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mitoxantrone and Osteogenic Sarcoma

mitoxantrone has been researched along with Osteogenic Sarcoma in 7 studies

Mitoxantrone: An anthracenedione-derived antineoplastic agent.
mitoxantrone : A dihydroxyanthraquinone that is 1,4-dihydroxy-9,10-anthraquinone which is substituted by 6-hydroxy-1,4-diazahexyl groups at positions 5 and 8.

Research Excerpts

ExcerptRelevanceReference
" To determine whether IL-6 or IL-8 overexpression contributes directly to the drug resistant phenotype, IL-6 or IL-8 cDNA were introduced into the paclitaxel sensitive human osteosarcoma cell line U-2OS using the pIRESneo bicistronic expression vector."7.71Overexpression of IL-6 but not IL-8 increases paclitaxel resistance of U-2OS human osteosarcoma cells. ( Duan, Z; Kronish, KM; Lamendola, DE; Penson, RT; Seiden, MV, 2002)
" In particular, we found that treatment of U-2 OS osteosarcoma cells with the anthracycine daunorubicin or with ultraviolet (UV-C) light resulted in a form of NF-kappaB that repressed rather than induced NF-kappaB reporter plasmids and the expression of specific anti-apoptotic genes."3.73Differential regulation of NF-kappaB activation and function by topoisomerase II inhibitors. ( Campbell, KJ; O'Shea, JM; Perkins, ND, 2006)
" To determine whether IL-6 or IL-8 overexpression contributes directly to the drug resistant phenotype, IL-6 or IL-8 cDNA were introduced into the paclitaxel sensitive human osteosarcoma cell line U-2OS using the pIRESneo bicistronic expression vector."3.71Overexpression of IL-6 but not IL-8 increases paclitaxel resistance of U-2OS human osteosarcoma cells. ( Duan, Z; Kronish, KM; Lamendola, DE; Penson, RT; Seiden, MV, 2002)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19901 (14.29)18.7374
1990's1 (14.29)18.2507
2000's2 (28.57)29.6817
2010's3 (42.86)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Workenhe, ST1
Pol, JG1
Lichty, BD1
Cummings, DT1
Mossman, KL1
Gopinath, SC1
Wadhwa, R1
Kumar, PK1
Zhang, F1
Throm, SL1
Murley, LL1
Miller, LA1
Steven Zatechka, D1
Kiplin Guy, R1
Kennedy, R1
Stewart, CF1
Campbell, KJ1
O'Shea, JM1
Perkins, ND1
Moser, K1
Pohl, A1
Ogilvie, GK1
Straw, RC1
Jameson, VJ1
Walters, LM1
Lafferty, MH1
Powers, BE1
Withrow, SJ1
Duan, Z1
Lamendola, DE1
Penson, RT1
Kronish, KM1
Seiden, MV1

Reviews

1 review available for mitoxantrone and Osteogenic Sarcoma

ArticleYear
[Recent developments in chemotherapy of malignant diseases].
    Wiener klinische Wochenschrift, 1982, Dec-10, Volume: 94, Issue:23

    Topics: Anthraquinones; Antibodies, Monoclonal; Antineoplastic Agents; Antineoplastic Combined Chemotherapy

1982

Other Studies

6 other studies available for mitoxantrone and Osteogenic Sarcoma

ArticleYear
Combining oncolytic HSV-1 with immunogenic cell death-inducing drug mitoxantrone breaks cancer immune tolerance and improves therapeutic efficacy.
    Cancer immunology research, 2013, Volume: 1, Issue:5

    Topics: Animals; Antineoplastic Agents; Bone Neoplasms; CD8-Positive T-Lymphocytes; Cell Death; Cell Line, T

2013
Expression of noncoding vault RNA in human malignant cells and its importance in mitoxantrone resistance.
    Molecular cancer research : MCR, 2010, Volume: 8, Issue:11

    Topics: Antineoplastic Agents; Base Sequence; Bone Neoplasms; Cell Line, Tumor; Drug Resistance, Neoplasm; G

2010
MDM2 antagonist nutlin-3a reverses mitoxantrone resistance by inhibiting breast cancer resistance protein mediated drug transport.
    Biochemical pharmacology, 2011, Jul-01, Volume: 82, Issue:1

    Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette

2011
Differential regulation of NF-kappaB activation and function by topoisomerase II inhibitors.
    BMC cancer, 2006, Apr-21, Volume: 6

    Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Catechin; Cell Line, Tumor; Daunorubicin; DNA Da

2006
Evaluation of single-agent chemotherapy for treatment of clinically evident osteosarcoma metastases in dogs: 45 cases (1987-1991).
    Journal of the American Veterinary Medical Association, 1993, Jan-15, Volume: 202, Issue:2

    Topics: Animals; Antineoplastic Agents; Bone Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Dog Diseases; Dog

1993
Overexpression of IL-6 but not IL-8 increases paclitaxel resistance of U-2OS human osteosarcoma cells.
    Cytokine, 2002, Mar-07, Volume: 17, Issue:5

    Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamil

2002