Page last updated: 2024-10-31

mitoxantrone and Neutropenia

mitoxantrone has been researched along with Neutropenia in 88 studies

Mitoxantrone: An anthracenedione-derived antineoplastic agent.
mitoxantrone : A dihydroxyanthraquinone that is 1,4-dihydroxy-9,10-anthraquinone which is substituted by 6-hydroxy-1,4-diazahexyl groups at positions 5 and 8.

Neutropenia: A decrease in the number of NEUTROPHILS found in the blood.

Research Excerpts

ExcerptRelevanceReference
"Cabazitaxel significantly improves overall survival (OS) in men with metastatic castration-resistant prostate cancer (mCRPC) progressing during or after docetaxel, but is associated with a higher rate of grade ≥3 neutropenia compared with docetaxel."9.22Severe neutropenia during cabazitaxel treatment is associated with survival benefit in men with metastatic castration-resistant prostate cancer (mCRPC): A post-hoc analysis of the TROPIC phase III trial. ( de Bono, J; de Wit, R; Liewen, H; Meisel, A; Sartor, O; Stenner-Liewen, F; Vogt, DR; von Felten, S, 2016)
"Gemcitabine and mitoxantrone are active agents for the treatment of metastatic breast cancer."9.11Gemcitabine and mitoxantrone in metastatic breast cancer: a phase-I-study. ( Akrivakis, K; Flath, B; Heilmann, V; Kreienberg, R; Mergenthaler, HG; Possinger, K; Schmid, P; Sezer, O, 2005)
"This study evaluated mitoxantrone and paclitaxel combination chemotherapy in the treatment of patients with metastatic breast cancer."9.09Mitoxantrone and paclitaxel combination chemotherapy in metastatic breast cancer. ( Campbell, M; Cantrell, J; Cartmell, A; Ghalie, R; Harvey, J; Modiano, M; Newcomb, T; Rubin, A; Schuster, M; Urba, W, 2001)
"To intensify a regimen of high-dose cyclophosphamide, mitoxantrone, and carboplatin that had previously produced high complete and overall response rates in metastatic breast cancer (MBC)."9.09Phase I/II trial of cyclophosphamide, mitoxantrone, and escalated doses of carboplatin supported by peripheral-blood stem cells in women with metastatic breast cancer. ( Crump, M; Goss, P; Keating, A; MacKinnon, J; Nagy, T; Patnaik, A; Stewart, K, 2000)
"To evaluate the activity and tolerance of docetaxel in combination with mitoxantrone and granulocyte colony-stimulating factor (G-CSF) as front-line treatment in patients with metastatic breast cancer (MBC)."9.09Docetaxel in combination with mitoxantrone and granulocyte colony-stimulating factor as front-line chemotherapy in metastatic breast cancer: a multicenter phase II study. ( Agelaki, S; Alexopoulos, A; Georgoulias, V; Kakolyris, S; Kalbakis, K; Kosmas, C; Kouroussis, C; Malamos, N; Mavroudis, D; Rigatos, G; Sarra, E; Vlachonicolis, J, 2001)
"To define the maximum-tolerated dose (MTD) and the dose-limiting toxicities (DLTs) of docetaxel in combination with mitoxantrone in patients with metastatic breast cancer (MBC)."9.09Dose-escalation study of docetaxel in combination with mitoxantrone as first-line treatment in patients with metastatic breast cancer. ( Androulakis, N; Georgoulias, V; Hatzidaki, D; Kakolyris, S; Katsogridakis, K; Kotsakis, T; Kouroussis, C; Mavroudis, D; Samonis, G; Souglakos, J; Vardakis, N; Vlachonikolis, J, 1999)
"A prospective, randomized, double-blind placebo-controlled trial was designed to evaluate the impact of granulocyte/macrophage-colony-stimulating factor (GM-CSF) on the efficacy of sequential high-dose cytosine arabinoside/mitoxantrone chemotherapy (S-HAM) in adult patients with high-risk myelodysplastic syndromes (MDS)."9.09Results of a randomized double-blind placebo-controlled trial evaluating sequential high-dose cytosine arabinoside/mitoxantrone chemotherapy with or without granulocyte/macrophage-colony-stimulating factor in high-risk myelodysplastic syndromes. ( Aul, C; Balleisen, L; Bennett, J; Büchner, T; Fonatsch, C; Haase, D; Heinecke, A; Hiddemann, W; Hinrichs, HF; Koch, P; Rowe, JM; Verbeek, W; Wörmann, B, 1999)
"Mitoxantrone (MTZ) and vinorelbine (VNR) have shown a good efficacy in advanced breast cancer."9.08Mitoxantrone plus vinorelbine with granulocyte-colony stimulating factor (G-CSF) support in advanced breast cancer patients. A dose and schedule finding study. ( Comella, G; Comella, P; Cremone, L; Della Volpe, N; Frasci, G; Imbriani, A; Persico, G; Salzano, F, 1995)
"To assess efficacy and toxicity of less toxic analogs for advanced breast cancer in elderly women, we performed a phase II study using the combination mitoxantrone (MTZ)-vinorelbine (VNR)."9.08[A phase II study with mitoxantrone-vinorelbine association in the treatment of advanced breast cancer in elderly women]. ( Bugat, R; Caunes, N; Chevreau, C; Gladieff, L; Houyau, P; Martinez, M; Mihura, J; Roché, H, 1996)
"60 patients with metastatic breast cancer were entered in a phase II study using folinic acid, 5-fluorouracil bolus and infusion and mitoxantrone with or without cyclophosphamide."9.07Folinic acid, 5-fluorouracil bolus and infusion and mitoxantrone with or without cyclophosphamide in metastatic breast cancer. ( Beerblock, K; de Gramont, A; Demuynck, B; Guillot, T; Krulik, M; Louvet, C; Marpeau, L; Pigné, A; Soubrane, D; Varette, C, 1993)
" The objective of the current study was to investigate the effects of combined fludarabine, mitoxantrone, and dexamethasone (FND) followed by interferon/dexamethasone on myelosuppression (absolute neutrophil counts), immunosuppression (CD4 and CD8 counts), and infectious complications in patients with previously untreated, Stage IV indolent lymphoma."7.73Immunosuppression and infectious complications in patients with stage IV indolent lymphoma treated with a fludarabine, mitoxantrone, and dexamethasone regimen. ( Ayala, A; Cabanillas, F; Feng, L; Hagemeister, FB; McLaughlin, P; Rodriguez, MA; Romaguera, J; Smith, TL; Tsimberidou, AM; Younes, A, 2005)
"Grade 3/4 neutropenia was observed in 29 patients (58%) with four neutropenic episodes."6.69First-line treatment of metastatic breast cancer with mitoxantrone, vinorelbine, and carboplatin. ( Agelaki, S; Androulakis, N; Georgoulias, V; Hatzidaki, D; Kakolyris, S; Koukourakis, M; Kourousis, C; Samonis, G; Tsiftsis, D; Vamvakas, L, 1999)
"All patients had advanced metastatic breast cancer and have been extensively pretreated with chemotherapy (28 patients), radiotherapy (13 patients), and hormonotherapy (24 patients)."6.68Treatment of advanced and relapsing breast cancer with a combination of paclitaxel and mitoxantrone. South-Central Hellenic Oncology Group. ( Panagos, GE, 1997)
"Patients with advanced breast cancer were randomised to 3M (mitozantrone 6."6.67Mitozantrone and methotrexate chemotherapy with and without mitomycin C in the treatment of advanced breast cancer: a randomised clinical trial. ( Barton, C; Bliss, JM; Bower, M; Coombes, RC; Ford, HT; Gazet, JC; Law, M; Stein, RC, 1992)
"A disseminated Fusarium infection due to F."5.39Refractory disseminated fusariosis by Fusarium verticillioides in a patient with acute myeloid leukaemia relapsed after allogeneic hematopoietic stem cell transplantation: a case report and literature review. ( Bartolesi, AM; Fanci, R; Pecile, P; Pini, G, 2013)
"Mitoxantrone is an active well-tolerated agent in the treatment of advanced breast carcinoma, but the risk of neutropenia requires careful supervision."5.27Mitoxantrone: an active new agent in the treatment of advanced breast cancer. ( Bozek, T; Pavlidis, NA; Smith, IE; Stuart-Harris, RC, 1984)
"Cabazitaxel significantly improves overall survival (OS) in men with metastatic castration-resistant prostate cancer (mCRPC) progressing during or after docetaxel, but is associated with a higher rate of grade ≥3 neutropenia compared with docetaxel."5.22Severe neutropenia during cabazitaxel treatment is associated with survival benefit in men with metastatic castration-resistant prostate cancer (mCRPC): A post-hoc analysis of the TROPIC phase III trial. ( de Bono, J; de Wit, R; Liewen, H; Meisel, A; Sartor, O; Stenner-Liewen, F; Vogt, DR; von Felten, S, 2016)
"Gemcitabine and mitoxantrone are active agents for the treatment of metastatic breast cancer."5.11Gemcitabine and mitoxantrone in metastatic breast cancer: a phase-I-study. ( Akrivakis, K; Flath, B; Heilmann, V; Kreienberg, R; Mergenthaler, HG; Possinger, K; Schmid, P; Sezer, O, 2005)
"To intensify a regimen of high-dose cyclophosphamide, mitoxantrone, and carboplatin that had previously produced high complete and overall response rates in metastatic breast cancer (MBC)."5.09Phase I/II trial of cyclophosphamide, mitoxantrone, and escalated doses of carboplatin supported by peripheral-blood stem cells in women with metastatic breast cancer. ( Crump, M; Goss, P; Keating, A; MacKinnon, J; Nagy, T; Patnaik, A; Stewart, K, 2000)
"To define the maximum-tolerated dose (MTD) and the dose-limiting toxicities (DLTs) of docetaxel in combination with mitoxantrone in patients with metastatic breast cancer (MBC)."5.09Dose-escalation study of docetaxel in combination with mitoxantrone as first-line treatment in patients with metastatic breast cancer. ( Androulakis, N; Georgoulias, V; Hatzidaki, D; Kakolyris, S; Katsogridakis, K; Kotsakis, T; Kouroussis, C; Mavroudis, D; Samonis, G; Souglakos, J; Vardakis, N; Vlachonikolis, J, 1999)
"A prospective, randomized, double-blind placebo-controlled trial was designed to evaluate the impact of granulocyte/macrophage-colony-stimulating factor (GM-CSF) on the efficacy of sequential high-dose cytosine arabinoside/mitoxantrone chemotherapy (S-HAM) in adult patients with high-risk myelodysplastic syndromes (MDS)."5.09Results of a randomized double-blind placebo-controlled trial evaluating sequential high-dose cytosine arabinoside/mitoxantrone chemotherapy with or without granulocyte/macrophage-colony-stimulating factor in high-risk myelodysplastic syndromes. ( Aul, C; Balleisen, L; Bennett, J; Büchner, T; Fonatsch, C; Haase, D; Heinecke, A; Hiddemann, W; Hinrichs, HF; Koch, P; Rowe, JM; Verbeek, W; Wörmann, B, 1999)
"This study evaluated mitoxantrone and paclitaxel combination chemotherapy in the treatment of patients with metastatic breast cancer."5.09Mitoxantrone and paclitaxel combination chemotherapy in metastatic breast cancer. ( Campbell, M; Cantrell, J; Cartmell, A; Ghalie, R; Harvey, J; Modiano, M; Newcomb, T; Rubin, A; Schuster, M; Urba, W, 2001)
"To evaluate the activity and tolerance of docetaxel in combination with mitoxantrone and granulocyte colony-stimulating factor (G-CSF) as front-line treatment in patients with metastatic breast cancer (MBC)."5.09Docetaxel in combination with mitoxantrone and granulocyte colony-stimulating factor as front-line chemotherapy in metastatic breast cancer: a multicenter phase II study. ( Agelaki, S; Alexopoulos, A; Georgoulias, V; Kakolyris, S; Kalbakis, K; Kosmas, C; Kouroussis, C; Malamos, N; Mavroudis, D; Rigatos, G; Sarra, E; Vlachonicolis, J, 2001)
"Prior studies of the combination of fludarabine, mitoxantrone and dexamethasone have yielded high response rates but are associated with a significant risk of opportunistic infections, predominantly Pneumocystis Carinii pneumonia (PCP) requiring routine prophylaxis."5.09Fludarabine and mitoxantrone: effective and well-tolerated salvage therapy in relapsed indolent lymphoproliferative disorders. ( Fox, RM; Grigg, AP; Seymour, JF; Szer, J, 2001)
"Mitoxantrone (MTZ) and vinorelbine (VNR) have shown a good efficacy in advanced breast cancer."5.08Mitoxantrone plus vinorelbine with granulocyte-colony stimulating factor (G-CSF) support in advanced breast cancer patients. A dose and schedule finding study. ( Comella, G; Comella, P; Cremone, L; Della Volpe, N; Frasci, G; Imbriani, A; Persico, G; Salzano, F, 1995)
"To assess efficacy and toxicity of less toxic analogs for advanced breast cancer in elderly women, we performed a phase II study using the combination mitoxantrone (MTZ)-vinorelbine (VNR)."5.08[A phase II study with mitoxantrone-vinorelbine association in the treatment of advanced breast cancer in elderly women]. ( Bugat, R; Caunes, N; Chevreau, C; Gladieff, L; Houyau, P; Martinez, M; Mihura, J; Roché, H, 1996)
"60 patients with metastatic breast cancer were entered in a phase II study using folinic acid, 5-fluorouracil bolus and infusion and mitoxantrone with or without cyclophosphamide."5.07Folinic acid, 5-fluorouracil bolus and infusion and mitoxantrone with or without cyclophosphamide in metastatic breast cancer. ( Beerblock, K; de Gramont, A; Demuynck, B; Guillot, T; Krulik, M; Louvet, C; Marpeau, L; Pigné, A; Soubrane, D; Varette, C, 1993)
"Mitoxantrone is used for aggressive multiple sclerosis (MS), but concerns about safety, including cardiotoxicity and other laboratory measures, prevail."3.76Cardiotoxicity and other adverse events associated with mitoxantrone treatment for MS. ( Geddes, J; Isserow, S; Kingwell, E; Koch, M; Leung, B; Rieckmann, P; Tremlett, H, 2010)
" The objective of the current study was to investigate the effects of combined fludarabine, mitoxantrone, and dexamethasone (FND) followed by interferon/dexamethasone on myelosuppression (absolute neutrophil counts), immunosuppression (CD4 and CD8 counts), and infectious complications in patients with previously untreated, Stage IV indolent lymphoma."3.73Immunosuppression and infectious complications in patients with stage IV indolent lymphoma treated with a fludarabine, mitoxantrone, and dexamethasone regimen. ( Ayala, A; Cabanillas, F; Feng, L; Hagemeister, FB; McLaughlin, P; Rodriguez, MA; Romaguera, J; Smith, TL; Tsimberidou, AM; Younes, A, 2005)
"Cabazitaxel is a novel tubulin-binding taxane drug with antitumour activity in docetaxel-resistant cancers."2.75Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial. ( Bodrogi, I; de Bono, JS; Gravis, G; Gupta, S; Hansen, S; Kocak, I; Machiels, JP; Mackenzie, MJ; Oudard, S; Ozguroglu, M; Roessner, M; Sartor, AO; Shen, L, 2010)
"In this prospective randomized trial, we compared the efficacy and toxicity of cladribine (2-CdA) alone to 2-CdA combined with cyclophosphamide (CC) or cyclophosphamide and mitoxantrone (CMC) in untreated progressive chronic lymphocytic leukemia (CLL)."2.72Cladribine alone and in combination with cyclophosphamide or cyclophosphamide plus mitoxantrone in the treatment of progressive chronic lymphocytic leukemia: report of a prospective, multicenter, randomized trial of the Polish Adult Leukemia Group (PALG C ( Blonski, JZ; Calbecka, M; Ceglarek, B; Dmoszynska, A; Dwilewicz-Trojaczek, J; Gora-Tybor, J; Jamroziak, K; Kasznicki, M; Kloczko, J; Konopka, L; Kowal, M; Kuliczkowski, K; Robak, T; Skotnicki, AB; Stella-Holowiecka, B; Sulek, K; Tomaszewska, A; Warzocha, K; Zawilska, K, 2006)
"Acute renal failure and bacterial infection occurred as non-hematologic dose limiting toxicities."2.70A dose escalation study for salvage chemotherapy in patients with refractory lymphoma prior to high-dose myeloablative therapy with stem cell transplantation. ( de Magalhaes-Silverman, M; Gingrich, RD; Hayashi, M; Hohl, RJ; Lee, CK; Schlueter, A; Strauss, RG, 2002)
" However, some trials showed that increasing the dosage of anthracyclines within induction therapy improved treatment outcome substantially."2.70Intensified double induction therapy with high dose mitoxantrone, etoposide, m-amsacrine and high dose ara-C for elderly acute myeloid leukemia patients aged 61-65 years. ( Aulitzky, W; Bodenstein, H; Clemens, M; Ehninger, G; Illmer, T; Neubauer, A; Repp, R; Schaich, M; Schäkel, U; Soucek, S; Wandt, H, 2002)
" The maximal acceptable dosage of mitoxantrone was 10 mg/m2 x 2 due to serious hematologic toxicity."2.69Mitoxantrone-DHAP with GM-CSF: an active but myelosuppressive salvage therapy for relapsed/refractory aggressive non-Hodgkin's lymphoma. ( Berinstein, NL; Franssen, E; Haq, R; Sawka, CA, 1999)
"Mitoxantrone (Novantrone) is an anthracene derivative that has demonstrated antitumor activity in patients with breast cancer, ovarian cancer, acute leukemia, and lymphoma."2.69A phase I trial of vinorelbine in combination with mitoxantrone in patients with refractory solid tumors. ( Bigley, J; Burris, HA; Dieras, V; Eckardt, JR; Hardy, J; Hohneker, J; Jones, SF; Peacock, NW; Rodriguez, GI; Smith, L; Von Hoff, DD, 1998)
"Grade 3/4 neutropenia was observed in 29 patients (58%) with four neutropenic episodes."2.69First-line treatment of metastatic breast cancer with mitoxantrone, vinorelbine, and carboplatin. ( Agelaki, S; Androulakis, N; Georgoulias, V; Hatzidaki, D; Kakolyris, S; Koukourakis, M; Kourousis, C; Samonis, G; Tsiftsis, D; Vamvakas, L, 1999)
" Because its toxicities are minimal and do not overlap with the toxicities of standard chemotherapy, it is an appealing agent to use in combination with chemotherapy."2.69Safety of fludarabine, mitoxantrone, and dexamethasone combined with rituximab in the treatment of stage IV indolent lymphoma. ( Cabanillas, F; Dang, NH; Hagemeister, FB; Lee, MS; McAda, N; McLaughlin, P; Pate, O; Preti, AH; Rodriguez, MA; Romaguera, JE; Sarris, AH; Younes, A, 2000)
"All patients had advanced metastatic breast cancer and have been extensively pretreated with chemotherapy (28 patients), radiotherapy (13 patients), and hormonotherapy (24 patients)."2.68Treatment of advanced and relapsing breast cancer with a combination of paclitaxel and mitoxantrone. South-Central Hellenic Oncology Group. ( Panagos, GE, 1997)
"67 patients with relapsed or resistant multiple myeloma were randomized to receive either VAD (vincristine, doxorubicin, dexamethasone) or MOD (mitozantrone, vincristine, dexamethasone)."2.68A randomized study of MOD versus VAD in the treatment of relapsed and resistant multiple myeloma. ( Cawley, JC; Davies, JM; Newland, AC; Pearce, R; Phillips, JK; Reilly, JT; Sherlaw-Johnson, C, 1995)
" Ten dogs were given mitoxantrone at a dosage of 5."2.67Toxicoses associated with the administration of mitoxantrone to dogs with malignant tumors: a dose escalation study. ( Atwater, SW; Bergman, PJ; Chen, C; Ciekot, PA; Moore, AS; Ogilvie, GK; Walters, LM, 1994)
"Patients with advanced breast cancer were randomised to 3M (mitozantrone 6."2.67Mitozantrone and methotrexate chemotherapy with and without mitomycin C in the treatment of advanced breast cancer: a randomised clinical trial. ( Barton, C; Bliss, JM; Bower, M; Coombes, RC; Ford, HT; Gazet, JC; Law, M; Stein, RC, 1992)
"132 patients with advanced recurrent breast cancer were treated with four courses of mitozantrone 14 mg/m2 intravenously every 3 weeks (9 weeks)."2.67Comparison of short-term and continuous chemotherapy (mitozantrone) for advanced breast cancer. ( Cantwell, BM; Carmichael, J; Dawes, P; Evans, RG; Farndon, J; Ghani, S; Harris, AL; Wilson, R, 1990)
" Neutropenia is the most common toxicity associated with mitoxantone therapy and may necessitate dosage reduction in some patients."2.40Mitoxantrone. A review of its pharmacology and clinical efficacy in the management of hormone-resistant advanced prostate cancer. ( Spencer, CM; Wiseman, LR, 1997)
"A disseminated Fusarium infection due to F."1.39Refractory disseminated fusariosis by Fusarium verticillioides in a patient with acute myeloid leukaemia relapsed after allogeneic hematopoietic stem cell transplantation: a case report and literature review. ( Bartolesi, AM; Fanci, R; Pecile, P; Pini, G, 2013)
"Neutropenia was present in 74."1.32Infectious complications in pediatric acute myeloid leukemia: analysis of the prospective multi-institutional clinical trial AML-BFM 93. ( Creutzig, U; Kaiser, J; Klingebiel, T; Lehrnbecher, T; Reinhardt, D; Varwig, D, 2004)
"As compared with metastatic breast cancer (MBC), high risk breast cancer showed a 2."1.31Infectious complications in breast cancer patients undergoing peripheral blood stem cell transplantation: a single center retrospective analysis towards outpatient strategy. ( Barbaro, P; Console, G; Iacopino, P; Irrera, G; Martino, M; Messina, G; Morabito, F; Oliva, E; Palazzo, S; Pucci, G, 2001)
"Severe infections are a major problem in patients suffering from acute nonlymphocytic leukemia (ANLL) undergoing myeloablative chemotherapy."1.30Suppressed neutrophil function as a risk factor for severe infection after cytotoxic chemotherapy in patients with acute nonlymphocytic leukemia. ( Diehl, V; Engert, A; Hegener, K; Hübel, K; Mansmann, G; Oberhäuser, F; Schnell, R; Staib, P, 1999)
"Mucormycosis is a rare fungal infection that has been described mainly in oncologic and diabetic patients."1.29[Pulmonary mucormycosis in leukemic patients. Apropos of 2 cases]. ( Cancelas, JA; Cerveró, C; García-Laraña, J; López, J; Navarro, JL; Odriozola, J; Pérez-Oteyza, J; Sánchez-Sousa, A; Sastre, JL, 1994)
"Neutropenic fever has been one of the most difficult complications in the recovery period following high-dose chemotherapy and autologous haematopoietic progenitor cell transplantation."1.29Neutropenic fever in patients after high-dose chemotherapy followed by autologous haematopoietic progenitor cell transplantation and human recombinant granulocyte-macrophage colony stimulating factor. ( Gagnon, A; Glück, S, 1994)
"Myelosuppression with subsequent infections was the major toxicity of this regimen."1.28Mitoxantrone and high-dose cytarabine as salvage therapy for refractory non-Hodgkin's lymphoma. ( del Valle, F; Dörken, B; Hiddemann, W; Ho, AD; Hunstein, W; Meusers, P; Rückle, H; Schlimok, G; Schwammborn, J; Thiel, E, 1989)
"Mitoxantrone is an active well-tolerated agent in the treatment of advanced breast carcinoma, but the risk of neutropenia requires careful supervision."1.27Mitoxantrone: an active new agent in the treatment of advanced breast cancer. ( Bozek, T; Pavlidis, NA; Smith, IE; Stuart-Harris, RC, 1984)

Research

Studies (88)

TimeframeStudies, this research(%)All Research%
pre-19904 (4.55)18.7374
1990's39 (44.32)18.2507
2000's34 (38.64)29.6817
2010's11 (12.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kimura, S1
Wada, H1
Ishihara, Y1
Kawamura, K1
Sakamoto, K1
Yamasaki, R1
Ashizawa, M1
Machishima, T1
Sato, M1
Terasako, K1
Nakasone, H1
Kikuchi, M1
Okuda, S1
Kako, S1
Kanda, J1
Yamazaki, R1
Tanihara, A1
Nishida, J1
Kanda, Y1
Abrisqueta, P1
Villamor, N1
Terol, MJ1
González-Barca, E1
González, M1
Ferrà, C1
Abella, E1
Delgado, J1
García-Marco, JA1
González, Y1
Carbonell, F1
Ferrer, S1
Monzó, E1
Jarque, I1
Muntañola, A1
Constants, M1
Escoda, L1
Calvo, X1
Bobillo, S1
Montoro, JB1
Montserrat, E1
Bosch, F1
Meisel, A1
von Felten, S1
Vogt, DR1
Liewen, H1
de Wit, R1
de Bono, J1
Sartor, O1
Stenner-Liewen, F1
Munir, T1
Howard, DR1
McParland, L1
Pocock, C1
Rawstron, AC1
Hockaday, A1
Varghese, A1
Hamblin, M1
Bloor, A1
Pettitt, A1
Fegan, C1
Blundell, J1
Gribben, JG1
Phillips, D1
Hillmen, P1
Deenik, W1
Beverloo, HB1
van der Poel-van de Luytgaarde, SC1
Wattel, MM1
van Esser, JW1
Valk, PJ1
Cornelissen, JJ1
Braess, J1
Spiekermann, K1
Staib, P3
Grüneisen, A1
Wörmann, B4
Ludwig, WD2
Serve, H1
Reichle, A1
Peceny, R1
Oruzio, D1
Schmid, C1
Schiel, X1
Hentrich, M1
Sauerland, C1
Unterhalt, M1
Fiegl, M1
Kern, W2
Buske, C1
Bohlander, S1
Heinecke, A2
Baurmann, H1
Beelen, DW1
Berdel, WE1
Büchner, T4
Hiddemann, W5
McHayleh, W1
Sehgal, R1
Redner, RL1
Raptis, A1
Agha, M1
Natale, J1
Luong, TM1
Schlesselman, JJ1
Foon, KA1
Boyiadzis, M1
Kingwell, E1
Koch, M1
Leung, B1
Isserow, S1
Geddes, J1
Rieckmann, P1
Tremlett, H1
Godley, LA1
Njiaju, UO1
Green, M1
Weiner, H1
Lin, S1
Odenike, O1
Rich, ES1
Artz, A1
Van Besien, K1
Daugherty, CK1
Zhang, Y1
Le Beau, MM1
Stock, W1
Larson, RA1
Derbel, O1
Cannas, G1
Le, QH1
Elhamri, M1
Chelghoum, Y1
Nicolas-Virelizier, E1
Nicolini, F1
Troncy, J1
Barraco, F1
Michallet, M1
Thomas, X1
de Bono, JS1
Oudard, S1
Ozguroglu, M1
Hansen, S1
Machiels, JP1
Kocak, I1
Gravis, G1
Bodrogi, I1
Mackenzie, MJ1
Shen, L1
Roessner, M1
Gupta, S1
Sartor, AO1
Vehreschild, MJ1
Meissner, AM1
Cornely, OA1
Maschmeyer, G3
Neumann, S1
von Lilienfeld-Toal, M1
Karthaus, M1
Wattad, M1
Hellmich, M1
Christ, H1
Vehreschild, JJ1
Saini, L1
Minden, MD1
Schuh, AC1
Yee, KW1
Schimmer, AD1
Gupta, V1
Atenafu, EG1
Murray, C1
Nixon, S1
Brandwein, JM1
Fanci, R1
Pini, G1
Bartolesi, AM1
Pecile, P1
Schaich, M1
Illmer, T1
Aulitzky, W1
Bodenstein, H1
Clemens, M1
Neubauer, A1
Repp, R1
Schäkel, U1
Soucek, S1
Wandt, H1
Ehninger, G1
Lee, CK1
de Magalhaes-Silverman, M1
Hayashi, M1
Schlueter, A1
Strauss, RG1
Hohl, RJ1
Gingrich, RD1
Lehrnbecher, T2
Varwig, D1
Kaiser, J1
Reinhardt, D2
Klingebiel, T1
Creutzig, U2
Lyman, GH1
Delgado, DJ2
Löfgren, C2
Paul, C2
Aström, M1
Hast, R1
Hedenius, M1
Lerner, R1
Liliemark, J1
Nilsson, I1
Rödjer, S1
Simonsson, B1
Stockelberg, D1
Tidefelt, U2
Björkholm, M1
Hendry, L1
Bowen, A1
Matutes, E1
Swansbury, J1
Catovsky, D1
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Hsu, HC1
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Tseng, CS1
Ho, CH1
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Janisch, L1
Vogelzang, NJ1
Vokes, EE1
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Gladieff, L1
Houyau, P1
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Roché, H1
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Hermida, G1
Cortés, MA1
Richard, C1
Iriondo, A1
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Zubizarreta, A1
Panagos, GE1
Brodsky, AL1
Melero, MJ1
Minissale, CJ1
Sánchez Avalos, JC1
Wiseman, LR1
Spencer, CM1
Wang, WS1
Tzeng, CH1
Chiou, TJ1
Liu, JH1
Hsieh, RK1
Yen, CC1
Chen, PM1
Peacock, NW1
Burris, HA1
Dieras, V1
Smith, L1
Rodriguez, GI1
Eckardt, JR1
Jones, SF1
Hardy, J1
Hohneker, J1
Bigley, J1
Von Hoff, DD1
Aul, C2
Kuse, R1
Kerkhoff, A1
Grote-Metke, A1
Eimermacher, H1
Kubica, U1
Möllgård, L1
Sundman-Engberg, B1
Lehman, S1
Kouroussis, C2
Androulakis, N2
Kakolyris, S3
Souglakos, J1
Kotsakis, T1
Mavroudis, D2
Katsogridakis, K1
Vardakis, N1
Hatzidaki, D2
Samonis, G2
Vlachonikolis, J1
Georgoulias, V3
Hübel, K1
Hegener, K1
Schnell, R1
Mansmann, G1
Oberhäuser, F1
Diehl, V1
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Martino, R1
Guardia, R1
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Koukourakis, M1
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Clinical Trials (15)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Phase II Stereotactic Body Radiotherapy (SBRT) and Stereotactic Hypofractionated Radiotherapy (SHRT) for Oligometastatic Prostate Cancer[NCT01859221]39 participants (Actual)Interventional2013-05-31Completed
Prospective Pilot Clinical Trial of Ac225-PSMA Radioligand Therapy of Metastatic Castration-resistant Prostate Cancer[NCT04225910]Early Phase 120 participants (Anticipated)Interventional2020-01-01Not yet recruiting
Predictive fActors for toleraNce to Taxane Based CHemotherapy In Older adultS Affected by mEtastatic Prostate Cancer, a Prospective Observational Study (ANCHISES)[NCT05471427]118 participants (Actual)Observational2020-01-01Completed
A Randomized Phase II Trial Comparing Biomarker Directed Therapy Versus Clinician's Choice of Enzalutamide or Docetaxel in Patients With Advanced Prostate Cancer Post Abiraterone[NCT04015622]Phase 2100 participants (Anticipated)Interventional2020-10-07Recruiting
A Phase I/II Study of Alisertib in Combination With Abiraterone and Prednisone for Patients With Castration-Resistant Prostate Cancer After Progression on Abiraterone[NCT01848067]Phase 1/Phase 29 participants (Actual)Interventional2013-08-14Completed
A Randomized, Open Label Multi-Center Study of XRP6258 at 25 mg/m^2 in Combination With Prednisone Every 3 Weeks Compared to Mitoxantrone in Combination With Prednisone For The Treatment of Hormone Refractory Metastatic Prostate Cancer Previously Treated [NCT00417079]Phase 3755 participants (Actual)Interventional2007-01-31Completed
A Phase I Study of Entinostat in Combination With Enzalutamide for Treatment of Patients With Castration-Resistant Prostate Cancer[NCT03829930]Phase 16 participants (Actual)Interventional2019-05-01Terminated (stopped due to Sponsor discontinued the drug)
Phase I Study of Cabazitaxel - Platinum Fluorouracil Induction Chemotherapy in Patients With Locally Advanced Squamous Cell Carcinoma of the Head and Neck[NCT01379339]Phase 140 participants (Actual)Interventional2011-04-30Completed
A Randomized Phase II Study of OGX-427 (a Second-Generation Antisense Oligonucleotide to Heat Shock Protein-27) in Patients With Castration Resistant Prostate Cancer Who Have Not Previously Received Chemotherapy for Metastatic Disease[NCT01120470]Phase 274 participants (Actual)Interventional2010-09-30Completed
Survival Outcomes in Metastatic Prostate Cancer in the Brazilian Population - Analysis of Individual Characteristics and Treatment Modalities in Different National Health Institutions.[NCT04962919]590 participants (Anticipated)Observational2020-01-14Recruiting
An Open-label, Phase I/IIa Dose Escalation and Expansion Study to Determine the Safety and Clinical Activity of an Immune Priming Cell Therapy (INKmune) in Patients With Metastatic Castration Resistant Prostate Cancer (mCRPC)[NCT06056791]Phase 1/Phase 230 participants (Anticipated)Interventional2023-11-30Not yet recruiting
A Phase I Trial of Autologous CLL B Cells Transduced to Express Chimeric CD154 (ISF35)[NCT00779883]Phase 19 participants (Actual)Interventional2006-06-30Completed
A Phase 1B Extension Trial to Allow Repeat Dosing of Autologous CLL B Cells Transduced to Express Chimeric CD154 (ISF35) in Subjects Previously Treated in MDACC Protocol 2004-0914[NCT00783588]Phase 14 participants (Actual)Interventional2007-05-31Completed
A Pilot Study of Low Dose Melphalan and Bortezomib for Treatment of Acute Myelogenous Leukemia and High-Risk Myelodysplastic Syndromes[NCT00789256]26 participants (Actual)Interventional2004-09-30Completed
A Prospective, Open, Randomized Controlled, Multi-center Phase III Clinical Trial Comparing High-dose Epirubicin and Standard-dose Epirubicin in R±CEOP in Newly Diagnosed Young Patients With Medium/High-risk Diffuse Large B-cell Lymphoma[NCT03151044]Phase 3408 participants (Anticipated)Interventional2016-07-31Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Number of Participants With a PSA Value Equal to or Greater Than 25%

Compared between the two patient subsets using the nonparametric Mann-Whitney test. A comparison of CTC counts between baseline and at progression for those who have progressed will be carried out using either a paired t test or the nonparameteric Wilcoxon matched pairs test. (NCT01848067)
Timeframe: Baseline up to 3 months

InterventionParticipants (Count of Participants)
Treatment (Alisertib, Abiraterone Acetate, Prednisone)3

Phase I: Frequency of Dose Limiting Toxicities of Alisertib, Graded According to the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) v4.1

Summarized with descriptive statistics. (NCT01848067)
Timeframe: Up to 21 days

InterventionParticipants (Count of Participants)
Treatment (Alisertib, Abiraterone Acetate, Prednisone)2

Overall Survival

"Overall survival was defined as the time interval from the date of randomization to the date of death due to any cause.~In the absence of confirmation of death, the survival time was censored at the last date patient was known to be alive or at the cut-off date, whichever had come first." (NCT00417079)
Timeframe: From the date of randomization up to 104 weeks (study cut-off)

InterventionMonths (Median)
Mitoxantrone + Prednisone12.7
Cabazitaxel + Prednisone15.1

Overall Tumor Response

"Tumor Overall Response Rate (ORR) (only in patients with measurable disease):~Objective responses (Complete Response and Partial Response) for measurable disease as assessed by investigators according to RECIST criteria.~Complete Response (CR) is defined as: Disappearance of all target lesions. Partial Response (PR) is defined as: At least a 30% decrease in the sum of longest diameter (LD) of target lesions taking as reference baseline sum LD.~Confirmation of objective responses will be performed by repeat tumor imaging (CT scans, MRI, bone scans) after the first documentation of response." (NCT00417079)
Timeframe: From the date of randomization up to 104 weeks (study cut-off)

Interventionpercentage of participants (Number)
Mitoxantrone + Prednisone4.4
Cabazitaxel + Prednisone14.4

Pain Response

Pain Response was defined as a two-point or greater reduction from baseline median Present Pain Intensity (PPI) score without an increased Analgesic Score (AS) or a decrease of ≥50% in the AS without an increase in the PPI score, maintained for at least 3 weeks. (NCT00417079)
Timeframe: from baseline up to 104 weeks (study cut-off)

InterventionPercentage of participants (Number)
Mitoxantrone + Prednisone7.7
Cabazitaxel + Prednisone9.2

PSA (Prostate-Specific Antigen) Response

PSA response was defined as a ≥ 50% reduction in serum PSA, determined only for patients with a serum PSA ≥ 20ng/mL at baseline, confirmed by a repeat PSA ≥ 3 weeks later. (NCT00417079)
Timeframe: from baseline up to 104 weeks (study cut-off)

InterventionPercentage of participants (Number)
Mitoxantrone + Prednisone17.8
Cabazitaxel + Prednisone39.2

Time to Pain Progression

"Pain Progression is defined as an increase of ≥1 point in the median Personal Pain Intensity (PPI) from its nadir noted on 2 consecutive 3-week-apart visits or ≥25 % increase in the mean analgesic score compared with the baseline score & noted on 2 consecutive 3-week-apart visits or requirement for local palliative radiotherapy.~Evaluation of the PPI & analgesic scores are based on the short-form McGill Pain Questionnaire which consists of 15 descriptors (11 sensory; 4 affective) which are rated on an intensity scale as 0=none (best) 1=mild 2=moderate 3=severe (worst) (TOTAL: 0=best 45=worst)" (NCT00417079)
Timeframe: from baseline up to 104 weeks (study cut-off)

InterventionMonths (Median)
Mitoxantrone + PrednisoneNA
Cabazitaxel + Prednisone11.1

Time to Progression Free Survival (PFS)

Progression free survival was defined as a composite endpoint evaluated from the date of randomization to the date of tumor progression, PSA progression, pain progression, or death due to any cause, whichever occurred first (NCT00417079)
Timeframe: From the date of randomization up to 104 weeks (study cut-off)

InterventionMonths (Median)
Mitoxantrone + Prednisone1.4
Cabazitaxel + Prednisone2.8

Time to Prostatic Specific Antigen (PSA) Progression

"In PSA non-responders, progression will be defined as a 25% increase over nadir and increase in the absolute value PSA level by at least 5 ng/ml and confirmed by a second value at least 4 weeks later.~In PSA responders and in patients not evaluable for PSA response at baseline, progression will be defined as a ≥50% increase over nadir, provided that the increase is a minimum of 5 ng/ml and confirmed by a second value at least 1 week later." (NCT00417079)
Timeframe: at screening, day 1 of every treatment cycle, up to 104 weeks (study cut-off)

InterventionMonths (Median)
Mitoxantrone + Prednisone3.1
Cabazitaxel + Prednisone6.4

Time to Tumor Progression

Time to tumor progression is defined as the number of months from randomization until evidence of progressive disease (RECIST) (NCT00417079)
Timeframe: From the date of randomization up to 104 weeks (study cut-off)

InterventionMonths (Median)
Mitoxantrone + Prednisone5.4
Cabazitaxel + Prednisone8.8

Response Rate of the Combination of Bortezomib and Melphalan in Patients With AML and High-risk MDS.

Determine disease response to treatment using Cheson 2000 report of an international working group to standardize response criteria for myelodysplastic syndromes. (NCT00789256)
Timeframe: Post Cycle 1 through 28 days post-treatment

Interventionparticipants (Number)
Strata 15
Strata 22

Reviews

4 reviews available for mitoxantrone and Neutropenia

ArticleYear
Mitoxantrone (novantrone): a review of experimental and early clinical studies.
    Cancer treatment reviews, 1983, Volume: 10, Issue:2

    Topics: Animals; Anthraquinones; Antineoplastic Agents; Breast Neoplasms; Clinical Trials as Topic; Doxorubi

1983
Mitoxantrone. A review of its pharmacology and clinical efficacy in the management of hormone-resistant advanced prostate cancer.
    Drugs & aging, 1997, Volume: 10, Issue:6

    Topics: Antineoplastic Agents; Cardiovascular System; Drug Resistance, Neoplasm; Humans; Male; Mitoxantrone;

1997
High-dose cytarabine and mitoxantrone as salvage therapy for refractory non-Hodgkin's lymphoma.
    Japanese journal of clinical oncology, 1997, Volume: 27, Issue:3

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Cytarabine; Drug Administr

1997
Induction therapy of adult acute lymphocytic leukemia without the use of vincristine or prednisone.
    Hematology/oncology clinics of North America, 2001, Volume: 15, Issue:1

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Clinical Trials

2001

Trials

55 trials available for mitoxantrone and Neutropenia

ArticleYear
Rituximab maintenance after first-line therapy with rituximab, fludarabine, cyclophosphamide, and mitoxantrone (R-FCM) for chronic lymphocytic leukemia.
    Blood, 2013, Dec-05, Volume: 122, Issue:24

    Topics: Aged; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Area U

2013
Severe neutropenia during cabazitaxel treatment is associated with survival benefit in men with metastatic castration-resistant prostate cancer (mCRPC): A post-hoc analysis of the TROPIC phase III trial.
    European journal of cancer (Oxford, England : 1990), 2016, Volume: 56

    Topics: Antineoplastic Combined Chemotherapy Protocols; Disease-Free Survival; Docetaxel; Granulocyte Colony

2016
Results of the randomized phase IIB ADMIRE trial of FCR with or without mitoxantrone in previously untreated CLL.
    Leukemia, 2017, Volume: 31, Issue:10

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Disease-Free Survival

2017
Dose-dense induction with sequential high-dose cytarabine and mitoxantone (S-HAM) and pegfilgrastim results in a high efficacy and a short duration of critical neutropenia in de novo acute myeloid leukemia: a pilot study of the AMLCG.
    Blood, 2009, Apr-23, Volume: 113, Issue:17

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cytarabi

2009
Mitoxantrone and etoposide in patients with newly diagnosed acute myeloid leukemia with persistent leukemia after a course of therapy with cytarabine and idarubicin.
    Leukemia & lymphoma, 2009, Volume: 50, Issue:11

    Topics: Acute Disease; Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cytarabine;

2009
Treatment of therapy-related myeloid neoplasms with high-dose cytarabine/mitoxantrone followed by hematopoietic stem cell transplant.
    Leukemia & lymphoma, 2010, Volume: 51, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Th

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Co

2010
Clinically defined chemotherapy-associated bowel syndrome predicts severe complications and death in cancer patients.
    Haematologica, 2011, Volume: 96, Issue:12

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Female; Humans; Incidence; Inflam

2011
Intensified double induction therapy with high dose mitoxantrone, etoposide, m-amsacrine and high dose ara-C for elderly acute myeloid leukemia patients aged 61-65 years.
    Haematologica, 2002, Volume: 87, Issue:8

    Topics: Acute Disease; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; ATP Binding

2002
A dose escalation study for salvage chemotherapy in patients with refractory lymphoma prior to high-dose myeloablative therapy with stem cell transplantation.
    Bone marrow transplantation, 2002, Volume: 29, Issue:8

    Topics: Acute Kidney Injury; Adult; Antineoplastic Combined Chemotherapy Protocols; Bacterial Infections; Cy

2002
Granulocyte-macrophage colony-stimulating factor to increase efficacy of mitoxantrone, etoposide and cytarabine in previously untreated elderly patients with acute myeloid leukaemia: a Swedish multicentre randomized trial.
    British journal of haematology, 2004, Volume: 124, Issue:4

    Topics: Acute Disease; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cytarabine;

2004
Fludarabine, cyclophosphamide and mitoxantrone in relapsed or refractory chronic lymphocytic leukemia and low grade non-Hodgkin's lymphoma.
    Leukemia & lymphoma, 2004, Volume: 45, Issue:5

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Drug Administration S

2004
Fludarabine, cyclophosphamide and mitoxantrone in relapsed or refractory chronic lymphocytic leukemia and low grade non-Hodgkin's lymphoma.
    Leukemia & lymphoma, 2004, Volume: 45, Issue:5

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Drug Administration S

2004
Fludarabine, cyclophosphamide and mitoxantrone in relapsed or refractory chronic lymphocytic leukemia and low grade non-Hodgkin's lymphoma.
    Leukemia & lymphoma, 2004, Volume: 45, Issue:5

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Drug Administration S

2004
Fludarabine, cyclophosphamide and mitoxantrone in relapsed or refractory chronic lymphocytic leukemia and low grade non-Hodgkin's lymphoma.
    Leukemia & lymphoma, 2004, Volume: 45, Issue:5

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Drug Administration S

2004
[VNCOP-B (etoposide, mitoxantrone, cyclophosphamide, vincristine, predonisolone, bleomycin) therapy in elderly patients with aggressive non-Hodgkin lymphoma--a study of efficacy and safety, final report].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2005, Volume: 32, Issue:1

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cyclophosphamide; Drug Administrati

2005
Gemcitabine and mitoxantrone in metastatic breast cancer: a phase-I-study.
    Investigational new drugs, 2005, Volume: 23, Issue:4

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Breast

2005
Prospective randomized study comparing MEMID with a chop-like regimen in elderly patients with aggressive non-Hodgkin's lymphoma.
    Oncology, 2005, Volume: 69, Issue:1

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Dexamethasone; Disease-Free

2005
Cladribine alone and in combination with cyclophosphamide or cyclophosphamide plus mitoxantrone in the treatment of progressive chronic lymphocytic leukemia: report of a prospective, multicenter, randomized trial of the Polish Adult Leukemia Group (PALG C
    Blood, 2006, Jul-15, Volume: 108, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cladribine; Cyclopho

2006
Less toxicity by optimizing chemotherapy, but not by addition of granulocyte colony-stimulating factor in children and adolescents with acute myeloid leukemia: results of AML-BFM 98.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2006, Sep-20, Volume: 24, Issue:27

    Topics: Acute Disease; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool;

2006
A phase 2 trial of fludarabine and mitoxantrone chemotherapy followed by yttrium-90 ibritumomab tiuxetan for patients with previously untreated, indolent, nonfollicular, non-Hodgkin lymphoma.
    Cancer, 2008, Feb-15, Volume: 112, Issue:4

    Topics: Aged; Aged, 80 and over; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Fem

2008
Mitoxantrone (novantrone): a review of experimental and early clinical studies.
    Cancer treatment reviews, 1983, Volume: 10, Issue:2

    Topics: Animals; Anthraquinones; Antineoplastic Agents; Breast Neoplasms; Clinical Trials as Topic; Doxorubi

1983
The intramuscular administration of granulocyte colony-stimulating factor as an adjunct to chemotherapy in pretreated ovarian cancer patients: an Italian Trials in Medical Oncology (ITMO) Group pilot study.
    British journal of cancer, 1994, Volume: 69, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Female; Granulocyte Colony-S

1994
Mitoxantrone plus vinorelbine with granulocyte-colony stimulating factor (G-CSF) support in advanced breast cancer patients. A dose and schedule finding study.
    Breast cancer research and treatment, 1995, Volume: 35, Issue:2

    Topics: Adenocarcinoma; Adult; Age Factors; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neo

1995
A randomized study of MOD versus VAD in the treatment of relapsed and resistant multiple myeloma.
    Leukemia & lymphoma, 1995, Volume: 17, Issue:5-6

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Dexamethasone; Doxorubicin; Drug Resistance; F

1995
High-dose chemotherapy with hematopoietic rescue as primary treatment for metastatic breast cancer: a randomized trial.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1995, Volume: 13, Issue:10

    Topics: Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplant

1995
Four-step high-dose sequential chemotherapy with double hematopoietic progenitor-cell rescue for metastatic breast cancer.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1995, Volume: 13, Issue:4

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carboplatin; Combined Modal

1995
Toxicoses associated with the administration of mitoxantrone to dogs with malignant tumors: a dose escalation study.
    Journal of the American Veterinary Medical Association, 1994, Aug-15, Volume: 205, Issue:4

    Topics: Animals; Bone Marrow; Diarrhea; Dog Diseases; Dogs; Female; Follow-Up Studies; Leukocyte Count; Logi

1994
Folinic acid, 5-fluorouracil bolus and infusion and mitoxantrone with or without cyclophosphamide in metastatic breast cancer.
    European journal of cancer (Oxford, England : 1990), 1993, Volume: 29A, Issue:13

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Breast Neoplasms; Cyclo

1993
A phase II trial of a chemotherapy combination in elderly patients with aggressive lymphoma.
    Annals of oncology : official journal of the European Society for Medical Oncology, 1993, Volume: 4, Issue:2

    Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Etoposide

1993
Granulocyte colony-stimulating factor following chemotherapy in elderly patients with newly diagnosed acute myelogenous leukemia.
    Leukemia, 1996, Volume: 10, Issue:1

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Disease-Free Survival; Etoposide;

1996
Post-remission intensive consolidation with high-dose cytarabine-based chemotherapy and granulocyte colony-stimulatory factor in adults with acute myelogenous leukemia: a preliminary report.
    Zhonghua yi xue za zhi = Chinese medical journal; Free China ed, 1995, Volume: 56, Issue:5

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Etoposide; Female; Gr

1995
Phase I study of escalating doses of mitoxantrone and paclitaxel with granulocyte-macrophage colony stimulating factor support.
    Cancer, 1996, Jun-01, Volume: 77, Issue:11

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Female; Granulocyte-Macrophage Colony-S

1996
[A phase II study with mitoxantrone-vinorelbine association in the treatment of advanced breast cancer in elderly women].
    Bulletin du cancer, 1996, Volume: 83, Issue:9

    Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Pro

1996
Treatment of advanced and relapsing breast cancer with a combination of paclitaxel and mitoxantrone. South-Central Hellenic Oncology Group.
    Seminars in oncology, 1997, Volume: 24, Issue:1 Suppl 3

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cardiac Output, Low;

1997
[Chemotherapy schedules and bacteremia in adult patients with acute leukemia].
    Medicina, 1996, Volume: 56, Issue:4

    Topics: Acute Disease; Adolescent; Adult; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Anti

1996
High-dose cytarabine and mitoxantrone as salvage therapy for refractory non-Hodgkin's lymphoma.
    Japanese journal of clinical oncology, 1997, Volume: 27, Issue:3

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Cytarabine; Drug Administr

1997
A phase I trial of vinorelbine in combination with mitoxantrone in patients with refractory solid tumors.
    Investigational new drugs, 1998, Volume: 16, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Female; Humans; Male

1998
Granulocyte colony-stimulating factor shortens duration of critical neutropenia and prolongs disease-free survival after sequential high-dose cytosine arabinoside and mitoxantrone (S-HAM) salvage therapy for refractory and relapsed acute myeloid leukemia.
    Annals of hematology, 1998, Volume: 77, Issue:3

    Topics: Acute Disease; Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Critical Car

1998
High single dose of mitoxantrone and cytarabine in acute non-lymphocytic leukemia: a pharmacokinetic and clinical study.
    Therapeutic drug monitoring, 1998, Volume: 20, Issue:6

    Topics: Adult; Aged; Amsacrine; Chromatography, High Pressure Liquid; Cytarabine; Drug Administration Schedu

1998
Dose-escalation study of docetaxel in combination with mitoxantrone as first-line treatment in patients with metastatic breast cancer.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1999, Volume: 17, Issue:3

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Docetaxel; Dose-Respo

1999
Time sequential chemotherapy for primary refractory or relapsed adult acute myeloid leukemia: results of the phase II Gemia protocol.
    Haematologica, 1999, Volume: 84, Issue:3

    Topics: Acute Disease; Adult; Antineoplastic Combined Chemotherapy Protocols; Cell Cycle; Combined Modality

1999
Results of a randomized double-blind placebo-controlled trial evaluating sequential high-dose cytosine arabinoside/mitoxantrone chemotherapy with or without granulocyte/macrophage-colony-stimulating factor in high-risk myelodysplastic syndromes.
    Journal of cancer research and clinical oncology, 1999, Volume: 125, Issue:6

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Double-Blind Method; Evalua

1999
First-line treatment of metastatic breast cancer with mitoxantrone, vinorelbine, and carboplatin.
    American journal of clinical oncology, 1999, Volume: 22, Issue:6

    Topics: Adult; Aged; Alopecia; Anemia; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplas

1999
Mitoxantrone-DHAP with GM-CSF: an active but myelosuppressive salvage therapy for relapsed/refractory aggressive non-Hodgkin's lymphoma.
    Leukemia & lymphoma, 1999, Volume: 35, Issue:5-6

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cytarabine; Dexamethasone; D

1999
Granulocyte colony-stimulating factor after intensive consolidation chemotherapy in acute myeloid leukemia: results of a randomized trial of the Groupe Ouest-Est Leucémies Aigues Myeloblastiques.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2000, Volume: 18, Issue:4

    Topics: Acute Disease; Adolescent; Adult; Amsacrine; Anti-Bacterial Agents; Antimetabolites, Antineoplastic;

2000
Phase I/II trial of cyclophosphamide, mitoxantrone, and escalated doses of carboplatin supported by peripheral-blood stem cells in women with metastatic breast cancer.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2000, Volume: 18, Issue:12

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carboplatin; Cy

2000
Safety of fludarabine, mitoxantrone, and dexamethasone combined with rituximab in the treatment of stage IV indolent lymphoma.
    Seminars in oncology, 2000, Volume: 27, Issue:6 Suppl 12

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy

2000
Ifosfamide and mitoxantrone in the treatment of recurrent and/or metastatic squamous cell carcinoma of the head and neck.
    Anti-cancer drugs, 2001, Volume: 12, Issue:3

    Topics: Adult; Aged; Anemia; Antigens, Neoplasm; Antineoplastic Combined Chemotherapy Protocols; Carcinoma,

2001
Mitoxantrone and paclitaxel combination chemotherapy in metastatic breast cancer.
    Cancer investigation, 2001, Volume: 19, Issue:3

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Disease Progression;

2001
Docetaxel in combination with mitoxantrone and granulocyte colony-stimulating factor as front-line chemotherapy in metastatic breast cancer: a multicenter phase II study.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2001, Volume: 12, Issue:6

    Topics: Administration, Oral; Adult; Aged; Alopecia; Antineoplastic Combined Chemotherapy Protocols; Breast

2001
Fludarabine and mitoxantrone: effective and well-tolerated salvage therapy in relapsed indolent lymphoproliferative disorders.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2001, Volume: 12, Issue:10

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Female; Hematopoietic Stem Cell Mobiliz

2001
Primary treatment of low-grade non-Hodgkin's lymphoma with the combination of fludarabine and mitoxantrone: a phase II study of the Hellenic Cooperative Oncology Group.
    Leukemia & lymphoma, 2002, Volume: 43, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Female; Humans; Lymp

2002
Mitoxantrone and cisplatin in recurrent and/or metastatic salivary gland malignancies.
    Anti-cancer drugs, 2002, Volume: 13, Issue:5

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cisplatin; Dise

2002
Treatment of intermediate- and high-grade non-Hodgkin's lymphoma using CEOP versus CNOP.
    European journal of haematology, 2002, Volume: 68, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alopecia; Antineoplastic Combined Chemotherapy Protocols

2002
Mitozantrone and methotrexate chemotherapy with and without mitomycin C in the treatment of advanced breast cancer: a randomised clinical trial.
    European journal of cancer (Oxford, England : 1990), 1992, Volume: 28A, Issue:12

    Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Female; Humans; Methotrexate; Midd

1992
Phase III comparative trial (m-BACOD v m-BNCOD) in the treatment of stage II to IV non-Hodgkin's lymphomas with intermediate- or high-grade histology.
    Seminars in oncology, 1990, Volume: 17, Issue:6 Suppl 10

    Topics: Adult; Aged; Alopecia; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cyclophosphamide;

1990
Comparison of short-term and continuous chemotherapy (mitozantrone) for advanced breast cancer.
    Lancet (London, England), 1990, Jan-27, Volume: 335, Issue:8683

    Topics: Adult; Aged; Alopecia; Breast Neoplasms; Combined Modality Therapy; Doxorubicin; Drug Administration

1990

Other Studies

31 other studies available for mitoxantrone and Neutropenia

ArticleYear
D-index dose not predict the development of pulmonary infection in acute myeloid leukemia patients undergoing consolidation chemotherapy with high-dose cytarabine.
    Hematology (Amsterdam, Netherlands), 2014, Volume: 19, Issue:2

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Consol

2014
Rapid complete cytogenetic remission after upfront dasatinib monotherapy in a patient with a NUP214-ABL1-positive T-cell acute lymphoblastic leukemia.
    Leukemia, 2009, Volume: 23, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Combined Modality Therapy; Cytarabine;

2009
Cardiotoxicity and other adverse events associated with mitoxantrone treatment for MS.
    Neurology, 2010, Jun-01, Volume: 74, Issue:22

    Topics: Adult; Age Factors; Analgesics; Anemia; Female; Follow-Up Studies; Humans; Liver Diseases; Male; Mid

2010
A single dose pegfilgrastim for supporting neutrophil recovery in patients treated for high-risk acute myeloid leukemia by the EMA 2000 schedule.
    Hematology (Amsterdam, Netherlands), 2010, Volume: 15, Issue:3

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Drug Administration Schedule; Eto

2010
Feasibility of outpatient consolidation chemotherapy in older versus younger patients with acute myeloid leukemia.
    American journal of hematology, 2012, Volume: 87, Issue:3

    Topics: Acute Disease; Adult; Age Factors; Aged; Aged, 80 and over; Ambulatory Care; Anti-Infective Agents;

2012
Refractory disseminated fusariosis by Fusarium verticillioides in a patient with acute myeloid leukaemia relapsed after allogeneic hematopoietic stem cell transplantation: a case report and literature review.
    Revista iberoamericana de micologia, 2013, Jan-03, Volume: 30, Issue:1

    Topics: Adult; Amphotericin B; Antifungal Agents; Antineoplastic Combined Chemotherapy Protocols; Combined M

2013
Infectious complications in pediatric acute myeloid leukemia: analysis of the prospective multi-institutional clinical trial AML-BFM 93.
    Leukemia, 2004, Volume: 18, Issue:1

    Topics: Acute Disease; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bacteremia; Bacteria; Chi

2004
Risk and timing of hospitalization for febrile neutropenia in patients receiving CHOP, CHOP-R, or CNOP chemotherapy for intermediate-grade non-Hodgkin lymphoma.
    Cancer, 2003, Dec-01, Volume: 98, Issue:11

    Topics: Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemot

2003
A modified low-dose regimen of mitoxantrone and prednisolone in patients with androgen-independent prostate cancer.
    Japanese journal of clinical oncology, 2004, Volume: 34, Issue:6

    Topics: Aged; Anemia; Antineoplastic Combined Chemotherapy Protocols; Disease Progression; Drug Administrati

2004
Effective treatment of indolent non-hodgkin's lymphomas with mitoxantrone, chlorambucil and prednisone.
    Onkologie, 2005, Volume: 28, Issue:2

    Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Di

2005
Immunosuppression and infectious complications in patients with stage IV indolent lymphoma treated with a fludarabine, mitoxantrone, and dexamethasone regimen.
    Cancer, 2005, Jul-15, Volume: 104, Issue:2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; CD4 Lymphocyte Count; CD4-CD8 Ratio; De

2005
Paraneoplastic Sweet's syndrome and the pathergy phenomenon.
    Annals of hematology, 2007, Volume: 86, Issue:8

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Diagnosis, Differential; Drug Eruptions;

2007
Comment on: 'Non-Hodgkin's lymphoma in very elderly patients over 80 years. A descriptive analysis of clinical presentation and outcome'.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2008, Volume: 19, Issue:7

    Topics: Administration, Oral; Aged, 80 and over; Anemia; Antineoplastic Combined Chemotherapy Protocols; Ble

2008
Phase II clinical evaluation of dihydroxyanthracenedione in patients with advanced lung cancer.
    American journal of clinical oncology, 1984, Volume: 7, Issue:3

    Topics: Adenocarcinoma; Adult; Aged; Anthraquinones; Antineoplastic Agents; Carcinoma, Small Cell; Carcinoma

1984
Mitoxantrone: an active new agent in the treatment of advanced breast cancer.
    Cancer chemotherapy and pharmacology, 1984, Volume: 12, Issue:1

    Topics: Adult; Aged; Agranulocytosis; Anthraquinones; Breast Neoplasms; Doxorubicin; Drug Evaluation; Female

1984
Mesna/ifosfamide, mitoxantrone, etoposide, bleomycin, vincristine, prednisone (MINE-BOP) combination chemotherapy in the treatment of refractory and relapsed non-Hodgkin's lymphoma.
    Acta oncologica (Stockholm, Sweden), 1995, Volume: 34, Issue:7

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cisplatin; Cytar

1995
[Pulmonary mucormycosis in leukemic patients. Apropos of 2 cases].
    Sangre, 1994, Volume: 39, Issue:1

    Topics: Adult; Aged; Amphotericin B; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Fatal Outco

1994
Plasma levels of IL-1, TNF alpha, IL-6, IL-8, G-CSF, and IL1-RA during febrile neutropenia: results of a prospective study in patients undergoing chemotherapy for acute myelogenous leukemia.
    Annals of hematology, 1995, Volume: 71, Issue:4

    Topics: Adolescent; Adult; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Pr

1995
Granulocyte colony-stimulating factor supportive treatment following intensive chemotherapy in acute lymphocytic leukemia in first remission.
    Cancer, 1993, Nov-15, Volume: 72, Issue:10

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Granulocyte Colony-Stimulating Factor; H

1993
Neutropenic fever in patients after high-dose chemotherapy followed by autologous haematopoietic progenitor cell transplantation and human recombinant granulocyte-macrophage colony stimulating factor.
    Bone marrow transplantation, 1994, Volume: 14, Issue:6

    Topics: Breast Neoplasms; Combined Modality Therapy; Cyclophosphamide; Fever; Granulocyte-Macrophage Colony-

1994
Tandem transplants in solid tumors: marrow versus peripheral stem cell transplant: peripheral blood cells as now practiced are not the whole answer.
    Journal of hematotherapy, 1993,Fall, Volume: 2, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Blood Cell Count; Bone Marrow Transplantation; Breas

1993
Post-remission cytopenias following intense induction chemotherapy for acute myeloid leukemia.
    Leukemia, 1994, Volume: 8, Issue:4

    Topics: Acute Disease; Adolescent; Adult; Anemia; Antineoplastic Combined Chemotherapy Protocols; Bone Marro

1994
Selective discharge of patients with acute myeloid leukemia during chemotherapy-induced neutropenia.
    American journal of hematology, 1996, Volume: 51, Issue:1

    Topics: Acute Disease; Adult; Ambulatory Care; Antineoplastic Combined Chemotherapy Protocols; Bacterial Inf

1996
Autologous peripheral blood stem cell transplantation in a patient with previous invasive middle ear mucormycosis.
    Bone marrow transplantation, 1996, Volume: 18, Issue:6

    Topics: Acute Disease; Amphotericin B; Antifungal Agents; Antineoplastic Combined Chemotherapy Protocols; Co

1996
Suppressed neutrophil function as a risk factor for severe infection after cytotoxic chemotherapy in patients with acute nonlymphocytic leukemia.
    Annals of hematology, 1999, Volume: 78, Issue:2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Daunorubicin; Female; Fever

1999
Treatment of patients with recurrent and primary refractory acute myelogenous leukemia using mitoxantrone and intermediate-dose cytarabine: a pharmacologically based regimen.
    Cancer, 2000, May-01, Volume: 88, Issue:9

    Topics: Adult; Age Factors; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Com

2000
Patterns of chemotherapy administration in patients with intermediate-grade non-Hodgkin's lymphoma.
    Oncology (Williston Park, N.Y.), 2001, Volume: 15, Issue:10

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Disease-F

2001
Infectious complications in breast cancer patients undergoing peripheral blood stem cell transplantation: a single center retrospective analysis towards outpatient strategy.
    Bone marrow transplantation, 2001, Volume: 28, Issue:9

    Topics: Adult; Aged; Ambulatory Care; Anti-Bacterial Agents; Antineoplastic Agents, Alkylating; Antineoplast

2001
Recombinant human granulocyte-macrophage colony-stimulating factor after chemotherapy in patients with acute myeloid leukemia at higher age or after relapse.
    Blood, 1991, Sep-01, Volume: 78, Issue:5

    Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cytar

1991
Aspergillus appendicitis in acute myeloid leukaemia.
    Clinical and laboratory haematology, 1990, Volume: 12, Issue:4

    Topics: Adult; Amphotericin B; Antineoplastic Combined Chemotherapy Protocols; Appendicitis; Appendix; Asper

1990
Mitoxantrone and high-dose cytarabine as salvage therapy for refractory non-Hodgkin's lymphoma.
    Cancer, 1989, Oct-01, Volume: 64, Issue:7

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Drug Evaluation

1989