mk 473 has been researched along with Alzheimer Disease in 1 studies
MK 473: RN given refers to parent cpd without isomeric designation
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Although Abeta and its fragment 25-35 exert a direct toxic effect on neurons, they also activate microglia." | 1.32 | Involvement of the intracellular ion channel CLIC1 in microglia-mediated beta-amyloid-induced neurotoxicity. ( Breit, SN; Curmi, PM; Denti, MA; Fabrizi, C; Ferroni, A; Lauro, GM; Malchiodi-Albedi, F; Mazzanti, M; Novarino, G; Paradisi, S; Sacchetti, B; Tonini, R, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Novarino, G | 1 |
| Fabrizi, C | 1 |
| Tonini, R | 1 |
| Denti, MA | 1 |
| Malchiodi-Albedi, F | 1 |
| Lauro, GM | 1 |
| Sacchetti, B | 1 |
| Paradisi, S | 1 |
| Ferroni, A | 1 |
| Curmi, PM | 1 |
| Breit, SN | 1 |
| Mazzanti, M | 1 |
1 other study available for mk 473 and Alzheimer Disease
| Article | Year |
|---|---|
Involvement of the intracellular ion channel CLIC1 in microglia-mediated beta-amyloid-induced neurotoxicity.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Newborn; Apoptosis; Chloride Channels; G | 2004 |