modafinil has been researched along with Anxiety in 15 studies
Modafinil: A benzhydryl acetamide compound, central nervous system stimulant, and CYP3A4 inducing agent that is used in the treatment of NARCOLEPSY and SLEEP WAKE DISORDERS.
modafinil : A racemate comprising equimolar amounts of armodafinil and (S)-modafinil. A central nervous system stimulant, it is used for the treatment of sleeping disorders such as narcolepsy, obstructive sleep apnoea, and shift-work sleep disorder. The optical enantiomers of modafinil have similar pharmacological actions in animals.
2-[(diphenylmethyl)sulfinyl]acetamide : A sulfoxide that is dimethylsulfoxide in which two hydrogens attached to one of the methyl groups are replaced by phenyl groups, while one hydrogen attached to the other methyl group is replaced by a carbamoyl (aminocarbonyl) group.
Anxiety: Feelings or emotions of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Three patients discontinued modafinil because of AEs (nervousness, dizziness)." | 7.71 | Modafinil in treatment of fatigue in multiple sclerosis. Results of an open-label study. ( Maida, EM; Rupp, M; Schwarz, S; Zifko, UA; Zipko, HT, 2002) |
| " Both compounds induced potent wake-promoting effects in littermate wild-type and orexin-tTA; TetO-DTA mice when dosed at active and resting phases." | 5.91 | Comparison of Solriamfetol and Modafinil on Arousal and Anxiety-Related Behaviors in Narcoleptic Mice. ( Nishino, S; Sakai, N, 2023) |
| "Modafinil is a new drug used in the treatment of narcolepsy." | 5.29 | The stimulant effect of modafinil on wakefulness is not associated with an increase in anxiety in mice. A comparison with dexamphetamine. ( Costentin, J; Panissaud, C; Simon, P, 1994) |
| "The smaller dose of modafinil (32 mg/kg) impaired memory consolidation, without modifying anxiety or locomotion." | 3.81 | Effects of post-training modafinil administration in a discriminative avoidance task in mice. ( Bittencourt, LR; Bizerra, CS; Fernandes, HA; Frussa-Filho, R; Lopes-Silva, LB; Patti, Cde L; Tufik, S; Zanin, KA, 2015) |
| "Three patients discontinued modafinil because of AEs (nervousness, dizziness)." | 3.71 | Modafinil in treatment of fatigue in multiple sclerosis. Results of an open-label study. ( Maida, EM; Rupp, M; Schwarz, S; Zifko, UA; Zipko, HT, 2002) |
| "Excessive daytime sleepiness (EDS) is a common consequence of OSA and is associated with cognitive deficits and anxiety." | 3.30 | Solriamfetol enhances wakefulness and improves cognition and anxiety in a murine model of OSA. ( Badran, M; Barrow, MB; Gozal, D; Puech, C; Runion, AR, 2023) |
| " Headache, insomnia, and anxiety were the most common adverse events (AEs) reported, whereas akathisia, nausea, sedation/somnolence, and weight increase were uncommon." | 2.82 | Long-term safety and efficacy of armodafinil in bipolar depression: A 6-month open-label extension study. ( Amchin, J; Frye, MA; Gross, N; Ketter, TA, 2016) |
| "Modafinil or a placebo was administered once daily for 7 days." | 2.69 | A double-blind, placebo-controlled, ascending-dose evaluation of the pharmacokinetics and tolerability of modafinil tablets in healthy male volunteers. ( Grebow, PE; Hartman, LN; King, SP; Laughton, WB; McCormick, GC; Simcoe, D; Wong, YN, 1999) |
| "Modafinil is a nonamphetamine nootropic drug with an increasingly therapeutic interest due to its different sites of action and behavioral effects in comparison to cocaine or amphetamine." | 2.66 | Pharmacokinetic and pharmacodynamic of the cognitive enhancer modafinil: Relevant clinical and forensic aspects. ( Dinis-Oliveira, RJ; Sousa, A, 2020) |
| " Approaches to the management of residual symptoms include addressing treatment-emergent side effects and co-morbid conditions, optimizing antidepressant dosing and using augmentation therapy." | 2.43 | Pharmacological approaches to the treatment of residual symptoms. ( Fava, M, 2006) |
| " Both compounds induced potent wake-promoting effects in littermate wild-type and orexin-tTA; TetO-DTA mice when dosed at active and resting phases." | 1.91 | Comparison of Solriamfetol and Modafinil on Arousal and Anxiety-Related Behaviors in Narcoleptic Mice. ( Nishino, S; Sakai, N, 2023) |
| "Modafinil has a novel mechanism of action and may have antidepressant properties." | 1.33 | A retrospective chart review of the effects of modafinil on depression as monotherapy and as adjunctive therapy. ( Price, CS; Taylor, FB, 2005) |
| "Modafinil is a new drug used in the treatment of narcolepsy." | 1.29 | The stimulant effect of modafinil on wakefulness is not associated with an increase in anxiety in mice. A comparison with dexamphetamine. ( Costentin, J; Panissaud, C; Simon, P, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (13.33) | 18.2507 |
| 2000's | 4 (26.67) | 29.6817 |
| 2010's | 6 (40.00) | 24.3611 |
| 2020's | 3 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sakai, N | 1 |
| Nishino, S | 1 |
| Badran, M | 1 |
| Puech, C | 1 |
| Barrow, MB | 1 |
| Runion, AR | 1 |
| Gozal, D | 1 |
| Sousa, A | 1 |
| Dinis-Oliveira, RJ | 1 |
| Zager, A | 1 |
| Brandão, WN | 1 |
| Margatho, RO | 1 |
| Peron, JP | 1 |
| Tufik, S | 2 |
| Andersen, ML | 1 |
| Kornum, BR | 1 |
| Palermo-Neto, J | 1 |
| Dias, VT | 1 |
| Rosa, HZ | 1 |
| D'avila, LF | 1 |
| Vey, LT | 1 |
| Barcelos, RCS | 1 |
| Burger, ME | 1 |
| Ooi, T | 1 |
| Wong, SH | 1 |
| See, B | 1 |
| Barsevick, AM | 1 |
| Irwin, MR | 1 |
| Hinds, P | 1 |
| Miller, A | 1 |
| Berger, A | 1 |
| Jacobsen, P | 1 |
| Ancoli-Israel, S | 1 |
| Reeve, BB | 1 |
| Mustian, K | 1 |
| O'Mara, A | 1 |
| Lai, JS | 1 |
| Fisch, M | 1 |
| Cella, D | 1 |
| Fernandes, HA | 1 |
| Zanin, KA | 1 |
| Patti, Cde L | 1 |
| Lopes-Silva, LB | 1 |
| Bizerra, CS | 1 |
| Bittencourt, LR | 1 |
| Frussa-Filho, R | 1 |
| Ketter, TA | 1 |
| Amchin, J | 1 |
| Frye, MA | 1 |
| Gross, N | 1 |
| Zifko, UA | 1 |
| Rupp, M | 1 |
| Schwarz, S | 1 |
| Zipko, HT | 1 |
| Maida, EM | 1 |
| Price, CS | 1 |
| Taylor, FB | 1 |
| van Vliet, SA | 1 |
| Jongsma, MJ | 1 |
| Vanwersch, RA | 1 |
| Olivier, B | 1 |
| Philippens, IH | 1 |
| Fava, M | 1 |
| Simon, P | 1 |
| Panissaud, C | 1 |
| Costentin, J | 1 |
| Wong, YN | 1 |
| Simcoe, D | 1 |
| Hartman, LN | 1 |
| Laughton, WB | 1 |
| King, SP | 1 |
| McCormick, GC | 1 |
| Grebow, PE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Feasibility Study of a Hypnosis Intervention and a Cognitive Behavioral Therapy Intervention to Reduce Fatigue in Patients Undergoing Chemotherapy for Metastatic Colorectal Cancer[NCT04999306] | 60 participants (Anticipated) | Interventional | 2023-05-17 | Recruiting | |||
| Effect of Resistance Training Variable Manipulation (Intensity and Volume) on Body Composition, Fatigability and Functional Capacity in Postmenopausal Breast Cancer Survivors.[NCT03644329] | 80 participants (Anticipated) | Interventional | 2018-05-13 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for modafinil and Anxiety
| Article | Year |
|---|---|
Pharmacokinetic and pharmacodynamic of the cognitive enhancer modafinil: Relevant clinical and forensic aspects.
Topics: Anxiety; Diarrhea; Drug Eruptions; Drug Interactions; Erythema Multiforme; Forensic Sciences; Headac | 2020 |
Pharmacological approaches to the treatment of residual symptoms.
Topics: Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Benzhydryl Compounds; Benzodiazepines; Central | 2006 |
3 trials available for modafinil and Anxiety
| Article | Year |
|---|---|
Solriamfetol enhances wakefulness and improves cognition and anxiety in a murine model of OSA.
Topics: Animals; Anxiety; Cognition; Disease Models, Animal; Disorders of Excessive Somnolence; Male; Mice; | 2023 |
Long-term safety and efficacy of armodafinil in bipolar depression: A 6-month open-label extension study.
Topics: Adult; Aged; Anxiety; Benzhydryl Compounds; Bipolar Disorder; Double-Blind Method; Female; Headache; | 2016 |
A double-blind, placebo-controlled, ascending-dose evaluation of the pharmacokinetics and tolerability of modafinil tablets in healthy male volunteers.
Topics: Adolescent; Adult; Anxiety; Area Under Curve; Benzhydryl Compounds; Central Nervous System Stimulant | 1999 |
10 other studies available for modafinil and Anxiety
| Article | Year |
|---|---|
Comparison of Solriamfetol and Modafinil on Arousal and Anxiety-Related Behaviors in Narcoleptic Mice.
Topics: Animals; Anxiety; Arousal; Disorders of Excessive Somnolence; Mice; Modafinil; Narcolepsy | 2023 |
The wake-promoting drug Modafinil prevents motor impairment in sickness behavior induced by LPS in mice: Role for dopaminergic D1 receptor.
Topics: Animals; Anxiety; Benzazepines; Benzhydryl Compounds; Brain; Cell Movement; Depression; Disease Mode | 2018 |
Modafinil reduces amphetamine preference and prevents anxiety-like symptoms during drug withdrawal in young rats: Involvement of dopaminergic targets in VTA and striatum.
Topics: Amphetamine; Amphetamine-Related Disorders; Animals; Anxiety; Central Nervous System Stimulants; Cor | 2019 |
Modafinil as a Stimulant for Military Aviators.
Topics: Accidents, Aviation; Adult; Aerospace Medicine; Anxiety; Central Nervous System Stimulants; Diarrhea | 2019 |
Recommendations for high-priority research on cancer-related fatigue in children and adults.
Topics: Adult; Anxiety; Benzhydryl Compounds; Bupropion; Central Nervous System Stimulants; Child; Clinical | 2013 |
Recommendations for high-priority research on cancer-related fatigue in children and adults.
Topics: Adult; Anxiety; Benzhydryl Compounds; Bupropion; Central Nervous System Stimulants; Child; Clinical | 2013 |
Recommendations for high-priority research on cancer-related fatigue in children and adults.
Topics: Adult; Anxiety; Benzhydryl Compounds; Bupropion; Central Nervous System Stimulants; Child; Clinical | 2013 |
Recommendations for high-priority research on cancer-related fatigue in children and adults.
Topics: Adult; Anxiety; Benzhydryl Compounds; Bupropion; Central Nervous System Stimulants; Child; Clinical | 2013 |
Effects of post-training modafinil administration in a discriminative avoidance task in mice.
Topics: Animals; Anxiety; Avoidance Learning; Benzhydryl Compounds; Discrimination Learning; Disease Models, | 2015 |
Modafinil in treatment of fatigue in multiple sclerosis. Results of an open-label study.
Topics: Adult; Anxiety; Benzhydryl Compounds; Central Nervous System Stimulants; Dizziness; Fatigue; Female; | 2002 |
A retrospective chart review of the effects of modafinil on depression as monotherapy and as adjunctive therapy.
Topics: Adult; Anxiety; Benzhydryl Compounds; Central Nervous System Stimulants; Chemotherapy, Adjuvant; Dem | 2005 |
Behavioral effects of modafinil in marmoset monkeys.
Topics: Acoustic Stimulation; Animals; Anxiety; Behavior, Animal; Benzhydryl Compounds; Callithrix; Central | 2006 |
The stimulant effect of modafinil on wakefulness is not associated with an increase in anxiety in mice. A comparison with dexamphetamine.
Topics: Animals; Anxiety; Benzhydryl Compounds; Central Nervous System Stimulants; Dextroamphetamine; Explor | 1994 |