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moclobemide and Aging

moclobemide has been researched along with Aging in 4 studies

Moclobemide: A reversible inhibitor of monoamine oxidase type A; (RIMA); (see MONOAMINE OXIDASE INHIBITORS) that has antidepressive properties.
moclobemide : A member of the class of benzamides that is benzamide substituted by a chloro group at position 4 and a 2-(morpholin-4-yl)ethyl group at the nitrogen atom. It acts as a reversible monoamine oxidase inhibitor and is used in the treatment of depression.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
" To further investigate the possible involvement of MAO activity in changes of brain amino acid levels with aging, moclobemide and Ro 19-6327, short acting MAO-A and MAO-B inhibitors, respectively, were administered to female Wistar rats for their whole life-span."3.68The effects of lifelong treatment with MAO inhibitors on amino acid levels in rat brain. ( Cini, M; Da Prada, M; Dostert, P; Kettler, R; Marrari, P; Strolin Benedetti, M, 1990)
"The pharmacokinetic variability of moclobemide, a new short half-life reversible selective inhibitor of monoamine oxidase (MAO) was investigated through analysis of concentrations measured during early open clinical use."2.68Potential of concentration monitoring data for a short half-life drug: analysis of pharmacokinetic variability for moclobemide. ( Balant, LP; Balant-Gorgia, AE; Gex-Fabry, M, 1995)
" This applies particularly to the utilization of the recommended dosage range, especially in severely depressed states, and the consistent, syndrome-based combination treatment with hypnotics/sedatives or neuroleptics in the respective patient groups indicated."2.68Quality-monitoring of psychotropic drug therapy in post-marketing surveillance. Results of a drug utilization observation (DUO) study on moclobemide. ( Baier, D; Laux, G, 1997)
"Moclobemide is a selective inhibitor of monoamine oxidase type A."2.40Antidepressant use in the elderly. Current status of nefazodone, venlafaxine and moclobemide. ( Goldberg, RJ, 1997)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Gex-Fabry, M1
Balant-Gorgia, AE1
Balant, LP1
Laux, G1
Baier, D1
Goldberg, RJ1
Strolin Benedetti, M1
Kettler, R1
Marrari, P1
Cini, M1
Da Prada, M1
Dostert, P1

Reviews

1 review available for moclobemide and Aging

ArticleYear
Antidepressant use in the elderly. Current status of nefazodone, venlafaxine and moclobemide.
    Drugs & aging, 1997, Volume: 11, Issue:2

    Topics: Aged; Aging; Antidepressive Agents; Benzamides; Cyclohexanols; Cytochrome P-450 Enzyme Inhibitors; D

1997

Trials

2 trials available for moclobemide and Aging

ArticleYear
Potential of concentration monitoring data for a short half-life drug: analysis of pharmacokinetic variability for moclobemide.
    Therapeutic drug monitoring, 1995, Volume: 17, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Aging; Benzamides; Chromatography, Gas; Depressive Disorder; Drug In

1995
Quality-monitoring of psychotropic drug therapy in post-marketing surveillance. Results of a drug utilization observation (DUO) study on moclobemide.
    Pharmacopsychiatry, 1997, Volume: 30, Issue:1 Suppl

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Benzamides; Depressive Disorder; Drug Interaction

1997

Other Studies

1 other study available for moclobemide and Aging

ArticleYear
The effects of lifelong treatment with MAO inhibitors on amino acid levels in rat brain.
    Journal of neural transmission. Parkinson's disease and dementia section, 1990, Volume: 2, Issue:4

    Topics: Aging; Amino Acids; Animals; Benzamides; Brain Chemistry; Female; Moclobemide; Monoamine Oxidase Inh

1990