modafinil has been researched along with Apoplexy in 17 studies
Modafinil: A benzhydryl acetamide compound, central nervous system stimulant, and CYP3A4 inducing agent that is used in the treatment of NARCOLEPSY and SLEEP WAKE DISORDERS.
modafinil : A racemate comprising equimolar amounts of armodafinil and (S)-modafinil. A central nervous system stimulant, it is used for the treatment of sleeping disorders such as narcolepsy, obstructive sleep apnoea, and shift-work sleep disorder. The optical enantiomers of modafinil have similar pharmacological actions in animals.
2-[(diphenylmethyl)sulfinyl]acetamide : A sulfoxide that is dimethylsulfoxide in which two hydrogens attached to one of the methyl groups are replaced by phenyl groups, while one hydrogen attached to the other methyl group is replaced by a carbamoyl (aminocarbonyl) group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study aimed to assess the efficacy of modafinil, a wakefulness-promoting agent in alleviating post-stroke fatigue ≥3 months after stroke." | 9.24 | MIDAS (Modafinil in Debilitating Fatigue After Stroke): A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Trial. ( Attia, J; Bivard, A; Holliday, E; Krishnamurthy, V; Levi, CR; Lillicrap, T; Nilsson, M; Pagram, H; Parsons, M, 2017) |
| "MIDAS is a phase II, single-centre, prospective, double-blinded, randomised, crossover trial of modafinil for the treatment of persistent fatigue in survivors of ischaemic stroke." | 9.22 | Modafinil In Debilitating fatigue After Stroke (MIDAS): study protocol for a randomised, double-blinded, placebo-controlled, crossover trial. ( Attia, J; Bivard, A; Krishnamurthy, V; Levi, CR; Lillicrap, T; Nilsson, M; Parsons, MW, 2016) |
| "One thousand one hundred twenty-one patients with stroke were screened and 41 patients included, 21 received modafinil." | 9.20 | Modafinil May Alleviate Poststroke Fatigue: A Randomized, Placebo-Controlled, Double-Blinded Trial. ( Damgaard, B; Overgaard, K; Poulsen, MB; Rasmussen, RS; Zerahn, B, 2015) |
| "Amantadine and modafinil are neurostimulants that may improve cognitive and functional recovery post-stroke, but the existing study results vary, and no comprehensive review has been published." | 9.05 | Amantadine and Modafinil as Neurostimulants During Post-stroke Care: A Systematic Review. ( Brown, CS; Cote, J; Eldridge, A; Gagnon, DJ; Leclerc, AM; May, T; Nocella, K; Riker, RR; Seder, DB, 2020) |
| "We performed a systematic review in accordance with the Cochrane Handbook for Systematic Reviews of Interventions recommendations to assess the efficacy and safety of modafinil in poststroke patients." | 9.01 | Modafinil for poststroke patients: A systematic review. ( Cabrera Martimbianco, AL; da Silva, LDGM; Fernandes, CAA; Ferreira, DBGM; Hosni, ND; Latorraca, COC; Pacheco, RL; Riera, R; Vianna Pachito, D, 2019) |
| "Modafinil use in acute in-hospital stroke patients with moderate stroke complicated by lethargy and fatigue was associated with improved discharge disposition." | 7.96 | Modafinil in Recovery after Stroke (MIRAS): A Retrospective Study. ( Cross, DB; Czeisler, B; Golub, D; Hernandez, C; Ishida, K; Karoub, A; Lord, A; Medicherla, C; Tiu, J; Torres, J; Wu, C; Yaghi, S, 2020) |
| "This study explored the cost-effectiveness of modafinil in treating post-stroke fatigue in the Australian context, by determining its incremental cost-effectiveness ratio (ICER) and by simulating the potential cost-savings on a national scale, through a re-analysis of MIDAS trial data." | 7.96 | Exploring the Economic Benefits of Modafinil for Post-Stroke Fatigue in Australia: A Cost-Effectiveness Evaluation. ( Bajorek, B; Bivard, A; Gao, L; Garcia-Esperon, C; Holliday, E; Levi, C; Lillicrap, T; Parsons, M; Spratt, N, 2020) |
| "Modafinil has anecdotal response to neurological fatigue, but such an effect may depend on the type and location of cerebral impairment." | 7.75 | Effect of modafinil on subjective fatigue in multiple sclerosis and stroke patients. ( Annoni, JM; Bassetti, C; Brioschi, A; Gramigna, S; Ruffieux, C; Schluep, M; Staub, F; Werth, E, 2009) |
| "Post-stroke fatigue has a significant impact on stroke survivors' mental and physical well-being." | 6.90 | Modafinil treatment modulates functional connectivity in stroke survivors with severe fatigue. ( Bivard, A; Goodin, P; Levi, CR; Lillicrap, T; Parsons, MW; Spratt, NJ; Visser, MM, 2019) |
| "This study aimed to assess the efficacy of modafinil, a wakefulness-promoting agent in alleviating post-stroke fatigue ≥3 months after stroke." | 5.24 | MIDAS (Modafinil in Debilitating Fatigue After Stroke): A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Trial. ( Attia, J; Bivard, A; Holliday, E; Krishnamurthy, V; Levi, CR; Lillicrap, T; Nilsson, M; Pagram, H; Parsons, M, 2017) |
| "MIDAS is a phase II, single-centre, prospective, double-blinded, randomised, crossover trial of modafinil for the treatment of persistent fatigue in survivors of ischaemic stroke." | 5.22 | Modafinil In Debilitating fatigue After Stroke (MIDAS): study protocol for a randomised, double-blinded, placebo-controlled, crossover trial. ( Attia, J; Bivard, A; Krishnamurthy, V; Levi, CR; Lillicrap, T; Nilsson, M; Parsons, MW, 2016) |
| "One thousand one hundred twenty-one patients with stroke were screened and 41 patients included, 21 received modafinil." | 5.20 | Modafinil May Alleviate Poststroke Fatigue: A Randomized, Placebo-Controlled, Double-Blinded Trial. ( Damgaard, B; Overgaard, K; Poulsen, MB; Rasmussen, RS; Zerahn, B, 2015) |
| "Amantadine and modafinil are neurostimulants that may improve cognitive and functional recovery post-stroke, but the existing study results vary, and no comprehensive review has been published." | 5.05 | Amantadine and Modafinil as Neurostimulants During Post-stroke Care: A Systematic Review. ( Brown, CS; Cote, J; Eldridge, A; Gagnon, DJ; Leclerc, AM; May, T; Nocella, K; Riker, RR; Seder, DB, 2020) |
| "We performed a systematic review in accordance with the Cochrane Handbook for Systematic Reviews of Interventions recommendations to assess the efficacy and safety of modafinil in poststroke patients." | 5.01 | Modafinil for poststroke patients: A systematic review. ( Cabrera Martimbianco, AL; da Silva, LDGM; Fernandes, CAA; Ferreira, DBGM; Hosni, ND; Latorraca, COC; Pacheco, RL; Riera, R; Vianna Pachito, D, 2019) |
| "Modafinil use in acute in-hospital stroke patients with moderate stroke complicated by lethargy and fatigue was associated with improved discharge disposition." | 3.96 | Modafinil in Recovery after Stroke (MIRAS): A Retrospective Study. ( Cross, DB; Czeisler, B; Golub, D; Hernandez, C; Ishida, K; Karoub, A; Lord, A; Medicherla, C; Tiu, J; Torres, J; Wu, C; Yaghi, S, 2020) |
| "This study explored the cost-effectiveness of modafinil in treating post-stroke fatigue in the Australian context, by determining its incremental cost-effectiveness ratio (ICER) and by simulating the potential cost-savings on a national scale, through a re-analysis of MIDAS trial data." | 3.96 | Exploring the Economic Benefits of Modafinil for Post-Stroke Fatigue in Australia: A Cost-Effectiveness Evaluation. ( Bajorek, B; Bivard, A; Gao, L; Garcia-Esperon, C; Holliday, E; Levi, C; Lillicrap, T; Parsons, M; Spratt, N, 2020) |
| "Modafinil has anecdotal response to neurological fatigue, but such an effect may depend on the type and location of cerebral impairment." | 3.75 | Effect of modafinil on subjective fatigue in multiple sclerosis and stroke patients. ( Annoni, JM; Bassetti, C; Brioschi, A; Gramigna, S; Ruffieux, C; Schluep, M; Staub, F; Werth, E, 2009) |
| "Post-stroke fatigue has a significant impact on stroke survivors' mental and physical well-being." | 2.90 | Modafinil treatment modulates functional connectivity in stroke survivors with severe fatigue. ( Bivard, A; Goodin, P; Levi, CR; Lillicrap, T; Parsons, MW; Spratt, NJ; Visser, MM, 2019) |
| "Modafinil users were matched with nonusers." | 1.48 | Modafinil and the risk of cardiovascular events: Findings from three US claims databases. ( Goehring, EL; Jones, JK; Kaplan, S; Knebel, H; Melamed-Gal, S; Nguyen-Khoa, BA, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (11.76) | 29.6817 |
| 2010's | 10 (58.82) | 24.3611 |
| 2020's | 5 (29.41) | 2.80 |
| Authors | Studies |
|---|---|
| Yousefi-Manesh, H | 1 |
| Rashidian, A | 1 |
| Hemmati, S | 1 |
| Shirooie, S | 1 |
| Sadeghi, MA | 1 |
| Zarei, N | 1 |
| Dehpour, AR | 1 |
| Cross, DB | 1 |
| Tiu, J | 1 |
| Medicherla, C | 1 |
| Ishida, K | 1 |
| Lord, A | 1 |
| Czeisler, B | 1 |
| Wu, C | 1 |
| Golub, D | 1 |
| Karoub, A | 1 |
| Hernandez, C | 1 |
| Yaghi, S | 1 |
| Torres, J | 1 |
| Gagnon, DJ | 2 |
| Leclerc, AM | 2 |
| Riker, RR | 2 |
| Brown, CS | 2 |
| May, T | 2 |
| Nocella, K | 2 |
| Cote, J | 2 |
| Eldridge, A | 2 |
| Seder, DB | 2 |
| Bajorek, B | 1 |
| Gao, L | 1 |
| Lillicrap, T | 4 |
| Bivard, A | 5 |
| Garcia-Esperon, C | 2 |
| Parsons, M | 2 |
| Spratt, N | 1 |
| Holliday, E | 2 |
| Levi, C | 1 |
| Kakehi, S | 1 |
| Tompkins, DM | 1 |
| Krishnamurthy, V | 2 |
| Attia, J | 2 |
| Pagram, H | 1 |
| Nilsson, M | 2 |
| Levi, CR | 4 |
| Antelmi, E | 1 |
| Pizza, F | 1 |
| Vandi, S | 1 |
| Plazzi, G | 1 |
| Kaplan, S | 1 |
| Goehring, EL | 1 |
| Melamed-Gal, S | 1 |
| Nguyen-Khoa, BA | 1 |
| Knebel, H | 1 |
| Jones, JK | 1 |
| Pacheco, RL | 1 |
| Latorraca, COC | 1 |
| da Silva, LDGM | 1 |
| Ferreira, DBGM | 1 |
| Fernandes, CAA | 1 |
| Hosni, ND | 1 |
| Cabrera Martimbianco, AL | 1 |
| Vianna Pachito, D | 1 |
| Riera, R | 1 |
| Visser, MM | 2 |
| Maréchal, B | 1 |
| Goodin, P | 2 |
| Lillicrap, TP | 1 |
| Spratt, NJ | 2 |
| Parsons, MW | 3 |
| Geffen, S | 1 |
| Shum, K | 1 |
| Tan, HM | 1 |
| Poulsen, MB | 1 |
| Damgaard, B | 1 |
| Zerahn, B | 1 |
| Overgaard, K | 1 |
| Rasmussen, RS | 1 |
| Annoni, JM | 2 |
| Staub, F | 2 |
| Bogousslavsky, J | 1 |
| Brioschi, A | 2 |
| Gramigna, S | 1 |
| Werth, E | 1 |
| Ruffieux, C | 1 |
| Bassetti, C | 1 |
| Schluep, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Amantadine for Neuroenhancement in Acute Patients Study - A Prospective Pilot Proof of Concept Phase IIb Study in Intensive and Intermediate Care Unit Patients[NCT05479032] | Phase 2 | 50 participants (Anticipated) | Interventional | 2022-09-30 | Not yet recruiting | ||
| Managing Fatigue: The Individual Program in People Living With Parkinson's Disease- A Protocol for a Feasibility Study[NCT04267107] | 23 participants (Actual) | Interventional | 2020-11-02 | Completed | |||
| Treatment of Post Stroke Fatigue With Modafinil, Effect on Rehabilitation, Fatigue and Bonemass Index[NCT01800097] | Phase 3 | 41 participants (Actual) | Interventional | 2012-10-31 | Terminated (stopped due to Slow recruitment) | ||
| Strengthening Oropharyngeal Muscles as a Novel Approach to Treat Obstructive Sleep Apnea After Stroke: A Randomized Feasibility Study[NCT04212260] | 33 participants (Actual) | Interventional | 2019-04-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for modafinil and Apoplexy
| Article | Year |
|---|---|
Amantadine and Modafinil as Neurostimulants During Post-stroke Care: A Systematic Review.
Topics: Amantadine; Central Nervous System Stimulants; Dopamine Agents; Humans; Modafinil; Recovery of Funct | 2020 |
A Review of Pharmacologic Neurostimulant Use During Rehabilitation and Recovery After Brain Injury.
Topics: Brain Injuries; Humans; Modafinil; Prospective Studies; Risk Assessment; Stroke | 2021 |
Modafinil for poststroke patients: A systematic review.
Topics: Cognition; Fatigue; Humans; Modafinil; Quality of Life; Stroke; Wakefulness-Promoting Agents | 2019 |
Frequency, characterisation and therapies of fatigue after stroke.
Topics: Benzhydryl Compounds; Central Nervous System Stimulants; Cognitive Behavioral Therapy; Depressive Di | 2008 |
5 trials available for modafinil and Apoplexy
| Article | Year |
|---|---|
MIDAS (Modafinil in Debilitating Fatigue After Stroke): A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Trial.
Topics: Aged; Aged, 80 and over; Benzhydryl Compounds; Cross-Over Studies; Double-Blind Method; Fatigue; Fem | 2017 |
Predicting Modafinil-Treatment Response in Poststroke Fatigue Using Brain Morphometry and Functional Connectivity.
Topics: Adult; Aged; Brain; Caudate Nucleus; Cohort Studies; Cross-Over Studies; Double-Blind Method; Fatigu | 2019 |
Modafinil treatment modulates functional connectivity in stroke survivors with severe fatigue.
Topics: Brain Mapping; Central Nervous System Stimulants; Connectome; Double-Blind Method; Fatigue; Female; | 2019 |
Modafinil May Alleviate Poststroke Fatigue: A Randomized, Placebo-Controlled, Double-Blinded Trial.
Topics: Aged; Aged, 80 and over; Benzhydryl Compounds; Double-Blind Method; Fatigue; Female; Humans; Male; M | 2015 |
Modafinil In Debilitating fatigue After Stroke (MIDAS): study protocol for a randomised, double-blinded, placebo-controlled, crossover trial.
Topics: Affect; Benzhydryl Compounds; Clinical Protocols; Cognition; Cross-Over Studies; Double-Blind Method | 2016 |
8 other studies available for modafinil and Apoplexy
| Article | Year |
|---|---|
Therapeutic effects of modafinil in ischemic stroke; possible role of NF-κB downregulation.
Topics: Animals; Anti-Inflammatory Agents; Behavior, Animal; Brain Ischemia; Disease Models, Animal; Down-Re | 2019 |
Modafinil in Recovery after Stroke (MIRAS): A Retrospective Study.
Topics: Aged; Aged, 80 and over; Central Nervous System Stimulants; Disability Evaluation; Fatigue; Female; | 2020 |
Amantadine and Modafinil as Neurostimulants Following Acute Stroke: A Retrospective Study of Intensive Care Unit Patients.
Topics: Adult; Amantadine; Central Nervous System Stimulants; Humans; Intensive Care Units; Modafinil; Retro | 2021 |
Exploring the Economic Benefits of Modafinil for Post-Stroke Fatigue in Australia: A Cost-Effectiveness Evaluation.
Topics: Aged; Australia; Central Nervous System Stimulants; Clinical Trials, Phase II as Topic; Cost Savings | 2020 |
Stereotyped episodes of aphasia and immobility: how cataplexy mimics stroke in an elderly patient.
Topics: Adjuvants, Anesthesia; Age of Onset; Aphasia; Cataplexy; Diagnostic Errors; Electroencephalography; | 2017 |
Modafinil and the risk of cardiovascular events: Findings from three US claims databases.
Topics: Administrative Claims, Healthcare; Adolescent; Adult; Aged; Cause of Death; Confounding Factors, Epi | 2018 |
Novel use of modafinal to treat severe physical and cognitive impairment post-stroke.
Topics: Aged, 80 and over; Benzhydryl Compounds; Cognition Disorders; Humans; Male; Modafinil; Neuroprotecti | 2013 |
Effect of modafinil on subjective fatigue in multiple sclerosis and stroke patients.
Topics: Adult; Benzhydryl Compounds; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Fa | 2009 |