modafinil has been researched along with Age-Related Memory Disorders in 11 studies
Modafinil: A benzhydryl acetamide compound, central nervous system stimulant, and CYP3A4 inducing agent that is used in the treatment of NARCOLEPSY and SLEEP WAKE DISORDERS.
modafinil : A racemate comprising equimolar amounts of armodafinil and (S)-modafinil. A central nervous system stimulant, it is used for the treatment of sleeping disorders such as narcolepsy, obstructive sleep apnoea, and shift-work sleep disorder. The optical enantiomers of modafinil have similar pharmacological actions in animals.
2-[(diphenylmethyl)sulfinyl]acetamide : A sulfoxide that is dimethylsulfoxide in which two hydrogens attached to one of the methyl groups are replaced by phenyl groups, while one hydrogen attached to the other methyl group is replaced by a carbamoyl (aminocarbonyl) group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To assess the efficacy of modafinil for the treatment of new learning and memory deficits and fatigue in multiple sclerosis." | 9.22 | Cognitive effects of modafinil in patients with multiple sclerosis: A clinical trial. ( Chiaravalloti, ND; DeLuca, J; Elovic, E; Ford-Johnson, L; Lengenfelder, J; Zhang, J, 2016) |
| "To assess the efficacy of modafinil for the treatment of new learning and memory deficits and fatigue in multiple sclerosis." | 5.22 | Cognitive effects of modafinil in patients with multiple sclerosis: A clinical trial. ( Chiaravalloti, ND; DeLuca, J; Elovic, E; Ford-Johnson, L; Lengenfelder, J; Zhang, J, 2016) |
| "The smaller dose of modafinil (32 mg/kg) impaired memory consolidation, without modifying anxiety or locomotion." | 3.81 | Effects of post-training modafinil administration in a discriminative avoidance task in mice. ( Bittencourt, LR; Bizerra, CS; Fernandes, HA; Frussa-Filho, R; Lopes-Silva, LB; Patti, Cde L; Tufik, S; Zanin, KA, 2015) |
| "Modafinil-treated mice shared none of these effects and showed increased H3ac enrichment and mRNA expression at Adra1b." | 1.48 | Repeated methamphetamine and modafinil induce differential cognitive effects and specific histone acetylation and DNA methylation profiles in the mouse medial prefrontal cortex. ( Bernardi, A; Bisagno, V; Cadet, JL; García-Rill, E; Gomez, N; González, B; Jayanthi, S; Sosa, MH; Torres, OV; Urbano, FJ, 2018) |
| "Modafinil is a wake-promoting compound approved for the treatment of sleeping disorders." | 1.40 | Modafinil improves methamphetamine-induced object recognition deficits and restores prefrontal cortex ERK signaling in mice. ( Bisagno, V; Cadet, JL; García-Rill, E; González, B; Raineri, M; Urbano, FJ, 2014) |
| "Modafinil is a wake-promoting drug and has been approved for the treatment of excessive daytime sleepiness in narcolepsy and obstructive sleep apnea." | 1.39 | Differential effects of modafinil on memory in naïve and memory-impaired rats. ( Busato, SB; D'avila Portal, BC; Garcia, VA; Piazza, FC; Schröder, N; Souza de Freitas, B, 2013) |
| "Previous work showed that sleep deprivation (SD) impairs hippocampal-dependent cognitive function and synaptic plasticity, and a novel wake-promoting agent modafinil prevents SD-induced memory impairment in rat." | 1.37 | Modafinil treatment prevents REM sleep deprivation-induced brain function impairment by increasing MMP-9 expression. ( He, B; Peng, H; Zhao, Y; Zhao, Z; Zhou, H, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 10 (90.91) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| González, B | 2 |
| Jayanthi, S | 1 |
| Gomez, N | 1 |
| Torres, OV | 1 |
| Sosa, MH | 1 |
| Bernardi, A | 1 |
| Urbano, FJ | 2 |
| García-Rill, E | 2 |
| Cadet, JL | 2 |
| Bisagno, V | 2 |
| Garcia, VA | 1 |
| Souza de Freitas, B | 1 |
| Busato, SB | 1 |
| D'avila Portal, BC | 1 |
| Piazza, FC | 1 |
| Schröder, N | 1 |
| Reichel, CM | 1 |
| Gilstrap, MG | 1 |
| Ramsey, LA | 1 |
| See, RE | 1 |
| Raineri, M | 1 |
| Fernandes, HA | 1 |
| Zanin, KA | 1 |
| Patti, Cde L | 1 |
| Lopes-Silva, LB | 1 |
| Bizerra, CS | 1 |
| Bittencourt, LR | 1 |
| Tufik, S | 2 |
| Frussa-Filho, R | 1 |
| Ford-Johnson, L | 1 |
| DeLuca, J | 1 |
| Zhang, J | 1 |
| Elovic, E | 1 |
| Lengenfelder, J | 1 |
| Chiaravalloti, ND | 1 |
| Moeller, FG | 1 |
| Steinberg, JL | 1 |
| Schmitz, JM | 1 |
| Ma, L | 1 |
| Liu, S | 1 |
| Kjome, KL | 1 |
| Rathnayaka, N | 1 |
| Kramer, LA | 1 |
| Narayana, PA | 1 |
| Moreira, KM | 1 |
| Ferreira, TL | 1 |
| Hipolide, DC | 1 |
| Fornari, RV | 1 |
| Oliveira, MG | 1 |
| He, B | 1 |
| Peng, H | 1 |
| Zhao, Y | 1 |
| Zhou, H | 1 |
| Zhao, Z | 1 |
| Kalechstein, AD | 1 |
| Mahoney, JJ | 1 |
| Yoon, JH | 1 |
| Bennett, R | 1 |
| De la Garza, R | 1 |
| Hall, SS | 1 |
3 trials available for modafinil and Age-Related Memory Disorders
| Article | Year |
|---|---|
Cognitive effects of modafinil in patients with multiple sclerosis: A clinical trial.
Topics: Adult; Benzhydryl Compounds; Cognition; Cognition Disorders; Cross-Over Studies; Double-Blind Method | 2016 |
Working memory fMRI activation in cocaine-dependent subjects: association with treatment response.
Topics: Adult; Amphetamine; Analysis of Variance; Benzhydryl Compounds; Brain; Brain Mapping; Carbidopa; Cen | 2010 |
Modafinil, but not escitalopram, improves working memory and sustained attention in long-term, high-dose cocaine users.
Topics: Adult; Benzhydryl Compounds; Black or African American; Citalopram; Cocaine-Related Disorders; Cogni | 2013 |
8 other studies available for modafinil and Age-Related Memory Disorders
| Article | Year |
|---|---|
Repeated methamphetamine and modafinil induce differential cognitive effects and specific histone acetylation and DNA methylation profiles in the mouse medial prefrontal cortex.
Topics: Acetylation; Animals; Central Nervous System Stimulants; Cognition; DNA Methylation; Histones; Male; | 2018 |
Differential effects of modafinil on memory in naïve and memory-impaired rats.
Topics: Analysis of Variance; Animals; Animals, Newborn; Avoidance Learning; Benzhydryl Compounds; Disease M | 2013 |
Modafinil restores methamphetamine induced object-in-place memory deficits in rats independent of glutamate N-methyl-D-aspartate receptor expression.
Topics: Animals; Benzhydryl Compounds; Brain; Gene Expression Regulation; Male; Memory Disorders; Methamphet | 2014 |
Modafinil improves methamphetamine-induced object recognition deficits and restores prefrontal cortex ERK signaling in mice.
Topics: Animals; Benzhydryl Compounds; Central Nervous System Stimulants; Dose-Response Relationship, Drug; | 2014 |
Effects of post-training modafinil administration in a discriminative avoidance task in mice.
Topics: Animals; Anxiety; Avoidance Learning; Benzhydryl Compounds; Discrimination Learning; Disease Models, | 2015 |
Modafinil prevents inhibitory avoidance memory deficit induced by sleep deprivation in rats.
Topics: Analysis of Variance; Animals; Avoidance Learning; Behavior, Animal; Benzhydryl Compounds; Disease M | 2010 |
Modafinil treatment prevents REM sleep deprivation-induced brain function impairment by increasing MMP-9 expression.
Topics: Analysis of Variance; Animals; Benzhydryl Compounds; Central Nervous System Stimulants; Cognition; G | 2011 |
The quest for a smart pill.
Topics: Alzheimer Disease; Animals; Behavior, Animal; Benzhydryl Compounds; Caffeine; Central Nervous System | 2003 |