mobic has been researched along with Leukopenia* in 1 studies
1 other study(ies) available for mobic and Leukopenia
| Article | Year |
|---|---|
Meloxicam, an inhibitor of cyclooxygenase-2, increases the level of serum G-CSF and might be usable as an auxiliary means in G-CSF therapy.
Hematopoiesis-modulating action of meloxicam, a cyclooxyge-nase-2 inhibitor, has been evaluated in mice. Increased serum level of granulocyte colony-stimulating factor (G-CSF) after meloxicam administration has been found in sublethally gamma-irradiated animals. In further experiments hematopoiesis-stimulating effects of meloxicam and G-CSF given alone or in combination have been investigated. Granulocyte/macrophage progenitor cells counts were used to monitor these effects. Meloxicam and exogenous G-CSF did not act synergistically when given in combination, but could be mutually substituted during their repeated administration. The results suggest a promising possibility of using meloxicam as an auxiliary drug reducing the high costs of G-CSF therapy of myelosuppression. Topics: Animals; Bone Marrow; Cell Differentiation; Cyclooxygenase 2 Inhibitors; Drug Interactions; Drug Therapy, Combination; Granulocyte Colony-Stimulating Factor; Granulocytes; Hematopoiesis; Leukopenia; Male; Meloxicam; Mice; Mice, Inbred CBA; Thiazines; Thiazoles; Whole-Body Irradiation | 2008 |