Page last updated: 2024-10-31

modafinil and Mood Disorders

modafinil has been researched along with Mood Disorders in 5 studies

Modafinil: A benzhydryl acetamide compound, central nervous system stimulant, and CYP3A4 inducing agent that is used in the treatment of NARCOLEPSY and SLEEP WAKE DISORDERS.
modafinil : A racemate comprising equimolar amounts of armodafinil and (S)-modafinil. A central nervous system stimulant, it is used for the treatment of sleeping disorders such as narcolepsy, obstructive sleep apnoea, and shift-work sleep disorder. The optical enantiomers of modafinil have similar pharmacological actions in animals.
2-[(diphenylmethyl)sulfinyl]acetamide : A sulfoxide that is dimethylsulfoxide in which two hydrogens attached to one of the methyl groups are replaced by phenyl groups, while one hydrogen attached to the other methyl group is replaced by a carbamoyl (aminocarbonyl) group.

Mood Disorders: Those disorders that have a disturbance in mood as their predominant feature.

Research Excerpts

ExcerptRelevanceReference
" Relative to baseline, patients reported lower fatigue severity (CIS) and better motivation (CIS) in both the modafinil (P = ."9.17The effect of modafinil on fatigue, cognitive functioning, and mood in primary brain tumor patients: a multicenter randomized controlled trial. ( Boele, FW; Cleijne, W; de Groot, M; Douw, L; Heimans, JJ; Klein, M; Reijneveld, JC; Taphoorn, MJ; van Thuijl, HF, 2013)
" Relative to baseline, patients reported lower fatigue severity (CIS) and better motivation (CIS) in both the modafinil (P = ."5.17The effect of modafinil on fatigue, cognitive functioning, and mood in primary brain tumor patients: a multicenter randomized controlled trial. ( Boele, FW; Cleijne, W; de Groot, M; Douw, L; Heimans, JJ; Klein, M; Reijneveld, JC; Taphoorn, MJ; van Thuijl, HF, 2013)
"Adult affective disorder patients, whether unipolar or bipolar, can use modafinil to relieve symptoms of depression, including fatigue and sleepiness, without risking a switch in their mood or developing tolerance or abuse of this medication."3.73Absence of mood switch with and tolerance to modafinil: a replication study from a large private practice. ( Nasr, S; Steiner, K; Wendt, B, 2006)
"Modafinil has proven to be effective in the treatment of residual symptoms of unipolar and bipolar depression such as fatigue, excessive sleepiness and some cognitive impairment."2.66The role of eugeroics in the treatment of affective disorders. ( Cubała, WJ; Urban, AE, 2020)
"Modafinil was the most common drug used as a first-line treatment (93%) and in combination therapy (70%)."1.48Effectiveness and side-effect profile of stimulant therapy as monotherapy and in combination in the central hypersomnias in clinical practice. ( D'ancona, G; Drakatos, P; Kent, BD; Leschziner, GD; Nesbitt, A; Patel, K; Rosenzweig, I; Selsick, H; Steier, J; Thakrar, C; Williams, AJ, 2018)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (40.00)29.6817
2010's2 (40.00)24.3611
2020's1 (20.00)2.80

Authors

AuthorsStudies
Urban, AE1
Cubała, WJ1
Thakrar, C1
Patel, K1
D'ancona, G1
Kent, BD1
Nesbitt, A1
Selsick, H1
Steier, J1
Rosenzweig, I1
Williams, AJ1
Leschziner, GD1
Drakatos, P1
Boele, FW1
Douw, L1
de Groot, M1
van Thuijl, HF1
Cleijne, W1
Heimans, JJ1
Taphoorn, MJ1
Reijneveld, JC1
Klein, M1
Russo, M1
Maher, C1
Campbell, W1
Nasr, S1
Wendt, B1
Steiner, K1

Reviews

1 review available for modafinil and Mood Disorders

ArticleYear
The role of eugeroics in the treatment of affective disorders.
    Psychiatria polska, 2020, Feb-29, Volume: 54, Issue:1

    Topics: Adult; Antidepressive Agents; Central Nervous System Stimulants; Depressive Disorder, Major; Evidenc

2020

Trials

1 trial available for modafinil and Mood Disorders

ArticleYear
The effect of modafinil on fatigue, cognitive functioning, and mood in primary brain tumor patients: a multicenter randomized controlled trial.
    Neuro-oncology, 2013, Volume: 15, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Benzhydryl Compounds; Brain Neoplasms; Cognition Disorders; Cross-Ov

2013

Other Studies

3 other studies available for modafinil and Mood Disorders

ArticleYear
Effectiveness and side-effect profile of stimulant therapy as monotherapy and in combination in the central hypersomnias in clinical practice.
    Journal of sleep research, 2018, Volume: 27, Issue:4

    Topics: Adult; Central Nervous System Stimulants; Drug Therapy, Combination; Female; Follow-Up Studies; Head

2018
Cosmetic neurology: the controversy over enhancing movement, mentation, and mood.
    Neurology, 2005, Apr-12, Volume: 64, Issue:7

    Topics: Benzhydryl Compounds; Central Nervous System Stimulants; Humans; Judgment; Military Medicine; Modafi

2005
Absence of mood switch with and tolerance to modafinil: a replication study from a large private practice.
    Journal of affective disorders, 2006, Volume: 95, Issue:1-3

    Topics: Adult; Aged; Aged, 80 and over; Benzhydryl Compounds; Central Nervous System Stimulants; Drug Tolera

2006