mk-0916 and Hypertension

mk-0916 has been researched along with Hypertension* in 1 studies

Other Studies

1 other study(ies) available for mk-0916 and Hypertension

Article	Year
Evaluation of selective inhibitors of 11β-HSD1 for the treatment of hypertension. Bioorganic & medicinal chemistry letters, 2013, Jun-15, Volume: 23, Issue:12 In an effort to understand the origin of blood-pressure lowering effects observed in recent clinical trials with 11β-HSD1 inhibitors, we examined a set of 11β-HSD1 inhibitors in a series of relevant in vitro and in vivo assays. Select 11β-HSD1 inhibitors reduced blood pressure in our preclinical models but most or all of the blood pressure lowering may be mediated by a 11β-HSD1 independent pathway. Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Animals; Enzyme Inhibitors; Humans; Hypertension; Mice; Mice, Knockout; Rats; Rats, Inbred SHR; Triazoles	2013

Article

Year

Evaluation of selective inhibitors of 11β-HSD1 for the treatment of hypertension.

Bioorganic & medicinal chemistry letters, 2013, Jun-15, Volume: 23, Issue:12

In an effort to understand the origin of blood-pressure lowering effects observed in recent clinical trials with 11β-HSD1 inhibitors, we examined a set of 11β-HSD1 inhibitors in a series of relevant in vitro and in vivo assays. Select 11β-HSD1 inhibitors reduced blood pressure in our preclinical models but most or all of the blood pressure lowering may be mediated by a 11β-HSD1 independent pathway.

Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Animals; Enzyme Inhibitors; Humans; Hypertension; Mice; Mice, Knockout; Rats; Rats, Inbred SHR; Triazoles

2013