mobic and Temporomandibular-Joint-Disorders

In temporomandibular disorders (TMDs), unless splints are effective, combined therapies are performed. The aim of this study is to show the effectiveness of the local anaesthethic injections (trigger point injections) to the masticatory muscles.. The study was composed of TMD patients and the predictor variables were therapy combinations including stabilization splint (SS) therapy, SS+trigger point injection therapy (TPI) and arthrocentesis. The primary outcome variables were pain and jaw movements. The follow-ups were done at 1st and 3rd months. 56 patients who were treated for TMD with only SS or combined therapies were included in the study. The effects of additional TPIs were compared to SS therapy alone. Also the effect of arthrocentesis was evaluated too.. All groups revealed significant decreases in pain scores. Decreases in mouth openings were observed in some of the patients in the injection groups.. The combined treatment method in which the injections were applied at shorter time intervals, was a more effective method for decreasing VAS scores in TMD patients in this study but further studies are required.

Topics: Arthrocentesis; Clonidine; Combined Modality Therapy; Humans; Injections; Masticatory Muscles; Meloxicam; Myofascial Pain Syndromes; Occlusal Splints; Pain Measurement; Temporomandibular Joint Disorders; Temporomandibular Joint Dysfunction Syndrome; Treatment Outcome; Trigger Points; Turkey; Visual Analog Scale

To investigate the association between the analgesic effect of non-steroidal antiinflammatory drugs (NSAIDs) and sodium channel 1.7 (Nav1.7) expression in the trigeminal ganglion (TG).. Temporomandibular joint (TMJ) inflammation was induced by complete Freund's adjuvant (CFA) in female rats. Ibuprofen, diclofenac sodium and meloxicam were given intragastrically before induction of TMJ inflammation. Histopathological evaluation and scoring of TMJ inflammation was used to evaluate the level of inflammation. The head withdrawal threshold and food intake were measured to evaluate TMJ nociceptive responses. The mRNA and protein expression of trigeminal ganglionic Nav1.7 was examined using real-time polymerase chain reaction and western blot.. Twenty-four hours after the injection of CFA into the TMJs, NSAIDs attenuated hyperalgesia of inflamed TMJ and simultaneously blocked inflammation-induced upregulation of Nav1.7 mRNA and protein expression in the TG. However, ibuprofen and diclofenac sodium slightly attenuated TMJ inflammation and meloxicam did not affect TMJ inflammation.. Attenuation of hyperalgesia of inflamed TMJ by NSAIDs might be associated with their role in blocking upregulation of trigeminal ganglionic Nav1.7.

Topics: Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Diclofenac; Eating; Female; Freund's Adjuvant; Hyperalgesia; Ibuprofen; Meloxicam; NAV1.7 Voltage-Gated Sodium Channel; Nociception; Pain Threshold; Rats; Rats, Sprague-Dawley; Synovial Membrane; Temporomandibular Joint; Temporomandibular Joint Disorders; Thiazines; Thiazoles; Trigeminal Ganglion; Up-Regulation