ml-00253764 and Emaciation

ml-00253764 has been researched along with Emaciation* in 1 studies

Other Studies

1 other study(ies) available for ml-00253764 and Emaciation

Article	Year
Identification of 2-[2-[2-(5-bromo-2- methoxyphenyl)-ethyl]-3-fluorophenyl]-4,5-dihydro-1H-imidazole (ML00253764), a small molecule melanocortin 4 receptor antagonist that effectively reduces tumor-induced weight loss in a mouse model. Journal of medicinal chemistry, 2004, Mar-25, Volume: 47, Issue:7 The melanocortin 4 receptor (MC4R) plays an important role in body weight regulation and energy homeostasis. Administration of peptidic MC4R antagonists (usually by intracerebro ventricular injection) has been shown in the literature to increase body weight and/or food intake in several rodent models. We report here the identification of a novel nonpeptidic MC4R antagonist and its effects on tumor-induced weight loss in mice following peripheral administration. Topics: Administration, Cutaneous; Animals; Benzamidines; Emaciation; Imidazoles; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Neoplasms; Radioligand Assay; Receptor, Melanocortin, Type 4; Structure-Activity Relationship; Transplantation, Heterologous	2004

Article

Year

Identification of 2-[2-[2-(5-bromo-2- methoxyphenyl)-ethyl]-3-fluorophenyl]-4,5-dihydro-1H-imidazole (ML00253764), a small molecule melanocortin 4 receptor antagonist that effectively reduces tumor-induced weight loss in a mouse model.

Journal of medicinal chemistry, 2004, Mar-25, Volume: 47, Issue:7

The melanocortin 4 receptor (MC4R) plays an important role in body weight regulation and energy homeostasis. Administration of peptidic MC4R antagonists (usually by intracerebro ventricular injection) has been shown in the literature to increase body weight and/or food intake in several rodent models. We report here the identification of a novel nonpeptidic MC4R antagonist and its effects on tumor-induced weight loss in mice following peripheral administration.

Topics: Administration, Cutaneous; Animals; Benzamidines; Emaciation; Imidazoles; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Neoplasms; Radioligand Assay; Receptor, Melanocortin, Type 4; Structure-Activity Relationship; Transplantation, Heterologous

2004