modafinil has been researched along with Myotonic Dystrophy in 10 studies
Modafinil: A benzhydryl acetamide compound, central nervous system stimulant, and CYP3A4 inducing agent that is used in the treatment of NARCOLEPSY and SLEEP WAKE DISORDERS.
modafinil : A racemate comprising equimolar amounts of armodafinil and (S)-modafinil. A central nervous system stimulant, it is used for the treatment of sleeping disorders such as narcolepsy, obstructive sleep apnoea, and shift-work sleep disorder. The optical enantiomers of modafinil have similar pharmacological actions in animals.
2-[(diphenylmethyl)sulfinyl]acetamide : A sulfoxide that is dimethylsulfoxide in which two hydrogens attached to one of the methyl groups are replaced by phenyl groups, while one hydrogen attached to the other methyl group is replaced by a carbamoyl (aminocarbonyl) group.
Myotonic Dystrophy: Neuromuscular disorder characterized by PROGRESSIVE MUSCULAR ATROPHY; MYOTONIA, and various multisystem atrophies. Mild INTELLECTUAL DISABILITY may also occur. Abnormal TRINUCLEOTIDE REPEAT EXPANSION in the 3' UNTRANSLATED REGIONS of DMPK PROTEIN gene is associated with Myotonic Dystrophy 1. DNA REPEAT EXPANSION of zinc finger protein-9 gene intron is associated with Myotonic Dystrophy 2.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We performed a double-blind placebo-controlled crossover study in 13 patients with myotonic dystrophy to address the question whether modafinil, known to improve hypersomnolence in myotonic dystrophy, may improve levels of activity as well." | 9.12 | Does modafinil enhance activity of patients with myotonic dystrophy?: a double-blind placebo-controlled crossover study. ( Lammers, GJ; van Dijk, JG; Wintzen, AR, 2007) |
| "To evaluate the potential of modafinil in reducing excessive daytime somnolence (EDS) and enhancing indexes of quality of life and mood in patients with myotonic dystrophy (DM)." | 9.10 | Modafinil reduces excessive somnolence and enhances mood in patients with myotonic dystrophy. ( Hill, JD; MacDonald, JR; Tarnopolsky, MA, 2002) |
| "The authors conducted an open-label trial of modafinil for excessive daytime sleepiness in myotonic dystrophy." | 9.09 | Modafinil for excessive daytime sleepiness in myotonic dystrophy. ( Damian, MS; Gerlach , A; Lehmann , E; Reichmann, H; Schmidt, F, 2001) |
| "We report the beneficial and adverse effects of modafinil for daytime sleepiness in a 62-year-old female patient with myotonic dystrophy." | 7.76 | [An experience of administration of modafinil for excessive daytime sleepiness in a patient with myotonic dystorophy]. ( Kawai, M; Oya, Y; Suzuki, M, 2010) |
| "Treatment with modafinil showed a non-significant reduction in median Epworth Sleepiness Scale." | 6.71 | Reduction in excess daytime sleepiness by modafinil in patients with myotonic dystrophy. ( Crosby, J; Hilton-Jones, D; Stradling, J; Talbot, K, 2003) |
| "Excessive daytime sleepiness (EDS), of very similar pattern to that seen in narcolepsy syndrome, is extremely common in myotonic dystrophy type 1 (DM1)." | 5.38 | Modafinil for excessive daytime sleepiness in myotonic dystrophy type 1--the patients' perspective. ( Bowler, M; Hilton-Jones, D; Lochmueller, H; Longman, C; Petty, R; Roberts, M; Rogers, M; Turner, C; Wilcox, D, 2012) |
| "We performed a double-blind placebo-controlled crossover study in 13 patients with myotonic dystrophy to address the question whether modafinil, known to improve hypersomnolence in myotonic dystrophy, may improve levels of activity as well." | 5.12 | Does modafinil enhance activity of patients with myotonic dystrophy?: a double-blind placebo-controlled crossover study. ( Lammers, GJ; van Dijk, JG; Wintzen, AR, 2007) |
| "To evaluate the potential of modafinil in reducing excessive daytime somnolence (EDS) and enhancing indexes of quality of life and mood in patients with myotonic dystrophy (DM)." | 5.10 | Modafinil reduces excessive somnolence and enhances mood in patients with myotonic dystrophy. ( Hill, JD; MacDonald, JR; Tarnopolsky, MA, 2002) |
| "The authors conducted an open-label trial of modafinil for excessive daytime sleepiness in myotonic dystrophy." | 5.09 | Modafinil for excessive daytime sleepiness in myotonic dystrophy. ( Damian, MS; Gerlach , A; Lehmann , E; Reichmann, H; Schmidt, F, 2001) |
| " There is some evidence from two studies that modafinil may improve daytime sleepiness." | 4.83 | Psychostimulants for hypersomnia (excessive daytime sleepiness) in myotonic dystrophy. ( Annane, D; Barnes, PR; Miller, RG; Moore, DH, 2006) |
| " Treatment with continuous positive airway pressure (CPAP) for OSA, non-invasive ventilation (NIV) for respiratory failure, modafinil for excessive daytime sleepiness were commenced." | 3.83 | Sleepiness and Sleep-related Breathing Disorders in Myotonic Dystrophy and Responses to Treatment: A Prospective Cohort Study. ( Anderson, KN; Atalaia, A; Baudouin, SV; Hughes, J; Lochmüller, H; Marini-Bettolo, C; West, SD, 2016) |
| "We report the beneficial and adverse effects of modafinil for daytime sleepiness in a 62-year-old female patient with myotonic dystrophy." | 3.76 | [An experience of administration of modafinil for excessive daytime sleepiness in a patient with myotonic dystorophy]. ( Kawai, M; Oya, Y; Suzuki, M, 2010) |
| "Excessive daytime sleepiness (ie, hypersomnia) is a common complication of MMD1." | 2.74 | Modafinil for the treatment of hypersomnia associated with myotonic muscular dystrophy in adults: a multicenter, prospective, randomized, double-blind, placebo-controlled, 4-week trial. ( Annane, D; Chevret, S; Eymard, B; Laforêt, P; Lofaso, F; Orlikowski, D; Pouget, J; Quera-Salva, MA; Verschueren, A, 2009) |
| "Treatment with modafinil showed a non-significant reduction in median Epworth Sleepiness Scale." | 2.71 | Reduction in excess daytime sleepiness by modafinil in patients with myotonic dystrophy. ( Crosby, J; Hilton-Jones, D; Stradling, J; Talbot, K, 2003) |
| "Excessive daytime sleepiness (EDS), of very similar pattern to that seen in narcolepsy syndrome, is extremely common in myotonic dystrophy type 1 (DM1)." | 1.38 | Modafinil for excessive daytime sleepiness in myotonic dystrophy type 1--the patients' perspective. ( Bowler, M; Hilton-Jones, D; Lochmueller, H; Longman, C; Petty, R; Roberts, M; Rogers, M; Turner, C; Wilcox, D, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (60.00) | 29.6817 |
| 2010's | 4 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Laberge, L | 1 |
| Gagnon, C | 1 |
| Dauvilliers, Y | 1 |
| West, SD | 1 |
| Lochmüller, H | 1 |
| Hughes, J | 1 |
| Atalaia, A | 1 |
| Marini-Bettolo, C | 1 |
| Baudouin, SV | 1 |
| Anderson, KN | 1 |
| Orlikowski, D | 1 |
| Chevret, S | 1 |
| Quera-Salva, MA | 1 |
| Laforêt, P | 1 |
| Lofaso, F | 1 |
| Verschueren, A | 1 |
| Pouget, J | 1 |
| Eymard, B | 1 |
| Annane, D | 2 |
| Suzuki, M | 1 |
| Oya, Y | 1 |
| Kawai, M | 1 |
| Hilton-Jones, D | 2 |
| Bowler, M | 1 |
| Lochmueller, H | 1 |
| Longman, C | 1 |
| Petty, R | 1 |
| Roberts, M | 1 |
| Rogers, M | 1 |
| Turner, C | 1 |
| Wilcox, D | 1 |
| MacDonald, JR | 1 |
| Hill, JD | 1 |
| Tarnopolsky, MA | 1 |
| Talbot, K | 1 |
| Stradling, J | 1 |
| Crosby, J | 1 |
| Moore, DH | 1 |
| Barnes, PR | 1 |
| Miller, RG | 1 |
| Wintzen, AR | 1 |
| Lammers, GJ | 1 |
| van Dijk, JG | 1 |
| Damian, MS | 1 |
| Gerlach , A | 1 |
| Schmidt, F | 1 |
| Lehmann , E | 1 |
| Reichmann, H | 1 |
2 reviews available for modafinil and Myotonic Dystrophy
| Article | Year |
|---|---|
Daytime sleepiness and myotonic dystrophy.
Topics: Age of Onset; Alternative Splicing; Benzhydryl Compounds; Brain Chemistry; Brain Stem; Combined Moda | 2013 |
Psychostimulants for hypersomnia (excessive daytime sleepiness) in myotonic dystrophy.
Topics: Benzhydryl Compounds; Disorders of Excessive Somnolence; Humans; Modafinil; Monoamine Oxidase Inhibi | 2006 |
5 trials available for modafinil and Myotonic Dystrophy
| Article | Year |
|---|---|
Modafinil for the treatment of hypersomnia associated with myotonic muscular dystrophy in adults: a multicenter, prospective, randomized, double-blind, placebo-controlled, 4-week trial.
Topics: Adolescent; Adult; Aged; Benzhydryl Compounds; Central Nervous System Stimulants; Disorders of Exces | 2009 |
Modafinil reduces excessive somnolence and enhances mood in patients with myotonic dystrophy.
Topics: Activities of Daily Living; Adolescent; Adult; Affect; Benzhydryl Compounds; Central Nervous System | 2002 |
Reduction in excess daytime sleepiness by modafinil in patients with myotonic dystrophy.
Topics: Adult; Aged; Benzhydryl Compounds; Central Nervous System Stimulants; Cross-Over Studies; Disorders | 2003 |
Does modafinil enhance activity of patients with myotonic dystrophy?: a double-blind placebo-controlled crossover study.
Topics: Activities of Daily Living; Adult; Benzhydryl Compounds; Cross-Over Studies; Double-Blind Method; Fe | 2007 |
Modafinil for excessive daytime sleepiness in myotonic dystrophy.
Topics: Adult; Benzhydryl Compounds; Central Nervous System Stimulants; Female; Humans; Male; Middle Aged; M | 2001 |
3 other studies available for modafinil and Myotonic Dystrophy
| Article | Year |
|---|---|
Sleepiness and Sleep-related Breathing Disorders in Myotonic Dystrophy and Responses to Treatment: A Prospective Cohort Study.
Topics: Adolescent; Adult; Aged; Benzhydryl Compounds; Cohort Studies; Comorbidity; Continuous Positive Airw | 2016 |
[An experience of administration of modafinil for excessive daytime sleepiness in a patient with myotonic dystorophy].
Topics: Benzhydryl Compounds; Central Nervous System Stimulants; Disorders of Excessive Somnolence; Female; | 2010 |
Modafinil for excessive daytime sleepiness in myotonic dystrophy type 1--the patients' perspective.
Topics: Benzhydryl Compounds; Central Nervous System Stimulants; Disorders of Excessive Somnolence; Female; | 2012 |