mk-9470 and Parkinson-Disease

The endocannabinoid system plays a regulatory role in a number of physiological functions, including motor control but also mood, emotion, and cognition. A number of preclinical studies in Parkinson's disease (PD) models demonstrated that modulating the type 1 cannabinoid receptor (CB. Thirty-eight PD patients and ten age- and gender-matched controls underwent a [. PD patients with poorer performance in episodic memory, executive functioning, speed and mental flexibility (range P 0.003-0.03) showed lower CB. Decreased CB

Topics: Adult; Aged; Aged, 80 and over; Case-Control Studies; Cognition; Cognition Disorders; Female; Humans; Male; Middle Aged; Motor Skills; Parkinson Disease; Positron-Emission Tomography; Pyridines; Receptor, Cannabinoid, CB1