modafinil has been researched along with Cerebral Palsy in 5 studies
Modafinil: A benzhydryl acetamide compound, central nervous system stimulant, and CYP3A4 inducing agent that is used in the treatment of NARCOLEPSY and SLEEP WAKE DISORDERS.
modafinil : A racemate comprising equimolar amounts of armodafinil and (S)-modafinil. A central nervous system stimulant, it is used for the treatment of sleeping disorders such as narcolepsy, obstructive sleep apnoea, and shift-work sleep disorder. The optical enantiomers of modafinil have similar pharmacological actions in animals.
2-[(diphenylmethyl)sulfinyl]acetamide : A sulfoxide that is dimethylsulfoxide in which two hydrogens attached to one of the methyl groups are replaced by phenyl groups, while one hydrogen attached to the other methyl group is replaced by a carbamoyl (aminocarbonyl) group.
Cerebral Palsy: A heterogeneous group of nonprogressive motor disorders caused by chronic brain injuries that originate in the prenatal period, perinatal period, or first few years of life. The four major subtypes are spastic, athetoid, ataxic, and mixed cerebral palsy, with spastic forms being the most common. The motor disorder may range from difficulties with fine motor control to severe spasticity (see MUSCLE SPASTICITY) in all limbs. Spastic diplegia (Little disease) is the most common subtype, and is characterized by spasticity that is more prominent in the legs than in the arms. Pathologically, this condition may be associated with LEUKOMALACIA, PERIVENTRICULAR. (From Dev Med Child Neurol 1998 Aug;40(8):520-7)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Two patients with spastic cerebral palsy recently treated with modafinil at the Walter Reed Army Medical Center child neurology clinic have stopped drooling." | 7.73 | Modafinil for drooling in cerebral palsy. ( Cedrone, N; Hurst, D, 2006) |
| "A retrospective review was undertaken at Texas Tech University Health Sciences Center regarding the use of modafinil for the treatment of spasticity associated with cerebral palsy." | 7.72 | Retrospective review of modafinil use for cerebral palsy. ( Dinakar, P; Hurst, DL; Lajara-Nanson, WA; Schiffer, RB, 2004) |
| "After an initial patient with cerebral palsy had an apparent dramatic reduction in spasticity when placed on modafinil, a pilot study was undertaken in 10 pediatric patients to confirm or refute the benefit of modafinil in cerebral palsy." | 7.71 | Use of modafinil in spastic cerebral palsy. ( Hurst, DL; Lajara-Nanson, W, 2002) |
| "Two patients with spastic diplegia secondary to prematurity have had a dramatic improvement in gait during the first 6 months after starting modafinil." | 5.33 | Walking with modafinil and its use in diplegic cerebral palsy: retrospective review. ( Hurst, DL; Lajara-Nanson, WA; Lance-Fish, ME, 2006) |
| "This randomized double blind AB/BA cross-over trial evaluates the effect of oral modafinil versus placebo on spasticity, function, and quality of life in children with cerebral palsy (CP)." | 5.13 | Impact of modafinil on spasticity reduction and quality of life in children with CP. ( Best, A; Campbell, KA; Fehlings, D; Milo-Manson, G; Murphy, AM, 2008) |
| "Two patients with spastic cerebral palsy recently treated with modafinil at the Walter Reed Army Medical Center child neurology clinic have stopped drooling." | 3.73 | Modafinil for drooling in cerebral palsy. ( Cedrone, N; Hurst, D, 2006) |
| "A retrospective review was undertaken at Texas Tech University Health Sciences Center regarding the use of modafinil for the treatment of spasticity associated with cerebral palsy." | 3.72 | Retrospective review of modafinil use for cerebral palsy. ( Dinakar, P; Hurst, DL; Lajara-Nanson, WA; Schiffer, RB, 2004) |
| "After an initial patient with cerebral palsy had an apparent dramatic reduction in spasticity when placed on modafinil, a pilot study was undertaken in 10 pediatric patients to confirm or refute the benefit of modafinil in cerebral palsy." | 3.71 | Use of modafinil in spastic cerebral palsy. ( Hurst, DL; Lajara-Nanson, W, 2002) |
| "Two patients with spastic diplegia secondary to prematurity have had a dramatic improvement in gait during the first 6 months after starting modafinil." | 1.33 | Walking with modafinil and its use in diplegic cerebral palsy: retrospective review. ( Hurst, DL; Lajara-Nanson, WA; Lance-Fish, ME, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Murphy, AM | 1 |
| Milo-Manson, G | 1 |
| Best, A | 1 |
| Campbell, KA | 1 |
| Fehlings, D | 1 |
| Hurst, DL | 3 |
| Lajara-Nanson, WA | 2 |
| Dinakar, P | 1 |
| Schiffer, RB | 1 |
| Hurst, D | 1 |
| Cedrone, N | 1 |
| Lance-Fish, ME | 1 |
| Lajara-Nanson, W | 1 |
1 trial available for modafinil and Cerebral Palsy
| Article | Year |
|---|---|
Impact of modafinil on spasticity reduction and quality of life in children with CP.
Topics: Adolescent; Benzhydryl Compounds; Cerebral Palsy; Child; Double-Blind Method; Female; Humans; Male; | 2008 |
4 other studies available for modafinil and Cerebral Palsy
| Article | Year |
|---|---|
Retrospective review of modafinil use for cerebral palsy.
Topics: Benzhydryl Compounds; Central Nervous System Stimulants; Cerebral Palsy; Child; Humans; Modafinil; M | 2004 |
Modafinil for drooling in cerebral palsy.
Topics: Adolescent; Articulation Disorders; Benzhydryl Compounds; Central Nervous System Stimulants; Cerebra | 2006 |
Walking with modafinil and its use in diplegic cerebral palsy: retrospective review.
Topics: Adolescent; Benzhydryl Compounds; Cerebral Palsy; Child; Child, Preschool; Female; Gait Disorders, N | 2006 |
Use of modafinil in spastic cerebral palsy.
Topics: Adolescent; Benzhydryl Compounds; Body Weight; Central Nervous System Stimulants; Cerebral Palsy; Ch | 2002 |