Page last updated: 2024-10-31

modafinil and Age-Related Memory Disorders

modafinil has been researched along with Age-Related Memory Disorders in 11 studies

Modafinil: A benzhydryl acetamide compound, central nervous system stimulant, and CYP3A4 inducing agent that is used in the treatment of NARCOLEPSY and SLEEP WAKE DISORDERS.
modafinil : A racemate comprising equimolar amounts of armodafinil and (S)-modafinil. A central nervous system stimulant, it is used for the treatment of sleeping disorders such as narcolepsy, obstructive sleep apnoea, and shift-work sleep disorder. The optical enantiomers of modafinil have similar pharmacological actions in animals.
2-[(diphenylmethyl)sulfinyl]acetamide : A sulfoxide that is dimethylsulfoxide in which two hydrogens attached to one of the methyl groups are replaced by phenyl groups, while one hydrogen attached to the other methyl group is replaced by a carbamoyl (aminocarbonyl) group.

Research Excerpts

ExcerptRelevanceReference
"To assess the efficacy of modafinil for the treatment of new learning and memory deficits and fatigue in multiple sclerosis."9.22Cognitive effects of modafinil in patients with multiple sclerosis: A clinical trial. ( Chiaravalloti, ND; DeLuca, J; Elovic, E; Ford-Johnson, L; Lengenfelder, J; Zhang, J, 2016)
"To assess the efficacy of modafinil for the treatment of new learning and memory deficits and fatigue in multiple sclerosis."5.22Cognitive effects of modafinil in patients with multiple sclerosis: A clinical trial. ( Chiaravalloti, ND; DeLuca, J; Elovic, E; Ford-Johnson, L; Lengenfelder, J; Zhang, J, 2016)
"The smaller dose of modafinil (32 mg/kg) impaired memory consolidation, without modifying anxiety or locomotion."3.81Effects of post-training modafinil administration in a discriminative avoidance task in mice. ( Bittencourt, LR; Bizerra, CS; Fernandes, HA; Frussa-Filho, R; Lopes-Silva, LB; Patti, Cde L; Tufik, S; Zanin, KA, 2015)
"Modafinil-treated mice shared none of these effects and showed increased H3ac enrichment and mRNA expression at Adra1b."1.48Repeated methamphetamine and modafinil induce differential cognitive effects and specific histone acetylation and DNA methylation profiles in the mouse medial prefrontal cortex. ( Bernardi, A; Bisagno, V; Cadet, JL; García-Rill, E; Gomez, N; González, B; Jayanthi, S; Sosa, MH; Torres, OV; Urbano, FJ, 2018)
"Modafinil is a wake-promoting compound approved for the treatment of sleeping disorders."1.40Modafinil improves methamphetamine-induced object recognition deficits and restores prefrontal cortex ERK signaling in mice. ( Bisagno, V; Cadet, JL; García-Rill, E; González, B; Raineri, M; Urbano, FJ, 2014)
"Modafinil is a wake-promoting drug and has been approved for the treatment of excessive daytime sleepiness in narcolepsy and obstructive sleep apnea."1.39Differential effects of modafinil on memory in naïve and memory-impaired rats. ( Busato, SB; D'avila Portal, BC; Garcia, VA; Piazza, FC; Schröder, N; Souza de Freitas, B, 2013)
"Previous work showed that sleep deprivation (SD) impairs hippocampal-dependent cognitive function and synaptic plasticity, and a novel wake-promoting agent modafinil prevents SD-induced memory impairment in rat."1.37Modafinil treatment prevents REM sleep deprivation-induced brain function impairment by increasing MMP-9 expression. ( He, B; Peng, H; Zhao, Y; Zhao, Z; Zhou, H, 2011)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (9.09)29.6817
2010's10 (90.91)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
González, B2
Jayanthi, S1
Gomez, N1
Torres, OV1
Sosa, MH1
Bernardi, A1
Urbano, FJ2
García-Rill, E2
Cadet, JL2
Bisagno, V2
Garcia, VA1
Souza de Freitas, B1
Busato, SB1
D'avila Portal, BC1
Piazza, FC1
Schröder, N1
Reichel, CM1
Gilstrap, MG1
Ramsey, LA1
See, RE1
Raineri, M1
Fernandes, HA1
Zanin, KA1
Patti, Cde L1
Lopes-Silva, LB1
Bizerra, CS1
Bittencourt, LR1
Tufik, S2
Frussa-Filho, R1
Ford-Johnson, L1
DeLuca, J1
Zhang, J1
Elovic, E1
Lengenfelder, J1
Chiaravalloti, ND1
Moeller, FG1
Steinberg, JL1
Schmitz, JM1
Ma, L1
Liu, S1
Kjome, KL1
Rathnayaka, N1
Kramer, LA1
Narayana, PA1
Moreira, KM1
Ferreira, TL1
Hipolide, DC1
Fornari, RV1
Oliveira, MG1
He, B1
Peng, H1
Zhao, Y1
Zhou, H1
Zhao, Z1
Kalechstein, AD1
Mahoney, JJ1
Yoon, JH1
Bennett, R1
De la Garza, R1
Hall, SS1

Trials

3 trials available for modafinil and Age-Related Memory Disorders

ArticleYear
Cognitive effects of modafinil in patients with multiple sclerosis: A clinical trial.
    Rehabilitation psychology, 2016, Volume: 61, Issue:1

    Topics: Adult; Benzhydryl Compounds; Cognition; Cognition Disorders; Cross-Over Studies; Double-Blind Method

2016
Working memory fMRI activation in cocaine-dependent subjects: association with treatment response.
    Psychiatry research, 2010, Mar-30, Volume: 181, Issue:3

    Topics: Adult; Amphetamine; Analysis of Variance; Benzhydryl Compounds; Brain; Brain Mapping; Carbidopa; Cen

2010
Modafinil, but not escitalopram, improves working memory and sustained attention in long-term, high-dose cocaine users.
    Neuropharmacology, 2013, Volume: 64

    Topics: Adult; Benzhydryl Compounds; Black or African American; Citalopram; Cocaine-Related Disorders; Cogni

2013

Other Studies

8 other studies available for modafinil and Age-Related Memory Disorders

ArticleYear
Repeated methamphetamine and modafinil induce differential cognitive effects and specific histone acetylation and DNA methylation profiles in the mouse medial prefrontal cortex.
    Progress in neuro-psychopharmacology & biological psychiatry, 2018, 03-02, Volume: 82

    Topics: Acetylation; Animals; Central Nervous System Stimulants; Cognition; DNA Methylation; Histones; Male;

2018
Differential effects of modafinil on memory in naïve and memory-impaired rats.
    Neuropharmacology, 2013, Volume: 75

    Topics: Analysis of Variance; Animals; Animals, Newborn; Avoidance Learning; Benzhydryl Compounds; Disease M

2013
Modafinil restores methamphetamine induced object-in-place memory deficits in rats independent of glutamate N-methyl-D-aspartate receptor expression.
    Drug and alcohol dependence, 2014, Jan-01, Volume: 134

    Topics: Animals; Benzhydryl Compounds; Brain; Gene Expression Regulation; Male; Memory Disorders; Methamphet

2014
Modafinil improves methamphetamine-induced object recognition deficits and restores prefrontal cortex ERK signaling in mice.
    Neuropharmacology, 2014, Volume: 87

    Topics: Animals; Benzhydryl Compounds; Central Nervous System Stimulants; Dose-Response Relationship, Drug;

2014
Effects of post-training modafinil administration in a discriminative avoidance task in mice.
    Acta neuropsychiatrica, 2015, Volume: 27, Issue:4

    Topics: Animals; Anxiety; Avoidance Learning; Benzhydryl Compounds; Discrimination Learning; Disease Models,

2015
Modafinil prevents inhibitory avoidance memory deficit induced by sleep deprivation in rats.
    Sleep, 2010, Volume: 33, Issue:7

    Topics: Analysis of Variance; Animals; Avoidance Learning; Behavior, Animal; Benzhydryl Compounds; Disease M

2010
Modafinil treatment prevents REM sleep deprivation-induced brain function impairment by increasing MMP-9 expression.
    Brain research, 2011, Dec-02, Volume: 1426

    Topics: Analysis of Variance; Animals; Benzhydryl Compounds; Central Nervous System Stimulants; Cognition; G

2011
The quest for a smart pill.
    Scientific American, 2003, Volume: 289, Issue:3

    Topics: Alzheimer Disease; Animals; Behavior, Animal; Benzhydryl Compounds; Caffeine; Central Nervous System

2003