Page last updated: 2024-10-31

ml 7 and Inflammation

ml 7 has been researched along with Inflammation in 7 studies

ML-7 : An N-sulfonyldiazepane resullting from the formal condensation of 5-iodo-1-naphthylsulfonic acid with one of the nitrogens of 1,4-diazepane. It is a selective inhibitor of myosin light chain kinase (EC 2.7.11.18).

Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.

Research Excerpts

ExcerptRelevanceReference
"The mechanism of inflammation is under debate and could be neurogenic and/or the consequence of tight-junction opening with passage of exogenous pathogens into the lamina propria."1.32Proteinase-activated receptor-2-induced colonic inflammation in mice: possible involvement of afferent neurons, nitric oxide, and paracellular permeability. ( Bueno, L; Bunnett, NW; Cenac, N; Coelho, AM; Ferrier, L; Fioramonti, J; Garcia-Villar, R; Larauche, M; Vergnolle, N, 2003)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (14.29)18.2507
2000's2 (28.57)29.6817
2010's4 (57.14)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Huang, C1
Zhang, Z1
Wang, L1
Liu, J1
Gong, X1
Zhang, C1
Xiong, YJ1
Chu, HW1
Lin, Y1
Han, F1
Li, YC1
Wang, AG1
Wang, FJ1
Chen, DP1
Wang, JY1
Ait-Belgnaoui, A1
Durand, H1
Cartier, C1
Chaumaz, G1
Eutamene, H2
Ferrier, L2
Houdeau, E1
Fioramonti, J3
Bueno, L3
Theodorou, V2
Liu, X1
Xu, J1
Mei, Q1
Han, L1
Huang, J1
Cenac, N1
Garcia-Villar, R1
Larauche, M1
Vergnolle, N1
Bunnett, NW1
Coelho, AM1
Moriez, R1
Salvador-Cartier, C1
Garcia, JG1
Verin, AD1
Herenyiova, M1
English, D1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Double Blind Placebo Controlled Study on the Effects of a Probiotic on Autonomic and Psychological Stress Responses in Volunteers[NCT02417454]Phase 3128 participants (Anticipated)Interventional2015-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

7 other studies available for ml 7 and Inflammation

ArticleYear
ML-7 attenuates airway inflammation and remodeling via inhibiting the secretion of Th2 cytokines in mice model of asthma.
    Molecular medicine reports, 2018, Volume: 17, Issue:5

    Topics: Airway Remodeling; Animals; Asthma; Azepines; Cytokines; Disease Models, Animal; Female; Inflammatio

2018
Hesperidin alleviates rat postoperative ileus through anti-inflammation and stimulation of Ca(2+)-dependent myosin phosphorylation.
    Acta pharmacologica Sinica, 2016, Volume: 37, Issue:8

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Azepines; Calcium; Cecum; Cyclooxygenase 2; Cytoki

2016
Prevention of gut leakiness by a probiotic treatment leads to attenuated HPA response to an acute psychological stress in rats.
    Psychoneuroendocrinology, 2012, Volume: 37, Issue:11

    Topics: Acute Disease; Adrenocorticotropic Hormone; Animals; Anti-Bacterial Agents; Azepines; Colon; Cortico

2012
Myosin light chain kinase inhibitor inhibits dextran sulfate sodium-induced colitis in mice.
    Digestive diseases and sciences, 2013, Volume: 58, Issue:1

    Topics: Animals; Azepines; Colitis; Cytokines; Dextran Sulfate; Enzyme Inhibitors; Gene Expression Regulatio

2013
Proteinase-activated receptor-2-induced colonic inflammation in mice: possible involvement of afferent neurons, nitric oxide, and paracellular permeability.
    Journal of immunology (Baltimore, Md. : 1950), 2003, Apr-15, Volume: 170, Issue:8

    Topics: Administration, Rectal; Animals; Antigens; Antigens, Surface; Azepines; Calcitonin Gene-Related Pept

2003
Myosin light chain kinase is involved in lipopolysaccharide-induced disruption of colonic epithelial barrier and bacterial translocation in rats.
    The American journal of pathology, 2005, Volume: 167, Issue:4

    Topics: Animals; Azepines; Bacterial Translocation; Blotting, Western; Cell Membrane Permeability; Colon; Di

2005
Adherent neutrophils activate endothelial myosin light chain kinase: role in transendothelial migration.
    Journal of applied physiology (Bethesda, Md. : 1985), 1998, Volume: 84, Issue:5

    Topics: Alkaloids; Animals; Azepines; Capillary Permeability; Carbazoles; Cattle; Cell Adhesion; Cell Moveme

1998