modafinil has been researched along with Drug Withdrawal Symptoms in 19 studies
Modafinil: A benzhydryl acetamide compound, central nervous system stimulant, and CYP3A4 inducing agent that is used in the treatment of NARCOLEPSY and SLEEP WAKE DISORDERS.
modafinil : A racemate comprising equimolar amounts of armodafinil and (S)-modafinil. A central nervous system stimulant, it is used for the treatment of sleeping disorders such as narcolepsy, obstructive sleep apnoea, and shift-work sleep disorder. The optical enantiomers of modafinil have similar pharmacological actions in animals.
2-[(diphenylmethyl)sulfinyl]acetamide : A sulfoxide that is dimethylsulfoxide in which two hydrogens attached to one of the methyl groups are replaced by phenyl groups, while one hydrogen attached to the other methyl group is replaced by a carbamoyl (aminocarbonyl) group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "One hundred and fifty-seven treatment-seeking smokers received brief smoking cessation counseling and were randomized to: (1) 8 weeks of modafinil (200mg/day), or (2) 8 weeks of placebo." | 5.13 | A placebo-controlled trial of modafinil for nicotine dependence. ( Berrettini, W; Dackis, C; Gariti, P; Heitjan, DF; Leone, F; Lerman, C; Perkins, KA; Pinto, A; Schnoll, RA; Siegel, S; Wileyto, EP, 2008) |
| "Modafinil was found to be tolerable and well accepted by methamphetamine users and feasible for short-term inpatient withdrawal, but the sample was too small to detect treatment effects." | 2.78 | A pilot randomised controlled trial of modafinil during acute methamphetamine withdrawal: feasibility, tolerability and clinical outcomes. ( Ferris, J; Hester, R; Lee, N; McKetin, R; Nielsen, S; Pennay, A, 2013) |
| "Modafinil was associated with increased daytime sleep latency, as measured by the Multiple Sleep Latency Test, and a nearly significant decrease in subjective daytime sleepiness." | 2.75 | Normalizing effects of modafinil on sleep in chronic cocaine users. ( Malison, RT; Morgan, PT; Pace-Schott, E; Pittman, B; Stickgold, R, 2010) |
| "Modafinil-treated participants had a milder withdrawal syndrome as measured by the Amphetamine Cessation Symptom Assessment and less sleep disturbance in comparison to mirtazapine." | 2.73 | Symptoms and sleep patterns during inpatient treatment of methamphetamine withdrawal: a comparison of mirtazapine and modafinil with treatment as usual. ( McGregor, C; Mitchell, A; Srisurapanont, M; White, JM; Wickes, W, 2008) |
| "Modafinil was generally well tolerated." | 2.72 | Modafinil film-coated tablets in children and adolescents with attention-deficit/hyperactivity disorder: results of a randomized, double-blind, placebo-controlled, fixed-dose study followed by abrupt discontinuation. ( Biederman, J; Earl, CQ; Greenhill, LL; Jiang, JG; Lopez, FA; Sedillo, A; Swanson, JM, 2006) |
| "Modafinil-treated patients provided significantly more BE-negative urine samples (p=0." | 2.71 | A double-blind, placebo-controlled trial of modafinil for cocaine dependence. ( Dackis, CA; Kampman, KM; Lynch, KG; O'Brien, CP; Pettinati, HM, 2005) |
| "Cocaine addiction is a chronic relapsing disorder associated with severe medical and psychosocial complications." | 2.44 | Modafinil: a useful medication for cocaine addiction? Review of the evidence from neuropharmacological, experimental and clinical studies. ( Cepeda, S; Knecht, C; Martínez-Raga, J, 2008) |
| "Modafinil is a wake-promoting compound approved for the treatment of sleeping disorders." | 1.40 | Modafinil improves methamphetamine-induced object recognition deficits and restores prefrontal cortex ERK signaling in mice. ( Bisagno, V; Cadet, JL; García-Rill, E; González, B; Raineri, M; Urbano, FJ, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 9 (47.37) | 29.6817 |
| 2010's | 10 (52.63) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dias, VT | 1 |
| Rosa, HZ | 1 |
| D'avila, LF | 1 |
| Vey, LT | 1 |
| Barcelos, RCS | 1 |
| Burger, ME | 1 |
| Martin, CA | 1 |
| Lile, J | 1 |
| Guenthner, G | 1 |
| Anestis, JC | 1 |
| Batten, SR | 1 |
| Kelly, TH | 1 |
| González, B | 1 |
| Raineri, M | 1 |
| Cadet, JL | 1 |
| García-Rill, E | 1 |
| Urbano, FJ | 1 |
| Bisagno, V | 1 |
| Schnoll, RA | 1 |
| Wileyto, EP | 1 |
| Pinto, A | 1 |
| Leone, F | 1 |
| Gariti, P | 1 |
| Siegel, S | 1 |
| Perkins, KA | 1 |
| Dackis, C | 2 |
| Heitjan, DF | 1 |
| Berrettini, W | 1 |
| Lerman, C | 1 |
| Martínez-Raga, J | 1 |
| Knecht, C | 1 |
| Cepeda, S | 1 |
| Morgan, PT | 1 |
| Pace-Schott, E | 1 |
| Pittman, B | 1 |
| Stickgold, R | 1 |
| Malison, RT | 1 |
| O'Brien, CP | 3 |
| Paterson, NE | 1 |
| Fedolak, A | 1 |
| Olivier, B | 1 |
| Hanania, T | 1 |
| Ghavami, A | 1 |
| Caldarone, B | 1 |
| Hester, R | 2 |
| Lee, N | 2 |
| Pennay, A | 2 |
| Nielsen, S | 2 |
| Ferris, J | 2 |
| Mahoney, JJ | 1 |
| Jackson, BJ | 1 |
| Kalechstein, AD | 1 |
| De La Garza, R | 1 |
| Chang, LC | 1 |
| Newton, TF | 1 |
| Dackis, CA | 2 |
| Kampman, KM | 3 |
| Lynch, KG | 2 |
| Plebani, JG | 1 |
| Pettinati, HM | 2 |
| Sparkman, T | 1 |
| McKetin, R | 1 |
| Swanson, JM | 1 |
| Greenhill, LL | 1 |
| Lopez, FA | 1 |
| Sedillo, A | 1 |
| Earl, CQ | 1 |
| Jiang, JG | 1 |
| Biederman, J | 1 |
| Ling, W | 2 |
| Rawson, R | 1 |
| Shoptaw, S | 1 |
| Sofuoglu, M | 1 |
| Waters, AJ | 1 |
| Mooney, M | 1 |
| McGregor, C | 1 |
| Srisurapanont, M | 1 |
| Mitchell, A | 1 |
| Wickes, W | 1 |
| White, JM | 1 |
| Shearer, J | 1 |
3 reviews available for modafinil and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Modafinil: a useful medication for cocaine addiction? Review of the evidence from neuropharmacological, experimental and clinical studies.
Topics: Animals; Benzhydryl Compounds; Brain; Central Nervous System Stimulants; Cocaine; Cocaine-Related Di | 2008 |
Management of methamphetamine abuse and dependence.
Topics: Baclofen; Benzhydryl Compounds; Brain; Bupropion; Cognition Disorders; Cognitive Behavioral Therapy; | 2006 |
The principles of agonist pharmacotherapy for psychostimulant dependence.
Topics: Benzhydryl Compounds; Central Nervous System Stimulants; Dopamine Agonists; Heroin Dependence; Human | 2008 |
11 trials available for modafinil and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Behavioral effects of modafinil and nicotine, alone and in combination, in tobacco-deprived young adult smokers.
Topics: Adolescent; Benzhydryl Compounds; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2014 |
A placebo-controlled trial of modafinil for nicotine dependence.
Topics: Adult; Benzhydryl Compounds; Central Nervous System Stimulants; Double-Blind Method; Female; Humans; | 2008 |
Normalizing effects of modafinil on sleep in chronic cocaine users.
Topics: Adult; Benzhydryl Compounds; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; | 2010 |
The effects of modafinil treatment on neuropsychological and attentional bias performance during 7-day inpatient withdrawal from methamphetamine dependence.
Topics: Adult; Amphetamine-Related Disorders; Attention; Benzhydryl Compounds; Central Nervous System Stimul | 2010 |
Acute modafinil exposure reduces daytime sleepiness in abstinent methamphetamine-dependent volunteers.
Topics: Adult; Amphetamine-Related Disorders; Benzhydryl Compounds; Central Nervous System Stimulants; Cogni | 2012 |
A double-blind, placebo-controlled trial of modafinil for cocaine dependence.
Topics: Adult; Benzhydryl Compounds; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; | 2012 |
A pilot randomised controlled trial of modafinil during acute methamphetamine withdrawal: feasibility, tolerability and clinical outcomes.
Topics: Adult; Amphetamine-Related Disorders; Benzhydryl Compounds; Central Nervous System Stimulants; Doubl | 2013 |
A double-blind, placebo-controlled trial of modafinil for cocaine dependence.
Topics: Adult; Benzhydryl Compounds; Central Nervous System Stimulants; Cocaine-Related Disorders; Double-Bl | 2005 |
Modafinil film-coated tablets in children and adolescents with attention-deficit/hyperactivity disorder: results of a randomized, double-blind, placebo-controlled, fixed-dose study followed by abrupt discontinuation.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Benzhydryl Compounds; Body Weight; Centra | 2006 |
Modafinil and nicotine interactions in abstinent smokers.
Topics: Adult; Benzhydryl Compounds; Blood Pressure; Central Nervous System Stimulants; Cross-Over Studies; | 2008 |
Symptoms and sleep patterns during inpatient treatment of methamphetamine withdrawal: a comparison of mirtazapine and modafinil with treatment as usual.
Topics: Adult; Amphetamine-Related Disorders; Antidepressive Agents, Tricyclic; Benzhydryl Compounds; Centra | 2008 |
5 other studies available for modafinil and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Modafinil reduces amphetamine preference and prevents anxiety-like symptoms during drug withdrawal in young rats: Involvement of dopaminergic targets in VTA and striatum.
Topics: Amphetamine; Amphetamine-Related Disorders; Animals; Anxiety; Central Nervous System Stimulants; Cor | 2019 |
Modafinil improves methamphetamine-induced object recognition deficits and restores prefrontal cortex ERK signaling in mice.
Topics: Animals; Benzhydryl Compounds; Central Nervous System Stimulants; Dose-Response Relationship, Drug; | 2014 |
Normalizing effects of modafinil on cocaine-induced sleep abnormalities.
Topics: Benzhydryl Compounds; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Double- | 2010 |
Psychostimulant-like discriminative stimulus and locomotor sensitization properties of the wake-promoting agent modafinil in rodents.
Topics: Animals; Benzhydryl Compounds; Biogenic Monoamines; Central Nervous System Stimulants; Cocaine; Dopa | 2010 |
The search for medications to treat stimulant dependence.
Topics: Amphetamine-Related Disorders; Benzhydryl Compounds; Brain; Bupropion; Cocaine; Cocaine-Related Diso | 2008 |