | 105 participants (Actual) | Interventional | 2016-02-29 | Terminated | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Length of time of above compared between groups (NCT02494102)
Timeframe: 24 hours
| Intervention | minutes (Mean) |
|---|---|
| Placebo | 53.5 |
| Modafinil | 61.0 |
Postanesthesia quality recovery scale (PQRS). Component and aggregate scoring on the scale. Measures physiology, nociceptive, emotional activities of daily living cognitive and overall patient perspective. The scale is dimensionless and the aggregate of all individually tested dimensions is scaled from 17-65. A higher value implies improved postanesthesia recovery. Mean difference was assessed in each patient and aggregated thus patients with no difference between pre- and post-operative scores were zeroed (received a zero score if the difference was zero). A negative value was associated with worse outcome. (NCT02494102)
Timeframe: baseline and 6 hours after surgery
| Intervention | units on a scale (Mean) |
|---|---|
| Placebo | -5.67 |
| Modafinil | -8.91 |
1 trial available for modafinil and Pain, Postoperative
| Article | Year |
|---|---|
Modafinil improves recovery after general anesthesia.
Topics: Adolescent; Adult; Aged; Ambulatory Surgical Procedures; Anesthesia Recovery Period; Anesthesia, Gen | 2004 |
2 other studies available for modafinil and Pain, Postoperative
| Article | Year |
|---|---|
Anesthetic management of a patient with narcolepsy.
Topics: Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Anti-Inflammatory Agents, Non-Steroid | 2011 |
[Narcolepsy and anesthesia].
Topics: Analgesia, Epidural; Anesthesia, Intravenous; Antiemetics; Benzhydryl Compounds; Chemical and Drug I | 2007 |