mk 473 has been researched along with Cystic Fibrosis in 1 studies
MK 473: RN given refers to parent cpd without isomeric designation
Cystic Fibrosis: An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate cellular mechanisms involved in the regulation of basolateral Na-K-Cl cotransport in airway epithelia, we determined saturable basolateral [3H]bumetanide binding, a measure of functioning cotransporters, in primary cultures of canine tracheal and human nasal epithelial cells, including cells from patients with cystic fibrosis (CF)." | 3.68 | Dual mechanisms for Na-K-Cl cotransport regulation in airway epithelial cells. ( Haas, M; McBrayer, DG; Yankaskas, JR, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Haas, M | 1 |
| McBrayer, DG | 1 |
| Yankaskas, JR | 1 |
1 other study available for mk 473 and Cystic Fibrosis
| Article | Year |
|---|---|
Dual mechanisms for Na-K-Cl cotransport regulation in airway epithelial cells.
Topics: Adenosine Triphosphate; Animals; Bumetanide; Carrier Proteins; Cells, Cultured; Cystic Fibrosis; Dog | 1993 |