modafinil has been researched along with Brain Neoplasms in 9 studies
Modafinil: A benzhydryl acetamide compound, central nervous system stimulant, and CYP3A4 inducing agent that is used in the treatment of NARCOLEPSY and SLEEP WAKE DISORDERS.
modafinil : A racemate comprising equimolar amounts of armodafinil and (S)-modafinil. A central nervous system stimulant, it is used for the treatment of sleeping disorders such as narcolepsy, obstructive sleep apnoea, and shift-work sleep disorder. The optical enantiomers of modafinil have similar pharmacological actions in animals.
2-[(diphenylmethyl)sulfinyl]acetamide : A sulfoxide that is dimethylsulfoxide in which two hydrogens attached to one of the methyl groups are replaced by phenyl groups, while one hydrogen attached to the other methyl group is replaced by a carbamoyl (aminocarbonyl) group.
Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A phase II, multi-institutional, placebo-controlled randomized trial assessed feasibility of armodafinil 150 mg/day in participants receiving brain RT, from whom we obtained estimates of variability for fatigue, sleepiness, QOL, cognitive function, and treatment effect." | 9.20 | Phase II double-blind placebo-controlled randomized study of armodafinil for brain radiation-induced fatigue. ( Bryant, D; Case, D; Chan, MD; Grisell, D; Lesser, GJ; Lu, L; Monitto, DC; Naughton, MJ; Page, BR; Rapp, SR; Savona, SR; Shah, S; Shaw, EG, 2015) |
| " Relative to baseline, patients reported lower fatigue severity (CIS) and better motivation (CIS) in both the modafinil (P = ." | 9.17 | The effect of modafinil on fatigue, cognitive functioning, and mood in primary brain tumor patients: a multicenter randomized controlled trial. ( Boele, FW; Cleijne, W; de Groot, M; Douw, L; Heimans, JJ; Klein, M; Reijneveld, JC; Taphoorn, MJ; van Thuijl, HF, 2013) |
| " Studies in early radiotherapy treatment phase (five studies) Pharmacological studies in the "early radiotherapy treatment phase" were designed to prevent or ameliorate cognitive deficits and included drugs used in dementia (memantine) and fatigue (d-threo-methylphenidate hydrochloride)." | 5.22 | Interventions for preventing and ameliorating cognitive deficits in adults treated with cranial irradiation. ( Brown, PD; Day, J; Gehring, K; Grosshans, D; Kirkman, MA; Li, J; Taphoorn, M; Zienius, K, 2022) |
| "A phase II, multi-institutional, placebo-controlled randomized trial assessed feasibility of armodafinil 150 mg/day in participants receiving brain RT, from whom we obtained estimates of variability for fatigue, sleepiness, QOL, cognitive function, and treatment effect." | 5.20 | Phase II double-blind placebo-controlled randomized study of armodafinil for brain radiation-induced fatigue. ( Bryant, D; Case, D; Chan, MD; Grisell, D; Lesser, GJ; Lu, L; Monitto, DC; Naughton, MJ; Page, BR; Rapp, SR; Savona, SR; Shah, S; Shaw, EG, 2015) |
| " Relative to baseline, patients reported lower fatigue severity (CIS) and better motivation (CIS) in both the modafinil (P = ." | 5.17 | The effect of modafinil on fatigue, cognitive functioning, and mood in primary brain tumor patients: a multicenter randomized controlled trial. ( Boele, FW; Cleijne, W; de Groot, M; Douw, L; Heimans, JJ; Klein, M; Reijneveld, JC; Taphoorn, MJ; van Thuijl, HF, 2013) |
| "Fatigue is a common and disabling symptom in people with a primary brain tumour (PBT)." | 2.82 | Interventions for the management of fatigue in adults with a primary brain tumour. ( Bulbeck, H; Cachia, D; Day, J; Rooney, AG; Tremont Lukats, IW; Wefel, J; Yust-Katz, S, 2022) |
| "Fatigue is a common and disabling symptom in people with a primary brain tumour (PBT)." | 2.53 | Interventions for the management of fatigue in adults with a primary brain tumour. ( Armstrong, T; Bulbeck, H; Cachia, D; Day, J; Katz, LH; Rooney, AG; Tremont, I; Wefel, J; Yust-Katz, S, 2016) |
| "Survivors of childhood cancer frequently experience cancer-related cognitive dysfunction, commonly months to years after treatment for pediatric brain tumors, acute lymphoblastic leukemia (ALL), or tumors involving the head and neck." | 2.50 | Developing interventions for cancer-related cognitive dysfunction in childhood cancer survivors. ( Castellino, SM; Lange, BJ; Ullrich, NJ; Whelen, MJ, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 6 (66.67) | 24.3611 |
| 2020's | 2 (22.22) | 2.80 |
| Authors | Studies |
|---|---|
| Day, J | 5 |
| Yust-Katz, S | 2 |
| Cachia, D | 2 |
| Wefel, J | 2 |
| Tremont Lukats, IW | 1 |
| Bulbeck, H | 2 |
| Rooney, AG | 2 |
| Kirkman, MA | 3 |
| Gehring, K | 4 |
| Zienius, K | 3 |
| Grosshans, D | 3 |
| Taphoorn, M | 3 |
| Li, J | 3 |
| Brown, PD | 3 |
| Boele, FW | 1 |
| Douw, L | 1 |
| de Groot, M | 1 |
| van Thuijl, HF | 1 |
| Cleijne, W | 1 |
| Heimans, JJ | 1 |
| Taphoorn, MJ | 1 |
| Reijneveld, JC | 1 |
| Klein, M | 1 |
| Denlinger, CS | 1 |
| Ligibel, JA | 1 |
| Are, M | 1 |
| Baker, KS | 1 |
| Demark-Wahnefried, W | 1 |
| Friedman, DL | 1 |
| Goldman, M | 1 |
| Jones, L | 1 |
| King, A | 1 |
| Ku, GH | 1 |
| Kvale, E | 1 |
| Langbaum, TS | 1 |
| Leonardi-Warren, K | 1 |
| McCabe, MS | 1 |
| Melisko, M | 1 |
| Montoya, JG | 1 |
| Mooney, K | 1 |
| Morgan, MA | 1 |
| Moslehi, JJ | 1 |
| O'Connor, T | 1 |
| Overholser, L | 1 |
| Paskett, ED | 1 |
| Raza, M | 1 |
| Syrjala, KL | 1 |
| Urba, SG | 1 |
| Wakabayashi, MT | 1 |
| Zee, P | 1 |
| McMillian, NR | 1 |
| Freedman-Cass, DA | 1 |
| Castellino, SM | 1 |
| Ullrich, NJ | 1 |
| Whelen, MJ | 1 |
| Lange, BJ | 1 |
| Page, BR | 1 |
| Shaw, EG | 1 |
| Lu, L | 1 |
| Bryant, D | 1 |
| Grisell, D | 1 |
| Lesser, GJ | 1 |
| Monitto, DC | 1 |
| Naughton, MJ | 1 |
| Rapp, SR | 1 |
| Savona, SR | 1 |
| Shah, S | 1 |
| Case, D | 1 |
| Chan, MD | 1 |
| Katz, LH | 1 |
| Tremont, I | 1 |
| Armstrong, T | 1 |
| Patwardhan, SY | 1 |
| Collins, R | 1 |
| Groves, MD | 1 |
| Etzel, CJ | 1 |
| Meyers, CA | 1 |
| Wefel, JS | 1 |
| Marcus, CL | 1 |
| Trescher, WH | 1 |
| Halbower, AC | 1 |
| Lutz, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| MentalPlus® for Assessment and Rehabilitation of Cognitive Functions After Remission of Symptoms of COVID-19[NCT04632719] | 200 participants (Anticipated) | Interventional | 2020-11-08 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for modafinil and Brain Neoplasms
| Article | Year |
|---|---|
Interventions for the management of fatigue in adults with a primary brain tumour.
Topics: Adult; Brain Neoplasms; Dextroamphetamine; Fatigue; Glioma; Humans; Modafinil | 2022 |
Interventions for preventing and ameliorating cognitive deficits in adults treated with cranial irradiation.
Topics: Adult; Brain Neoplasms; Cognition; Cognitive Dysfunction; Cranial Irradiation; Dementia; Donepezil; | 2022 |
Interventions for preventing and ameliorating cognitive deficits in adults treated with cranial irradiation.
Topics: Adult; Brain Neoplasms; Cognition; Cognitive Dysfunction; Cranial Irradiation; Dementia; Donepezil; | 2022 |
Interventions for preventing and ameliorating cognitive deficits in adults treated with cranial irradiation.
Topics: Adult; Brain Neoplasms; Cognition; Cognitive Dysfunction; Cranial Irradiation; Dementia; Donepezil; | 2022 |
Interventions for preventing and ameliorating cognitive deficits in adults treated with cranial irradiation.
Topics: Adult; Brain Neoplasms; Cognition; Cognitive Dysfunction; Cranial Irradiation; Dementia; Donepezil; | 2022 |
Interventions for preventing and ameliorating cognitive deficits in adults treated with cranial irradiation.
Topics: Adult; Brain Neoplasms; Cognition; Cognitive Dysfunction; Cranial Irradiation; Dementia; Donepezil; | 2022 |
Interventions for preventing and ameliorating cognitive deficits in adults treated with cranial irradiation.
Topics: Adult; Brain Neoplasms; Cognition; Cognitive Dysfunction; Cranial Irradiation; Dementia; Donepezil; | 2022 |
Interventions for preventing and ameliorating cognitive deficits in adults treated with cranial irradiation.
Topics: Adult; Brain Neoplasms; Cognition; Cognitive Dysfunction; Cranial Irradiation; Dementia; Donepezil; | 2022 |
Interventions for preventing and ameliorating cognitive deficits in adults treated with cranial irradiation.
Topics: Adult; Brain Neoplasms; Cognition; Cognitive Dysfunction; Cranial Irradiation; Dementia; Donepezil; | 2022 |
Interventions for preventing and ameliorating cognitive deficits in adults treated with cranial irradiation.
Topics: Adult; Brain Neoplasms; Cognition; Cognitive Dysfunction; Cranial Irradiation; Dementia; Donepezil; | 2022 |
Developing interventions for cancer-related cognitive dysfunction in childhood cancer survivors.
Topics: Adolescent; Adult; Age Factors; Antimetabolites, Antineoplastic; Attention; Benzhydryl Compounds; Br | 2014 |
Interventions for the management of fatigue in adults with a primary brain tumour.
Topics: Adult; Benzhydryl Compounds; Brain Neoplasms; Fatigue; Humans; Modafinil; Randomized Controlled Tria | 2016 |
3 trials available for modafinil and Brain Neoplasms
| Article | Year |
|---|---|
The effect of modafinil on fatigue, cognitive functioning, and mood in primary brain tumor patients: a multicenter randomized controlled trial.
Topics: Adult; Aged; Aged, 80 and over; Benzhydryl Compounds; Brain Neoplasms; Cognition Disorders; Cross-Ov | 2013 |
Phase II double-blind placebo-controlled randomized study of armodafinil for brain radiation-induced fatigue.
Topics: Adult; Aged; Benzhydryl Compounds; Brain Neoplasms; Double-Blind Method; Fatigue; Female; Glioblasto | 2015 |
A randomized trial on the efficacy of methylphenidate and modafinil for improving cognitive functioning and symptoms in patients with a primary brain tumor.
Topics: Adult; Benzhydryl Compounds; Brain Neoplasms; Central Nervous System Stimulants; Cognition Disorders | 2012 |
2 other studies available for modafinil and Brain Neoplasms
| Article | Year |
|---|---|
Survivorship: cognitive function, version 1.2014.
Topics: Adaptation, Psychological; Benzhydryl Compounds; Brain Neoplasms; Central Nervous System Stimulants; | 2014 |
Secondary narcolepsy in children with brain tumors.
Topics: Adolescent; Benzhydryl Compounds; Brain Neoplasms; Central Nervous System Stimulants; Child; Child, | 2002 |