mitoxantrone has been researched along with Pregnancy in 27 studies
Mitoxantrone: An anthracenedione-derived antineoplastic agent.
mitoxantrone : A dihydroxyanthraquinone that is 1,4-dihydroxy-9,10-anthraquinone which is substituted by 6-hydroxy-1,4-diazahexyl groups at positions 5 and 8.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mitoxantrone does not affect the ability to conceive or pregnancy outcomes." | 7.88 | Pregnancy planning and outcomes in patients with multiple sclerosis after mitoxantrone therapy: a monocentre assessment. ( Casanova, P; Cocco, E; Coghe, G; Fenu, G; Frau, J; Lorefice, L; Marrosu, MG; Sardu, C, 2018) |
| "Mitoxantrone is an antineoplastic agent considered a potential human teratogen because of its mechanism of action and is classified by the US Food and Drug Administration in pregnancy category risk D." | 7.74 | The first case of mitoxantrone exposure in early pregnancy. ( Batocchi, AP; Caruso, A; Cavaliere, AF; De Santis, M; Rosati, P; Straface, G, 2007) |
| "Mitoxantrone does not affect the ability to conceive or pregnancy outcomes." | 3.88 | Pregnancy planning and outcomes in patients with multiple sclerosis after mitoxantrone therapy: a monocentre assessment. ( Casanova, P; Cocco, E; Coghe, G; Fenu, G; Frau, J; Lorefice, L; Marrosu, MG; Sardu, C, 2018) |
| " The experience with mitoxantrone (MIX) especially in the first trimenon is very limited, until now only one case of a pregnant woman with MS who was exposed to MIX in early pregnancy and delivered a growth restricted but healthy child was published." | 3.77 | A newborn with Pierre Robin sequence after preconceptional mitoxantrone exposure of a female with multiple sclerosis. ( Chan, A; Epplen, J; Gold, R; Hellwig, K; Schimrigk, S, 2011) |
| "Mitoxantrone is an antineoplastic agent considered a potential human teratogen because of its mechanism of action and is classified by the US Food and Drug Administration in pregnancy category risk D." | 3.74 | The first case of mitoxantrone exposure in early pregnancy. ( Batocchi, AP; Caruso, A; Cavaliere, AF; De Santis, M; Rosati, P; Straface, G, 2007) |
| " As a functional consequence, knockdown of BCRP by siRNAs increased the sensitivity of human choriocarcinoma BeWo cells to mitoxantrone and topotecan by 10." | 3.72 | Modulation of breast cancer resistance protein (BCRP/ABCG2) gene expression using RNA interference. ( Beck, WT; Ee, PL; He, X; Ross, DD, 2004) |
| "Glyburide (200 ng/mL) was introduced to maternal and fetal compartments through a recirculating 2 hour perfusion, and its transplacental transport was tested with (n = 8) or without (n = 8) cannabidoil." | 1.39 | Cannabidiol enhances xenobiotic permeability through the human placental barrier by direct inhibition of breast cancer resistance protein: an ex vivo study. ( Ben-Zvi, Z; Erez, O; Eshkoli, T; Feinshtein, V; Holcberg, G; Sheiner, E; Sheizaf, B, 2013) |
| " To avoid the confounding drug transport provided by P-glycoprotein (P-gp), the roles of Bcrp1 in the bioavailability of topotecan and the effect of GF120918 were studied in both wild-type and P-gp-deficient mice and their fetuses." | 1.31 | Role of breast cancer resistance protein in the bioavailability and fetal penetration of topotecan. ( Beijnen, JH; Brinkhuis, RF; Jonker, JW; Maliepaard, M; Schellens, JH; Schinkel, AH; Smit, JW, 2000) |
| "This paper describes two cases of acute promyelocytic leukemia diagnosed during the second trimester of pregnancy and the most suitable approach to the management of this situation is analyzed." | 1.29 | Acute leukemia during pregnancy: obstetric management and perinatal outcome of two cases. ( Gonzalez-Gonzalez, A; Pinilla, J; Requena, A; Velasco, JG, 1995) |
| "Ametantrone acetate is an antineoplastic drug chemically described as 1,4-bis [[2-[(2-hydroxyethyl)-amino] ethyl]amino] -9,10-anthracenedione diacetate salt." | 1.27 | Teratology studies of ametantrone acetate in rats and rabbits. ( Anderson, JA; de la Iglesia, FA; Fitzgerald, JE; Kim, SN; Petrere, JA; Schardein, JL, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (7.41) | 18.7374 |
| 1990's | 4 (14.81) | 18.2507 |
| 2000's | 9 (33.33) | 29.6817 |
| 2010's | 9 (33.33) | 24.3611 |
| 2020's | 3 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Cheng, NM | 1 |
| Chang, WH | 1 |
| Wang, PH | 2 |
| Cheng, M | 1 |
| Lee, NR | 1 |
| Jareemit, N | 1 |
| Horowitz, NS | 1 |
| Goldstein, DP | 1 |
| Berkowitz, RS | 1 |
| Elias, KM | 1 |
| Karagiannis, P | 1 |
| Alsdorf, W | 1 |
| Tallarek, AC | 1 |
| Blohm, ME | 1 |
| Oelrich, J | 1 |
| Waizenegger, JS | 1 |
| Wolschke, C | 1 |
| Hecher, K | 1 |
| Singer, D | 1 |
| Bokemeyer, C | 1 |
| Fiedler, W | 1 |
| Callegari, I | 1 |
| Derfuss, T | 1 |
| Galli, E | 1 |
| Frau, J | 1 |
| Coghe, G | 1 |
| Casanova, P | 1 |
| Sardu, C | 1 |
| Lorefice, L | 1 |
| Fenu, G | 1 |
| Marrosu, MG | 1 |
| Cocco, E | 1 |
| Marrie, RA | 1 |
| Montalban, X | 1 |
| Feinshtein, V | 1 |
| Erez, O | 1 |
| Ben-Zvi, Z | 1 |
| Eshkoli, T | 1 |
| Sheizaf, B | 1 |
| Sheiner, E | 1 |
| Holcberg, G | 1 |
| Yu, P | 1 |
| Diao, W | 1 |
| Jiang, X | 1 |
| Chandacham, A | 1 |
| Kietpeerakool, C | 1 |
| Khunamornpong, S | 1 |
| Suprasert, P | 1 |
| Srisomboon, J | 1 |
| Charoenkwan, K | 1 |
| Phongnarisorn, C | 1 |
| Cheewakraingkrai, C | 1 |
| Siriaree, S | 1 |
| Tantipalakorn, C | 1 |
| Hellwig, K | 1 |
| Schimrigk, S | 1 |
| Chan, A | 1 |
| Epplen, J | 1 |
| Gold, R | 1 |
| Petropoulos, S | 1 |
| Gibb, W | 1 |
| Matthews, SG | 1 |
| Kummu, M | 1 |
| Sieppi, E | 1 |
| Wallin, K | 1 |
| Rautio, A | 1 |
| Vähäkangas, K | 1 |
| Myllynen, P | 1 |
| Ee, PL | 1 |
| He, X | 1 |
| Ross, DD | 1 |
| Beck, WT | 1 |
| Kolwankar, D | 1 |
| Glover, DD | 1 |
| Ware, JA | 1 |
| Tracy, TS | 1 |
| Yasuda, S | 1 |
| Itagaki, S | 1 |
| Hirano, T | 1 |
| Iseki, K | 1 |
| Wang, H | 1 |
| Zhou, L | 1 |
| Gupta, A | 1 |
| Vethanayagam, RR | 1 |
| Zhang, Y | 1 |
| Unadkat, JD | 1 |
| Mao, Q | 1 |
| De Santis, M | 1 |
| Straface, G | 1 |
| Cavaliere, AF | 1 |
| Rosati, P | 1 |
| Batocchi, AP | 1 |
| Caruso, A | 1 |
| Evseenko, DA | 1 |
| Paxton, JW | 1 |
| Keelan, JA | 1 |
| Inhorn, RC | 1 |
| Aster, JC | 1 |
| Roach, SA | 1 |
| Slapak, CA | 1 |
| Soiffer, R | 1 |
| Tantravahi, R | 1 |
| Stone, RM | 1 |
| Azuno, Y | 1 |
| Kaku, K | 1 |
| Fujita, N | 1 |
| Okubo, M | 1 |
| Kaneko, T | 1 |
| Matsumoto, N | 1 |
| Requena, A | 1 |
| Velasco, JG | 1 |
| Pinilla, J | 1 |
| Gonzalez-Gonzalez, A | 1 |
| Jonker, JW | 1 |
| Smit, JW | 1 |
| Brinkhuis, RF | 1 |
| Maliepaard, M | 1 |
| Beijnen, JH | 1 |
| Schellens, JH | 1 |
| Schinkel, AH | 1 |
| Jain, KK | 1 |
| Djaldetti, M | 1 |
| Gilgal, R | 1 |
| Sheinberg, A | 1 |
| Klein, B | 1 |
| Zahavi, I | 1 |
| Lazarus, HM | 1 |
| Berger, NA | 1 |
| Petrere, JA | 1 |
| Kim, SN | 1 |
| Anderson, JA | 1 |
| Fitzgerald, JE | 1 |
| de la Iglesia, FA | 1 |
| Schardein, JL | 1 |
4 reviews available for mitoxantrone and Pregnancy
| Article | Year |
|---|---|
Update on treatment in multiple sclerosis.
Topics: Abnormalities, Drug-Induced; Algorithms; Antibodies, Monoclonal, Humanized; Cladribine; Crotonates; | 2021 |
A syndrome of lymphoblastic lymphoma, eosinophilia, and myeloid hyperplasia/malignancy associated with t(8;13)(p11;q11): description of a distinctive clinicopathologic entity.
Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Prot | 1995 |
Evaluation of mitoxantrone for the treatment of multiple sclerosis.
Topics: Animals; Female; Humans; Mitoxantrone; Multiple Sclerosis, Chronic Progressive; Pregnancy | 2000 |
Chemotherapy of malignant disease: an update.
Topics: Amsacrine; Antineoplastic Agents; Cisplatin; Coformycin; Etoposide; Female; Humans; Ifosfamide; Male | 1988 |
23 other studies available for mitoxantrone and Pregnancy
| Article | Year |
|---|---|
The first-line therapy for low-risk gestational trophoblastic neoplasia: Does single agent or multi-agent work?
Topics: Antineoplastic Combined Chemotherapy Protocols; Etoposide; Female; Gestational Trophoblastic Disease | 2019 |
The use of VMP regimen as the first line chemotherapy for low-risk gestational trophoblastic neoplasia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Etoposide; Female; Gestational Trophoblastic Disease | 2019 |
EMA vs EMACO in the treatment of gestational trophoblastic neoplasia.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Dactinomycin; Doxorubicin; Etopos | 2020 |
Treatment of refractory acute myeloid leukaemia during pregnancy with venetoclax, high-dose cytarabine and mitoxantrone.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bridged Bicyclo Compounds, Heterocyclic; Cyta | 2021 |
Pregnancy planning and outcomes in patients with multiple sclerosis after mitoxantrone therapy: a monocentre assessment.
Topics: Abortion, Spontaneous; Adult; Cohort Studies; Disability Evaluation; Female; Fertility; Humans; Infa | 2018 |
Disease-modifying therapy in multiple sclerosis: Two guidelines (almost) passing in the night.
Topics: Adolescent; Adult; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Female; Humans; Immunog | 2018 |
Cannabidiol enhances xenobiotic permeability through the human placental barrier by direct inhibition of breast cancer resistance protein: an ex vivo study.
Topics: Analysis of Variance; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette | 2013 |
A Successfully Treated Metastatic Choriocarcinoma Coexistent With Pregnancy: A Case Report of a 4-Year Follow-Up.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cesarean Section; Choriocarcinoma; Cyclophosp | 2016 |
Successfully conservative treatment of large cervical choriocarcinoma with profuse vaginal bleeding.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Choriocarcinoma; Cytarabine; Diagnosis, Diffe | 2009 |
A newborn with Pierre Robin sequence after preconceptional mitoxantrone exposure of a female with multiple sclerosis.
Topics: Abnormalities, Drug-Induced; Adult; Antiemetics; Antineoplastic Agents; Female; Humans; Infant, Newb | 2011 |
Glucocorticoid regulation of placental breast cancer resistance protein (Bcrp1) in the mouse.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; | 2011 |
Cadmium inhibits ABCG2 transporter function in BeWo choriocarcinoma cells and MCF-7 cells overexpressing ABCG2.
Topics: ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Cadmium | 2012 |
Modulation of breast cancer resistance protein (BCRP/ABCG2) gene expression using RNA interference.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette | 2004 |
Expression and function of ABCB1 and ABCG2 in human placental tissue.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily | 2005 |
Expression level of ABCG2 in the placenta decreases from the mid stage to the end of gestation.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; | 2005 |
Regulation of BCRP/ABCG2 expression by progesterone and 17beta-estradiol in human placental BeWo cells.
Topics: ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Cell Lin | 2006 |
The first case of mitoxantrone exposure in early pregnancy.
Topics: Adult; Analgesics; Apgar Score; Female; Fetal Growth Retardation; Humans; Magnetic Resonance Imaging | 2007 |
Independent regulation of apical and basolateral drug transporter expression and function in placental trophoblasts by cytokines, steroids, and growth factors.
Topics: ATP-Binding Cassette Transporters; Cells, Cultured; Cytokines; Digoxin; Epidermal Growth Factor; Est | 2007 |
Mitoxantrone and etoposide in breast milk.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Etoposide; Female; Humans; Leukemia, Promyelo | 1995 |
Acute leukemia during pregnancy: obstetric management and perinatal outcome of two cases.
Topics: Abnormalities, Drug-Induced; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Tran | 1995 |
Role of breast cancer resistance protein in the bioavailability and fetal penetration of topotecan.
Topics: Acridines; Administration, Oral; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, S | 2000 |
Effect of anthracycline drugs on the element content of cultured embryonic rat cardiomyocytes.
Topics: Animals; Animals, Newborn; Antibiotics, Antineoplastic; Calcium Radioisotopes; Cells, Cultured; Doxo | 1991 |
Teratology studies of ametantrone acetate in rats and rabbits.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Dose-Response Relationship, Drug; Female; Gestati | 1986 |