mobic and Dehydration

mobic has been researched along with Dehydration* in 2 studies

Other Studies

2 other study(ies) available for mobic and Dehydration

Article	Year
Unveiling meloxicam monohydrate process of dehydration by an at-line vibrational multi-spectroscopy approach. Journal of pharmaceutical and biomedical analysis, 2021, Aug-05, Volume: 202 Meloxicam (MLX) is a non-steroidal anti-inflammatory drug, extensively used for inflammatory diseases and pain treatments, which exhibits five known solids forms. Form IV of MLX, a zwitterionic monohydrate (MH), is an emblematic hydrate case with promissory dissolution properties in a poorly soluble drug. However, the lack of information about MH stability regarding the dehydration process and phase transition impedes the development of further stability studies. A multi-spectroscopic/chemometric approach was implemented coupling middle- (MIR), near-infrared (NIR) and Raman spectroscopies to monitor the heat-mediated dehydration process of MH. The application of multivariate curve resolution-alternating least squares (MCR-ALS) to multi-source spectra by data fusion allow a complete view of the phenomena, improving the selectivity and precision to establish the transition temperatures and to identify involved species. It was revealed a two-step mechanism, where MH changes to Form V at 90 °C obtaining its complete dehydration at 130 °C, Form V remains unchanged during the temperature range 130-190 °C and then the polymorphic conversion to Form I starts, which reaches 100 % at 230 °C before melting MLX (248 °C). The findings of this work allow set targets in the process control of products using MH. Additionally, MCR-ALS detected an event not evidenced by conventional thermal analysis, the transformation of Form V to Form I. Topics: Anti-Inflammatory Agents, Non-Steroidal; Dehydration; Humans; Least-Squares Analysis; Meloxicam; Spectrum Analysis, Raman	2021
Acute pancreatitis attributed to dietary indiscretion in a female mixed breed canine. The Canadian veterinary journal = La revue veterinaire canadienne, 2010, Volume: 51, Issue:2 A female, mixed-breed dog was presented with signs of abdominal discomfort and vomiting of 24 h duration following an episode of dietary indiscretion. Clinical signs, previous medical history, and diagnostic tests supported a diagnosis of acute pancreatitis. Specific and supportive treatment was instituted, and clinical signs resolved 10 d after presentation. Topics: Acute Disease; Animal Feed; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Cell Count; Dehydration; Dog Diseases; Dogs; Female; Medical History Taking; Meloxicam; Pancreatitis; Quinuclidines; Radiography; Tachycardia; Thiazines; Thiazoles; Treatment Outcome; Vomiting	2010

Article

Year

Unveiling meloxicam monohydrate process of dehydration by an at-line vibrational multi-spectroscopy approach.

Journal of pharmaceutical and biomedical analysis, 2021, Aug-05, Volume: 202

Meloxicam (MLX) is a non-steroidal anti-inflammatory drug, extensively used for inflammatory diseases and pain treatments, which exhibits five known solids forms. Form IV of MLX, a zwitterionic monohydrate (MH), is an emblematic hydrate case with promissory dissolution properties in a poorly soluble drug. However, the lack of information about MH stability regarding the dehydration process and phase transition impedes the development of further stability studies. A multi-spectroscopic/chemometric approach was implemented coupling middle- (MIR), near-infrared (NIR) and Raman spectroscopies to monitor the heat-mediated dehydration process of MH. The application of multivariate curve resolution-alternating least squares (MCR-ALS) to multi-source spectra by data fusion allow a complete view of the phenomena, improving the selectivity and precision to establish the transition temperatures and to identify involved species. It was revealed a two-step mechanism, where MH changes to Form V at 90 °C obtaining its complete dehydration at 130 °C, Form V remains unchanged during the temperature range 130-190 °C and then the polymorphic conversion to Form I starts, which reaches 100 % at 230 °C before melting MLX (248 °C). The findings of this work allow set targets in the process control of products using MH. Additionally, MCR-ALS detected an event not evidenced by conventional thermal analysis, the transformation of Form V to Form I.

Topics: Anti-Inflammatory Agents, Non-Steroidal; Dehydration; Humans; Least-Squares Analysis; Meloxicam; Spectrum Analysis, Raman

2021

Acute pancreatitis attributed to dietary indiscretion in a female mixed breed canine.

The Canadian veterinary journal = La revue veterinaire canadienne, 2010, Volume: 51, Issue:2

A female, mixed-breed dog was presented with signs of abdominal discomfort and vomiting of 24 h duration following an episode of dietary indiscretion. Clinical signs, previous medical history, and diagnostic tests supported a diagnosis of acute pancreatitis. Specific and supportive treatment was instituted, and clinical signs resolved 10 d after presentation.

Topics: Acute Disease; Animal Feed; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Cell Count; Dehydration; Dog Diseases; Dogs; Female; Medical History Taking; Meloxicam; Pancreatitis; Quinuclidines; Radiography; Tachycardia; Thiazines; Thiazoles; Treatment Outcome; Vomiting

2010