mobic has been researched along with Duodenal-Ulcer* in 3 studies
1 trial(s) available for mobic and Duodenal-Ulcer
| Article | Year |
|---|---|
Small bowel injury induced by selective cyclooxygenase-2 inhibitors: a prospective, double-blind, randomized clinical trial comparing celecoxib and meloxicam.
Selective cyclooxygenase (COX)-2 inhibitors are less harmful to the small bowel mucosa than non-selective anti-inflammatory drugs. We aimed to compare the severity of small bowel mucosal injury in healthy volunteers induced by two selective COX-2 inhibitors, celecoxib and meloxicam, in a randomized, double-blind trial, using capsule endoscopy (CE).. Twenty-nine healthy subjects were randomized to take either celecoxib (200 mg twice daily) or meloxicam (10 mg once daily) for 2 weeks. The incidence and the number of small bowel mucosal injuries (bleeding, ulcers, and erosions) observed by CE were compared between the two groups.. The overall incidence of small bowel mucosal injury was not different between the celecoxib group (6 of 14 subjects, 42.9%) and the meloxicam group (4 of 15 subjects, 26.7%, P = 0.45). In subjects with positive CE findings, the number of ulcers was greater in the meloxicam group than in the celecoxib group (P = 0.02), while such a trend was not found with regard to erosions (P = 0.52). The distribution of mucosal lesions within the small bowel was similar in the two groups.. Selective COX-2 inhibitors are not completely safe for the small bowel. The mucosal lesions may be less severe with celecoxib than with meloxicam. Topics: Adult; Capsule Endoscopes; Celecoxib; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Duodenal Ulcer; Female; Humans; Intestinal Mucosa; Intestine, Small; Male; Meloxicam; Middle Aged; Prospective Studies; Pyrazoles; Sulfonamides; Thiazines; Thiazoles; Young Adult | 2012 |
2 other study(ies) available for mobic and Duodenal-Ulcer
| Article | Year |
|---|---|
Challenging diagnosis--icterus associated with a single perforating duodenal ulcer after long-term nonsteroidal antiinflammatory drug administration in a dog.
A dog developed icterus, vomiting, and anorexia 2 wk after orthopedic surgery and treatment with meloxicam for approximately 1 y. Exploratory laparotomy revealed a single perforated duodenal ulcer. The most likely cause of the hyperbilirubinemia was intrahepatic cholestasis resulting from peritonitis associated with the perforation. Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diagnosis, Differential; Dog Diseases; Dogs; Duodenal Ulcer; Jaundice; Liver; Male; Meloxicam; Peptic Ulcer Hemorrhage; Peptic Ulcer Perforation; Thiazines; Thiazoles | 2004 |
Nonsteroidal anti-inflammatory drug-induced duodenal ulceration and perforation in a mature rottweiler.
A mature male rottweiler was evaluated for acute collapse and abdominal pain. The history consisted of concurrent administration of meloxicam and aspirin. On exploratory laparotomy, a large perforated ulcer was discovered in the proximal duodenum, with secondary peritonitis. The pathogenesis of NSAID-induced gastrointestinal ulceration and the supposed safety of COX-2 selective agents are discussed. Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dog Diseases; Dogs; Duodenal Ulcer; Male; Meloxicam; Peptic Ulcer Perforation; Thiazines; Thiazoles | 2002 |