ml 7 has been researched along with Invasiveness, Neoplasm in 4 studies
ML-7 : An N-sulfonyldiazepane resullting from the formal condensation of 5-iodo-1-naphthylsulfonic acid with one of the nitrogens of 1,4-diazepane. It is a selective inhibitor of myosin light chain kinase (EC 2.7.11.18).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Invasion and metastasis of pancreatic cancer (PC) require cell motility and adhesion, which depend on the activity of cytoskeleton." | 1.31 | Myosin light chain kinase inhibitors can block invasion and adhesion of human pancreatic cancer cell lines. ( Kaneko, K; Masamune, A; Satoh, A; Satoh, K; Shimosegawa, T, 2002) |
| " The inhibition of in vitro haptotaxis follows the dose-response relationship expected for competitive inhibition of myosin light chain kinase by these drugs and is seen at drug concentrations that are nontoxic." | 1.30 | Glioma migration can be blocked by nontoxic inhibitors of myosin II. ( Gillespie, GY; Gladson, CL; Manning, TJ; Rosenfeld, SS; Soroceanu, L, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mierke, CT | 1 |
| Frey, B | 1 |
| Fellner, M | 1 |
| Herrmann, M | 1 |
| Fabry, B | 1 |
| Tohtong, R | 1 |
| Phattarasakul, K | 1 |
| Jiraviriyakul, A | 1 |
| Sutthiphongchai, T | 1 |
| Gillespie, GY | 1 |
| Soroceanu, L | 1 |
| Manning, TJ | 1 |
| Gladson, CL | 1 |
| Rosenfeld, SS | 1 |
| Kaneko, K | 1 |
| Satoh, K | 1 |
| Masamune, A | 1 |
| Satoh, A | 1 |
| Shimosegawa, T | 1 |
4 other studies available for ml 7 and Invasiveness, Neoplasm
| Article | Year |
|---|---|
Integrin α5β1 facilitates cancer cell invasion through enhanced contractile forces.
Topics: Azepines; Cell Adhesion; Cell Line, Tumor; Cell Movement; Enzyme Inhibitors; Extracellular Matrix; H | 2011 |
Dependence of metastatic cancer cell invasion on MLCK-catalyzed phosphorylation of myosin regulatory light chain.
Topics: Adenocarcinoma; Animals; Azepines; Cell Division; Cell Line, Tumor; Cell Movement; Dose-Response Rel | 2003 |
Glioma migration can be blocked by nontoxic inhibitors of myosin II.
Topics: Actin Cytoskeleton; Alkaloids; Azepines; Carbazoles; Cell Adhesion; Cell Movement; Cell Survival; Gl | 1999 |
Myosin light chain kinase inhibitors can block invasion and adhesion of human pancreatic cancer cell lines.
Topics: Azepines; Cell Adhesion; Cell Movement; Cell Survival; Enzyme Inhibitors; Humans; Integrin beta1; My | 2002 |