Page last updated: 2024-10-31

modafinil and Epithelial Ovarian Cancer

modafinil has been researched along with Epithelial Ovarian Cancer in 2 studies

Modafinil: A benzhydryl acetamide compound, central nervous system stimulant, and CYP3A4 inducing agent that is used in the treatment of NARCOLEPSY and SLEEP WAKE DISORDERS.
modafinil : A racemate comprising equimolar amounts of armodafinil and (S)-modafinil. A central nervous system stimulant, it is used for the treatment of sleeping disorders such as narcolepsy, obstructive sleep apnoea, and shift-work sleep disorder. The optical enantiomers of modafinil have similar pharmacological actions in animals.
2-[(diphenylmethyl)sulfinyl]acetamide : A sulfoxide that is dimethylsulfoxide in which two hydrogens attached to one of the methyl groups are replaced by phenyl groups, while one hydrogen attached to the other methyl group is replaced by a carbamoyl (aminocarbonyl) group.

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's2 (100.00)2.80

Authors

AuthorsStudies
Rocconi, RP2
Monk, BJ2
Walter, A2
Herzog, TJ1
Galanis, E2
Manning, L2
Bognar, E2
Wallraven, G2
Stanbery, L2
Aaron, P2
Senzer, N1
Coleman, RL2
Nemunaitis, J2
Stevens, EE1
Bottsford-Miller, JN1
Ghamande, SA1
Elder, J1
DeMars, LL1
Munkarah, A1
Manley, M1
Horvath, S1
Herzog, T1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomized, Double-Blind, Placebo-Controlled Phase 2 Trial of Vigil Engineered Autologous Tumor Cell Immunotherapy in Subjects With Stage IIIb-IV Ovarian Cancer in Clinical Complete Response Following Surgery and Primary Chemotherapy[NCT02346747]Phase 292 participants (Actual)Interventional2015-02-28Active, not recruiting
A Randomized, Intra-patient Crossover, Safety, Biomarker and Anti-Tumor Activity Assessment of the Combination of Atezolizumab and Vigil in Patients With Advanced Gynecological Cancers (A Companion Study to CL-PTL-119)[NCT03073525]Phase 225 participants (Actual)Interventional2017-05-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Overall Survival (OS)

OS is defined as time of randomization to date of death due to any cause. (NCT03073525)
Timeframe: OS will be evaluated from time of randomization up to 37 months following documented disease progression.

InterventionMonths (Median)
Part 1: Vigil + Atezo8.2
Part 2: Vigil Then Vigil + Atezo37.0
Part 2: Atezo Then Vigil + Atezo15.1

Radiographic Overall Response Rate (ORR)

"Radiographic ORR is defined as the percentage of participants achieving a Complete Response (CR) or Partial Response (PR), as assessed by investigators using RECIST 1.1.~In Part 1, ORR was assessed at baseline and every third cycle thereafter. In Part 2, the disease was assessed at baseline, at the end of Cycle 2 of single-agent therapy, and every third cycle thereafter.~95% confidence interval from exact binomial distribution (Blopper-Pearson method)." (NCT03073525)
Timeframe: From first dose to end of study treatment (up to 9 months)

Interventionpercentage of participants with response (Number)
Part 1: Vigil + Atezo33
Part 2: Vigil Then Vigil + Atezo9
Part 2: Atezo Then Vigil + Atezo10

Time to Progression

"Overall assessment of time to progression and survival will be measured by Radiological Tumor Assessment by local investigators using the Response Evaluation Criteria in Solid Tumors (RECIST) Version 1.1.~In Part 1, disease progression was assessed at baseline and every third cycle thereafter. In Part 2, the disease was assessed at baseline, at the end of Cycle 2 of single-agent therapy, and every third cycle thereafter." (NCT03073525)
Timeframe: From baseline (prior to treatment) up to 3 years

Interventionmonths (Median)
Part 1: Vigil + Atezo3.42
Part 2: Vigil Then Vigil + Atezo3.42
Part 2: Atezo Then Vigil + Atezo2.86

Number of Treatment-emergent AEs of Vigil + Atezolizumab

The safety evaluation included Adverse Events (AEs), Adverse Events of Special Interest (AESIs), Serious Adverse Events (SAEs) and changes from baseline in laboratory evaluations, vital signs, electrocardiograms and physical examinations. AEs were graded according to the National Cancer Institute (NCI) CTCAE v4.03 and coded using the Medical Dictionary for Regulatory Activities. Laboratory abnormalities were graded according to the NCI CTCAE v4.03, if applicable. (NCT03073525)
Timeframe: AEs reported from first treatment dose and up to 30 days after last treatment, about 12 months.

,,
Interventionadverse events (Number)
Grade 4 Atezolizumab-RelatedGrade 4 Vigil-RelatedGrade 3 Atezolizumab-RelatedGrade 3 Vigil-Related
Part 1: Vigil + Atezo0000
Part 2: Atezo Then Vigil + Atezo0040
Part 2: Vigil Then Vigil + Atezo0010

Trials

2 trials available for modafinil and Epithelial Ovarian Cancer

ArticleYear
Gemogenovatucel-T (Vigil) immunotherapy demonstrates clinical benefit in homologous recombination proficient (HRP) ovarian cancer.
    Gynecologic oncology, 2021, Volume: 161, Issue:3

    Topics: Aged; Aged, 80 and over; Carcinoma, Ovarian Epithelial; Disease-Free Survival; Double-Blind Method;

2021
Gemogenovatucel-T (Vigil) immunotherapy demonstrates clinical benefit in homologous recombination proficient (HRP) ovarian cancer.
    Gynecologic oncology, 2021, Volume: 161, Issue:3

    Topics: Aged; Aged, 80 and over; Carcinoma, Ovarian Epithelial; Disease-Free Survival; Double-Blind Method;

2021
Gemogenovatucel-T (Vigil) immunotherapy demonstrates clinical benefit in homologous recombination proficient (HRP) ovarian cancer.
    Gynecologic oncology, 2021, Volume: 161, Issue:3

    Topics: Aged; Aged, 80 and over; Carcinoma, Ovarian Epithelial; Disease-Free Survival; Double-Blind Method;

2021
Gemogenovatucel-T (Vigil) immunotherapy demonstrates clinical benefit in homologous recombination proficient (HRP) ovarian cancer.
    Gynecologic oncology, 2021, Volume: 161, Issue:3

    Topics: Aged; Aged, 80 and over; Carcinoma, Ovarian Epithelial; Disease-Free Survival; Double-Blind Method;

2021
Proof of principle study of sequential combination atezolizumab and Vigil in relapsed ovarian cancer.
    Cancer gene therapy, 2022, Volume: 29, Issue:3-4

    Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Ovaria

2022