ml 7 and Glioma
ml 7 has been researched along with Glioma in 2 studies
ML-7 : An N-sulfonyldiazepane resullting from the formal condensation of 5-iodo-1-naphthylsulfonic acid with one of the nitrogens of 1,4-diazepane. It is a selective inhibitor of myosin light chain kinase (EC 2.7.11.18).
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| " The inhibition of in vitro haptotaxis follows the dose-response relationship expected for competitive inhibition of myosin light chain kinase by these drugs and is seen at drug concentrations that are nontoxic." | 1.30 | Glioma migration can be blocked by nontoxic inhibitors of myosin II. ( Gillespie, GY; Gladson, CL; Manning, TJ; Rosenfeld, SS; Soroceanu, L, 1999) |
Research
Studies (2)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Shrode, LD | 1 |
| Klein, JD | 1 |
| Douglas, PB | 1 |
| O'Neill, WC | 1 |
| Putnam, RW | 1 |
| Gillespie, GY | 1 |
| Soroceanu, L | 1 |
| Manning, TJ | 1 |
| Gladson, CL | 1 |
| Rosenfeld, SS | 1 |
Other Studies
2 other studies available for ml 7 and Glioma
| Article | Year |
|---|---|
Shrinkage-induced activation of Na+/H+ exchange: role of cell density and myosin light chain phosphorylation.
Topics: Amiloride; Ammonium Chloride; Animals; Astrocytes; Azepines; Calmodulin; Enzyme Inhibitors; Glioma; | 1997 |
Glioma migration can be blocked by nontoxic inhibitors of myosin II.
Topics: Actin Cytoskeleton; Alkaloids; Azepines; Carbazoles; Cell Adhesion; Cell Movement; Cell Survival; Gl | 1999 |