modafinil has been researched along with Amyotrophic Lateral Sclerosis in 3 studies
Modafinil: A benzhydryl acetamide compound, central nervous system stimulant, and CYP3A4 inducing agent that is used in the treatment of NARCOLEPSY and SLEEP WAKE DISORDERS.
modafinil : A racemate comprising equimolar amounts of armodafinil and (S)-modafinil. A central nervous system stimulant, it is used for the treatment of sleeping disorders such as narcolepsy, obstructive sleep apnoea, and shift-work sleep disorder. The optical enantiomers of modafinil have similar pharmacological actions in animals.
2-[(diphenylmethyl)sulfinyl]acetamide : A sulfoxide that is dimethylsulfoxide in which two hydrogens attached to one of the methyl groups are replaced by phenyl groups, while one hydrogen attached to the other methyl group is replaced by a carbamoyl (aminocarbonyl) group.
Amyotrophic Lateral Sclerosis: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our objective was to determine whether modafinil alleviates fatigue in patients with amyotrophic lateral sclerosis (ALS)." | 9.14 | Modafinil treatment of fatigue in patients with ALS: a placebo-controlled study. ( Chew, S; Gordon, PH; McElhiney, M; Mitsumoto, H; Rabkin, JG; Rabkin, R, 2009) |
| "Our objective was to determine whether modafinil alleviates fatigue in patients with amyotrophic lateral sclerosis (ALS)." | 5.14 | Modafinil treatment of fatigue in patients with ALS: a placebo-controlled study. ( Chew, S; Gordon, PH; McElhiney, M; Mitsumoto, H; Rabkin, JG; Rabkin, R, 2009) |
| "There were 1948 treatment histories for modafinil and 1394 treatment reports for amitriptyline reported across five PatientsLikeMe communities (multiple sclerosis, Parkinson's disease, mood conditions, fibromyalgia/chronic fatigue syndrome, and amyotrophic lateral sclerosis)." | 3.77 | Patient-reported outcomes as a source of evidence in off-label prescribing: analysis of data from PatientsLikeMe. ( Frost, J; Heywood, J; Okun, S; Vaughan, T; Wicks, P, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gibbons, C | 1 |
| Pagnini, F | 1 |
| Friede, T | 1 |
| Young, CA | 1 |
| Rabkin, JG | 1 |
| Gordon, PH | 1 |
| McElhiney, M | 1 |
| Rabkin, R | 1 |
| Chew, S | 1 |
| Mitsumoto, H | 1 |
| Frost, J | 1 |
| Okun, S | 1 |
| Vaughan, T | 1 |
| Heywood, J | 1 |
| Wicks, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Quantifying Fatigue of the Respiratory and Swallowing Musculature in Patients With Amyotrophic Lateral Sclerosis[NCT04468191] | 0 participants (Actual) | Interventional | 2021-02-10 | Withdrawn (stopped due to COVID-19 pandemic restrictions for data collection) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for modafinil and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Treatment of fatigue in amyotrophic lateral sclerosis/motor neuron disease.
Topics: Amyotrophic Lateral Sclerosis; Benzhydryl Compounds; Breathing Exercises; Fatigue; Humans; Modafinil | 2018 |
1 trial available for modafinil and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Modafinil treatment of fatigue in patients with ALS: a placebo-controlled study.
Topics: Adult; Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Benzhydryl Compounds; Central Nervous | 2009 |
1 other study available for modafinil and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Patient-reported outcomes as a source of evidence in off-label prescribing: analysis of data from PatientsLikeMe.
Topics: Amitriptyline; Amyotrophic Lateral Sclerosis; Benzhydryl Compounds; Cognition Disorders; Community N | 2011 |