modafinil has been researched along with Lewy Body Disease in 3 studies
Modafinil: A benzhydryl acetamide compound, central nervous system stimulant, and CYP3A4 inducing agent that is used in the treatment of NARCOLEPSY and SLEEP WAKE DISORDERS.
modafinil : A racemate comprising equimolar amounts of armodafinil and (S)-modafinil. A central nervous system stimulant, it is used for the treatment of sleeping disorders such as narcolepsy, obstructive sleep apnoea, and shift-work sleep disorder. The optical enantiomers of modafinil have similar pharmacological actions in animals.
2-[(diphenylmethyl)sulfinyl]acetamide : A sulfoxide that is dimethylsulfoxide in which two hydrogens attached to one of the methyl groups are replaced by phenyl groups, while one hydrogen attached to the other methyl group is replaced by a carbamoyl (aminocarbonyl) group.
Lewy Body Disease: A neurodegenerative disease characterized by dementia, mild parkinsonism, and fluctuations in attention and alertness. The neuropsychiatric manifestations tend to precede the onset of bradykinesia, MUSCLE RIGIDITY, and other extrapyramidal signs. DELUSIONS and visual HALLUCINATIONS are relatively frequent in this condition. Histologic examination reveals LEWY BODIES in the CEREBRAL CORTEX and BRAIN STEM. SENILE PLAQUES and other pathologic features characteristic of ALZHEIMER DISEASE may also be present. (From Neurology 1997;48:376-380; Neurology 1996;47:1113-1124)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Modafinil is a wakefulness-promoting agent that is considered to have limited interaction with the dopaminergic system." | 2.48 | Agitation and psychosis associated with dementia with lewy bodies exacerbated by modafinil use. ( Apostolova, LG; Marrocos, R; Ngo, M; Paholpak, P; Porter, V; Prado, E; Ringman, JM, 2012) |
| " Tolerability was assessed by analysis of adverse events." | 1.46 | Efficacy, Safety, and Tolerability of Armodafinil Therapy for Hypersomnia Associated with Dementia with Lewy Bodies: A Pilot Study. ( Aakre, JA; Allen, LA; Boeve, BF; Drubach, DA; Kremers, W; Kuntz, KM; Lapid, MI; Lundt, ES; Mason, SS, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lapid, MI | 1 |
| Kuntz, KM | 1 |
| Mason, SS | 1 |
| Aakre, JA | 1 |
| Lundt, ES | 1 |
| Kremers, W | 1 |
| Allen, LA | 1 |
| Drubach, DA | 1 |
| Boeve, BF | 1 |
| Varanese, S | 1 |
| Perfetti, B | 1 |
| Gilbert-Wolf, R | 1 |
| Thomas, A | 1 |
| Onofrj, M | 1 |
| Di Rocco, A | 1 |
| Prado, E | 1 |
| Paholpak, P | 1 |
| Ngo, M | 1 |
| Porter, V | 1 |
| Apostolova, LG | 1 |
| Marrocos, R | 1 |
| Ringman, JM | 1 |
1 review available for modafinil and Lewy Body Disease
| Article | Year |
|---|---|
Agitation and psychosis associated with dementia with lewy bodies exacerbated by modafinil use.
Topics: Aged; Aged, 80 and over; Akathisia, Drug-Induced; Benzhydryl Compounds; Central Nervous System Stimu | 2012 |
2 other studies available for modafinil and Lewy Body Disease
| Article | Year |
|---|---|
Efficacy, Safety, and Tolerability of Armodafinil Therapy for Hypersomnia Associated with Dementia with Lewy Bodies: A Pilot Study.
Topics: Aged; Benzhydryl Compounds; Disorders of Excessive Somnolence; Drug Monitoring; Female; Humans; Lewy | 2017 |
Modafinil and armodafinil improve attention and global mental status in Lewy bodies disorders: preliminary evidence.
Topics: Aged; Attention; Benzhydryl Compounds; Brief Psychiatric Rating Scale; Female; Humans; Lewy Body Dis | 2013 |