ml 7 has been researched along with Inflammation in 7 studies
ML-7 : An N-sulfonyldiazepane resullting from the formal condensation of 5-iodo-1-naphthylsulfonic acid with one of the nitrogens of 1,4-diazepane. It is a selective inhibitor of myosin light chain kinase (EC 2.7.11.18).
Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The mechanism of inflammation is under debate and could be neurogenic and/or the consequence of tight-junction opening with passage of exogenous pathogens into the lamina propria." | 1.32 | Proteinase-activated receptor-2-induced colonic inflammation in mice: possible involvement of afferent neurons, nitric oxide, and paracellular permeability. ( Bueno, L; Bunnett, NW; Cenac, N; Coelho, AM; Ferrier, L; Fioramonti, J; Garcia-Villar, R; Larauche, M; Vergnolle, N, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Huang, C | 1 |
| Zhang, Z | 1 |
| Wang, L | 1 |
| Liu, J | 1 |
| Gong, X | 1 |
| Zhang, C | 1 |
| Xiong, YJ | 1 |
| Chu, HW | 1 |
| Lin, Y | 1 |
| Han, F | 1 |
| Li, YC | 1 |
| Wang, AG | 1 |
| Wang, FJ | 1 |
| Chen, DP | 1 |
| Wang, JY | 1 |
| Ait-Belgnaoui, A | 1 |
| Durand, H | 1 |
| Cartier, C | 1 |
| Chaumaz, G | 1 |
| Eutamene, H | 2 |
| Ferrier, L | 2 |
| Houdeau, E | 1 |
| Fioramonti, J | 3 |
| Bueno, L | 3 |
| Theodorou, V | 2 |
| Liu, X | 1 |
| Xu, J | 1 |
| Mei, Q | 1 |
| Han, L | 1 |
| Huang, J | 1 |
| Cenac, N | 1 |
| Garcia-Villar, R | 1 |
| Larauche, M | 1 |
| Vergnolle, N | 1 |
| Bunnett, NW | 1 |
| Coelho, AM | 1 |
| Moriez, R | 1 |
| Salvador-Cartier, C | 1 |
| Garcia, JG | 1 |
| Verin, AD | 1 |
| Herenyiova, M | 1 |
| English, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Double Blind Placebo Controlled Study on the Effects of a Probiotic on Autonomic and Psychological Stress Responses in Volunteers[NCT02417454] | Phase 3 | 128 participants (Anticipated) | Interventional | 2015-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 other studies available for ml 7 and Inflammation
| Article | Year |
|---|---|
ML-7 attenuates airway inflammation and remodeling via inhibiting the secretion of Th2 cytokines in mice model of asthma.
Topics: Airway Remodeling; Animals; Asthma; Azepines; Cytokines; Disease Models, Animal; Female; Inflammatio | 2018 |
Hesperidin alleviates rat postoperative ileus through anti-inflammation and stimulation of Ca(2+)-dependent myosin phosphorylation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Azepines; Calcium; Cecum; Cyclooxygenase 2; Cytoki | 2016 |
Prevention of gut leakiness by a probiotic treatment leads to attenuated HPA response to an acute psychological stress in rats.
Topics: Acute Disease; Adrenocorticotropic Hormone; Animals; Anti-Bacterial Agents; Azepines; Colon; Cortico | 2012 |
Myosin light chain kinase inhibitor inhibits dextran sulfate sodium-induced colitis in mice.
Topics: Animals; Azepines; Colitis; Cytokines; Dextran Sulfate; Enzyme Inhibitors; Gene Expression Regulatio | 2013 |
Proteinase-activated receptor-2-induced colonic inflammation in mice: possible involvement of afferent neurons, nitric oxide, and paracellular permeability.
Topics: Administration, Rectal; Animals; Antigens; Antigens, Surface; Azepines; Calcitonin Gene-Related Pept | 2003 |
Myosin light chain kinase is involved in lipopolysaccharide-induced disruption of colonic epithelial barrier and bacterial translocation in rats.
Topics: Animals; Azepines; Bacterial Translocation; Blotting, Western; Cell Membrane Permeability; Colon; Di | 2005 |
Adherent neutrophils activate endothelial myosin light chain kinase: role in transendothelial migration.
Topics: Alkaloids; Animals; Azepines; Capillary Permeability; Carbazoles; Cattle; Cell Adhesion; Cell Moveme | 1998 |