mobiflex and Stomatitis--Aphthous

Recurrent aphthous ulcer (RAU) is a well-known painful, inflammatory disease with uncertain etiology for which local symptomatic therapy is only available. The aim of this study was to formulate and characterize muco-adhesive sponges containing a mixture of tenoxicam and miconazole nitrate to manage pain, inflammation and avoid candida infection that may accompany RAU due to poor oral hygiene. Two polymers at different concentrations were used to prepare sponges applying simple freeze-drying. Medicated chitosan (2%) sponges (mC2) showed acceptable physical appearance, surface pH (6.3 ± 0.042), porosity (25.7% ± 1.8), swelling index (5.7 ± 0.11),

Topics: Adhesives; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antifungal Agents; Carboxymethylcellulose Sodium; Chitosan; Dose-Response Relationship, Drug; Drug Carriers; Drug Liberation; Freeze Drying; Hydrogen-Ion Concentration; Miconazole; Microscopy, Electron, Scanning; Piroxicam; Rats; Stomatitis, Aphthous; Wound Healing