modafinil has been researched along with Mental Disorders in 7 studies
Modafinil: A benzhydryl acetamide compound, central nervous system stimulant, and CYP3A4 inducing agent that is used in the treatment of NARCOLEPSY and SLEEP WAKE DISORDERS.
modafinil : A racemate comprising equimolar amounts of armodafinil and (S)-modafinil. A central nervous system stimulant, it is used for the treatment of sleeping disorders such as narcolepsy, obstructive sleep apnoea, and shift-work sleep disorder. The optical enantiomers of modafinil have similar pharmacological actions in animals.
2-[(diphenylmethyl)sulfinyl]acetamide : A sulfoxide that is dimethylsulfoxide in which two hydrogens attached to one of the methyl groups are replaced by phenyl groups, while one hydrogen attached to the other methyl group is replaced by a carbamoyl (aminocarbonyl) group.
Mental Disorders: Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of thought, feeling, and behavior producing either distress or impairment of function.
| Excerpt | Relevance | Reference |
|---|---|---|
| "For more than two decades psychiatrists have known about and have promoted modafinil, a very promising stimulant that boosts wakefulness in cases of narcolepsy and also enhances cognitive functions." | 4.86 | [Modafinil in psychiatric disorders: the promising state reconsidered]. ( Docx, L; Dom, G; Joos, L; Sabbe, BG; Schmaal, L, 2010) |
| "Modafinil has a number of neurochemical actions in the brain, which may be related to primary effects on catecholaminergic systems." | 2.44 | Modafinil: a review of neurochemical actions and effects on cognition. ( Carter, CS; Minzenberg, MJ, 2008) |
| "Respondents who had reported a psychiatric diagnosis declared higher subjective benefits of modafinil." | 1.56 | The off-prescription use of modafinil: An online survey of perceived risks and benefits. ( Rycroft, N; Smith-Spark, JH; Teodorini, RD, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 5 (71.43) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Teodorini, RD | 1 |
| Rycroft, N | 1 |
| Smith-Spark, JH | 1 |
| Black, W | 1 |
| Hoey, P | 1 |
| Mayze, T | 1 |
| Ortega-Albás, JJ | 1 |
| López-Bernabé, R | 1 |
| Serrano, AL | 1 |
| Díaz, JR | 1 |
| Joos, L | 1 |
| Docx, L | 1 |
| Schmaal, L | 1 |
| Sabbe, BG | 1 |
| Dom, G | 1 |
| Ferraro, L | 1 |
| Antonelli, T | 1 |
| Beggiato, S | 1 |
| Cristina Tomasini, M | 1 |
| Fuxe, K | 1 |
| Tanganelli, S | 1 |
| Herdener, M | 1 |
| Oppliger, R | 1 |
| Stohler, R | 1 |
| Caflisch, C | 1 |
| Minzenberg, MJ | 1 |
| Carter, CS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Neurochemical Modulation Cognitive Performance and Subjective Wellbeing In Healthy Controls[NCT02051153] | 64 participants (Actual) | Interventional | 2009-10-31 | Completed | |||
| A Randomized, Double Blind, Placebo Controlled Evaluation of Modafinil vs Placebo for the Treatment of General Anesthesia Related Delayed Emergence in Patients With the Diagnosis of Obstructive Sleep Apnea[NCT02494102] | Phase 4 | 105 participants (Actual) | Interventional | 2016-02-29 | Terminated | ||
| Does Modafinil Have Pro-cognitive Effects in Those With Residual Cognitive Impairment Despite Remitted Depression?[NCT03620253] | Phase 3 | 9 participants (Actual) | Interventional | 2018-10-15 | Terminated (stopped due to Principal Investigator left study site) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Length of time of above compared between groups (NCT02494102)
Timeframe: 24 hours
| Intervention | minutes (Mean) |
|---|---|
| Placebo | 53.5 |
| Modafinil | 61.0 |
Postanesthesia quality recovery scale (PQRS). Component and aggregate scoring on the scale. Measures physiology, nociceptive, emotional activities of daily living cognitive and overall patient perspective. The scale is dimensionless and the aggregate of all individually tested dimensions is scaled from 17-65. A higher value implies improved postanesthesia recovery. Mean difference was assessed in each patient and aggregated thus patients with no difference between pre- and post-operative scores were zeroed (received a zero score if the difference was zero). A negative value was associated with worse outcome. (NCT02494102)
Timeframe: baseline and 6 hours after surgery
| Intervention | units on a scale (Mean) |
|---|---|
| Placebo | -5.67 |
| Modafinil | -8.91 |
4 reviews available for modafinil and Mental Disorders
| Article | Year |
|---|---|
[Modafinil in psychiatric disorders: the promising state reconsidered].
Topics: Attention Deficit Disorder with Hyperactivity; Benzhydryl Compounds; Central Nervous System Stimulan | 2010 |
The vigilance promoting drug modafinil modulates serotonin transmission in the rat prefrontal cortex and dorsal raphe nucleus. Possible relevance for its postulated antidepressant activity.
Topics: Animals; Antidepressive Agents; Benzhydryl Compounds; Disease Models, Animal; Dopamine; Humans; Ment | 2013 |
[Treating cocaine addiction].
Topics: Acetylcysteine; Alcohol Deterrents; Baclofen; Benzhydryl Compounds; Central Nervous System Stimulant | 2012 |
Modafinil: a review of neurochemical actions and effects on cognition.
Topics: Animals; Benzhydryl Compounds; Brain Chemistry; Cognition; Humans; Mental Disorders; Modafinil; Neur | 2008 |
Modafinil: a review of neurochemical actions and effects on cognition.
Topics: Animals; Benzhydryl Compounds; Brain Chemistry; Cognition; Humans; Mental Disorders; Modafinil; Neur | 2008 |
Modafinil: a review of neurochemical actions and effects on cognition.
Topics: Animals; Benzhydryl Compounds; Brain Chemistry; Cognition; Humans; Mental Disorders; Modafinil; Neur | 2008 |
Modafinil: a review of neurochemical actions and effects on cognition.
Topics: Animals; Benzhydryl Compounds; Brain Chemistry; Cognition; Humans; Mental Disorders; Modafinil; Neur | 2008 |
Modafinil: a review of neurochemical actions and effects on cognition.
Topics: Animals; Benzhydryl Compounds; Brain Chemistry; Cognition; Humans; Mental Disorders; Modafinil; Neur | 2008 |
Modafinil: a review of neurochemical actions and effects on cognition.
Topics: Animals; Benzhydryl Compounds; Brain Chemistry; Cognition; Humans; Mental Disorders; Modafinil; Neur | 2008 |
Modafinil: a review of neurochemical actions and effects on cognition.
Topics: Animals; Benzhydryl Compounds; Brain Chemistry; Cognition; Humans; Mental Disorders; Modafinil; Neur | 2008 |
Modafinil: a review of neurochemical actions and effects on cognition.
Topics: Animals; Benzhydryl Compounds; Brain Chemistry; Cognition; Humans; Mental Disorders; Modafinil; Neur | 2008 |
Modafinil: a review of neurochemical actions and effects on cognition.
Topics: Animals; Benzhydryl Compounds; Brain Chemistry; Cognition; Humans; Mental Disorders; Modafinil; Neur | 2008 |
3 other studies available for modafinil and Mental Disorders
| Article | Year |
|---|---|
The off-prescription use of modafinil: An online survey of perceived risks and benefits.
Topics: Adolescent; Adult; Aged; Dose-Response Relationship, Drug; Female; Humans; Internet; Male; Mental Di | 2020 |
Modafinil use in patients with a primary psychiatric illness.
Topics: Adult; Affect; Arousal; Benzhydryl Compounds; Bipolar Disorder; Brain Injury, Chronic; Central Nervo | 2010 |
Sodium oxybate and modafinil: a good combination?
Topics: Benzhydryl Compounds; Drug Interactions; Drug Therapy, Combination; Humans; Hypnotics and Sedatives; | 2010 |