mk-7246 and Lung-Diseases

mk-7246 has been researched along with Lung-Diseases* in 1 studies

Other Studies

1 other study(ies) available for mk-7246 and Lung-Diseases

Article	Year
Discovery of MK-7246, a selective CRTH2 antagonist for the treatment of respiratory diseases. Bioorganic & medicinal chemistry letters, 2011, Jan-01, Volume: 21, Issue:1 In this manuscript we wish to report the discovery of MK-7246 (4), a potent and selective CRTH2 (DP2) antagonist. SAR studies leading to MK-7246 along with two synthetic sequences enabling the preparation of this novel class of CRTH2 antagonist are reported. Finally, the pharmacokinetic and metabolic profile of MK-7246 is disclosed. Topics: Animals; Carbolines; Humans; Lung Diseases; Macaca mulatta; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Receptors, Immunologic; Receptors, Prostaglandin; Structure-Activity Relationship	2011

Article

Year

Discovery of MK-7246, a selective CRTH2 antagonist for the treatment of respiratory diseases.

Bioorganic & medicinal chemistry letters, 2011, Jan-01, Volume: 21, Issue:1

In this manuscript we wish to report the discovery of MK-7246 (4), a potent and selective CRTH2 (DP2) antagonist. SAR studies leading to MK-7246 along with two synthetic sequences enabling the preparation of this novel class of CRTH2 antagonist are reported. Finally, the pharmacokinetic and metabolic profile of MK-7246 is disclosed.

Topics: Animals; Carbolines; Humans; Lung Diseases; Macaca mulatta; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Receptors, Immunologic; Receptors, Prostaglandin; Structure-Activity Relationship

2011