Page last updated: 2024-10-31

ml 7 and Glioma

ml 7 has been researched along with Glioma in 2 studies

ML-7 : An N-sulfonyldiazepane resullting from the formal condensation of 5-iodo-1-naphthylsulfonic acid with one of the nitrogens of 1,4-diazepane. It is a selective inhibitor of myosin light chain kinase (EC 2.7.11.18).

Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)

Research Excerpts

ExcerptRelevanceReference
" The inhibition of in vitro haptotaxis follows the dose-response relationship expected for competitive inhibition of myosin light chain kinase by these drugs and is seen at drug concentrations that are nontoxic."1.30Glioma migration can be blocked by nontoxic inhibitors of myosin II. ( Gillespie, GY; Gladson, CL; Manning, TJ; Rosenfeld, SS; Soroceanu, L, 1999)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Shrode, LD1
Klein, JD1
Douglas, PB1
O'Neill, WC1
Putnam, RW1
Gillespie, GY1
Soroceanu, L1
Manning, TJ1
Gladson, CL1
Rosenfeld, SS1

Other Studies

2 other studies available for ml 7 and Glioma

ArticleYear
Shrinkage-induced activation of Na+/H+ exchange: role of cell density and myosin light chain phosphorylation.
    The American journal of physiology, 1997, Volume: 272, Issue:6 Pt 1

    Topics: Amiloride; Ammonium Chloride; Animals; Astrocytes; Azepines; Calmodulin; Enzyme Inhibitors; Glioma;

1997
Glioma migration can be blocked by nontoxic inhibitors of myosin II.
    Cancer research, 1999, May-01, Volume: 59, Issue:9

    Topics: Actin Cytoskeleton; Alkaloids; Azepines; Carbazoles; Cell Adhesion; Cell Movement; Cell Survival; Gl

1999