moclobemide has been researched along with Hypertension in 13 studies
Moclobemide: A reversible inhibitor of monoamine oxidase type A; (RIMA); (see MONOAMINE OXIDASE INHIBITORS) that has antidepressive properties.
moclobemide : A member of the class of benzamides that is benzamide substituted by a chloro group at position 4 and a 2-(morpholin-4-yl)ethyl group at the nitrogen atom. It acts as a reversible monoamine oxidase inhibitor and is used in the treatment of depression.
Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Severe adverse hemodynamic events, such as hypertension and tachycardia, did not occur more frequently in users of both the irreversible MAOI tranylcypromine and the reversible MAO-A inhibitor moclobemide compared to nonusers." | 3.78 | Antidepressive treatment with monoamine oxidase inhibitors and the occurrence of intraoperative hemodynamic events: a retrospective observational cohort study. ( Doodeman, HJ; Egberts, TC; Kalkman, CJ; van Haelst, IM; van Klei, WA, 2012) |
| "Treatment with moclobemide and selegiline alone was well tolerated, whereas combined treatment led to a slight increase in adverse events." | 2.68 | Tyramine pressor sensitivity in healthy subjects during combined treatment with moclobemide and selegiline. ( Dingemanse, J; Korn, A; Moritz, E; Wagner, B, 1996) |
| "Moclobemide was given in a daily dose of 450 mg to be taken in three divided doses at the end of the meals." | 2.66 | Interaction of moclobemide, a new reversible monoamine oxidase inhibitor with oral tyramine. ( Amrein, R; Gieschke, R; Schmid-Burgk, W, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (38.46) | 18.7374 |
| 1990's | 6 (46.15) | 18.2507 |
| 2000's | 1 (7.69) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| van Haelst, IM | 1 |
| van Klei, WA | 1 |
| Doodeman, HJ | 1 |
| Kalkman, CJ | 1 |
| Egberts, TC | 1 |
| Miller, MC | 1 |
| Coulter, DM | 1 |
| Pillans, PI | 1 |
| Boyd, IW | 1 |
| Youdim, MB | 1 |
| Laux, G | 2 |
| Philipp, M | 2 |
| Kohnen, R | 2 |
| Korn, A | 2 |
| Wagner, B | 1 |
| Moritz, E | 1 |
| Dingemanse, J | 1 |
| Delini-Stula, A | 1 |
| Baier, D | 1 |
| Scholz, HJ | 1 |
| Bieck, PR | 1 |
| Müller, T | 1 |
| Gieschke, R | 2 |
| Ziegler, WH | 1 |
| Da Prada, M | 2 |
| Raffesberg, W | 1 |
| Allen, S | 1 |
| Gasic, S | 1 |
| Zürcher, G | 1 |
| Wüthrich, I | 1 |
| Haefely, WE | 1 |
| Schmid-Burgk, W | 1 |
| Amrein, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Open-Label Dose-Ranging Study of Oral SM-001 in Healthy Adults[NCT05894902] | Phase 1 | 12 participants (Anticipated) | Interventional | 2023-10-01 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for moclobemide and Hypertension
| Article | Year |
|---|---|
The advent of selective monoamine oxidase A inhibitor antidepressants devoid of the cheese reaction.
Topics: Benzamides; Cheese; Clorgyline; Depressive Disorder; Humans; Hypertension; Moclobemide; Monoamine Ox | 1995 |
On tyramine, food, beverages and the reversible MAO inhibitor moclobemide.
Topics: Animals; Benzamides; Beverages; Drug Synergism; Food; Humans; Hypertension; Moclobemide; Monoamine O | 1988 |
3 trials available for moclobemide and Hypertension
| Article | Year |
|---|---|
Tyramine pressor sensitivity in healthy subjects during combined treatment with moclobemide and selegiline.
Topics: Adrenergic Agents; Adult; Analysis of Variance; Benzamides; Blood Pressure; Double-Blind Method; Dru | 1996 |
Undesirable blood pressure changes under naturalistic treatment with moclobemide, a reversible MAO-A inhibitor--results of the drug utilization observation studies.
Topics: Adult; Aged; Benzamides; Blood Pressure; Cardiovascular Diseases; Comorbidity; Depression; Depressiv | 1999 |
Interaction of moclobemide, a new reversible monoamine oxidase inhibitor with oral tyramine.
Topics: Administration, Oral; Adult; Benzamides; Clinical Trials as Topic; Double-Blind Method; Drug Synergi | 1988 |
8 other studies available for moclobemide and Hypertension
| Article | Year |
|---|---|
Antidepressive treatment with monoamine oxidase inhibitors and the occurrence of intraoperative hemodynamic events: a retrospective observational cohort study.
Topics: Adult; Aged; Antidepressive Agents; Blood Pressure; Cohort Studies; Female; Heart Rate; Hemodynamics | 2012 |
Questions & answers. My friend swears by her antidepressant, moclobemide, which she gets from Canada because it is not available in the United States. She is content with the relief she is getting and happy about the absence of sexual side effects. What i
Topics: Antidepressive Agents; Canada; Female; Humans; Hypertension; Moclobemide; Monoamine Oxidase Inhibito | 2003 |
Hypertension with moclobemide.
Topics: Adult; Aged; Antidepressive Agents; Benzamides; Cohort Studies; Drug Interactions; Female; Fluoxetin | 1995 |
Hypertension with moclobemide.
Topics: Adult; Aged; Aged, 80 and over; Benzamides; Female; Humans; Hypertension; Male; Middle Aged; Moclobe | 1995 |
Hypertension with moclobemide.
Topics: Antidepressive Agents; Benzamides; Humans; Hypertension; Middle Aged; Moclobemide; Monoamine Oxidase | 1996 |
[Hypertensive crises with reversible inhibitors of monoamine oxidases? Results of tyramine interaction studies].
Topics: Administration, Oral; Adult; Benzamides; Blood Pressure; Female; Humans; Hypertension; Male; Moclobe | 1989 |
Blood pressure response to tyramine-enriched meal before and during MAO-inhibition in man: influence of dosage regimen.
Topics: Administration, Oral; Adult; Benzamides; Drug Administration Schedule; Drug Synergism; Drug Toleranc | 1988 |
Tyramine pressor effect in man: studies with moclobemide, a novel, reversible monoamine oxidase inhibitor.
Topics: Adult; Benzamides; Drug Synergism; Humans; Hypertension; Male; Moclobemide; Monoamine Oxidase Inhibi | 1988 |