mk-0916 and Disease-Models--Animal

mk-0916 has been researched along with Disease-Models--Animal* in 1 studies

Other Studies

1 other study(ies) available for mk-0916 and Disease-Models--Animal

Article	Year
Phenylcyclobutyl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I. Bioorganic & medicinal chemistry letters, 2008, Jun-01, Volume: 18, Issue:11 3-(Phenylcyclobutyl)-1,2,4-triazoles were identified as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1). These were active both in vitro and in an in vivo mouse pharmacodynamic (PD) model. Fluorine substitution of the cyclobutane ring improved the pharmacokinetic profile significantly. The synthesis and structure-activity relationships are presented. Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Administration, Oral; Animals; Combinatorial Chemistry Techniques; Cortisone; Disease Models, Animal; Enzyme Inhibitors; Humans; Hydrocortisone; Mice; Models, Molecular; Molecular Structure; Structure-Activity Relationship; Triazoles	2008

Article

Year

Phenylcyclobutyl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I.

Bioorganic & medicinal chemistry letters, 2008, Jun-01, Volume: 18, Issue:11

3-(Phenylcyclobutyl)-1,2,4-triazoles were identified as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1). These were active both in vitro and in an in vivo mouse pharmacodynamic (PD) model. Fluorine substitution of the cyclobutane ring improved the pharmacokinetic profile significantly. The synthesis and structure-activity relationships are presented.

Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Administration, Oral; Animals; Combinatorial Chemistry Techniques; Cortisone; Disease Models, Animal; Enzyme Inhibitors; Humans; Hydrocortisone; Mice; Models, Molecular; Molecular Structure; Structure-Activity Relationship; Triazoles

2008