modafinil has been researched along with Cognitive Decline in 11 studies
Modafinil: A benzhydryl acetamide compound, central nervous system stimulant, and CYP3A4 inducing agent that is used in the treatment of NARCOLEPSY and SLEEP WAKE DISORDERS.
modafinil : A racemate comprising equimolar amounts of armodafinil and (S)-modafinil. A central nervous system stimulant, it is used for the treatment of sleeping disorders such as narcolepsy, obstructive sleep apnoea, and shift-work sleep disorder. The optical enantiomers of modafinil have similar pharmacological actions in animals.
2-[(diphenylmethyl)sulfinyl]acetamide : A sulfoxide that is dimethylsulfoxide in which two hydrogens attached to one of the methyl groups are replaced by phenyl groups, while one hydrogen attached to the other methyl group is replaced by a carbamoyl (aminocarbonyl) group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A double-blind, randomised, placebo-controlled single-dose crossover study of modafinil 200 mg examined this with two cognitive batteries [MATRICS Consensus Cognitive Battery (MCCB) and Cambridge Neuropsychological Test Automated Battery (CANTAB)] in 46 participants with under 3 years' duration of DSM-IV schizophrenia, on stable antipsychotic medication." | 9.24 | Modafinil and cognitive enhancement in schizophrenia and healthy volunteers: the effects of test battery in a randomised controlled trial. ( Bamford, C; Collier, T; Drake, RJ; Emsley, R; Kalpakidou, A; Kapur, S; Lees, J; Lewis, SW; Michalopoulou, PG; Pandina, G; Preston, S; Wykes, T, 2017) |
| "Modafinil effects were evaluated both within this patient group and compared to a healthy subject group." | 6.87 | Altered brainstem responses to modafinil in schizophrenia: implications for adjunctive treatment of cognition. ( Carter, CS; Minzenberg, MJ; Soosman, SK; Yoon, JH, 2018) |
| "A double-blind, randomised, placebo-controlled single-dose crossover study of modafinil 200 mg examined this with two cognitive batteries [MATRICS Consensus Cognitive Battery (MCCB) and Cambridge Neuropsychological Test Automated Battery (CANTAB)] in 46 participants with under 3 years' duration of DSM-IV schizophrenia, on stable antipsychotic medication." | 5.24 | Modafinil and cognitive enhancement in schizophrenia and healthy volunteers: the effects of test battery in a randomised controlled trial. ( Bamford, C; Collier, T; Drake, RJ; Emsley, R; Kalpakidou, A; Kapur, S; Lees, J; Lewis, SW; Michalopoulou, PG; Pandina, G; Preston, S; Wykes, T, 2017) |
| " Studies in early radiotherapy treatment phase (five studies) Pharmacological studies in the "early radiotherapy treatment phase" were designed to prevent or ameliorate cognitive deficits and included drugs used in dementia (memantine) and fatigue (d-threo-methylphenidate hydrochloride)." | 5.22 | Interventions for preventing and ameliorating cognitive deficits in adults treated with cranial irradiation. ( Brown, PD; Day, J; Gehring, K; Grosshans, D; Kirkman, MA; Li, J; Taphoorn, M; Zienius, K, 2022) |
| "Modafinil effects were evaluated both within this patient group and compared to a healthy subject group." | 2.87 | Altered brainstem responses to modafinil in schizophrenia: implications for adjunctive treatment of cognition. ( Carter, CS; Minzenberg, MJ; Soosman, SK; Yoon, JH, 2018) |
| "Cognitive dysfunction is a challenging adverse effect of chemotherapy and radiotherapy that has limited treatment options." | 2.61 | Pharmacologic management of cognitive impairment induced by cancer therapy. ( Dietrich, J; Karschnia, P; Parsons, MW, 2019) |
| "Memantine is an uncompetitive N-methyl-d-aspartic acid receptor antagonist and is approved for the management of moderate-to-severe AD." | 2.53 | Pharmacotherpy and Alzheimer's Disease: The M-Drugs (Melatonin, Minocycline, Modafinil, and Memantine) Approach. ( Daulatzai, MA, 2016) |
| "Survivors of childhood cancer frequently experience cancer-related cognitive dysfunction, commonly months to years after treatment for pediatric brain tumors, acute lymphoblastic leukemia (ALL), or tumors involving the head and neck." | 2.50 | Developing interventions for cancer-related cognitive dysfunction in childhood cancer survivors. ( Castellino, SM; Lange, BJ; Ullrich, NJ; Whelen, MJ, 2014) |
| "Modafinil has been proposed as a potentially effective clinical treatment for neuropsychiatric disorders characterized by cognitive control deficits." | 1.72 | Effects of modafinil on electroencephalographic microstates in healthy adults. ( Barnes, SA; Bergman, J; Breiger, M; Carlezon, WA; Der-Avakian, A; Iturra-Mena, AM; Kangas, BD; Linton, SR; Murphy, M; Pizzagalli, DA; Risbrough, VB; Schroder, HS, 2022) |
| "Potential causes include COVID-19 viral encephalopathy, toxic metabolic encephalopathy, post-intensive care unit syndrome and cerebrovascular pathology." | 1.62 | Treatment of unexplained coma and hypokinetic-rigid syndrome in a patient with COVID-19. ( Awad, N; Roy, D; Song, J; Zamudio, P, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 8 (72.73) | 24.3611 |
| 2020's | 3 (27.27) | 2.80 |
| Authors | Studies |
|---|---|
| Linton, SR | 1 |
| Murphy, M | 1 |
| Schroder, HS | 1 |
| Breiger, M | 1 |
| Iturra-Mena, AM | 1 |
| Kangas, BD | 1 |
| Bergman, J | 1 |
| Carlezon, WA | 1 |
| Risbrough, VB | 1 |
| Barnes, SA | 1 |
| Der-Avakian, A | 1 |
| Pizzagalli, DA | 1 |
| Kirkman, MA | 3 |
| Day, J | 3 |
| Gehring, K | 3 |
| Zienius, K | 3 |
| Grosshans, D | 3 |
| Taphoorn, M | 3 |
| Li, J | 3 |
| Brown, PD | 3 |
| Roy, D | 1 |
| Song, J | 1 |
| Awad, N | 1 |
| Zamudio, P | 1 |
| Lees, J | 1 |
| Michalopoulou, PG | 1 |
| Lewis, SW | 1 |
| Preston, S | 1 |
| Bamford, C | 1 |
| Collier, T | 1 |
| Kalpakidou, A | 1 |
| Wykes, T | 1 |
| Emsley, R | 1 |
| Pandina, G | 1 |
| Kapur, S | 1 |
| Drake, RJ | 1 |
| Minzenberg, MJ | 1 |
| Yoon, JH | 1 |
| Soosman, SK | 1 |
| Carter, CS | 1 |
| Nilsson, SRO | 1 |
| Heath, CJ | 1 |
| Takillah, S | 1 |
| Didienne, S | 1 |
| Fejgin, K | 1 |
| Nielsen, V | 1 |
| Nielsen, J | 1 |
| Saksida, LM | 1 |
| Mariani, J | 1 |
| Faure, P | 1 |
| Didriksen, M | 1 |
| Robbins, TW | 1 |
| Bussey, TJ | 1 |
| Mar, AC | 1 |
| Baakman, AC | 1 |
| Zuiker, R | 1 |
| van Gerven, JMA | 1 |
| Gross, N | 1 |
| Yang, R | 1 |
| Fetell, M | 1 |
| Gershon, A | 1 |
| Gilgun-Sherki, Y | 1 |
| Hellriegel, E | 1 |
| Spiegelstein, O | 1 |
| Karschnia, P | 1 |
| Parsons, MW | 1 |
| Dietrich, J | 1 |
| Miladi, N | 1 |
| Dossa, R | 1 |
| Dogba, MJ | 1 |
| Cléophat-Jolicoeur, MIF | 1 |
| Gagnon, B | 1 |
| Castellino, SM | 1 |
| Ullrich, NJ | 1 |
| Whelen, MJ | 1 |
| Lange, BJ | 1 |
| Daulatzai, MA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| MentalPlus® for Assessment and Rehabilitation of Cognitive Functions After Remission of Symptoms of COVID-19[NCT04632719] | 200 participants (Anticipated) | Interventional | 2020-11-08 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for modafinil and Cognitive Decline
| Article | Year |
|---|---|
Interventions for preventing and ameliorating cognitive deficits in adults treated with cranial irradiation.
Topics: Adult; Brain Neoplasms; Cognition; Cognitive Dysfunction; Cranial Irradiation; Dementia; Donepezil; | 2022 |
Interventions for preventing and ameliorating cognitive deficits in adults treated with cranial irradiation.
Topics: Adult; Brain Neoplasms; Cognition; Cognitive Dysfunction; Cranial Irradiation; Dementia; Donepezil; | 2022 |
Interventions for preventing and ameliorating cognitive deficits in adults treated with cranial irradiation.
Topics: Adult; Brain Neoplasms; Cognition; Cognitive Dysfunction; Cranial Irradiation; Dementia; Donepezil; | 2022 |
Interventions for preventing and ameliorating cognitive deficits in adults treated with cranial irradiation.
Topics: Adult; Brain Neoplasms; Cognition; Cognitive Dysfunction; Cranial Irradiation; Dementia; Donepezil; | 2022 |
Interventions for preventing and ameliorating cognitive deficits in adults treated with cranial irradiation.
Topics: Adult; Brain Neoplasms; Cognition; Cognitive Dysfunction; Cranial Irradiation; Dementia; Donepezil; | 2022 |
Interventions for preventing and ameliorating cognitive deficits in adults treated with cranial irradiation.
Topics: Adult; Brain Neoplasms; Cognition; Cognitive Dysfunction; Cranial Irradiation; Dementia; Donepezil; | 2022 |
Interventions for preventing and ameliorating cognitive deficits in adults treated with cranial irradiation.
Topics: Adult; Brain Neoplasms; Cognition; Cognitive Dysfunction; Cranial Irradiation; Dementia; Donepezil; | 2022 |
Interventions for preventing and ameliorating cognitive deficits in adults treated with cranial irradiation.
Topics: Adult; Brain Neoplasms; Cognition; Cognitive Dysfunction; Cranial Irradiation; Dementia; Donepezil; | 2022 |
Interventions for preventing and ameliorating cognitive deficits in adults treated with cranial irradiation.
Topics: Adult; Brain Neoplasms; Cognition; Cognitive Dysfunction; Cranial Irradiation; Dementia; Donepezil; | 2022 |
Pharmacologic management of cognitive impairment induced by cancer therapy.
Topics: Antineoplastic Agents; Central Nervous System Stimulants; Cholinesterase Inhibitors; Cognitive Dysfu | 2019 |
Psychostimulants for cancer-related cognitive impairment in adult cancer survivors: a systematic review and meta-analysis.
Topics: Adult; Cancer Survivors; Central Nervous System Stimulants; Cognition; Cognitive Dysfunction; Humans | 2019 |
Developing interventions for cancer-related cognitive dysfunction in childhood cancer survivors.
Topics: Adolescent; Adult; Age Factors; Antimetabolites, Antineoplastic; Attention; Benzhydryl Compounds; Br | 2014 |
Pharmacotherpy and Alzheimer's Disease: The M-Drugs (Melatonin, Minocycline, Modafinil, and Memantine) Approach.
Topics: Alzheimer Disease; Animals; Benzhydryl Compounds; Cognitive Dysfunction; Humans; Melatonin; Memantin | 2016 |
3 trials available for modafinil and Cognitive Decline
| Article | Year |
|---|---|
Modafinil and cognitive enhancement in schizophrenia and healthy volunteers: the effects of test battery in a randomised controlled trial.
Topics: Adolescent; Adult; Benzhydryl Compounds; Cognitive Dysfunction; Cross-Over Studies; Double-Blind Met | 2017 |
Altered brainstem responses to modafinil in schizophrenia: implications for adjunctive treatment of cognition.
Topics: Adult; Antipsychotic Agents; Central Nervous System Stimulants; Cognitive Dysfunction; Cross-Over St | 2018 |
Central nervous system effects of the histamine-3 receptor antagonist CEP-26401, in comparison with modafinil and donepezil, after a single dose in a cross-over study in healthy volunteers.
Topics: Adolescent; Adult; Brain; Cognition; Cognitive Dysfunction; Cohort Studies; Cross-Over Studies; Done | 2019 |
3 other studies available for modafinil and Cognitive Decline
| Article | Year |
|---|---|
Effects of modafinil on electroencephalographic microstates in healthy adults.
Topics: Adult; Brain; Cognition Disorders; Cognitive Dysfunction; Electroencephalography; Humans; Modafinil | 2022 |
Treatment of unexplained coma and hypokinetic-rigid syndrome in a patient with COVID-19.
Topics: Blood Coagulation; Brain Diseases; Carbidopa; Central Nervous System Stimulants; Cognitive Dysfuncti | 2021 |
Continuous performance test impairment in a 22q11.2 microdeletion mouse model: improvement by amphetamine.
Topics: Amphetamine; Animals; Attention; Behavior, Animal; Central Nervous System Stimulants; Cognitive Dysf | 2018 |