mivacurium has been researched along with Seizures* in 3 studies
1 review(s) available for mivacurium and Seizures
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Neuromuscular blocking agents for electroconvulsive therapy: a systematic review.
Electroconvulsive therapy (ECT) is the transcutaneous application of small electrical stimuli to the brain to induce generalised seizures for the treatment of selected psychiatric disorders. The clinical indications for ECT as an effective therapeutic modality have been considerably expanded since its introduction. Anaesthesia and neuromuscular blocking agents (NMBAs) are required to ensure patients' safety during ECT. The optimal dose of muscle relaxant for ECT reduces muscle contractions without inducing complete paralysis. Slight residual motor convulsive activity is helpful in ascertaining that a seizure has occurred, while total paralysis prolongs the procedure unnecessarily. Suxamethonium is commonly used, but nondepolarising NMBAs are indicated in patients with certain comorbidities. In this review, we summarise current concepts of NMBA management for ECT. Topics: Androstanols; Atracurium; Convulsants; Depressive Disorder; Electroconvulsive Therapy; gamma-Cyclodextrins; Humans; Isoquinolines; Mivacurium; Monitoring, Physiologic; Neuromuscular Blocking Agents; Neuromuscular Depolarizing Agents; Neuromuscular Nondepolarizing Agents; Rocuronium; Seizures; Succinylcholine; Sugammadex; Vecuronium Bromide | 2012 |
1 trial(s) available for mivacurium and Seizures
Article | Year |
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Low dose mivacurium is less effective than succinylcholine in electroconvulsive therapy.
To compare the efficacy of low dose (LD) mivacurium (0.08 mg.kg-1) with LD succinylcholine (0.5 mg.kg-1) in modifying seizure activity during electroconvulsive therapy (ECT). Partial muscle relaxation is used in ECT to prevent violent muscle contractions. Current practice is to use LD succinylcholine which has several undesirable side effects.. Sixteen depressed, but otherwise healthy, patients, aged 27-67 yr were studied. In a randomized, double-blind, cross-over study, either LD mivacurium or LD succinylcholine was given at consecutive ECTs 120 and 30 sec respectively before inducing ECT. Neuromuscular blockade following mivacurium was not reversed. Seizure modification was scored--0 = no seizure activity, 1 = over-modified, 2 = desired level, 3 = under-modified, 4 = unmodified. Duration of seizures, time to first breath and adequate ventilation, ability to protrude tongue and sustain hand grip for five seconds were recorded. Paired t-tests and Wilcoxon matched pairs test were used to compare data. P < 0.05 was considered significant.. Seizure modification was better (mean (range)) after succinylcholine 2.06(1-3) than after mivacurium 2.56(2-4) (P < 0.05). Mivacurium was unsatisfactory in eight cases compared with two cases after succinylcholine. The study was terminated early because of unsatisfactory seizure control. Clinical assessments of recovery from both relaxants were similar.. Low dose mivacurium is unsuitable for use in ECT. Topics: Adult; Aged; Anesthesia Recovery Period; Cross-Over Studies; Double-Blind Method; Electroconvulsive Therapy; Female; Hand Strength; Humans; Isoquinolines; Male; Middle Aged; Mivacurium; Muscle Contraction; Neuromuscular Blockade; Neuromuscular Depolarizing Agents; Neuromuscular Nondepolarizing Agents; Respiration; Seizures; Succinylcholine; Time Factors; Tongue | 1999 |
1 other study(ies) available for mivacurium and Seizures
Article | Year |
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[Prolonged neuromuscular block induced by mivacurium].
Topics: Adult; Anesthesia Recovery Period; Butyrylcholinesterase; Craniocerebral Trauma; Erythrocytes; Humans; Isoquinolines; Male; Mivacurium; Neuromuscular Junction; Neuromuscular Nondepolarizing Agents; Retinal Detachment; Seizures | 2006 |