mln8054 and Neoplasms

mln8054 has been researched along with Neoplasms* in 2 studies

Reviews

1 review(s) available for mln8054 and Neoplasms

Article	Year
Discovery and development of aurora kinase inhibitors as anticancer agents. Journal of medicinal chemistry, 2009, May-14, Volume: 52, Issue:9 Topics: Animals; Antineoplastic Agents; Aurora Kinases; Drug Discovery; Humans; Mitosis; Neoplasms; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases	2009

Other Studies

1 other study(ies) available for mln8054 and Neoplasms

Article	Year
Structure-based design of imidazo[1,2-a]pyrazine derivatives as selective inhibitors of Aurora-A kinase in cells. Bioorganic & medicinal chemistry letters, 2010, Oct-15, Volume: 20, Issue:20 Co-crystallisation of the imidazo[1,2-a]pyrazine derivative 15 (3-chloro-N-(4-morpholinophenyl)-6-(pyridin-3-yl)imidazo[1,2-a]pyrazin-8-amine) with Aurora-A provided an insight into the interactions of this class of compound with Aurora kinases. This led to the design and synthesis of potent Aurora-A inhibitors demonstrating up to 70-fold selectivity in cell-based Aurora kinase pharmacodynamic biomarker assays. Topics: Antineoplastic Agents; Aurora Kinases; Cell Line, Tumor; Crystallography, X-Ray; Humans; Models, Molecular; Neoplasms; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrazines; Structure-Activity Relationship	2010

Article

Year

Structure-based design of imidazo[1,2-a]pyrazine derivatives as selective inhibitors of Aurora-A kinase in cells.

Bioorganic & medicinal chemistry letters, 2010, Oct-15, Volume: 20, Issue:20

Co-crystallisation of the imidazo[1,2-a]pyrazine derivative 15 (3-chloro-N-(4-morpholinophenyl)-6-(pyridin-3-yl)imidazo[1,2-a]pyrazin-8-amine) with Aurora-A provided an insight into the interactions of this class of compound with Aurora kinases. This led to the design and synthesis of potent Aurora-A inhibitors demonstrating up to 70-fold selectivity in cell-based Aurora kinase pharmacodynamic biomarker assays.

Topics: Antineoplastic Agents; Aurora Kinases; Cell Line, Tumor; Crystallography, X-Ray; Humans; Models, Molecular; Neoplasms; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrazines; Structure-Activity Relationship

2010