Page last updated: 2024-10-31

moclobemide and Seizures

moclobemide has been researched along with Seizures in 4 studies

Moclobemide: A reversible inhibitor of monoamine oxidase type A; (RIMA); (see MONOAMINE OXIDASE INHIBITORS) that has antidepressive properties.
moclobemide : A member of the class of benzamides that is benzamide substituted by a chloro group at position 4 and a 2-(morpholin-4-yl)ethyl group at the nitrogen atom. It acts as a reversible monoamine oxidase inhibitor and is used in the treatment of depression.

Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.

Research Excerpts

ExcerptRelevanceReference
" In this study, we examined the effect of both acute and chronic treatment with moclobemide on seizures and the action of first-generation antiepileptic drugs: valproate, carbamazepine, phenobarbital and phenytoin."4.02Acute and chronic treatment with moclobemide, a reversible MAO-inhibitor, potentiates the antielectroshock activity of conventional antiepileptic drugs in mice. ( Banach, M; Borowicz-Reutt, KK, 2021)
"Effects of chronic moclobemide administration on ethanol consumption, blood ethanol level, motor coordination and seizures induced by an audiogenic stimulus during ethanol withdrawal syndrome have been investigated in chronically ethanol intoxicated rats."3.69Investigation of the effects of moclobemide in chronic ethanol feeding rats. ( Ayhan, IH; Celik, T; Sever, B; Uzbay, IT, 1995)
"The reversible MAO-A inhibitor moclobemide (5 mg/kg) was shown to prevent seizures in rats during exposure to toxic oxygen (6 ata)."3.67[Effect of benzamide derivatives on convulsions induced by the toxic action of oxygen in rats]. ( Demurov, EA; Gol'dina, OA; Koloskov, IuB; Tepliakov, VG; ZagorevskiÄ­, VA, 1987)
" While clinical aspects will be presented in a subsequent review, this article focuses primarily on moclobemide's evolution, pharmacodynamic and pharmacokinetic properties."2.41Moclobemide: evolution, pharmacodynamic, and pharmacokinetic properties. ( Bonnet, U, 2002)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19901 (25.00)18.7374
1990's1 (25.00)18.2507
2000's1 (25.00)29.6817
2010's0 (0.00)24.3611
2020's1 (25.00)2.80

Authors

AuthorsStudies
Borowicz-Reutt, KK1
Banach, M1
Bonnet, U1
Uzbay, IT1
Sever, B1
Celik, T1
Ayhan, IH1
Gol'dina, OA1
Tepliakov, VG1
Demurov, EA1
Koloskov, IuB1
ZagorevskiÄ­, VA1

Reviews

1 review available for moclobemide and Seizures

ArticleYear
Moclobemide: evolution, pharmacodynamic, and pharmacokinetic properties.
    CNS drug reviews, 2002,Fall, Volume: 8, Issue:3

    Topics: Animals; Antidepressive Agents; Anxiety; Cognition Disorders; Depression; Disease Models, Animal; Dr

2002

Other Studies

3 other studies available for moclobemide and Seizures

ArticleYear
Acute and chronic treatment with moclobemide, a reversible MAO-inhibitor, potentiates the antielectroshock activity of conventional antiepileptic drugs in mice.
    Pharmacology, biochemistry, and behavior, 2021, Volume: 201

    Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Disease Models, Animal; Dose-Response Relationship,

2021
Investigation of the effects of moclobemide in chronic ethanol feeding rats.
    Pharmacological research, 1995, Volume: 32, Issue:5

    Topics: Alcohol Drinking; Animals; Benzamides; Body Weight; Central Nervous System Depressants; Ethanol; Mal

1995
[Effect of benzamide derivatives on convulsions induced by the toxic action of oxygen in rats].
    Biulleten' eksperimental'noi biologii i meditsiny, 1987, Volume: 104, Issue:10

    Topics: Animals; Anticonvulsants; Benzamides; Brain; Clorgyline; Drug Evaluation, Preclinical; Heart; Male;

1987