mk-2206 and Esophageal-Squamous-Cell-Carcinoma

Long noncoding RNAs (lncRNAs) have critical roles in various malignancies. However, the specific expression and roles of lncRNA PTCSC1 in esophageal squamous cell carcinoma (ESCC) are still unknown. Here, we identified that lncRNA PTCSC1 was elevated in ESCC tissues and cell lines compared with adjacent noncancerous tissues and normal esophageal epithelial cell line, respectively. Enhanced expression of PTCSC1 facilitated ESCC cells proliferation and migration in vitro and ESCC xenograft growth in vivo. Conversely, deficiency of PTCSC1 suppressed ESCC cells proliferation and migration in vitro and ESCC tumor growth in vivo. Furthermore, PTCSC1 was found to activate Akt signaling in ESCC cells. Blocking Akt signaling with MK-2206 abolished the pro-proliferative and pro-migratory roles of PTCSC1. In summary, our findings demonstrated PTCSC1 as an oncogenic lncRNA in ESCC via activating Akt signaling and suggested that targeting PTCSC1 represents a promising therapeutic strategy against ESCC.

Topics: Animals; Apoptosis; Cell Movement; Cell Proliferation; Disease Progression; Esophageal Squamous Cell Carcinoma; Female; Gene Expression Regulation, Neoplastic; Heterocyclic Compounds, 3-Ring; Heterografts; Humans; Male; Mice; Neoplasm Invasiveness; Oncogene Protein v-akt; RNA, Long Noncoding; Signal Transduction

Overexpression or activation of AKT is very well known to control cell growth, survival, and gene expression in solid tumors. Oridonin, an inflammatory medical and diterpenoid compound isolated from

Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Diterpenes, Kaurane; Esophageal Squamous Cell Carcinoma; Gene Expression Regulation, Neoplastic; Heterocyclic Compounds, 3-Ring; Humans; Isodon; Mice; Oncogene Protein v-akt; Plant Extracts; Signal Transduction; Xenograft Model Antitumor Assays