Page last updated: 2024-10-31

modafinil and Lung Neoplasms

modafinil has been researched along with Lung Neoplasms in 4 studies

Modafinil: A benzhydryl acetamide compound, central nervous system stimulant, and CYP3A4 inducing agent that is used in the treatment of NARCOLEPSY and SLEEP WAKE DISORDERS.
modafinil : A racemate comprising equimolar amounts of armodafinil and (S)-modafinil. A central nervous system stimulant, it is used for the treatment of sleeping disorders such as narcolepsy, obstructive sleep apnoea, and shift-work sleep disorder. The optical enantiomers of modafinil have similar pharmacological actions in animals.
2-[(diphenylmethyl)sulfinyl]acetamide : A sulfoxide that is dimethylsulfoxide in which two hydrogens attached to one of the methyl groups are replaced by phenyl groups, while one hydrogen attached to the other methyl group is replaced by a carbamoyl (aminocarbonyl) group.

Lung Neoplasms: Tumors or cancer of the LUNG.

Research Excerpts

ExcerptRelevanceReference
"Modafinil had no effect on cancer-related fatigue and should not be prescribed outside a clinical trial setting."9.19Modafinil for the treatment of fatigue in lung cancer: results of a placebo-controlled, double-blind, randomized trial. ( Bahadori, R; Bates, N; Benepal, T; Blackhall, F; Dutton, S; Fife, K; O'Brien, M; Spathis, A; Stone, P; Wee, B; Wharton, R, 2014)
"Modafinil is a stimulant with a selective site of action in the brain that is better tolerated than traditional stimulants, such as methylphenidate."6.74Modafinil for the treatment of fatigue in lung cancer: a pilot study. ( Booden, D; Dhillan, R; Fife, K; Forbes, K; Spathis, A; Vrotsou, K, 2009)
"Modafinil had no effect on cancer-related fatigue and should not be prescribed outside a clinical trial setting."5.19Modafinil for the treatment of fatigue in lung cancer: results of a placebo-controlled, double-blind, randomized trial. ( Bahadori, R; Bates, N; Benepal, T; Blackhall, F; Dutton, S; Fife, K; O'Brien, M; Spathis, A; Stone, P; Wee, B; Wharton, R, 2014)
"Of 16 participants, ten completed the study; six participants, all in the expanded 100-mg cohort, discontinued because of adverse events during the modafinil lead-in dosing period."3.01The Effect of Modafinil on the Safety and Pharmacokinetics of Lorlatinib: A Phase I Study in Healthy Participants. ( Chen, J; Gong, J; LaBadie, RR; Li, J; Mfopou, JK; Pithavala, YK, 2021)
"Modafinil is a stimulant with a selective site of action in the brain that is better tolerated than traditional stimulants, such as methylphenidate."2.74Modafinil for the treatment of fatigue in lung cancer: a pilot study. ( Booden, D; Dhillan, R; Fife, K; Forbes, K; Spathis, A; Vrotsou, K, 2009)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (25.00)29.6817
2010's2 (50.00)24.3611
2020's1 (25.00)2.80

Authors

AuthorsStudies
Li, J1
Pithavala, YK1
Gong, J1
LaBadie, RR1
Mfopou, JK1
Chen, J1
Spathis, A2
Fife, K2
Blackhall, F1
Dutton, S1
Bahadori, R1
Wharton, R1
O'Brien, M1
Stone, P1
Benepal, T1
Bates, N1
Wee, B1
Ruddy, KJ1
Barton, D1
Loprinzi, CL1
Dhillan, R1
Booden, D1
Forbes, K1
Vrotsou, K1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
PHASE 1, OPEN-LABEL, FIXED SEQUENCE, 2-PERIOD STUDY TO INVESTIGATE THE EFFECT OF MULTIPLE DOSES OF MODAFINIL ON THE PHARMACOKINETICS OF SINGLE DOSE LORLATINIB (PF-06463922) IN HEALTHY PARTICIPANTS[NCT03961997]Phase 116 participants (Actual)Interventional2019-08-22Completed
Modafinil for the Treatment of Fatigue in Lung Cancer: a Multicentre, Randomised, Double-blinded, Placebo-controlled Trial[NCT00829322]Phase 4208 participants (Actual)Interventional2009-02-28Completed
Randomized Controlled Study to Evaluate the Effects of Modafinil in Cancer Related Fatigue in Patients Undergoing Radiation Therapy[NCT01440621]Phase 3217 participants (Actual)Interventional2010-08-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

3 trials available for modafinil and Lung Neoplasms

ArticleYear
The Effect of Modafinil on the Safety and Pharmacokinetics of Lorlatinib: A Phase I Study in Healthy Participants.
    Clinical pharmacokinetics, 2021, Volume: 60, Issue:10

    Topics: Aminopyridines; Area Under Curve; Carcinoma, Non-Small-Cell Lung; Drug Interactions; Healthy Volunte

2021
Modafinil for the treatment of fatigue in lung cancer: results of a placebo-controlled, double-blind, randomized trial.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014, Jun-20, Volume: 32, Issue:18

    Topics: Aged; Aged, 80 and over; Benzhydryl Compounds; Carcinoma, Non-Small-Cell Lung; Central Nervous Syste

2014
Modafinil for the treatment of fatigue in lung cancer: a pilot study.
    Palliative medicine, 2009, Volume: 23, Issue:4

    Topics: Aged; Aged, 80 and over; Benzhydryl Compounds; Carcinoma, Non-Small-Cell Lung; Central Nervous Syste

2009

Other Studies

1 other study available for modafinil and Lung Neoplasms

ArticleYear
Laying to rest psychostimulants for cancer-related fatigue?
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014, Jun-20, Volume: 32, Issue:18

    Topics: Benzhydryl Compounds; Carcinoma, Non-Small-Cell Lung; Central Nervous System Stimulants; Fatigue; Fe

2014