Page last updated: 2024-10-31

modafinil and Amphetamine Abuse

modafinil has been researched along with Amphetamine Abuse in 27 studies

Modafinil: A benzhydryl acetamide compound, central nervous system stimulant, and CYP3A4 inducing agent that is used in the treatment of NARCOLEPSY and SLEEP WAKE DISORDERS.
modafinil : A racemate comprising equimolar amounts of armodafinil and (S)-modafinil. A central nervous system stimulant, it is used for the treatment of sleeping disorders such as narcolepsy, obstructive sleep apnoea, and shift-work sleep disorder. The optical enantiomers of modafinil have similar pharmacological actions in animals.
2-[(diphenylmethyl)sulfinyl]acetamide : A sulfoxide that is dimethylsulfoxide in which two hydrogens attached to one of the methyl groups are replaced by phenyl groups, while one hydrogen attached to the other methyl group is replaced by a carbamoyl (aminocarbonyl) group.

Research Excerpts

ExcerptRelevanceReference
" In this study, we report the case of a patient with adult ADHD with co-morbid amphetamine abuse who was treated successfully with the non-stimulant alertness-promoting drug modafinil."7.75Modafinil treatment of amphetamine abuse in adult ADHD. ( Bitsios, P; Mann, N, 2009)
" In this study, we report the case of a patient with adult ADHD with co-morbid amphetamine abuse who was treated successfully with the non-stimulant alertness-promoting drug modafinil."3.75Modafinil treatment of amphetamine abuse in adult ADHD. ( Bitsios, P; Mann, N, 2009)
"Modafinil was found to be tolerable and well accepted by methamphetamine users and feasible for short-term inpatient withdrawal, but the sample was too small to detect treatment effects."2.78A pilot randomised controlled trial of modafinil during acute methamphetamine withdrawal: feasibility, tolerability and clinical outcomes. ( Ferris, J; Hester, R; Lee, N; McKetin, R; Nielsen, S; Pennay, A, 2013)
"Modafinil was tested for efficacy in decreasing use in methamphetamine-dependent participants, compared to placebo."2.77Modafinil for the treatment of methamphetamine dependence. ( Anderson, AL; Beresford, T; Biswas, K; Campbell, J; Chiang, N; Elkashef, AM; Haning, W; Holmes, T; Iturriaga, E; Kahn, R; Li, SH; Mawhinney, J; McCann, M; McSherry, F; Rawson, R; Stock, C; Weis, D; Yu, E, 2012)
"Modafinil has been shown to improve cognitive performance in neuropsychiatric patients and healthy volunteers."2.76Effect of modafinil on learning and task-related brain activity in methamphetamine-dependent and healthy individuals. ( Ghahremani, DG; Hellemann, G; London, ED; Monterosso, J; Poldrack, RA; Tabibnia, G, 2011)
"Modafinil was safe and well tolerated and did not increase cigarette smoking."2.75Randomized, double-blind, placebo-controlled trial of modafinil for the treatment of methamphetamine dependence. ( Cederblom, L; Heinzerling, KG; Kim, S; Ling, W; Moe, A; Shoptaw, S; Swanson, AN, 2010)
"Modafinil-treated participants had a milder withdrawal syndrome as measured by the Amphetamine Cessation Symptom Assessment and less sleep disturbance in comparison to mirtazapine."2.73Symptoms and sleep patterns during inpatient treatment of methamphetamine withdrawal: a comparison of mirtazapine and modafinil with treatment as usual. ( McGregor, C; Mitchell, A; Srisurapanont, M; White, JM; Wickes, W, 2008)
"Amphetamine dependence is a public health problem with medical, psychiatric, cognitive, legal and socioeconomic consequences."2.49Efficacy of psychostimulant drugs for amphetamine abuse or dependence. ( Capellà, D; Castells, X; Farre, M; Pérez-Mañá, C; Torrens, M, 2013)
"Pretreatment with modafinil (both 90 and 180 mg/kg) attenuated these effects but did not prevent METH induced decrease in locomotion."1.37Attenuated methamphetamine induced neurotoxicity by modafinil administration in mice. ( Bisagno, V; Giorgeri, S; Goitia, B; Peskin, V; Raineri, M; Taravini, IR; Urbano, FJ, 2011)
" By using the dosing time data collected, we determined that subjects who dosed at a consistent time daily were more likely to adhere to the prescribed regimen."1.37A simple, novel method for assessing medication adherence: capsule photographs taken with cellular telephones. ( Coyle, JR; Flower, K; Galloway, GP; Guillén, JE; Mendelson, JE, 2011)
"Modafinil (Provigil) is a wake-promoting drug characterized by cognitive enhancing abilities."1.36Modafinil effects on reinstatement of methamphetamine seeking in a rat model of relapse. ( Reichel, CM; See, RE, 2010)
"Modafinil was screened at various receptors and transporters using binding assays."1.35Evidence for the involvement of dopamine transporters in behavioral stimulant effects of modafinil. ( Baumann, MH; Jain, R; Partilla, JS; Prisinzano, TE; Roth, BL; Rothman, RB; Setola, V; Zolkowska, D, 2009)

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's8 (29.63)29.6817
2010's19 (70.37)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Dias, VT2
Vey, LT2
Rosa, HZ2
D'avila, LF2
Barcelos, RCS2
Burger, ME2
Lee, NK1
Jenner, L1
Harney, A1
Cameron, J1
Pérez-Mañá, C1
Castells, X1
Torrens, M1
Capellà, D1
Farre, M1
Dhillon, R1
Wu, X1
Bastiampillai, T1
Tibrewal, P1
Farah, MJ1
Mann, N1
Bitsios, P1
Marsden, J1
Shearer, J2
Darke, S2
Rodgers, C2
Slade, T1
van Beek, I2
Lewis, J1
Brady, D1
McKetin, R3
Mattick, RP2
Wodak, A1
Zolkowska, D1
Jain, R1
Rothman, RB1
Partilla, JS1
Roth, BL1
Setola, V1
Prisinzano, TE2
Baumann, MH1
McGaugh, J1
Mancino, MJ1
Feldman, Z1
Chopra, MP1
Gentry, WB1
Cargile, C1
Oliveto, A1
De La Garza, R2
Zorick, T1
London, ED3
Newton, TF2
Heinzerling, KG1
Swanson, AN1
Kim, S1
Cederblom, L1
Moe, A1
Ling, W1
Shoptaw, S1
Reichel, CM1
See, RE1
Shanahan, M1
Hester, R2
Lee, N2
Pennay, A2
Nielsen, S2
Ferris, J2
Ghahremani, DG1
Tabibnia, G1
Monterosso, J1
Hellemann, G2
Poldrack, RA1
Raineri, M1
Peskin, V1
Goitia, B1
Taravini, IR1
Giorgeri, S1
Urbano, FJ1
Bisagno, V1
Holtz, NA1
Lozama, A1
Carroll, ME1
Anderson, AL1
Li, SH1
Biswas, K1
McSherry, F1
Holmes, T1
Iturriaga, E1
Kahn, R1
Chiang, N1
Beresford, T1
Campbell, J1
Haning, W1
Mawhinney, J1
McCann, M1
Rawson, R1
Stock, C1
Weis, D1
Yu, E1
Elkashef, AM1
Galloway, GP1
Coyle, JR1
Guillén, JE1
Flower, K1
Mendelson, JE1
Dean, AC1
Sevak, RJ1
Monterosso, JR1
Sugar, CA1
Mahoney, JJ1
Jackson, BJ1
Kalechstein, AD1
Chang, LC1
Camacho, A1
Stein, MB1
McGregor, C1
Srisurapanont, M1
Mitchell, A1
Wickes, W1
White, JM1
Kampman, KM1

Clinical Trials (5)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Randomised Placebo-Controlled Trial of Modafinil for Methamphetamine Dependence[NCT00123370]Phase 287 participants (Anticipated)Interventional2006-07-31Active, not recruiting
A Randomized, Double-Blind, Placebo-Controlled Evaluation of Modafinil vs Placebo for the Treatment of Methamphetamine Dependence[NCT00469508]Phase 271 participants (Actual)Interventional2007-04-30Completed
Randomised Placebo-Controlled Trial of Modafinil for Cocaine Dependence[NCT00123383]Phase 210 participants (Anticipated)Interventional2005-07-31Active, not recruiting
Phase2, Double-blind, Placebo-controlled Trial of Modafinil for the Treatment of Methamphetamine Dependence[NCT00520286]Phase 2210 participants (Actual)Interventional2007-12-31Completed
A Behavioral Economics-Based Telehealth Intervention to Improve Post-MI Medication Adherence[NCT03022266]130 participants (Actual)Interventional2017-02-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

BDI Score

Self-reported depression: mean change on Beck Depression Index (BDI-II) assessed weekly during the 12 week medication phase. If the week12 measure was not available, the last observation was carried forward. 0 indicates no depression, 63 is the maximum indicating severe depression. (NCT00469508)
Timeframe: From baseline to end of treatment period (week 12).

Interventionunits on a scale (Mean)
Modafinil-11.8
Placebo-7

Clean Urine Drug Screen

Urine samples, collected thrice weekly, were tested for metabolites of MA using radioimmunoassay. Each subject had a possible of 36 urine drug screens to provide during the 12 weeks of medication. An aggregate measure of urine drug screen results was calculated - the Treatment Effectiveness Score (TES) - which is the average of the sum of MA-free urine specimens provided during the treatment period by participants in each treatment condition. (NCT00469508)
Timeframe: From randomization to end of week 12

InterventionClean urine drug screens (Mean)
Modafinil13.1
Placebo12.7

Retention

The number of persons who completed the medication phase of the trial (12 weeks of medication). (NCT00469508)
Timeframe: 12 weeks

Interventionparticipants (Number)
Modafinil14
Placebo13

VAS Score

To measure methamphetamine craving, mean change in craving based on visual analog scale (VAS) from 0 (not at all) to 100 (extremely) from baseline to the last week of observation during the 12 week treatment period. The last observation was carried forward if not available during week 12. (NCT00469508)
Timeframe: baseline and last observation during the 12 week treatment period

Interventionunits on a scale (Mean)
Modafinil-32.5
Placebo-47.3

Reduction of Craving

Number of subjects with 21 or more consecutive days of abstinence (NCT00520286)
Timeframe: 21 days

InterventionParticipants (Count of Participants)
Modafinil32
Placebo10

Abstinence (Week 1 - 12)

Number of participant who abstained from methamphetamine from weeks 1 through 12 (NCT00520286)
Timeframe: Weeks 1 - 12

,
InterventionParticipants (Count of Participants)
Week 1Week 2Week 3Week 4Week 5Week 6Week 7Week 8Week 9Week 10Week 11Week 12
Modafinil273839464139344035343734
Placebo141313151615141617141617

Reviews

2 reviews available for modafinil and Amphetamine Abuse

ArticleYear
Pharmacotherapy for amphetamine dependence: A systematic review.
    Drug and alcohol dependence, 2018, 10-01, Volume: 191

    Topics: Amphetamine; Amphetamine-Related Disorders; Dextroamphetamine; Humans; Medication Adherence; Methylp

2018
Efficacy of psychostimulant drugs for amphetamine abuse or dependence.
    The Cochrane database of systematic reviews, 2013, Sep-02, Issue:9

    Topics: Amphetamine-Related Disorders; Benzhydryl Compounds; Bupropion; Central Nervous System Stimulants; D

2013

Trials

12 trials available for modafinil and Amphetamine Abuse

ArticleYear
A double-blind, placebo-controlled trial of modafinil (200 mg/day) for methamphetamine dependence.
    Addiction (Abingdon, England), 2009, Volume: 104, Issue:2

    Topics: Adult; Amphetamine-Related Disorders; Australia; Benzhydryl Compounds; Central Nervous System Stimul

2009
Open-label pilot study of modafinil for methamphetamine dependence.
    Journal of clinical psychopharmacology, 2009, Volume: 29, Issue:5

    Topics: Adult; Amphetamine-Related Disorders; Benzhydryl Compounds; Female; Humans; Male; Methamphetamine; M

2009
Evaluation of modafinil effects on cardiovascular, subjective, and reinforcing effects of methamphetamine in methamphetamine-dependent volunteers.
    Drug and alcohol dependence, 2010, Jan-15, Volume: 106, Issue:2-3

    Topics: Adult; Amphetamine-Related Disorders; Benzhydryl Compounds; Blood Pressure; Central Nervous System S

2010
Randomized, double-blind, placebo-controlled trial of modafinil for the treatment of methamphetamine dependence.
    Drug and alcohol dependence, 2010, Jun-01, Volume: 109, Issue:1-3

    Topics: Adolescent; Adult; Amphetamine-Related Disorders; Benzhydryl Compounds; Central Nervous System Stimu

2010
A cost-effectiveness analysis of modafinil therapy for psychostimulant dependence.
    Drug and alcohol review, 2010, Volume: 29, Issue:3

    Topics: Adult; Amphetamine-Related Disorders; Benzhydryl Compounds; Central Nervous System Stimulants; Cocai

2010
A cost-effectiveness analysis of modafinil therapy for psychostimulant dependence.
    Drug and alcohol review, 2010, Volume: 29, Issue:3

    Topics: Adult; Amphetamine-Related Disorders; Benzhydryl Compounds; Central Nervous System Stimulants; Cocai

2010
A cost-effectiveness analysis of modafinil therapy for psychostimulant dependence.
    Drug and alcohol review, 2010, Volume: 29, Issue:3

    Topics: Adult; Amphetamine-Related Disorders; Benzhydryl Compounds; Central Nervous System Stimulants; Cocai

2010
A cost-effectiveness analysis of modafinil therapy for psychostimulant dependence.
    Drug and alcohol review, 2010, Volume: 29, Issue:3

    Topics: Adult; Amphetamine-Related Disorders; Benzhydryl Compounds; Central Nervous System Stimulants; Cocai

2010
The effects of modafinil treatment on neuropsychological and attentional bias performance during 7-day inpatient withdrawal from methamphetamine dependence.
    Experimental and clinical psychopharmacology, 2010, Volume: 18, Issue:6

    Topics: Adult; Amphetamine-Related Disorders; Attention; Benzhydryl Compounds; Central Nervous System Stimul

2010
Effect of modafinil on learning and task-related brain activity in methamphetamine-dependent and healthy individuals.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2011, Volume: 36, Issue:5

    Topics: Adult; Amphetamine-Related Disorders; Analysis of Variance; Association Learning; Benzhydryl Compoun

2011
Modafinil for the treatment of methamphetamine dependence.
    Drug and alcohol dependence, 2012, Jan-01, Volume: 120, Issue:1-3

    Topics: Adult; Amphetamine-Related Disorders; Benzhydryl Compounds; Central Nervous System Stimulants; Combi

2012
Acute modafinil effects on attention and inhibitory control in methamphetamine-dependent humans.
    Journal of studies on alcohol and drugs, 2011, Volume: 72, Issue:6

    Topics: Adult; Amphetamine-Related Disorders; Attention; Benzhydryl Compounds; Case-Control Studies; Cogniti

2011
Acute modafinil exposure reduces daytime sleepiness in abstinent methamphetamine-dependent volunteers.
    The international journal of neuropsychopharmacology, 2012, Volume: 15, Issue:9

    Topics: Adult; Amphetamine-Related Disorders; Benzhydryl Compounds; Central Nervous System Stimulants; Cogni

2012
A pilot randomised controlled trial of modafinil during acute methamphetamine withdrawal: feasibility, tolerability and clinical outcomes.
    Drug and alcohol review, 2013, Volume: 32, Issue:1

    Topics: Adult; Amphetamine-Related Disorders; Benzhydryl Compounds; Central Nervous System Stimulants; Doubl

2013
Symptoms and sleep patterns during inpatient treatment of methamphetamine withdrawal: a comparison of mirtazapine and modafinil with treatment as usual.
    Journal of substance abuse treatment, 2008, Volume: 35, Issue:3

    Topics: Adult; Amphetamine-Related Disorders; Antidepressive Agents, Tricyclic; Benzhydryl Compounds; Centra

2008

Other Studies

13 other studies available for modafinil and Amphetamine Abuse

ArticleYear
Could Modafinil Prevent Psychostimulant Addiction? An Experimental Study in Rats.
    Basic & clinical pharmacology & toxicology, 2017, Volume: 121, Issue:5

    Topics: Age Factors; Amphetamine; Amphetamine-Related Disorders; Animals; Antioxidants; Behavior, Animal; Be

2017
Modafinil reduces amphetamine preference and prevents anxiety-like symptoms during drug withdrawal in young rats: Involvement of dopaminergic targets in VTA and striatum.
    Progress in neuro-psychopharmacology & biological psychiatry, 2019, 06-08, Volume: 92

    Topics: Amphetamine; Amphetamine-Related Disorders; Animals; Anxiety; Central Nervous System Stimulants; Cor

2019
Could modafinil be a drug of dependence?
    The Australian and New Zealand journal of psychiatry, 2015, Volume: 49, Issue:5

    Topics: Amphetamine-Related Disorders; Benzhydryl Compounds; Disorders of Excessive Somnolence; Humans; Male

2015
NEUROSCIENCE. The unknowns of cognitive enhancement.
    Science (New York, N.Y.), 2015, Oct-23, Volume: 350, Issue:6259

    Topics: Amphetamine-Related Disorders; Amphetamines; Benzhydryl Compounds; Biomedical Enhancement; Central N

2015
Modafinil treatment of amphetamine abuse in adult ADHD.
    Journal of psychopharmacology (Oxford, England), 2009, Volume: 23, Issue:4

    Topics: Adult; Amphetamine-Related Disorders; Attention; Attention Deficit Disorder with Hyperactivity; Benz

2009
The long road to pharmacotherapies for stimulant dependence.
    Addiction (Abingdon, England), 2009, Volume: 104, Issue:2

    Topics: Amphetamine-Related Disorders; Benzhydryl Compounds; Central Nervous System Stimulants; Humans; Moda

2009
Evidence for the involvement of dopamine transporters in behavioral stimulant effects of modafinil.
    The Journal of pharmacology and experimental therapeutics, 2009, Volume: 329, Issue:2

    Topics: Amphetamine-Related Disorders; Animals; Behavior, Animal; Benzhydryl Compounds; Binding Sites; Centr

2009
Modafinil effects on reinstatement of methamphetamine seeking in a rat model of relapse.
    Psychopharmacology, 2010, Volume: 210, Issue:3

    Topics: Amphetamine-Related Disorders; Animals; Behavior, Addictive; Benzhydryl Compounds; Disease Models, A

2010
Attenuated methamphetamine induced neurotoxicity by modafinil administration in mice.
    Synapse (New York, N.Y.), 2011, Volume: 65, Issue:10

    Topics: Amphetamine-Related Disorders; Animals; Benzhydryl Compounds; Central Nervous System Stimulants; Dru

2011
Reinstatement of methamphetamine seeking in male and female rats treated with modafinil and allopregnanolone.
    Drug and alcohol dependence, 2012, Jan-01, Volume: 120, Issue:1-3

    Topics: Amphetamine-Related Disorders; Animals; Benzhydryl Compounds; Central Nervous System Depressants; Ce

2012
A simple, novel method for assessing medication adherence: capsule photographs taken with cellular telephones.
    Journal of addiction medicine, 2011, Volume: 5, Issue:3

    Topics: Adult; Amphetamine-Related Disorders; Benzhydryl Compounds; Cell Phone; Female; Humans; Male; Medica

2011
Modafinil for social phobia and amphetamine dependence.
    The American journal of psychiatry, 2002, Volume: 159, Issue:11

    Topics: Amphetamine-Related Disorders; Benzhydryl Compounds; Central Nervous System Stimulants; Comorbidity;

2002
The search for medications to treat stimulant dependence.
    Addiction science & clinical practice, 2008, Volume: 4, Issue:2

    Topics: Amphetamine-Related Disorders; Benzhydryl Compounds; Brain; Bupropion; Cocaine; Cocaine-Related Diso

2008