modafinil has been researched along with Lung Neoplasms in 4 studies
Modafinil: A benzhydryl acetamide compound, central nervous system stimulant, and CYP3A4 inducing agent that is used in the treatment of NARCOLEPSY and SLEEP WAKE DISORDERS.
modafinil : A racemate comprising equimolar amounts of armodafinil and (S)-modafinil. A central nervous system stimulant, it is used for the treatment of sleeping disorders such as narcolepsy, obstructive sleep apnoea, and shift-work sleep disorder. The optical enantiomers of modafinil have similar pharmacological actions in animals.
2-[(diphenylmethyl)sulfinyl]acetamide : A sulfoxide that is dimethylsulfoxide in which two hydrogens attached to one of the methyl groups are replaced by phenyl groups, while one hydrogen attached to the other methyl group is replaced by a carbamoyl (aminocarbonyl) group.
Lung Neoplasms: Tumors or cancer of the LUNG.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Modafinil had no effect on cancer-related fatigue and should not be prescribed outside a clinical trial setting." | 9.19 | Modafinil for the treatment of fatigue in lung cancer: results of a placebo-controlled, double-blind, randomized trial. ( Bahadori, R; Bates, N; Benepal, T; Blackhall, F; Dutton, S; Fife, K; O'Brien, M; Spathis, A; Stone, P; Wee, B; Wharton, R, 2014) |
| "Modafinil is a stimulant with a selective site of action in the brain that is better tolerated than traditional stimulants, such as methylphenidate." | 6.74 | Modafinil for the treatment of fatigue in lung cancer: a pilot study. ( Booden, D; Dhillan, R; Fife, K; Forbes, K; Spathis, A; Vrotsou, K, 2009) |
| "Modafinil had no effect on cancer-related fatigue and should not be prescribed outside a clinical trial setting." | 5.19 | Modafinil for the treatment of fatigue in lung cancer: results of a placebo-controlled, double-blind, randomized trial. ( Bahadori, R; Bates, N; Benepal, T; Blackhall, F; Dutton, S; Fife, K; O'Brien, M; Spathis, A; Stone, P; Wee, B; Wharton, R, 2014) |
| "Of 16 participants, ten completed the study; six participants, all in the expanded 100-mg cohort, discontinued because of adverse events during the modafinil lead-in dosing period." | 3.01 | The Effect of Modafinil on the Safety and Pharmacokinetics of Lorlatinib: A Phase I Study in Healthy Participants. ( Chen, J; Gong, J; LaBadie, RR; Li, J; Mfopou, JK; Pithavala, YK, 2021) |
| "Modafinil is a stimulant with a selective site of action in the brain that is better tolerated than traditional stimulants, such as methylphenidate." | 2.74 | Modafinil for the treatment of fatigue in lung cancer: a pilot study. ( Booden, D; Dhillan, R; Fife, K; Forbes, K; Spathis, A; Vrotsou, K, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, J | 1 |
| Pithavala, YK | 1 |
| Gong, J | 1 |
| LaBadie, RR | 1 |
| Mfopou, JK | 1 |
| Chen, J | 1 |
| Spathis, A | 2 |
| Fife, K | 2 |
| Blackhall, F | 1 |
| Dutton, S | 1 |
| Bahadori, R | 1 |
| Wharton, R | 1 |
| O'Brien, M | 1 |
| Stone, P | 1 |
| Benepal, T | 1 |
| Bates, N | 1 |
| Wee, B | 1 |
| Ruddy, KJ | 1 |
| Barton, D | 1 |
| Loprinzi, CL | 1 |
| Dhillan, R | 1 |
| Booden, D | 1 |
| Forbes, K | 1 |
| Vrotsou, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| PHASE 1, OPEN-LABEL, FIXED SEQUENCE, 2-PERIOD STUDY TO INVESTIGATE THE EFFECT OF MULTIPLE DOSES OF MODAFINIL ON THE PHARMACOKINETICS OF SINGLE DOSE LORLATINIB (PF-06463922) IN HEALTHY PARTICIPANTS[NCT03961997] | Phase 1 | 16 participants (Actual) | Interventional | 2019-08-22 | Completed | ||
| Modafinil for the Treatment of Fatigue in Lung Cancer: a Multicentre, Randomised, Double-blinded, Placebo-controlled Trial[NCT00829322] | Phase 4 | 208 participants (Actual) | Interventional | 2009-02-28 | Completed | ||
| Randomized Controlled Study to Evaluate the Effects of Modafinil in Cancer Related Fatigue in Patients Undergoing Radiation Therapy[NCT01440621] | Phase 3 | 217 participants (Actual) | Interventional | 2010-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for modafinil and Lung Neoplasms
| Article | Year |
|---|---|
The Effect of Modafinil on the Safety and Pharmacokinetics of Lorlatinib: A Phase I Study in Healthy Participants.
Topics: Aminopyridines; Area Under Curve; Carcinoma, Non-Small-Cell Lung; Drug Interactions; Healthy Volunte | 2021 |
Modafinil for the treatment of fatigue in lung cancer: results of a placebo-controlled, double-blind, randomized trial.
Topics: Aged; Aged, 80 and over; Benzhydryl Compounds; Carcinoma, Non-Small-Cell Lung; Central Nervous Syste | 2014 |
Modafinil for the treatment of fatigue in lung cancer: a pilot study.
Topics: Aged; Aged, 80 and over; Benzhydryl Compounds; Carcinoma, Non-Small-Cell Lung; Central Nervous Syste | 2009 |
1 other study available for modafinil and Lung Neoplasms
| Article | Year |
|---|---|
Laying to rest psychostimulants for cancer-related fatigue?
Topics: Benzhydryl Compounds; Carcinoma, Non-Small-Cell Lung; Central Nervous System Stimulants; Fatigue; Fe | 2014 |