modafinil has been researched along with Muscle Spasticity in 3 studies
Modafinil: A benzhydryl acetamide compound, central nervous system stimulant, and CYP3A4 inducing agent that is used in the treatment of NARCOLEPSY and SLEEP WAKE DISORDERS.
modafinil : A racemate comprising equimolar amounts of armodafinil and (S)-modafinil. A central nervous system stimulant, it is used for the treatment of sleeping disorders such as narcolepsy, obstructive sleep apnoea, and shift-work sleep disorder. The optical enantiomers of modafinil have similar pharmacological actions in animals.
2-[(diphenylmethyl)sulfinyl]acetamide : A sulfoxide that is dimethylsulfoxide in which two hydrogens attached to one of the methyl groups are replaced by phenyl groups, while one hydrogen attached to the other methyl group is replaced by a carbamoyl (aminocarbonyl) group.
Muscle Spasticity: A form of muscle hypertonia associated with upper MOTOR NEURON DISEASE. Resistance to passive stretch of a spastic muscle results in minimal initial resistance (a free interval) followed by an incremental increase in muscle tone. Tone increases in proportion to the velocity of stretch. Spasticity is usually accompanied by HYPERREFLEXIA and variable degrees of MUSCLE WEAKNESS. (From Adams et al., Principles of Neurology, 6th ed, p54)
| Excerpt | Relevance | Reference |
|---|---|---|
| "A retrospective review was undertaken at Texas Tech University Health Sciences Center regarding the use of modafinil for the treatment of spasticity associated with cerebral palsy." | 7.72 | Retrospective review of modafinil use for cerebral palsy. ( Dinakar, P; Hurst, DL; Lajara-Nanson, WA; Schiffer, RB, 2004) |
| "This randomized double blind AB/BA cross-over trial evaluates the effect of oral modafinil versus placebo on spasticity, function, and quality of life in children with cerebral palsy (CP)." | 5.13 | Impact of modafinil on spasticity reduction and quality of life in children with CP. ( Best, A; Campbell, KA; Fehlings, D; Milo-Manson, G; Murphy, AM, 2008) |
| "A retrospective review was undertaken at Texas Tech University Health Sciences Center regarding the use of modafinil for the treatment of spasticity associated with cerebral palsy." | 3.72 | Retrospective review of modafinil use for cerebral palsy. ( Dinakar, P; Hurst, DL; Lajara-Nanson, WA; Schiffer, RB, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Murphy, AM | 1 |
| Milo-Manson, G | 1 |
| Best, A | 1 |
| Campbell, KA | 1 |
| Fehlings, D | 1 |
| Garrison, MK | 1 |
| Yates, CC | 1 |
| Reese, NB | 1 |
| Skinner, RD | 1 |
| Garcia-Rill, E | 1 |
| Hurst, DL | 1 |
| Lajara-Nanson, WA | 1 |
| Dinakar, P | 1 |
| Schiffer, RB | 1 |
1 trial available for modafinil and Muscle Spasticity
| Article | Year |
|---|---|
Impact of modafinil on spasticity reduction and quality of life in children with CP.
Topics: Adolescent; Benzhydryl Compounds; Cerebral Palsy; Child; Double-Blind Method; Female; Humans; Male; | 2008 |
2 other studies available for modafinil and Muscle Spasticity
| Article | Year |
|---|---|
Wind-up of stretch reflexes as a measure of spasticity in chronic spinalized rats: The effects of passive exercise and modafinil.
Topics: Analysis of Variance; Animals; Benzhydryl Compounds; Chronic Disease; Disease Models, Animal; Electr | 2011 |
Retrospective review of modafinil use for cerebral palsy.
Topics: Benzhydryl Compounds; Central Nervous System Stimulants; Cerebral Palsy; Child; Humans; Modafinil; M | 2004 |