modafinil has been researched along with Fatigue Syndrome, Chronic in 8 studies
Modafinil: A benzhydryl acetamide compound, central nervous system stimulant, and CYP3A4 inducing agent that is used in the treatment of NARCOLEPSY and SLEEP WAKE DISORDERS.
modafinil : A racemate comprising equimolar amounts of armodafinil and (S)-modafinil. A central nervous system stimulant, it is used for the treatment of sleeping disorders such as narcolepsy, obstructive sleep apnoea, and shift-work sleep disorder. The optical enantiomers of modafinil have similar pharmacological actions in animals.
2-[(diphenylmethyl)sulfinyl]acetamide : A sulfoxide that is dimethylsulfoxide in which two hydrogens attached to one of the methyl groups are replaced by phenyl groups, while one hydrogen attached to the other methyl group is replaced by a carbamoyl (aminocarbonyl) group.
Fatigue Syndrome, Chronic: A syndrome characterized by persistent or recurrent fatigue, diffuse musculoskeletal pain, sleep disturbances, and subjective cognitive impairment of 6 months duration or longer. Symptoms are not caused by ongoing exertion; are not relieved by rest; and result in a substantial reduction of previous levels of occupational, educational, social, or personal activities. Minor alterations of immune, neuroendocrine, and autonomic function may be associated with this syndrome. There is also considerable overlap between this condition and FIBROMYALGIA. (From Semin Neurol 1998;18(2):237-42; Ann Intern Med 1994 Dec 15;121(12): 953-9)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Modafinil was titrated up over 4 weeks to maximum of 400 mg/day." | 2.75 | Modafinil for Parkinson's disease fatigue. ( Baker, GA; Steiger, MJ; Taylor, J; Tyne, HL, 2010) |
| "Many patients with chronic fatigue syndrome (CFS) fail to derive benefit from evidence-based treatments such as cognitive-behavioural therapy (CBT) and graded exercise therapy leading to permanent disability." | 1.62 | Recovery from refractory chronic fatigue syndrome with CBT and modafinil. ( Douglas, M; Garg, H; Turkington, D; Turkington, GD, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (75.00) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Garg, H | 1 |
| Douglas, M | 1 |
| Turkington, GD | 1 |
| Turkington, D | 2 |
| Annoni, JM | 1 |
| Staub, F | 1 |
| Bogousslavsky, J | 1 |
| Brioschi, A | 1 |
| Tyne, HL | 1 |
| Taylor, J | 1 |
| Baker, GA | 1 |
| Steiger, MJ | 1 |
| Hedwat, D | 1 |
| Rider, I | 1 |
| Young, AH | 1 |
| Bobo, WV | 1 |
| Hall, WC | 1 |
| Randall, DC | 1 |
| Cafferty, FH | 1 |
| Shneerson, JM | 1 |
| Smith, IE | 1 |
| Llewelyn, MB | 1 |
| File, SE | 1 |
| Kraft, GH | 1 |
| Bowen, J | 1 |
| Rammohan, KW | 1 |
| Lynn, DJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Strengthening Oropharyngeal Muscles as a Novel Approach to Treat Obstructive Sleep Apnea After Stroke: A Randomized Feasibility Study[NCT04212260] | 33 participants (Actual) | Interventional | 2019-04-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for modafinil and Fatigue Syndrome, Chronic
| Article | Year |
|---|---|
Frequency, characterisation and therapies of fatigue after stroke.
Topics: Benzhydryl Compounds; Central Nervous System Stimulants; Cognitive Behavioral Therapy; Depressive Di | 2008 |
2 trials available for modafinil and Fatigue Syndrome, Chronic
| Article | Year |
|---|---|
Modafinil for Parkinson's disease fatigue.
Topics: Aged; Benzhydryl Compounds; Central Nervous System Stimulants; Disability Evaluation; Dose-Response | 2010 |
Chronic treatment with modafinil may not be beneficial in patients with chronic fatigue syndrome.
Topics: Adult; Affect; Arousal; Benzhydryl Compounds; Central Nervous System Stimulants; Cross-Over Studies; | 2005 |
5 other studies available for modafinil and Fatigue Syndrome, Chronic
| Article | Year |
|---|---|
Recovery from refractory chronic fatigue syndrome with CBT and modafinil.
Topics: Cognitive Behavioral Therapy; Fatigue Syndrome, Chronic; Humans; Modafinil; Quality of Life; Retrosp | 2021 |
Recovery from chronic fatigue syndrome with modafinil.
Topics: Adult; Benzhydryl Compounds; Central Nervous System Stimulants; Fatigue Syndrome, Chronic; Female; H | 2004 |
On chronic fatigue syndrome.
Topics: Benzhydryl Compounds; Central Nervous System Stimulants; Cognition; Drug Therapy, Combination; Fatig | 2004 |
Modafinil for fatigue in MS: a randomized placebo-controlled double-blind study.
Topics: Benzhydryl Compounds; Central Nervous System Stimulants; Depressive Disorder; Diagnostic Errors; Dos | 2005 |
Modafinil for fatigue in MS: a randomized placebo-controlled double-blind study.
Topics: Benzhydryl Compounds; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Fatigue S | 2005 |