mk-7246 and Disease-Models--Animal

mk-7246 has been researched along with Disease-Models--Animal* in 1 studies

Other Studies

1 other study(ies) available for mk-7246 and Disease-Models--Animal

Article	Year
Novel tricyclic antagonists of the prostaglandin D2 receptor DP2 with efficacy in a murine model of allergic rhinitis. Bioorganic & medicinal chemistry letters, 2009, Aug-15, Volume: 19, Issue:16 The synthesis of a series of tricyclic antagonists for the prostaglandin D(2) receptor DP2 (CRTH2) is disclosed. The activities of the compounds were evaluated in a human DP2 binding assay and a human whole blood eosinophil shape change assay. Potential metabolic liabilities of the compounds were addressed through in vitro CYP studies. The lead compound was demonstrated to have efficacy in a mouse model of allergic rhinitis following oral dosing. Topics: Animals; Anti-Allergic Agents; Anti-Inflammatory Agents; Cytochrome P-450 Enzyme System; Disease Models, Animal; Female; Heterocyclic Compounds, 3-Ring; Humans; Mice; Receptors, Immunologic; Receptors, Prostaglandin; Rhinitis, Allergic, Perennial	2009

Article

Year

Novel tricyclic antagonists of the prostaglandin D2 receptor DP2 with efficacy in a murine model of allergic rhinitis.

Bioorganic & medicinal chemistry letters, 2009, Aug-15, Volume: 19, Issue:16

The synthesis of a series of tricyclic antagonists for the prostaglandin D(2) receptor DP2 (CRTH2) is disclosed. The activities of the compounds were evaluated in a human DP2 binding assay and a human whole blood eosinophil shape change assay. Potential metabolic liabilities of the compounds were addressed through in vitro CYP studies. The lead compound was demonstrated to have efficacy in a mouse model of allergic rhinitis following oral dosing.

Topics: Animals; Anti-Allergic Agents; Anti-Inflammatory Agents; Cytochrome P-450 Enzyme System; Disease Models, Animal; Female; Heterocyclic Compounds, 3-Ring; Humans; Mice; Receptors, Immunologic; Receptors, Prostaglandin; Rhinitis, Allergic, Perennial

2009