Page last updated: 2024-10-31

modafinil and Inadequate Sleep

modafinil has been researched along with Inadequate Sleep in 85 studies

Modafinil: A benzhydryl acetamide compound, central nervous system stimulant, and CYP3A4 inducing agent that is used in the treatment of NARCOLEPSY and SLEEP WAKE DISORDERS.
modafinil : A racemate comprising equimolar amounts of armodafinil and (S)-modafinil. A central nervous system stimulant, it is used for the treatment of sleeping disorders such as narcolepsy, obstructive sleep apnoea, and shift-work sleep disorder. The optical enantiomers of modafinil have similar pharmacological actions in animals.
2-[(diphenylmethyl)sulfinyl]acetamide : A sulfoxide that is dimethylsulfoxide in which two hydrogens attached to one of the methyl groups are replaced by phenyl groups, while one hydrogen attached to the other methyl group is replaced by a carbamoyl (aminocarbonyl) group.

Research Excerpts

ExcerptRelevanceReference
"To evaluate the impact of modafinil on "free" and "cued" recall of clinical information in fatigued but nonsleep-deprived clinicians."9.22Structured cues or modafinil for fatigue amelioration in clinicians? A double-blind, randomized controlled trial of critical clinical information recall in fatigued clinicians. ( Darzi, A; Flindall, I; Goodship, J; Leff, DR; Sugden, C, 2016)
"The extent to which modafinil and caffeine reverse fatigue effects (defined as performance decrements with time on task) during total sleep deprivation was investigated."7.72Modafinil vs. caffeine: effects on fatigue during sleep deprivation. ( Balkin, TJ; Belenky, G; Kautz, MA; Thorne, DR; Wesensten, NJ, 2004)
"Modafinil can effectively reduced the subjective fatigue and sleepiness levels during SD."7.72[Effects of modafinil on visual and auditory reaction abilities and subjective fatigue level during 48 h sleep deprivation]. ( Li, T; Li, YF; Tang, GX; Wei, SH; Xin, YM; Zhan, H, 2003)
"To evaluate the impact of modafinil on "free" and "cued" recall of clinical information in fatigued but nonsleep-deprived clinicians."5.22Structured cues or modafinil for fatigue amelioration in clinicians? A double-blind, randomized controlled trial of critical clinical information recall in fatigued clinicians. ( Darzi, A; Flindall, I; Goodship, J; Leff, DR; Sugden, C, 2016)
"Modafinil is an alerting substance which has been used successfully to treat narcolepsy."5.08Effect of modafinil on plasma melatonin, cortisol and growth hormone rhythms, rectal temperature and performance in healthy subjects during a 36 h sleep deprivation. ( Bastuji, H; Boissy, I; Brun, J; Chamba, G; Claustrat, B; Girard, P; Khalfallah, Y; Sassolas, G, 1998)
" On the contrary, suppression of EEG delta power using a wake-promoting agent modafinil significantly attenuated mechanical allodynia."3.96High cortical delta power correlates with aggravated allodynia by activating anterior cingulate cortex GABAergic neurons in neuropathic pain mice. ( Ge, J; Hong, ZY; Huang, ZL; Lazarus, M; Li, YD; Luo, YJ; Qu, WM; Wang, J; Xu, W, 2020)
" Withdrawal of the narcolepsy treatment and initiation of haloperidol 1 mg/day (the only antipsychotic treatment she could tolerate) improved the delusions, hallucinations and dysphoria but worsened the narcolepsy symptoms."3.85Narcolepsy-cataplexy and psychosis: a case study. ( Arango-Lopez, C; Canellas-Dols, F; Delgado, C; Peraita-Adrados, R, 2017)
"Although modafinil did not sustain performance at predeprivation levels, the present study suggests that modafinil should be considered for the military's armament of short-term fatigue countermeasures."3.72Modafinil's effects on simulator performance and mood in pilots during 37 h without sleep. ( Brown, DL; Caldwell, JA; Caldwell, JL; Smith, JK, 2004)
"The extent to which modafinil and caffeine reverse fatigue effects (defined as performance decrements with time on task) during total sleep deprivation was investigated."3.72Modafinil vs. caffeine: effects on fatigue during sleep deprivation. ( Balkin, TJ; Belenky, G; Kautz, MA; Thorne, DR; Wesensten, NJ, 2004)
"Modafinil can effectively reduced the subjective fatigue and sleepiness levels during SD."3.72[Effects of modafinil on visual and auditory reaction abilities and subjective fatigue level during 48 h sleep deprivation]. ( Li, T; Li, YF; Tang, GX; Wei, SH; Xin, YM; Zhan, H, 2003)
"Compared with before sleep deprivation, the amplitudes of the event-related potentials (ERPs) increased in the N2 component and decreased in the P3 component after sleep deprivation in the placebo condition."3.11Modafinil ameliorates the decline in pronunciation-related working memory caused by 36-h acute total sleep deprivation: An ERP study. ( Dai, C; Lv, J; Peng, Z; Shao, Y; Song, T; Wang, L; Xu, L; Xu, M; Yang, X, 2022)
"Individual responses to the effects of inadequate sleep have been well documented; some people are more vulnerable to the effects of sleep loss than others."2.94Differential effects of modafinil on performance of low-performing and high-performing individuals during total sleep deprivation. ( Caldwell, JL; Kunkle, CL; Schroeder, VM; Stephenson, HG, 2020)
"Modafinil is an eugeroic drug that has been examined to maintain or recover wakefulness, alertness, and cognitive performance when sleep deprived."2.82A State-of-the-Art Review on the Use of Modafinil as A Performance-enhancing Drug in the Context of Military Operationality. ( Lacroix, E; Pattyn, N; Van Cutsem, J; Van Puyvelde, M, 2022)
"In a study of acute sleep deprivation in healthy male volunteers randomized to double-blind treatment with lisdexamfetamine dimesylate (20, 50, or 70 mg), placebo control, or an active control (armodafinil 250 mg), Maintenance of Wakefulness Test data were compared using a generalized estimating equation analysis to eliminate the need for unequivocal sleep latency imputation."2.79A generalized estimating equation approach to analysis of maintenance of wakefulness testing in a study of lisdexamfetamine dimesylate, armodafinil, and placebo in sleep-deprived adults. ( Donnelly, P; Ferreira-Cornwell, MC; Freeman, J; Gao, J; Gasior, M; Roth, T; Zammit, G, 2014)
"These effects of sleep deprivation are counteracted by the adenosine receptor antagonist caffeine, implying involvement of the adenosine neuromodulator/receptor system."2.77Polymorphisms of ADORA2A modulate psychomotor vigilance and the effects of caffeine on neurobehavioural performance and sleep EEG after sleep deprivation. ( Bachmann, V; Bodenmann, S; Deckert, J; Freitag, C; Hohoff, C; Landolt, HP; Rétey, JV, 2012)
"After placebo, sleep deprivation was associated with enhancements in delta and theta and reductions in alpha and beta activity."2.76Effect of a novel histamine subtype-3 receptor inverse agonist and modafinil on EEG power spectra during sleep deprivation and recovery sleep in male volunteers. ( Boyle, J; Calder, N; Cerchio, K; Dijk, DJ; Gottesdiener, K; Hargreaves, R; Iannone, R; James, LM; Murphy, MG; Palcza, J; Renger, JJ, 2011)
"Treatment with modafinil significantly attenuated the performance decrements seen for several parameters including cognitive-psychomotor speed, visual attention and reaction times both with progressive hours awake and when working at adverse circadian phases."2.75Effect of modafinil on impairments in neurobehavioral performance and learning associated with extended wakefulness and circadian misalignment. ( Aeschbach, D; Czeisler, CA; Grady, S; Wright, KP, 2010)
"Modafinil treatment reduced lane deviation but had less effect on speed deviation, off-road incidents and reaction time to a concurrent task."2.73Effects of modafinil on simulator driving and self-assessment of driving following sleep deprivation. ( Broadbear, JH; Gurtman, CG; Redman, JR, 2008)
"Following 47 h of sleep deprivation, the study examined the effect of three stimulant medications (modafinil 400 mg, dextroamphetamine 20 mg, caffeine 600 mg) or placebo on the ability of 54 healthy participants to discriminate and label simple emotional expressions versus complex affect blends (created by morphing photographs of two different affective facial expressions)."2.73The effects of modafinil, caffeine, and dextroamphetamine on judgments of simple versus complex emotional expressions following sleep deprivation. ( Grugle, NL; Huck, NO; Kendall, AP; Killgore, WD; McBride, SA, 2008)
"Armodafinil doses were well tolerated, with the most common adverse events including abdominal pain, nausea, and headache."2.72Pharmacodynamic effects on alertness of single doses of armodafinil in healthy subjects during a nocturnal period of acute sleep loss. ( Arora, S; Darwish, M; Dinges, DF; Niebler, GE, 2006)
"Modafinil is a selective wakefulness-promoting agent that has been shown to enhance cognitive performance under conditions of sleep deprivation but which has equivocal effects in normal young volunteers."2.71The cognitive-enhancing properties of modafinil are limited in non-sleep-deprived middle-aged volunteers. ( File, SE; Fleck, NL; Randall, DC; Shneerson, JM, 2004)
"Modafinil was without effect in several tests of reaction time and attention, but the 200-mg group was faster at simple color naming of dots and performed better than placebo in the Rapid Visual Information Processing test of sustained attention."2.71Does modafinil enhance cognitive performance in young volunteers who are not sleep-deprived? ( Bharania, P; Elsabagh, SM; File, SE; Hartley, DE; Randall, DC; Shneerson, JM; Viswanath, A, 2005)
"We studied the circadian rhythm of rectal temperature (CRTre) during 62 h of SD alone or with three dosage levels of modafinil."2.70Circadian rhythm of rectal temperature during sleep deprivation with modafinil. ( Besnard, Y; Bittel, J; Guinet, A; Lallement, G; Launay, JC; Savourey, G, 2002)
"The occurrence of chronic sleep deprivation in the population is commonplace."2.43Sleep deprivation. ( Kaplan, J; Malik, SW, 2005)
"Modafinil also impairs post-sleep deprivation recovery sleep, but from the few studies available addressing this issue, it is unclear whether these sleep impairments translate into post-sleep performance impairments."2.43Effects of modafinil on cognitive performance and alertness during sleep deprivation. ( Wesensten, NJ, 2006)
"Armodafinil is a wake-promoting agent against sleep deprivation related disorders."1.62Application of armodafinil-loaded microneedle patches against the negative influence induced by sleep deprivation. ( Du, L; Jin, Y; Li, Q; Ou, G; Wang, L; Yu, X; Zhang, S; Zhang, Y; Zhu, L; Zhu, S; Zhuang, X, 2021)
"In the PLACEBO condition, the sleep deprivation induced an increase and a decrease in posterior delta (2-4 Hz) and alpha (8-13 Hz) source activities, respectively."1.51Sleep deprivation and Modafinil affect cortical sources of resting state electroencephalographic rhythms in healthy young adults. ( Babiloni, C; Bartrés-Faz, D; Blin, O; Bordet, R; Bourriez, JL; Casse-Perrot, C; Chauveau, N; Del Percio, C; Deplanque, D; Derambure, P; Dukart, J; Ferri, R; Lanteaume, L; Lizio, R; Méligne, D; Noce, G; Pascarelli, MT; Payoux, P; Richardson, JC; Thalamas, C, 2019)
"The consequences of chronic insufficient sleep for health remain uncertain."1.46Decreased alertness due to sleep loss increases pain sensitivity in mice. ( Alexandre, C; Ferreira, A; Latremoliere, A; Miracca, G; Scammell, TE; Woolf, CJ; Yamamoto, M, 2017)
"Caffeine treatment prevented the SD induced down-regulation of synaptophysin and synapsin I proteins with no change in PSD-95 protein in hippocampus."1.42Caffeine and modafinil given during 48 h sleep deprivation modulate object recognition memory and synaptic proteins in the hippocampus of the rat. ( Kauser, H; Kumari, P; Panjwani, U; Ray, K; Sahu, S; Wadhwa, M, 2015)
"Sleep deprivation is known to be a stressor, affecting multiple body functions such as the cognition."1.39Modafinil ameliorates cognitive deficits induced by maternal separation and sleep deprivation. ( Alvarenga, T; Andersen, ML; Garcia, VA; Hirotsu, C; Kapczinski, F; Matos, G; Pires, GN; Schröder, N; Tufik, S, 2013)
"Caffeine treatment during SD, significantly increased early proliferative and post-mitotic stages of doublecortin (DCX) positive cells while modafinil treatment during SD, increased intermediate and post-mitotic stages of DCX positive cells compared to SD+Vehicle group."1.39Caffeine and modafinil promote adult neuronal cell proliferation during 48 h of total sleep deprivation in rat dentate gyrus. ( Kauser, H; Kishore, K; Kumar, S; Panjwani, U; Ray, K; Sahu, S, 2013)
"Modafinil is a wake-promoting drug and has been approved for the treatment of excessive daytime sleepiness in narcolepsy and obstructive sleep apnea."1.39Differential effects of modafinil on memory in naïve and memory-impaired rats. ( Busato, SB; D'avila Portal, BC; Garcia, VA; Piazza, FC; Schröder, N; Souza de Freitas, B, 2013)
"Previous work showed that sleep deprivation (SD) impairs hippocampal-dependent cognitive function and synaptic plasticity, and a novel wake-promoting agent modafinil prevents SD-induced memory impairment in rat."1.37Modafinil treatment prevents REM sleep deprivation-induced brain function impairment by increasing MMP-9 expression. ( He, B; Peng, H; Zhao, Y; Zhao, Z; Zhou, H, 2011)
"We showed that a 10-hr total sleep deprivation impaired the CSD task but not the SSD one."1.37Differential effects of total sleep deprivation on contextual and spatial memory: modulatory effects of modafinil. ( Beracochea, D; Chauveau, F; Corio, M; Coutan, M; Krazem, A; Liscia, P; Pierard, C, 2011)
"Wakefulness was maintained by "gentle sleep deprivation" method (GSD) or by administration of the wakefulness-promoting drug modafinil (MOD) (200 mg/kg i."1.36Metabolic response of the cerebral cortex following gentle sleep deprivation and modafinil administration. ( Borbély, AA; Kopp, C; Magistretti, PJ; Morgenthaler, F; Petit, JM; Tobler, I, 2010)
"The effects of sleep deprivation are a burden in our 24-h society."1.35Efficacy of caffeine and modafinil in counteracting sleep deprivation in the marmoset monkey. ( Jongsma, MJ; Olivier, B; Philippens, IH; van Vliet, SA; Vanwersch, RA, 2008)
"For this purpose, an original sleep deprivation apparatus was developed and validated with continuous electroencephalography recording."1.34Modafinil restores memory performance and neural activity impaired by sleep deprivation in mice. ( Béracochéa, D; Chauveau, F; Drouet, I; Jouanin, JC; Lafon, T; Liscia, P; Mons, N; Philippin, JN; Piérard, C; Serra, A; Van Beers, P, 2007)
"Modafinil is a wakefulness-promoting substance whose profile differs from that of the classical psychostimulants."1.31Comparison of the effects of modafinil and sleep deprivation on sleep and cortical EEG spectra in mice. ( Borbély, AA; Kopp, C; Magistretti, P; Petit, JM; Tobler, I, 2002)
"Modafinil is a newly discovered waking substance now being used in the treatment of hypersomnia and narcolepsy."1.31Effects of amphetamine and modafinil on the sleep/wake cycle during experimental hypersomnia induced by sleep deprivation in the cat. ( Frydman, A; Gervasoni, D; Hou, Y; Jouvet, M; Lin, JS; Rambert, F; Vanni-Mercier, G, 2000)
"Modafinil treatment did not significantly modify the brain cortex content of any of the amino acids tested."1.29Paradoxical sleep deprivation increases the content of glutamate and glutamine in rat cerebral cortex. ( Bettendorff, L; Margineanu, I; Sallanon-Moulin, M; Schoffeniels, E; Touret, M; Wins, P, 1996)

Research

Studies (85)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (7.06)18.2507
2000's37 (43.53)29.6817
2010's33 (38.82)24.3611
2020's9 (10.59)2.80

Authors

AuthorsStudies
Van Puyvelde, M1
Van Cutsem, J1
Lacroix, E1
Pattyn, N1
Zhu, L1
Zhang, S1
Yu, X2
Zhu, S1
Ou, G1
Li, Q3
Zhang, Y1
Wang, L2
Zhuang, X1
Du, L1
Jin, Y1
Xu, L1
Yang, X1
Peng, Z1
Song, T1
Dai, C1
Xu, M1
Shao, Y1
Lv, J1
Wingelaar-Jagt, YQ2
Bottenheft, C2
Riedel, WJ2
Ramaekers, JG2
Puech, C1
Badran, M1
Barrow, MB1
Runion, AR1
Gozal, D1
Sauvet, F1
Erblang, M1
Gomez-Merino, D1
Rabat, A1
Guillard, M1
Dubourdieu, D1
Lefloch, H1
Drogou, C1
Van Beers, P3
Bougard, C1
Bourrrilhon, C1
Arnal, P1
Rein, W1
Mouthon, F1
Brunner-Ferber, F1
Leger, D1
Dauvilliers, Y1
Chennaoui, M1
Charvériat, M1
Li, YD1
Ge, J1
Luo, YJ1
Xu, W1
Wang, J1
Lazarus, M1
Hong, ZY1
Qu, WM1
Huang, ZL1
Caldwell, JL2
Schroeder, VM1
Kunkle, CL1
Stephenson, HG1
Sholtes, D1
Kravitz, HM1
Deka, A1
Westrick, J1
Fogg, LF1
Gottlieb, M1
Ehlert, AM1
Wilson, PB1
Alexandre, C1
Latremoliere, A1
Ferreira, A1
Miracca, G1
Yamamoto, M1
Scammell, TE1
Woolf, CJ1
Canellas-Dols, F1
Delgado, C1
Arango-Lopez, C1
Peraita-Adrados, R1
Ma, Y1
Harding, EC1
Yustos, R1
Vyssotski, AL1
Franks, NP1
Wisden, W1
Cao, Y1
Liu, L1
Wu, H1
Huang, F1
Wang, C1
Lan, Y1
Zheng, F1
Xing, F1
Zhou, Q1
Shi, H1
Zhang, B1
Wang, Z1
Wu, X1
Del Percio, C1
Derambure, P1
Noce, G1
Lizio, R1
Bartrés-Faz, D1
Blin, O1
Payoux, P1
Deplanque, D1
Méligne, D1
Chauveau, N1
Bourriez, JL1
Casse-Perrot, C1
Lanteaume, L1
Thalamas, C1
Dukart, J1
Ferri, R1
Pascarelli, MT1
Richardson, JC1
Bordet, R1
Babiloni, C1
Garcia, VA2
Hirotsu, C1
Matos, G1
Alvarenga, T1
Pires, GN1
Kapczinski, F1
Schröder, N2
Tufik, S3
Andersen, ML2
Conrado, DJ1
Bewernitz, M1
Ding, M1
Cibula, J1
Seubert, C1
Sy, SK1
Eisenschenk, S1
Derendorf, H1
Sahu, S3
Kauser, H2
Ray, K3
Kishore, K1
Kumar, S2
Panjwani, U3
Souza de Freitas, B1
Busato, SB1
D'avila Portal, BC1
Piazza, FC1
Barsevick, AM1
Irwin, MR1
Hinds, P1
Miller, A1
Berger, A1
Jacobsen, P1
Ancoli-Israel, S1
Reeve, BB1
Mustian, K1
O'Mara, A1
Lai, JS1
Fisch, M1
Cella, D1
Gasior, M2
Freeman, J2
Zammit, G2
Donnelly, P2
Gao, J2
Ferreira-Cornwell, MC2
Roth, T2
Loomis, S1
McCarthy, A1
Baxter, C1
Kellett, DO1
Edgar, DM1
Tricklebank, M1
Gilmour, G1
Wadhwa, M1
Kumari, P1
Flindall, I1
Leff, DR1
Goodship, J1
Sugden, C2
Darzi, A2
Parker, RS1
Parker, P1
Killgore, WD8
Rupp, TL1
Grugle, NL6
Reichardt, RM2
Lipizzi, EL1
Balkin, TJ10
Ramsey, CS1
Werchan, PM1
Isdahl, WM1
Fischer, J1
Gibbons, JA1
Killgore, DB5
Leavitt, BP1
Watlington, GI1
McNair, S1
Muckle, AE1
Bodenmann, S3
Xu, S1
Luhmann, UF1
Arand, M1
Berger, W1
Jung, HH1
Landolt, HP3
Gurtman, CG1
Broadbear, JH1
Redman, JR1
Kahn-Greene, ET1
Beck, J1
Hemmeter, U1
Brand, S1
Muheim, F1
Hatzinger, M1
Holsboer-Trachsler, E1
Grady, S1
Aeschbach, D1
Wright, KP1
Czeisler, CA1
Buxton, OM1
Pavlova, M1
Reid, EW1
Wang, W1
Simonson, DC1
Adler, GK1
Petit, JM2
Tobler, I2
Kopp, C2
Morgenthaler, F1
Borbély, AA2
Magistretti, PJ1
Moreira, KM1
Ferreira, TL1
Hipolide, DC1
Fornari, RV1
Oliveira, MG1
Liu, YP2
Tung, CS2
Lin, YL1
Chuang, CH2
Pierard, C2
Liscia, P2
Chauveau, F2
Coutan, M1
Corio, M1
Krazem, A1
Beracochea, D2
Lo, SM1
Ku, YC1
James, LM1
Iannone, R1
Palcza, J1
Renger, JJ1
Calder, N1
Cerchio, K1
Gottesdiener, K1
Hargreaves, R1
Murphy, MG1
Boyle, J1
Dijk, DJ1
Arias-Carrión, O1
Palomero-Rivero, M1
Millán-Aldaco, D1
Haro, R1
Drucker-Colín, R1
Murillo-Rodríguez, E1
Hohoff, C1
Freitag, C1
Deckert, J1
Rétey, JV1
Bachmann, V1
Housden, CR1
Aggarwal, R1
Sahakian, BJ1
He, B1
Peng, H1
Zhao, Y1
Zhou, H1
Zhao, Z1
Chatterjee, A1
Ghosh, S1
Thakur, L1
Anand, JP1
Magistretti, P1
Launay, JC1
Savourey, G1
Guinet, A1
Lallement, G1
Besnard, Y1
Bittel, J1
McLellan, TM1
Ducharme, MB1
Canini, F1
Moroz, D1
Bell, DG1
Baranski, JV2
Gil, V1
Buguet, A1
Radomski, MW1
Ponomarenko, AA1
Lin, JS3
Selbach, O1
Haas, HL1
Li, YF1
Zhan, H1
Xin, YM1
Tang, GX1
Wei, SH1
Li, T1
Randall, DC2
Fleck, NL1
Shneerson, JM2
File, SE2
Wesensten, NJ5
Belenky, G2
Thorne, DR2
Kautz, MA2
Caldwell, JA1
Smith, JK1
Brown, DL1
Viswanath, A1
Bharania, P1
Elsabagh, SM1
Hartley, DE1
Russo, M1
Maher, C1
Campbell, W1
Malik, SW1
Kaplan, J1
Giles, J1
Bonnet, MH1
Dinges, DF2
Roehrs, T1
Rogers, NL1
Even, C1
Thuile, J1
Santos, J1
Bourgin, P1
Arora, S1
Darwish, M1
Niebler, GE1
McBride, SA2
Thomas, RJ1
Kwong, K1
Eliyahu, U1
Berlin, S1
Hadad, E1
Heled, Y1
Moran, DS1
Philippin, JN1
Mons, N1
Lafon, T1
Drouet, I1
Serra, A1
Jouanin, JC1
van Vliet, SA1
Jongsma, MJ1
Vanwersch, RA1
Olivier, B1
Philippens, IH1
Tononi, G1
Cirelli, C1
Rao, Y1
Liu, ZW1
Borok, E1
Rabenstein, RL1
Shanabrough, M1
Lu, M1
Picciotto, MR1
Horvath, TL1
Gao, XB1
Soya, A1
Song, YH1
Kodama, T1
Honda, Y1
Fujiki, N1
Nishino, S1
Martins, RC1
Shih, MC1
Plante, DT1
Huck, NO1
Kendall, AP1
Lagarde, D1
Batejat, D1
Sarafian, D1
Pradella, S1
Bettendorff, L1
Sallanon-Moulin, M1
Touret, M1
Wins, P1
Margineanu, I1
Schoffeniels, E1
Pigeau, RA1
Brun, J1
Chamba, G1
Khalfallah, Y1
Girard, P1
Boissy, I1
Bastuji, H1
Sassolas, G1
Claustrat, B1
Batéjat, DM1
Lagarde, DP1
Gervasoni, D1
Hou, Y1
Vanni-Mercier, G1
Rambert, F1
Frydman, A1
Jouvet, M1
Hou, YP1

Clinical Trials (11)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Therapeutic Impact of THN102 on Attention, Wakefulness and Cognitive Performance During Total Sleep Deprivation in Healthy Subjects[NCT03182413]Phase 120 participants (Actual)Interventional2015-09-30Completed
Feasibility Study of a Hypnosis Intervention and a Cognitive Behavioral Therapy Intervention to Reduce Fatigue in Patients Undergoing Chemotherapy for Metastatic Colorectal Cancer[NCT04999306]60 participants (Anticipated)Interventional2023-05-17Recruiting
Effect of Resistance Training Variable Manipulation (Intensity and Volume) on Body Composition, Fatigability and Functional Capacity in Postmenopausal Breast Cancer Survivors.[NCT03644329]80 participants (Anticipated)Interventional2018-05-13Recruiting
A Head-to-Head Comparison of the 2B-Alert Caffeine Optimization Algorithm Versus Standard Caffeine Dosing on Performance During Sleep Deprivation (2B-2)[NCT05588934]180 participants (Anticipated)Interventional2023-02-28Not yet recruiting
Impact of Sleep Restriction on Cardiometabolic Risk Factors in Pre vs Postmenopausal Women[NCT02835261]54 participants (Actual)Interventional2016-09-01Completed
Sleep Restriction, Impaired Glucose Metabolism, and Performance: The Effects of Modafinil to Counteract the Adverse Metabolic Consequences of Sleep Restriction[NCT00895570]20 participants (Actual)Interventional2005-01-31Completed
The SLuMBER Study: The Sleep Lengthening and Metabolic Health, Body Composition, Energy Balance and Cardiovascular Risk Study[NCT02787577]43 participants (Actual)Interventional2016-04-30Completed
Sleep for Health: A Randomized Clinical Trial Examining the Effects of Cognitive Behavioral Therapy for Insomnia on Diabetes Risk[NCT06067139]300 participants (Anticipated)Interventional2023-08-01Recruiting
Sleep Duration and Glycemic Control in Adolescents With Type 2 Diabetes Mellitus[NCT04213547]31 participants (Actual)Interventional2020-09-16Active, not recruiting
The Effect of Caffeine on the Narcoleptic Patients Randomized Controlled Clinical Trial[NCT02832336]Phase 1/Phase 216 participants (Actual)Interventional2016-10-01Completed
Neurochemical Modulation Cognitive Performance and Subjective Wellbeing In Healthy Controls[NCT02051153]64 participants (Actual)Interventional2009-10-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

7 reviews available for modafinil and Inadequate Sleep

ArticleYear
A State-of-the-Art Review on the Use of Modafinil as A Performance-enhancing Drug in the Context of Military Operationality.
    Military medicine, 2022, 01-04, Volume: 187, Issue:1-2

    Topics: Benzhydryl Compounds; Central Nervous System Stimulants; Cognition; Double-Blind Method; Humans; Mil

2022
Optimising sleep and performance during night float: A systematic review of evidence and implications for graduate medical education trainees.
    Journal of sleep research, 2021, Volume: 30, Issue:4

    Topics: Adaptation, Physiological; Attention; Caffeine; Education, Medical, Graduate; Energy Drinks; Fatigue

2021
Stimulant Use as a Fatigue Countermeasure in Aviation.
    Aerospace medicine and human performance, 2021, Mar-01, Volume: 92, Issue:3

    Topics: Aerospace Medicine; Aviation; Central Nervous System Stimulants; Fatigue; Humans; Modafinil; Sleep D

2021
The impact of sleep deprivation in military surgical teams: a systematic review.
    Journal of the Royal Army Medical Corps, 2017, Volume: 163, Issue:3

    Topics: Benzhydryl Compounds; Clinical Competence; Cognition; Fatigue; Health Personnel; Humans; Military Me

2017
Sleep deprivation.
    Primary care, 2005, Volume: 32, Issue:2

    Topics: Benzhydryl Compounds; Caffeine; Disorders of Excessive Somnolence; Humans; Modafinil; Primary Health

2005
The use of stimulants to modify performance during sleep loss: a review by the sleep deprivation and Stimulant Task Force of the American Academy of Sleep Medicine.
    Sleep, 2005, Volume: 28, Issue:9

    Topics: Benzhydryl Compounds; Caffeine; Central Nervous System Stimulants; Humans; Methamphetamine; Modafini

2005
Effects of modafinil on cognitive performance and alertness during sleep deprivation.
    Current pharmaceutical design, 2006, Volume: 12, Issue:20

    Topics: Arousal; Benzhydryl Compounds; Central Nervous System Stimulants; Cognition; Dose-Response Relations

2006

Trials

34 trials available for modafinil and Inadequate Sleep

ArticleYear
Modafinil ameliorates the decline in pronunciation-related working memory caused by 36-h acute total sleep deprivation: An ERP study.
    Neurobiology of learning and memory, 2022, Volume: 192

    Topics: Benzhydryl Compounds; Caffeine; Central Nervous System Stimulants; Humans; Male; Memory, Short-Term;

2022
Effects of modafinil and caffeine on night-time vigilance of air force crewmembers: A randomized controlled trial.
    Journal of psychopharmacology (Oxford, England), 2023, Volume: 37, Issue:2

    Topics: Benzhydryl Compounds; Caffeine; Central Nervous System Stimulants; Double-Blind Method; Fatigue; Hum

2023
Effects of modafinil and caffeine on night-time vigilance of air force crewmembers: A randomized controlled trial.
    Journal of psychopharmacology (Oxford, England), 2023, Volume: 37, Issue:2

    Topics: Benzhydryl Compounds; Caffeine; Central Nervous System Stimulants; Double-Blind Method; Fatigue; Hum

2023
Effects of modafinil and caffeine on night-time vigilance of air force crewmembers: A randomized controlled trial.
    Journal of psychopharmacology (Oxford, England), 2023, Volume: 37, Issue:2

    Topics: Benzhydryl Compounds; Caffeine; Central Nervous System Stimulants; Double-Blind Method; Fatigue; Hum

2023
Effects of modafinil and caffeine on night-time vigilance of air force crewmembers: A randomized controlled trial.
    Journal of psychopharmacology (Oxford, England), 2023, Volume: 37, Issue:2

    Topics: Benzhydryl Compounds; Caffeine; Central Nervous System Stimulants; Double-Blind Method; Fatigue; Hum

2023
Efficacy of THN102 (a combination of modafinil and flecainide) on vigilance and cognition during 40-hour total sleep deprivation in healthy subjects: Glial connexins as a therapeutic target.
    British journal of clinical pharmacology, 2019, Volume: 85, Issue:11

    Topics: Adult; Arousal; Cognition; Connexins; Cross-Over Studies; Drug Combinations; Flecainide; Healthy Vol

2019
Differential effects of modafinil on performance of low-performing and high-performing individuals during total sleep deprivation.
    Pharmacology, biochemistry, and behavior, 2020, Volume: 196

    Topics: Adult; Double-Blind Method; Humans; Male; Modafinil; Placebos; Psychomotor Performance; Reaction Tim

2020
Electroencephalogram effects of armodafinil: comparison with behavioral alertness.
    Journal of clinical pharmacology, 2013, Volume: 53, Issue:10

    Topics: Adult; Behavior; Benzhydryl Compounds; Cross-Over Studies; Double-Blind Method; Electroencephalograp

2013
Maintenance of wakefulness with lisdexamfetamine dimesylate, compared with placebo and armodafinil in healthy adult males undergoing acute sleep loss.
    Journal of clinical psychopharmacology, 2014, Volume: 34, Issue:6

    Topics: Administration, Oral; Adult; Benzhydryl Compounds; Dextroamphetamine; Double-Blind Method; Health St

2014
A generalized estimating equation approach to analysis of maintenance of wakefulness testing in a study of lisdexamfetamine dimesylate, armodafinil, and placebo in sleep-deprived adults.
    Journal of clinical psychopharmacology, 2014, Volume: 34, Issue:5

    Topics: Adolescent; Adult; Benzhydryl Compounds; Central Nervous System Stimulants; Double-Blind Method; Hea

2014
Structured cues or modafinil for fatigue amelioration in clinicians? A double-blind, randomized controlled trial of critical clinical information recall in fatigued clinicians.
    Surgery, 2016, Volume: 159, Issue:4

    Topics: Adolescent; Adult; Benzhydryl Compounds; Cues; Double-Blind Method; Drug Administration Schedule; Fa

2016
Effects of dextroamphetamine, caffeine and modafinil on psychomotor vigilance test performance after 44 h of continuous wakefulness.
    Journal of sleep research, 2008, Volume: 17, Issue:3

    Topics: Adolescent; Adult; Arousal; Attention; Benzhydryl Compounds; Caffeine; Central Nervous System Stimul

2008
Restoration of risk-propensity during sleep deprivation: caffeine, dextroamphetamine, and modafinil.
    Aviation, space, and environmental medicine, 2008, Volume: 79, Issue:9

    Topics: Adult; Benzhydryl Compounds; Caffeine; Central Nervous System Stimulants; Cognition; Decision Making

2008
Pharmacogenetics of modafinil after sleep loss: catechol-O-methyltransferase genotype modulates waking functions but not recovery sleep.
    Clinical pharmacology and therapeutics, 2009, Volume: 85, Issue:3

    Topics: Benzhydryl Compounds; Catechol O-Methyltransferase; Cross-Over Studies; Double-Blind Method; Genotyp

2009
Effects of modafinil on simulator driving and self-assessment of driving following sleep deprivation.
    Human psychopharmacology, 2008, Volume: 23, Issue:8

    Topics: Administration, Oral; Adult; Attention; Automobile Driving; Benzhydryl Compounds; Central Nervous Sy

2008
Sustaining executive functions during sleep deprivation: A comparison of caffeine, dextroamphetamine, and modafinil.
    Sleep, 2009, Volume: 32, Issue:2

    Topics: Adolescent; Adult; Arousal; Attention; Benzhydryl Compounds; Caffeine; Central Nervous System Stimul

2009
Modafinil reduces microsleep during partial sleep deprivation in depressed patients.
    Journal of psychiatric research, 2010, Volume: 44, Issue:13

    Topics: Adult; Benzhydryl Compounds; Central Nervous System Stimulants; Depressive Disorder, Major; Double-B

2010
Odor identification ability predicts executive function deficits following sleep deprivation.
    The International journal of neuroscience, 2010, Volume: 120, Issue:5

    Topics: Benzhydryl Compounds; Caffeine; Central Nervous System Stimulants; Dextroamphetamine; Executive Func

2010
Effect of modafinil on impairments in neurobehavioral performance and learning associated with extended wakefulness and circadian misalignment.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2010, Volume: 35, Issue:9

    Topics: Adult; Analysis of Variance; Benzhydryl Compounds; Body Temperature; Cognition Disorders; Double-Bli

2010
Sleep restriction for 1 week reduces insulin sensitivity in healthy men.
    Diabetes, 2010, Volume: 59, Issue:9

    Topics: Adult; Attention; Basal Metabolism; Benzhydryl Compounds; Blood Glucose; Calorimetry, Indirect; Cent

2010
Sleep restriction for 1 week reduces insulin sensitivity in healthy men.
    Diabetes, 2010, Volume: 59, Issue:9

    Topics: Adult; Attention; Basal Metabolism; Benzhydryl Compounds; Blood Glucose; Calorimetry, Indirect; Cent

2010
Sleep restriction for 1 week reduces insulin sensitivity in healthy men.
    Diabetes, 2010, Volume: 59, Issue:9

    Topics: Adult; Attention; Basal Metabolism; Benzhydryl Compounds; Blood Glucose; Calorimetry, Indirect; Cent

2010
Sleep restriction for 1 week reduces insulin sensitivity in healthy men.
    Diabetes, 2010, Volume: 59, Issue:9

    Topics: Adult; Attention; Basal Metabolism; Benzhydryl Compounds; Blood Glucose; Calorimetry, Indirect; Cent

2010
Sleep restriction for 1 week reduces insulin sensitivity in healthy men.
    Diabetes, 2010, Volume: 59, Issue:9

    Topics: Adult; Attention; Basal Metabolism; Benzhydryl Compounds; Blood Glucose; Calorimetry, Indirect; Cent

2010
Sleep restriction for 1 week reduces insulin sensitivity in healthy men.
    Diabetes, 2010, Volume: 59, Issue:9

    Topics: Adult; Attention; Basal Metabolism; Benzhydryl Compounds; Blood Glucose; Calorimetry, Indirect; Cent

2010
Sleep restriction for 1 week reduces insulin sensitivity in healthy men.
    Diabetes, 2010, Volume: 59, Issue:9

    Topics: Adult; Attention; Basal Metabolism; Benzhydryl Compounds; Blood Glucose; Calorimetry, Indirect; Cent

2010
Sleep restriction for 1 week reduces insulin sensitivity in healthy men.
    Diabetes, 2010, Volume: 59, Issue:9

    Topics: Adult; Attention; Basal Metabolism; Benzhydryl Compounds; Blood Glucose; Calorimetry, Indirect; Cent

2010
Sleep restriction for 1 week reduces insulin sensitivity in healthy men.
    Diabetes, 2010, Volume: 59, Issue:9

    Topics: Adult; Attention; Basal Metabolism; Benzhydryl Compounds; Blood Glucose; Calorimetry, Indirect; Cent

2010
Sleep restriction for 1 week reduces insulin sensitivity in healthy men.
    Diabetes, 2010, Volume: 59, Issue:9

    Topics: Adult; Attention; Basal Metabolism; Benzhydryl Compounds; Blood Glucose; Calorimetry, Indirect; Cent

2010
Sleep restriction for 1 week reduces insulin sensitivity in healthy men.
    Diabetes, 2010, Volume: 59, Issue:9

    Topics: Adult; Attention; Basal Metabolism; Benzhydryl Compounds; Blood Glucose; Calorimetry, Indirect; Cent

2010
Sleep restriction for 1 week reduces insulin sensitivity in healthy men.
    Diabetes, 2010, Volume: 59, Issue:9

    Topics: Adult; Attention; Basal Metabolism; Benzhydryl Compounds; Blood Glucose; Calorimetry, Indirect; Cent

2010
Sleep restriction for 1 week reduces insulin sensitivity in healthy men.
    Diabetes, 2010, Volume: 59, Issue:9

    Topics: Adult; Attention; Basal Metabolism; Benzhydryl Compounds; Blood Glucose; Calorimetry, Indirect; Cent

2010
Sleep restriction for 1 week reduces insulin sensitivity in healthy men.
    Diabetes, 2010, Volume: 59, Issue:9

    Topics: Adult; Attention; Basal Metabolism; Benzhydryl Compounds; Blood Glucose; Calorimetry, Indirect; Cent

2010
Sleep restriction for 1 week reduces insulin sensitivity in healthy men.
    Diabetes, 2010, Volume: 59, Issue:9

    Topics: Adult; Attention; Basal Metabolism; Benzhydryl Compounds; Blood Glucose; Calorimetry, Indirect; Cent

2010
Sleep restriction for 1 week reduces insulin sensitivity in healthy men.
    Diabetes, 2010, Volume: 59, Issue:9

    Topics: Adult; Attention; Basal Metabolism; Benzhydryl Compounds; Blood Glucose; Calorimetry, Indirect; Cent

2010
Sleep restriction for 1 week reduces insulin sensitivity in healthy men.
    Diabetes, 2010, Volume: 59, Issue:9

    Topics: Adult; Attention; Basal Metabolism; Benzhydryl Compounds; Blood Glucose; Calorimetry, Indirect; Cent

2010
Sleep restriction for 1 week reduces insulin sensitivity in healthy men.
    Diabetes, 2010, Volume: 59, Issue:9

    Topics: Adult; Attention; Basal Metabolism; Benzhydryl Compounds; Blood Glucose; Calorimetry, Indirect; Cent

2010
Sleep restriction for 1 week reduces insulin sensitivity in healthy men.
    Diabetes, 2010, Volume: 59, Issue:9

    Topics: Adult; Attention; Basal Metabolism; Benzhydryl Compounds; Blood Glucose; Calorimetry, Indirect; Cent

2010
Sleep restriction for 1 week reduces insulin sensitivity in healthy men.
    Diabetes, 2010, Volume: 59, Issue:9

    Topics: Adult; Attention; Basal Metabolism; Benzhydryl Compounds; Blood Glucose; Calorimetry, Indirect; Cent

2010
Sleep restriction for 1 week reduces insulin sensitivity in healthy men.
    Diabetes, 2010, Volume: 59, Issue:9

    Topics: Adult; Attention; Basal Metabolism; Benzhydryl Compounds; Blood Glucose; Calorimetry, Indirect; Cent

2010
Sleep restriction for 1 week reduces insulin sensitivity in healthy men.
    Diabetes, 2010, Volume: 59, Issue:9

    Topics: Adult; Attention; Basal Metabolism; Benzhydryl Compounds; Blood Glucose; Calorimetry, Indirect; Cent

2010
Sleep restriction for 1 week reduces insulin sensitivity in healthy men.
    Diabetes, 2010, Volume: 59, Issue:9

    Topics: Adult; Attention; Basal Metabolism; Benzhydryl Compounds; Blood Glucose; Calorimetry, Indirect; Cent

2010
Sleep restriction for 1 week reduces insulin sensitivity in healthy men.
    Diabetes, 2010, Volume: 59, Issue:9

    Topics: Adult; Attention; Basal Metabolism; Benzhydryl Compounds; Blood Glucose; Calorimetry, Indirect; Cent

2010
Sleep restriction for 1 week reduces insulin sensitivity in healthy men.
    Diabetes, 2010, Volume: 59, Issue:9

    Topics: Adult; Attention; Basal Metabolism; Benzhydryl Compounds; Blood Glucose; Calorimetry, Indirect; Cent

2010
Effects of modafinil on the sleep EEG depend on Val158Met genotype of COMT.
    Sleep, 2010, Volume: 33, Issue:8

    Topics: Alleles; Benzhydryl Compounds; Catechol O-Methyltransferase; Central Nervous System Stimulants; Cros

2010
Effect of a novel histamine subtype-3 receptor inverse agonist and modafinil on EEG power spectra during sleep deprivation and recovery sleep in male volunteers.
    Psychopharmacology, 2011, Volume: 215, Issue:4

    Topics: Adolescent; Adult; Benzhydryl Compounds; Cross-Over Studies; Dopamine Agents; Dose-Response Relation

2011
Polymorphisms of ADORA2A modulate psychomotor vigilance and the effects of caffeine on neurobehavioural performance and sleep EEG after sleep deprivation.
    British journal of pharmacology, 2012, Volume: 165, Issue:6

    Topics: Adult; Aged; Attention; Benzhydryl Compounds; Caffeine; Central Nervous System Stimulants; Cross-Ove

2012
Effect of pharmacological enhancement on the cognitive and clinical psychomotor performance of sleep-deprived doctors: a randomized controlled trial.
    Annals of surgery, 2012, Volume: 255, Issue:2

    Topics: Adult; Analysis of Variance; Benzhydryl Compounds; Central Nervous System Stimulants; Cognition; Com

2012
Circadian rhythm of rectal temperature during sleep deprivation with modafinil.
    Aviation, space, and environmental medicine, 2002, Volume: 73, Issue:10

    Topics: Adult; Benzhydryl Compounds; Body Temperature; Central Nervous System Stimulants; Circadian Rhythm;

2002
Effect of modafinil on core temperature during sustained wakefulness and exercise in a warm environment.
    Aviation, space, and environmental medicine, 2002, Volume: 73, Issue:11

    Topics: Adult; Benzhydryl Compounds; Body Temperature; Central Nervous System Stimulants; Dose-Response Rela

2002
The cognitive-enhancing properties of modafinil are limited in non-sleep-deprived middle-aged volunteers.
    Pharmacology, biochemistry, and behavior, 2004, Volume: 77, Issue:3

    Topics: Aged; Analysis of Variance; Benzhydryl Compounds; Cognition; Dose-Response Relationship, Drug; Doubl

2004
Does modafinil enhance cognitive performance in young volunteers who are not sleep-deprived?
    Journal of clinical psychopharmacology, 2005, Volume: 25, Issue:2

    Topics: Adult; Benzhydryl Compounds; Cognition; Double-Blind Method; Female; Humans; Male; Modafinil; Neurop

2005
Pharmacodynamic effects on alertness of single doses of armodafinil in healthy subjects during a nocturnal period of acute sleep loss.
    Current medical research and opinion, 2006, Volume: 22, Issue:1

    Topics: Adolescent; Adult; Benzhydryl Compounds; Central Nervous System Stimulants; Double-Blind Method; Hum

2006
The effects of caffeine, dextroamphetamine, and modafinil on humor appreciation during sleep deprivation.
    Sleep, 2006, Volume: 29, Issue:6

    Topics: Adolescent; Adult; Benzhydryl Compounds; Caffeine; Central Nervous System Stimulants; Cognition; Dex

2006
Modafinil activates cortical and subcortical sites in the sleep-deprived state.
    Sleep, 2006, Volume: 29, Issue:11

    Topics: Adult; Arousal; Attention; Benzhydryl Compounds; Brain; Brain Mapping; Central Nervous System Stimul

2006
The effects of modafinil, caffeine, and dextroamphetamine on judgments of simple versus complex emotional expressions following sleep deprivation.
    The International journal of neuroscience, 2008, Volume: 118, Issue:4

    Topics: Adolescent; Adult; Benzhydryl Compounds; Caffeine; Central Nervous System Stimulants; Cognition; Dex

2008
Interest of modafinil, a new psychostimulant, during a sixty-hour sleep deprivation experiment.
    Fundamental & clinical pharmacology, 1995, Volume: 9, Issue:3

    Topics: Adult; Benzhydryl Compounds; Central Nervous System Stimulants; Electroencephalography; Humans; Male

1995
Self-monitoring cognitive performance during sleep deprivation: effects of modafinil, d-amphetamine and placebo.
    Journal of sleep research, 1997, Volume: 6, Issue:2

    Topics: Adult; Benzhydryl Compounds; Central Nervous System Stimulants; Cognition; Dextroamphetamine; Double

1997
Effect of modafinil on plasma melatonin, cortisol and growth hormone rhythms, rectal temperature and performance in healthy subjects during a 36 h sleep deprivation.
    Journal of sleep research, 1998, Volume: 7, Issue:2

    Topics: Adult; Benzhydryl Compounds; Body Temperature; Central Nervous System Stimulants; Health Status; Hum

1998
Naps and modafinil as countermeasures for the effects of sleep deprivation on cognitive performance.
    Aviation, space, and environmental medicine, 1999, Volume: 70, Issue:5

    Topics: Adult; Benzhydryl Compounds; Central Nervous System Stimulants; Circadian Rhythm; Cognition; Double-

1999
Maintaining alertness and performance during sleep deprivation: modafinil versus caffeine.
    Psychopharmacology, 2002, Volume: 159, Issue:3

    Topics: Administration, Oral; Adolescent; Adult; Analysis of Variance; Benzhydryl Compounds; Body Temperatur

2002

Other Studies

44 other studies available for modafinil and Inadequate Sleep

ArticleYear
Application of armodafinil-loaded microneedle patches against the negative influence induced by sleep deprivation.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2021, Volume: 169

    Topics: Administration, Cutaneous; Animals; Cognition; Drug Delivery Systems; Drug Monitoring; Mice; Microte

2021
Solriamfetol improves chronic sleep fragmentation-induced increases in sleep propensity and ameliorates explicit memory in male mice.
    Sleep, 2023, 05-10, Volume: 46, Issue:5

    Topics: Animals; Disorders of Excessive Somnolence; Male; Mice; Mice, Inbred C57BL; Modafinil; Sleep; Sleep

2023
High cortical delta power correlates with aggravated allodynia by activating anterior cingulate cortex GABAergic neurons in neuropathic pain mice.
    Pain, 2020, Volume: 161, Issue:2

    Topics: Adrenergic Uptake Inhibitors; Animals; Cerebral Cortex; Cholinergic Antagonists; Cortical Synchroniz

2020
Decreased alertness due to sleep loss increases pain sensitivity in mice.
    Nature medicine, 2017, Volume: 23, Issue:6

    Topics: Acute Disease; Analgesics; Animals; Behavior, Animal; Benzhydryl Compounds; Caffeine; Chronic Diseas

2017
Narcolepsy-cataplexy and psychosis: a case study.
    Revista de neurologia, 2017, Jul-16, Volume: 65, Issue:2

    Topics: Adolescent; Antipsychotic Agents; Attention Deficit Disorder with Hyperactivity; Benzhydryl Compound

2017
Genetic lesioning of histamine neurons increases sleep-wake fragmentation and reveals their contribution to modafinil-induced wakefulness.
    Sleep, 2019, 05-01, Volume: 42, Issue:5

    Topics: Animals; Electroencephalography; Genetic Vectors; Histamine; Homeostasis; Male; Mice; Mice, Inbred C

2019
Modafinil protects hippocampal neurons by suppressing excessive autophagy and apoptosis in mice with sleep deprivation.
    British journal of pharmacology, 2019, Volume: 176, Issue:9

    Topics: Animals; Apoptosis; Autophagy; Central Nervous System Stimulants; Hippocampus; Male; Mice; Mice, Inb

2019
Sleep deprivation and Modafinil affect cortical sources of resting state electroencephalographic rhythms in healthy young adults.
    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2019, Volume: 130, Issue:9

    Topics: Adult; Alpha Rhythm; Beta Rhythm; Brain Waves; Cerebral Cortex; Cross-Over Studies; Delta Rhythm; El

2019
Modafinil ameliorates cognitive deficits induced by maternal separation and sleep deprivation.
    Behavioural brain research, 2013, Sep-15, Volume: 253

    Topics: Analysis of Variance; Animals; Anxiety, Separation; Benzhydryl Compounds; Central Nervous System Sti

2013
Caffeine and modafinil promote adult neuronal cell proliferation during 48 h of total sleep deprivation in rat dentate gyrus.
    Experimental neurology, 2013, Volume: 248

    Topics: Animals; Benzhydryl Compounds; Brain-Derived Neurotrophic Factor; Caffeine; Cell Count; Cell Prolife

2013
Differential effects of modafinil on memory in naïve and memory-impaired rats.
    Neuropharmacology, 2013, Volume: 75

    Topics: Analysis of Variance; Animals; Animals, Newborn; Avoidance Learning; Benzhydryl Compounds; Disease M

2013
Recommendations for high-priority research on cancer-related fatigue in children and adults.
    Journal of the National Cancer Institute, 2013, Oct-02, Volume: 105, Issue:19

    Topics: Adult; Anxiety; Benzhydryl Compounds; Bupropion; Central Nervous System Stimulants; Child; Clinical

2013
Recommendations for high-priority research on cancer-related fatigue in children and adults.
    Journal of the National Cancer Institute, 2013, Oct-02, Volume: 105, Issue:19

    Topics: Adult; Anxiety; Benzhydryl Compounds; Bupropion; Central Nervous System Stimulants; Child; Clinical

2013
Recommendations for high-priority research on cancer-related fatigue in children and adults.
    Journal of the National Cancer Institute, 2013, Oct-02, Volume: 105, Issue:19

    Topics: Adult; Anxiety; Benzhydryl Compounds; Bupropion; Central Nervous System Stimulants; Child; Clinical

2013
Recommendations for high-priority research on cancer-related fatigue in children and adults.
    Journal of the National Cancer Institute, 2013, Oct-02, Volume: 105, Issue:19

    Topics: Adult; Anxiety; Benzhydryl Compounds; Bupropion; Central Nervous System Stimulants; Child; Clinical

2013
Distinct pro-vigilant profile induced in rats by the mGluR5 potentiator LSN2814617.
    Psychopharmacology, 2015, Volume: 232, Issue:21-22

    Topics: Animals; Arousal; Benzhydryl Compounds; Biofeedback, Psychology; Caffeine; Central Nervous System St

2015
Caffeine and modafinil given during 48 h sleep deprivation modulate object recognition memory and synaptic proteins in the hippocampus of the rat.
    Behavioural brain research, 2015, Nov-01, Volume: 294

    Topics: Animals; Benzhydryl Compounds; Caffeine; Disease Models, Animal; Disks Large Homolog 4 Protein; Drug

2015
Acceleration tolerance at night with acute fatigue and stimulants.
    Aviation, space, and environmental medicine, 2008, Volume: 79, Issue:8

    Topics: Acceleration; Adaptation, Physiological; Adult; Aerospace Medicine; Amphetamine; Analysis of Varianc

2008
Sex differences in cognitive estimation during sleep deprivation: effects of stimulant countermeasures.
    The International journal of neuroscience, 2008, Volume: 118, Issue:11

    Topics: Adenosine; Adult; Benzhydryl Compounds; Caffeine; Central Nervous System Stimulants; Cognition; Cogn

2008
Metabolic response of the cerebral cortex following gentle sleep deprivation and modafinil administration.
    Sleep, 2010, Volume: 33, Issue:7

    Topics: Animals; Benzhydryl Compounds; Central Nervous System Stimulants; Cerebral Cortex; Disease Models, A

2010
Modafinil prevents inhibitory avoidance memory deficit induced by sleep deprivation in rats.
    Sleep, 2010, Volume: 33, Issue:7

    Topics: Analysis of Variance; Animals; Avoidance Learning; Behavior, Animal; Benzhydryl Compounds; Disease M

2010
Wake-promoting agent modafinil worsened attentional performance following REM sleep deprivation in a young-adult rat model of 5-choice serial reaction time task.
    Psychopharmacology, 2011, Volume: 213, Issue:1

    Topics: Age Factors; Animals; Attention; Benzhydryl Compounds; Central Nervous System Stimulants; Choice Beh

2011
Differential effects of total sleep deprivation on contextual and spatial memory: modulatory effects of modafinil.
    Pharmacology, biochemistry, and behavior, 2011, Volume: 97, Issue:3

    Topics: Animals; Behavior, Animal; Benzhydryl Compounds; Central Nervous System Stimulants; Corticosterone;

2011
Tail-pinch stress and REM sleep deprivation differentially affect sensorimotor gating function in modafinil-treated rats.
    Behavioural brain research, 2011, May-16, Volume: 219, Issue:1

    Topics: Acoustic Stimulation; Animals; Benzhydryl Compounds; Central Nervous System Stimulants; Male; Modafi

2011
Infusion of modafinil into anterior hypothalamus or pedunculopontine tegmental nucleus at different time-points enhances waking and blocks the expression of recovery sleep in rats after sleep deprivation.
    Experimental neurology, 2011, Volume: 229, Issue:2

    Topics: Analysis of Variance; Animals; Benzhydryl Compounds; Central Nervous System Stimulants; Electroencep

2011
Modafinil treatment prevents REM sleep deprivation-induced brain function impairment by increasing MMP-9 expression.
    Brain research, 2011, Dec-02, Volume: 1426

    Topics: Analysis of Variance; Animals; Benzhydryl Compounds; Central Nervous System Stimulants; Cognition; G

2011
Modafinil improves event related potentials P300 and contingent negative variation after 24 h sleep deprivation.
    Life sciences, 2012, Aug-21, Volume: 91, Issue:3-4

    Topics: Actigraphy; Adult; Benzhydryl Compounds; Body Weight; Central Nervous System Stimulants; Cognition;

2012
Comparison of the effects of modafinil and sleep deprivation on sleep and cortical EEG spectra in mice.
    Neuropharmacology, 2002, Volume: 43, Issue:1

    Topics: Analysis of Variance; Animals; Benzhydryl Compounds; Central Nervous System Stimulants; Electroencep

2002
Temporal pattern of hippocampal high-frequency oscillations during sleep after stimulant-evoked waking.
    Neuroscience, 2003, Volume: 121, Issue:3

    Topics: Amphetamine; Animals; Benzhydryl Compounds; Central Nervous System Stimulants; Dose-Response Relatio

2003
[Effects of modafinil on visual and auditory reaction abilities and subjective fatigue level during 48 h sleep deprivation].
    Hang tian yi xue yu yi xue gong cheng = Space medicine & medical engineering, 2003, Volume: 16, Issue:4

    Topics: Adolescent; Adult; Attention; Auditory Perception; Benzhydryl Compounds; Central Nervous System Stim

2003
Modafinil vs. caffeine: effects on fatigue during sleep deprivation.
    Aviation, space, and environmental medicine, 2004, Volume: 75, Issue:6

    Topics: Adolescent; Adult; Benzhydryl Compounds; Caffeine; Central Nervous System Stimulants; Dose-Response

2004
Modafinil's effects on simulator performance and mood in pilots during 37 h without sleep.
    Aviation, space, and environmental medicine, 2004, Volume: 75, Issue:9

    Topics: Adult; Affect; Aviation; Benzhydryl Compounds; Central Nervous System Stimulants; Computer Simulatio

2004
Cosmetic neurology: the controversy over enhancing movement, mentation, and mood.
    Neurology, 2005, Apr-12, Volume: 64, Issue:7

    Topics: Benzhydryl Compounds; Central Nervous System Stimulants; Humans; Judgment; Military Medicine; Modafi

2005
Performance and alertness effects of caffeine, dextroamphetamine, and modafinil during sleep deprivation.
    Journal of sleep research, 2005, Volume: 14, Issue:3

    Topics: Adult; Arousal; Benzhydryl Compounds; Caffeine; Central Nervous System Stimulants; Cognition; Dextro

2005
Alertness drug arouses fears about 'lifestyle' misuse.
    Nature, 2005, Aug-25, Volume: 436, Issue:7054

    Topics: Alzheimer Disease; Animals; Attention; Benzhydryl Compounds; Clinical Trials as Topic; Cognition; Gl

2005
Modafinil as an adjunctive treatment to sleep deprivation in depression.
    Journal of psychiatry & neuroscience : JPN, 2005, Volume: 30, Issue:6

    Topics: Aged; Benzhydryl Compounds; Bipolar Disorder; Central Nervous System Stimulants; Depressive Disorder

2005
Psychostimulants and military operations.
    Military medicine, 2007, Volume: 172, Issue:4

    Topics: Adult; Benzhydryl Compounds; Central Nervous System Stimulants; Circadian Rhythm; Cognition; Dextroa

2007
Modafinil restores memory performance and neural activity impaired by sleep deprivation in mice.
    Pharmacology, biochemistry, and behavior, 2007, Volume: 88, Issue:1

    Topics: Animals; Benzhydryl Compounds; Central Nervous System Stimulants; Electroencephalography; Genes, fos

2007
Efficacy of caffeine and modafinil in counteracting sleep deprivation in the marmoset monkey.
    Psychopharmacology, 2008, Volume: 197, Issue:1

    Topics: Administration, Oral; Animals; Arousal; Attention; Benzhydryl Compounds; Callithrix; Central Nervous

2008
Staying awake puts pressure on brain arousal systems.
    The Journal of clinical investigation, 2007, Volume: 117, Issue:12

    Topics: Animals; Benzhydryl Compounds; Central Nervous System Stimulants; Cyclic AMP; Dopamine; Female; Hypo

2007
Prolonged wakefulness induces experience-dependent synaptic plasticity in mouse hypocretin/orexin neurons.
    The Journal of clinical investigation, 2007, Volume: 117, Issue:12

    Topics: Animals; Benzhydryl Compounds; Central Nervous System Stimulants; Cyclic AMP; Dopamine; Female; Hypo

2007
CSF histamine levels in rats reflect the central histamine neurotransmission.
    Neuroscience letters, 2008, Jan-17, Volume: 430, Issue:3

    Topics: Amphetamine; Animals; Benzhydryl Compounds; Brain; Central Nervous System Stimulants; Circadian Rhyt

2008
Effects of cocaine, methamphetamine and modafinil challenge on sleep rebound after paradoxical sleep deprivation in rats.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2008, Volume: 41, Issue:1

    Topics: Analysis of Variance; Animals; Benzhydryl Compounds; Central Nervous System Stimulants; Cocaine; Mal

2008
Treatment-emergent hypomania or mania with modafinil.
    The American journal of psychiatry, 2008, Volume: 165, Issue:1

    Topics: Adult; Antidepressive Agents; Benzhydryl Compounds; Bipolar Disorder; Central Nervous System Stimula

2008
Paradoxical sleep deprivation increases the content of glutamate and glutamine in rat cerebral cortex.
    Sleep, 1996, Volume: 19, Issue:1

    Topics: Animals; Arousal; Benzhydryl Compounds; Central Nervous System Stimulants; Cerebral Cortex; gamma-Am

1996
Effects of amphetamine and modafinil on the sleep/wake cycle during experimental hypersomnia induced by sleep deprivation in the cat.
    Journal of sleep research, 2000, Volume: 9, Issue:1

    Topics: Amphetamine; Animals; Benzhydryl Compounds; Cats; Central Nervous System Stimulants; Disorders of Ex

2000
Effects of modafinil and amphetamine on sleep-wake cycle after sleep deprivation in cats.
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1999, Volume: 20, Issue:9

    Topics: Amphetamine; Animals; Benzhydryl Compounds; Cats; Central Nervous System Stimulants; Electroencephal

1999