moclobemide has been researched along with Disease Models, Animal in 18 studies
Moclobemide: A reversible inhibitor of monoamine oxidase type A; (RIMA); (see MONOAMINE OXIDASE INHIBITORS) that has antidepressive properties.
moclobemide : A member of the class of benzamides that is benzamide substituted by a chloro group at position 4 and a 2-(morpholin-4-yl)ethyl group at the nitrogen atom. It acts as a reversible monoamine oxidase inhibitor and is used in the treatment of depression.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The anxiolytic effects of aniracetam have not been proven in animals despite its clinical usefulness for post-stroke anxiety." | 7.71 | Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism. ( Kurasawa, M; Nakamura, K, 2001) |
| " In this study, we examined the effect of both acute and chronic treatment with moclobemide on seizures and the action of first-generation antiepileptic drugs: valproate, carbamazepine, phenobarbital and phenytoin." | 4.02 | Acute and chronic treatment with moclobemide, a reversible MAO-inhibitor, potentiates the antielectroshock activity of conventional antiepileptic drugs in mice. ( Banach, M; Borowicz-Reutt, KK, 2021) |
| "The anxiolytic effects of aniracetam have not been proven in animals despite its clinical usefulness for post-stroke anxiety." | 3.71 | Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism. ( Kurasawa, M; Nakamura, K, 2001) |
| " While clinical aspects will be presented in a subsequent review, this article focuses primarily on moclobemide's evolution, pharmacodynamic and pharmacokinetic properties." | 2.41 | Moclobemide: evolution, pharmacodynamic, and pharmacokinetic properties. ( Bonnet, U, 2002) |
| "Moclobemide significantly reversed parkinsonism (by 39%, P < 0." | 1.56 | Monoamine oxidase A inhibition as monotherapy reverses parkinsonism in the MPTP-lesioned marmoset. ( Bédard, D; Frouni, I; Gourdon, JC; Hamadjida, A; Huot, P; Kwan, C; Nuara, SG, 2020) |
| "This reduction of parkinsonism was not accompanied by an exacerbation of dyskinesia or PLBs." | 1.56 | Monoamine oxidase A inhibition with moclobemide enhances the anti-parkinsonian effect of L-DOPA in the MPTP-lesioned marmoset. ( Bédard, D; Frouni, I; Gourdon, JC; Hamadjida, A; Huot, P; Kwan, C; Nuara, SG, 2020) |
| "Ferulic acid is a polyphenol that has antioxidant, anti-inflammatory and anticancer properties." | 1.42 | Antidepressant-like effects of ferulic acid: involvement of serotonergic and norepinergic systems. ( Cao, L; Chen, J; Li, G; Li, J; Lin, D; Pan, J; Pang, C; Ruan, L; Xie, X; Xu, Y; Yan, Q; Yu, X; Zhang, C; Zhang, N, 2015) |
| "Neuropathic pain is a debilitating condition that is often resistant to common analgesics, such as opioids, but is sensitive to some antidepressants, an effect that seems to be mediated by spinal cord 5-HT3 receptors." | 1.39 | The antinociceptive effect of reversible monoamine oxidase-A inhibitors in a mouse neuropathic pain model. ( Bonacorso, HG; Fachinetto, R; Ferreira, J; Machado, P; Martins, MA; Oliveira, SM; Pinheiro, Fde V; Pinheiro, Kde V; Villarinho, JG; Zanatta, N, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (22.22) | 18.2507 |
| 2000's | 2 (11.11) | 29.6817 |
| 2010's | 8 (44.44) | 24.3611 |
| 2020's | 4 (22.22) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Hamadjida, A | 2 |
| Nuara, SG | 2 |
| Frouni, I | 2 |
| Kwan, C | 2 |
| Bédard, D | 2 |
| Gourdon, JC | 2 |
| Huot, P | 2 |
| Borowicz-Reutt, KK | 1 |
| Banach, M | 1 |
| Huuskonen, C | 1 |
| Hämäläinen, M | 2 |
| Paavonen, T | 2 |
| Moilanen, E | 2 |
| Mennander, A | 2 |
| Villarinho, JG | 2 |
| Pinheiro, Kde V | 1 |
| Pinheiro, Fde V | 1 |
| Oliveira, SM | 1 |
| Machado, P | 2 |
| Martins, MA | 1 |
| Bonacorso, HG | 1 |
| Zanatta, N | 2 |
| Fachinetto, R | 2 |
| Ferreira, J | 2 |
| Aswar, UM | 1 |
| Kalshetti, PP | 1 |
| Shelke, SM | 1 |
| Bhosale, SH | 1 |
| Bodhankar, SL | 1 |
| Chen, J | 1 |
| Lin, D | 1 |
| Zhang, C | 1 |
| Li, G | 1 |
| Zhang, N | 1 |
| Ruan, L | 1 |
| Yan, Q | 1 |
| Li, J | 1 |
| Yu, X | 1 |
| Xie, X | 1 |
| Pang, C | 1 |
| Cao, L | 1 |
| Pan, J | 1 |
| Xu, Y | 1 |
| Vuohelainen, V | 1 |
| Karlsson, S | 1 |
| Sant'Ana, AB | 1 |
| Weffort, LF | 1 |
| de Oliveira Sergio, T | 1 |
| Gomes, RC | 1 |
| Frias, AT | 1 |
| Matthiesen, M | 1 |
| Vilela-Costa, HH | 1 |
| Yamashita, PS | 1 |
| Vasconcelos, AT | 1 |
| de Bortoli, V | 1 |
| Del-Ben, CM | 1 |
| Zangrossi, H | 1 |
| de Vargas Pinheiro, F | 1 |
| da Silva Sant'Anna, G | 1 |
| Dombrowski, PA | 1 |
| da Cunha, C | 1 |
| de Almeida Cabrini, D | 1 |
| Pinto Martins, MA | 1 |
| Gauze Bonacorso, H | 1 |
| Antonello Rubin, M | 1 |
| Bonnet, U | 1 |
| Moreau, JL | 1 |
| Jenck, F | 1 |
| Martin, JR | 1 |
| Mortas, P | 1 |
| Haefely, W | 1 |
| Griebel, G | 1 |
| Perrault, G | 1 |
| Sanger, DJ | 1 |
| Sillaber, I | 1 |
| Montkowski, A | 1 |
| Landgraf, R | 1 |
| Barden, N | 1 |
| Holsboer, F | 1 |
| Spanagel, R | 1 |
| Rogde, S | 1 |
| Hilberg, T | 1 |
| Teige, B | 1 |
| Nakamura, K | 1 |
| Kurasawa, M | 1 |
1 review available for moclobemide and Disease Models, Animal
| Article | Year |
|---|---|
Moclobemide: evolution, pharmacodynamic, and pharmacokinetic properties.
Topics: Animals; Antidepressive Agents; Anxiety; Cognition Disorders; Depression; Disease Models, Animal; Dr | 2002 |
17 other studies available for moclobemide and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Monoamine oxidase A inhibition as monotherapy reverses parkinsonism in the MPTP-lesioned marmoset.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antiparkinson Agents; Basal Ganglia; Behavior | 2020 |
Monoamine oxidase A inhibition with moclobemide enhances the anti-parkinsonian effect of L-DOPA in the MPTP-lesioned marmoset.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antiparkinson Agents; Basal Ganglia; Behavior | 2020 |
Acute and chronic treatment with moclobemide, a reversible MAO-inhibitor, potentiates the antielectroshock activity of conventional antiepileptic drugs in mice.
Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, | 2021 |
Monoamine oxidase A inhibition protects the myocardium after experimental acute volume overload.
Topics: Animals; Atrial Natriuretic Factor; Disease Models, Animal; Heart Failure; Moclobemide; Monoamine Ox | 2019 |
The antinociceptive effect of reversible monoamine oxidase-A inhibitors in a mouse neuropathic pain model.
Topics: Analgesics; Analysis of Variance; Animals; Anisoles; Disease Models, Animal; Dose-Response Relations | 2013 |
Effect of newly synthesized 1,2,4-triazino[5,6-b]indole-3-thione derivatives on olfactory bulbectomy induced depression in rats.
Topics: Acetamides; Acetanilides; Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Mode | 2012 |
Antidepressant-like effects of ferulic acid: involvement of serotonergic and norepinergic systems.
Topics: Animals; Antidepressive Agents; Corpus Striatum; Coumaric Acids; Disease Models, Animal; Drug Evalua | 2015 |
Inhibition of monoamine oxidase A increases recovery after experimental cardiac arrest.
Topics: Animals; Coronary Vessels; Disease Models, Animal; Heart; Heart Arrest; Heart Transplantation; Ligat | 2015 |
Panic-modulating effects of alprazolam, moclobemide and sumatriptan in the rat elevated T-maze.
Topics: Alprazolam; Animals; Anti-Anxiety Agents; Brain; Disease Models, Animal; Escape Reaction; Explorator | 2016 |
Antidepressant-like effect of the novel MAO inhibitor 2-(3,4-dimethoxy-phenyl)-4,5-dihydro-1H-imidazole (2-DMPI) in mice.
Topics: Animals; Anisoles; Antidepressive Agents; Behavior, Animal; Biogenic Monoamines; Brain; Depression; | 2012 |
Effects of moclobemide, a new generation reversible Mao-A inhibitor, in a novel animal model of depression.
Topics: Animals; Benzamides; Depression; Disease Models, Animal; Male; Moclobemide; Monoamine Oxidase Inhibi | 1993 |
Behavioural profiles of the reversible monoamine-oxidase-A inhibitors befloxatone and moclobemide in an experimental model for screening anxiolytic and anti-panic drugs.
Topics: Animals; Anxiety; Avoidance Learning; Benzamides; Disease Models, Animal; Dose-Response Relationship | 1997 |
Enhanced morphine-induced behavioural effects and dopamine release in the nucleus accumbens in a transgenic mouse model of impaired glucocorticoid (type II) receptor function: influence of long-term treatment with the antidepressant moclobemide.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Benzamides; Corticosterone; Disease Models, Animal | 1998 |
Fatal combined intoxication with new antidepressants. Human cases and an experimental study of postmortem moclobemide redistribution.
Topics: Adult; Animals; Antidepressive Agents; Autopsy; Benzamides; Cause of Death; Disease Models, Animal; | 1999 |
Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Bro | 2001 |