modafinil has been researched along with MPTP Neurotoxicity Syndrome in 5 studies
Modafinil: A benzhydryl acetamide compound, central nervous system stimulant, and CYP3A4 inducing agent that is used in the treatment of NARCOLEPSY and SLEEP WAKE DISORDERS.
modafinil : A racemate comprising equimolar amounts of armodafinil and (S)-modafinil. A central nervous system stimulant, it is used for the treatment of sleeping disorders such as narcolepsy, obstructive sleep apnoea, and shift-work sleep disorder. The optical enantiomers of modafinil have similar pharmacological actions in animals.
2-[(diphenylmethyl)sulfinyl]acetamide : A sulfoxide that is dimethylsulfoxide in which two hydrogens attached to one of the methyl groups are replaced by phenyl groups, while one hydrogen attached to the other methyl group is replaced by a carbamoyl (aminocarbonyl) group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Modafinil treatment dose-dependently reduced the loss of specific [3H]-mazindol binding." | 1.31 | Antiparkinsonian and neuroprotective effects of modafinil in the mptp-treated common marmoset. ( Chancharme, L; Jenner, P; Moachon, G; Pearce, RK; Smith, LA; Tel, B; Zeng, BY, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zeng, BY | 2 |
| Smith, LA | 2 |
| Pearce, RK | 2 |
| Tel, B | 2 |
| Chancharme, L | 2 |
| Moachon, G | 2 |
| Jenner, P | 2 |
| Xiao, YL | 1 |
| Fu, JM | 1 |
| Dong, Z | 1 |
| Yang, JQ | 1 |
| Zeng, FX | 1 |
| Zhu, LX | 1 |
| He, BC | 1 |
| Aguirre, JA | 1 |
| Cintra, A | 1 |
| Hillion, J | 1 |
| Narváez, JA | 1 |
| Jansson, A | 1 |
| Antonelli, T | 1 |
| Ferraro, L | 1 |
| Rambert, FA | 1 |
| Fuxe, K | 2 |
| Janson, AM | 1 |
| Rosén, L | 1 |
| Finnman, UB | 1 |
| Tanganelli, S | 1 |
| Morari, M | 1 |
| Goldstein, M | 1 |
| Agnati, LF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized, Double-Blinded, Placebo Controlled Study of the Effects of Modafinil on Cognitive Function in Patients With Schizophrenia and Normal Controls Based on COMT Genotype[NCT00057707] | Phase 1 | 176 participants (Actual) | Interventional | 2003-03-26 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 other studies available for modafinil and MPTP Neurotoxicity Syndrome
| Article | Year |
|---|---|
Modafinil prevents the MPTP-induced increase in GABAA receptor binding in the internal globus pallidus of MPTP-treated common marmosets.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Benzhydryl Compounds; Callithrix; Dopamine Ag | 2004 |
Neuroprotective mechanism of modafinil on Parkinson disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Topics: Animals; Benzhydryl Compounds; Corpus Striatum; Dopamine; gamma-Aminobutyric Acid; Male; Mice; Mice, | 2004 |
A stereological study on the neuroprotective actions of acute modafinil treatment on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced nigral lesions of the male black mouse.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Benzhydryl Compounds; Dopamine; Male; Mice; M | 1999 |
Antiparkinsonian and neuroprotective effects of modafinil in the mptp-treated common marmoset.
Topics: Animals; Autoradiography; Behavior, Animal; Benzhydryl Compounds; Callithrix; Dopamine; Dopamine Upt | 2000 |
Evidence for a protective action of the vigilance promoting drug modafinil on the MPTP-induced degeneration of the nigrostriatal dopamine neurons in the black mouse: an immunocytochemical and biochemical analysis.
Topics: 3,4-Dihydroxyphenylacetic Acid; Anesthesia, General; Animals; Benzhydryl Compounds; Central Nervous | 1992 |