ml 7 has been researched along with Muscle Contraction in 17 studies
ML-7 : An N-sulfonyldiazepane resullting from the formal condensation of 5-iodo-1-naphthylsulfonic acid with one of the nitrogens of 1,4-diazepane. It is a selective inhibitor of myosin light chain kinase (EC 2.7.11.18).
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Dexmedetomidine dose-response curves were generated in the presence or absence of the following inhibitors: the pan-PKC inhibitor, chelerythrine; the PKC-α and -β inhibitor, Go6976; the PKC-α inhibitor, safingol; the PKC-β inhibitor, ruboxistaurin; the PKC-δ inhibitor, rottlerin; the c-Jun NH2-terminal kinase (JNK) inhibitor, SP600125; and the myosin light chain kinase inhibitor, ML-7 hydrochloride." | 1.42 | Dexmedetomidine-Induced Contraction in the Isolated Endothelium-Denuded Rat Aorta Involves PKC-δ-mediated JNK Phosphorylation. ( Cho, H; Choi, MJ; Chung, YK; Kim, WH; Kwon, SC; Lee, HK; Ok, SH; Park, J; Shin, IW; Sohn, JT; Yu, J, 2015) |
| "Emodin has a direct contractile effect on colonic smooth muscle cell." | 1.32 | Signal pathways involved in emodin-induced contraction of smooth muscle cells from rat colon. ( Dong, ZL; Ma, T; Qi, QH; Xu, J; Yang, WX, 2004) |
| "Sustained smooth muscle contraction is mediated by protein kinase C (PKC) through a signal transduction cascade leading to contraction." | 1.30 | HSP27 in signal transduction and association with contractile proteins in smooth muscle cells. ( Bitar, KN; Groblewski, G; Ibitayo, AI; Louis-Jacques, O; Sladick, J; Tuteja, S; Welsh, M; Yamada, H, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (5.88) | 18.2507 |
| 2000's | 10 (58.82) | 29.6817 |
| 2010's | 5 (29.41) | 24.3611 |
| 2020's | 1 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Pérez-Domínguez, S | 1 |
| López-Alonso, J | 1 |
| Lafont, F | 1 |
| Radmacher, M | 1 |
| Yu, J | 1 |
| Ok, SH | 1 |
| Kim, WH | 1 |
| Cho, H | 1 |
| Park, J | 1 |
| Shin, IW | 1 |
| Lee, HK | 1 |
| Chung, YK | 1 |
| Choi, MJ | 1 |
| Kwon, SC | 1 |
| Sohn, JT | 1 |
| Xiong, YJ | 1 |
| Chu, HW | 1 |
| Lin, Y | 1 |
| Han, F | 1 |
| Li, YC | 1 |
| Wang, AG | 1 |
| Wang, FJ | 1 |
| Chen, DP | 1 |
| Wang, JY | 1 |
| Wang, W | 2 |
| Nepiyushchikh, Z | 1 |
| Zawieja, DC | 2 |
| Chakraborty, S | 2 |
| Zawieja, SD | 1 |
| Gashev, AA | 1 |
| Davis, MJ | 2 |
| Muthuchamy, M | 2 |
| Connolly, SC | 1 |
| Smith, PG | 1 |
| Fairbank, NJ | 1 |
| Lall, CA | 1 |
| Cole, DJ | 1 |
| Mackinnon, JD | 1 |
| Maksym, GN | 1 |
| Nepiyushchikh, ZV | 1 |
| Raqeeb, A | 1 |
| Jiao, Y | 1 |
| Syyong, HT | 1 |
| Paré, PD | 1 |
| Seow, CY | 1 |
| Lamounier-Zepter, V | 1 |
| Baltas, LG | 1 |
| Morano, I | 1 |
| Ma, T | 1 |
| Qi, QH | 1 |
| Xu, J | 1 |
| Dong, ZL | 1 |
| Yang, WX | 1 |
| Dhawan, J | 1 |
| Helfman, DM | 1 |
| Laudadio, RE | 1 |
| Millet, EJ | 1 |
| Fabry, B | 1 |
| An, SS | 1 |
| Butler, JP | 1 |
| Fredberg, JJ | 1 |
| Moriez, R | 1 |
| Salvador-Cartier, C | 1 |
| Theodorou, V | 1 |
| Fioramonti, J | 1 |
| Eutamene, H | 1 |
| Bueno, L | 1 |
| Mbikou, P | 1 |
| Fajmut, A | 1 |
| Brumen, M | 1 |
| Roux, E | 1 |
| Kim, JI | 1 |
| Jeon, SB | 1 |
| Baek, I | 1 |
| Seok, YM | 1 |
| Shin, HM | 1 |
| Kim, IK | 1 |
| Ibitayo, AI | 1 |
| Sladick, J | 1 |
| Tuteja, S | 1 |
| Louis-Jacques, O | 1 |
| Yamada, H | 1 |
| Groblewski, G | 1 |
| Welsh, M | 1 |
| Bitar, KN | 1 |
| Parizi, M | 1 |
| Howard, EW | 1 |
| Tomasek, JJ | 1 |
| Cao, W | 1 |
| Chen, Q | 1 |
| Sohn, UD | 1 |
| Kim, N | 1 |
| Kirber, MT | 1 |
| Harnett, KM | 1 |
| Behar, J | 1 |
| Biancani, P | 1 |
17 other studies available for ml 7 and Muscle Contraction
| Article | Year |
|---|---|
Comparison of Rheological Properties of Healthy versus Dupuytren Fibroblasts When Treated with a Cell Contraction Inhibitor by Atomic Force Microscope.
Topics: Cytoskeleton; Dupuytren Contracture; Fibroblasts; Humans; Mechanical Phenomena; Microscopy, Atomic F | 2023 |
Dexmedetomidine-Induced Contraction in the Isolated Endothelium-Denuded Rat Aorta Involves PKC-δ-mediated JNK Phosphorylation.
Topics: Animals; Aorta; Azepines; Benzophenanthridines; Carbazoles; Dexmedetomidine; Endothelium, Vascular; | 2015 |
Hesperidin alleviates rat postoperative ileus through anti-inflammation and stimulation of Ca(2+)-dependent myosin phosphorylation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Azepines; Calcium; Cecum; Cyclooxygenase 2; Cytoki | 2016 |
Inhibition of myosin light chain phosphorylation decreases rat mesenteric lymphatic contractile activity.
Topics: Animals; Azepines; Enzyme Inhibitors; Immunohistochemistry; Lymphatic System; Male; Mesentery; Muscl | 2009 |
Chronic oscillatory strain induces MLCK associated rapid recovery from acute stretch in airway smooth muscle cells.
Topics: Animals; Asthma; Azepines; Cells, Cultured; Dogs; Muscle Contraction; Muscle, Smooth; Myocytes, Smoo | 2011 |
Differential effects of myosin light chain kinase inhibition on contractility, force development and myosin light chain 20 phosphorylation of rat cervical and thoracic duct lymphatics.
Topics: Animals; Azepines; Enzyme Inhibitors; In Vitro Techniques; Lymphatic System; Lymphatic Vessels; Male | 2011 |
Regulatable stiffness in relaxed airway smooth muscle: a target for asthma treatment?
Topics: Amides; Animals; Asthma; Azepines; Calcium; Imidazoles; In Vitro Techniques; Molecular Targeted Ther | 2012 |
Distinct contractile systems for electromechanical and pharmacomechanical coupling in smooth muscle.
Topics: Alternative Splicing; Animals; Animals, Newborn; Azepines; Dose-Response Relationship, Drug; Electro | 2003 |
Signal pathways involved in emodin-induced contraction of smooth muscle cells from rat colon.
Topics: Animals; Azepines; Calcium; Calcium Signaling; Colon; Emodin; Enzyme Inhibitors; Muscle Contraction; | 2004 |
Modulation of acto-myosin contractility in skeletal muscle myoblasts uncouples growth arrest from differentiation.
Topics: Actomyosin; Animals; Antimetabolites; Azepines; Bridged Bicyclo Compounds, Heterocyclic; Bromodeoxyu | 2004 |
Rat airway smooth muscle cell during actin modulation: rheology and glassy dynamics.
Topics: Actins; Animals; Azepines; Biomechanical Phenomena; Bridged Bicyclo Compounds, Heterocyclic; Buclade | 2005 |
Myosin light chain kinase is involved in lipopolysaccharide-induced disruption of colonic epithelial barrier and bacterial translocation in rats.
Topics: Animals; Azepines; Bacterial Translocation; Blotting, Western; Cell Membrane Permeability; Colon; Di | 2005 |
Theoretical and experimental investigation of calcium-contraction coupling in airway smooth muscle.
Topics: Androstadienes; Animals; Azepines; Calcium; Carbachol; Cholinergic Agents; Enzyme Activation; In Vit | 2006 |
Heat shock augments myosin phosphatase target-subunit phosphorylation.
Topics: Amides; Amino Acid Sequence; Animals; Azepines; Carrier Proteins; Heat-Shock Response; Intracellular | 2007 |
HSP27 in signal transduction and association with contractile proteins in smooth muscle cells.
Topics: Actins; Animals; Azepines; Biological Transport; Calcium-Calmodulin-Dependent Protein Kinases; Calmo | 1999 |
Regulation of LPA-promoted myofibroblast contraction: role of Rho, myosin light chain kinase, and myosin light chain phosphatase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; ADP Ribose Transferases; Alkaloids; Azepines; Botulin | 2000 |
Ca2+-induced contraction of cat esophageal circular smooth muscle cells.
Topics: Adrenergic beta-Antagonists; Alkaloids; Animals; Antibodies; Azepines; Benzophenanthridines; Bridged | 2001 |