mk-8245 and Obesity

mk-8245 has been researched along with Obesity* in 1 studies

Other Studies

1 other study(ies) available for mk-8245 and Obesity

Article	Year
Discovery of potent and liver-selective stearoyl-CoA desaturase (SCD) inhibitors in an acyclic linker series. Bioorganic & medicinal chemistry letters, 2012, Jan-01, Volume: 22, Issue:1 Elevated levels of stearoyl-CoA desaturase (SCD) activity have been implicated in metabolic disorders such as obesity and type II diabetes. To circumvent skin and eye adverse events observed in rodents with systemically-distributed inhibitors, our research efforts have been focused on the search for new liver-targeting compounds. This work has led to the discovery of novel, potent and liver-selective acyclic linker SCD inhibitors. These compounds possess suitable cellular activity and pharmacokinetic properties to inhibit liver SCD activity in a mouse pharmacodynamic model. Topics: Acetates; Animals; Chemistry, Pharmaceutical; Diabetes Mellitus, Type 2; Drug Design; Enzyme Inhibitors; Hydrolysis; Inhibitory Concentration 50; Liver; Mice; Mice, Inbred C57BL; Models, Chemical; Obesity; Stearoyl-CoA Desaturase; Structure-Activity Relationship; Tetrazoles	2012

Article

Year

Discovery of potent and liver-selective stearoyl-CoA desaturase (SCD) inhibitors in an acyclic linker series.

Bioorganic & medicinal chemistry letters, 2012, Jan-01, Volume: 22, Issue:1

Elevated levels of stearoyl-CoA desaturase (SCD) activity have been implicated in metabolic disorders such as obesity and type II diabetes. To circumvent skin and eye adverse events observed in rodents with systemically-distributed inhibitors, our research efforts have been focused on the search for new liver-targeting compounds. This work has led to the discovery of novel, potent and liver-selective acyclic linker SCD inhibitors. These compounds possess suitable cellular activity and pharmacokinetic properties to inhibit liver SCD activity in a mouse pharmacodynamic model.

Topics: Acetates; Animals; Chemistry, Pharmaceutical; Diabetes Mellitus, Type 2; Drug Design; Enzyme Inhibitors; Hydrolysis; Inhibitory Concentration 50; Liver; Mice; Mice, Inbred C57BL; Models, Chemical; Obesity; Stearoyl-CoA Desaturase; Structure-Activity Relationship; Tetrazoles

2012