Page last updated: 2024-10-31

mitoxantrone and Minimal Disease, Residual

mitoxantrone has been researched along with Minimal Disease, Residual in 37 studies

Mitoxantrone: An anthracenedione-derived antineoplastic agent.
mitoxantrone : A dihydroxyanthraquinone that is 1,4-dihydroxy-9,10-anthraquinone which is substituted by 6-hydroxy-1,4-diazahexyl groups at positions 5 and 8.

Research Excerpts

ExcerptRelevanceReference
"No cases of progression occurred in minimal residual disease (MRD) negative patients after six years of follow-up."2.94The UK NCRI study of chlorambucil, mitoxantrone and dexamethasone (CMD) versus fludarabine, mitoxantrone and dexamethasone (FMD) for untreated advanced stage follicular lymphoma: molecular response strongly predicts prolonged overall survival. ( Bishton, MJ; Clifton-Hadley, L; Haynes, A; Lush, R; McMillan, A; Patmore, R; Rule, S; Turner, D; Wilson, W, 2020)
"Outcomes for children with acute myeloid leukemia (AML) have improved over the past 20 years even though the medications used for induction therapy have not changed."2.84Decreased relapsed rate and treatment-related mortality contribute to improved outcomes for pediatric acute myeloid leukemia in successive clinical trials. ( Alexander, TB; Inaba, H; Pounds, S; Pui, CH; Ribeiro, RC; Rubnitz, JE; Triplett, BM; Wang, L, 2017)
"Maintenance treatment also reduced minimal residual disease (detected by WT1 and CBFβ-MYH11) in five of eight evaluable patients."2.79Survival improvement of poor-prognosis AML/MDS patients by maintenance treatment with low-dose chemotherapy and differentiating agents. ( Audisio, E; Boccadoro, M; Bruno, B; Crisà, E; Ferrero, D; Festuccia, M; Frairia, C; Gatti, T; Giai, V; Marmont, F; Passera, R; Riera, L, 2014)
"In addition, minimal residual disease (MRD) in the marrow was studied 2 months after therapy, with MRD negativity defined as <0·01% CLL cells."2.76A randomized phase II trial of fludarabine, cyclophosphamide and mitoxantrone (FCM) with or without rituximab in previously treated chronic lymphocytic leukaemia. ( Booth, GA; Brown, J; Cocks, K; Cohen, DR; Dearden, C; Ezekwisili, R; Fegan, C; Hillmen, P; Kennedy, DB; Mercieca, J; Milligan, DW; Pettitt, A; Pocock, C; Radford, J; Rawstron, AC; Sayala, HA; Smith, AF; Varghese, AM, 2011)
" During 2004 and 2005, 45 patients with newly diagnosed Ph+ ALL were treated in the Group for Research on Adult Acute Lymphoblastic Leukemia (GRAAPH) 2003 study, in which imatinib was started with HAM (mitoxantrone with intermediate-dose cytarabine) consolidation in good early responders (corticosensitive and chemosensitive ALL) or earlier during the induction course in combination with dexamethasone and vincristine in poor early responders (corticoresistant and/or chemoresistant ALL)."2.73Imatinib combined with induction or consolidation chemotherapy in patients with de novo Philadelphia chromosome-positive acute lymphoblastic leukemia: results of the GRAAPH-2003 study. ( Buzyn, A; Cayuela, JM; Chalandon, Y; de Labarthe, A; Delabesse, E; Dombret, H; Escoffre, M; Huguet-Rigal, F; Ifrah, N; Lhéritier, V; MacIntyre, E; Maury, S; Pigneux, A; Réa, D; Reman, O; Rousselot, P; Thomas, X; Vekemans, MC; Vernant, JP; Witz, F, 2007)
"To determine prognosis of acute promyelocytic leukemia (APL) failing to front-line therapy with all-trans retinoic acid (ATRA) and anthracyclines, outcome of 52 patients (32 M/20 F; age: 37, 3-72) included in PETHEMA trials LPA96 and LPA99 who presented with either molecular failure (MOLrel, n=16) or hematological relapse (HEMrel, n=36) was analyzed."2.73Outcome of patients with acute promyelocytic leukemia failing to front-line treatment with all-trans retinoic acid and anthracycline-based chemotherapy (PETHEMA protocols LPA96 and LPA99): benefit of an early intervention. ( Alvarez, C; Bolufer, P; Brunet, S; Colomer, D; Díaz-Mediavilla, J; Escoda, L; Esteve, J; González San Miguel, JD; González, M; Martín, G; Rivas, C; Rubio, V; Sánchez Godoy, P; Sanz, MA; Sayas, MJ; Tomás, JF; Tormo, M, 2007)
"The clinical significance of eradicating minimal residual disease (MRD) was also analyzed."2.73Fludarabine, cyclophosphamide, and mitoxantrone as initial therapy of chronic lymphocytic leukemia: high response rate and disease eradication. ( Abella, E; Altés, A; Asensi, A; Aymerich, M; Bertazzoni, P; Bosch, F; Briones, J; Escoda, L; Ferrer, A; Font, L; Gardella, S; Giné, E; González, M; González-Barca, E; Montserrat, E; Muntañola, A; Pérez-Ceballos, E; Rozman, M; Sayas, MJ; Villamor, N, 2008)
"In this prospective randomized trial, we compared the efficacy and toxicity of cladribine (2-CdA) alone to 2-CdA combined with cyclophosphamide (CC) or cyclophosphamide and mitoxantrone (CMC) in untreated progressive chronic lymphocytic leukemia (CLL)."2.72Cladribine alone and in combination with cyclophosphamide or cyclophosphamide plus mitoxantrone in the treatment of progressive chronic lymphocytic leukemia: report of a prospective, multicenter, randomized trial of the Polish Adult Leukemia Group (PALG C ( Blonski, JZ; Calbecka, M; Ceglarek, B; Dmoszynska, A; Dwilewicz-Trojaczek, J; Gora-Tybor, J; Jamroziak, K; Kasznicki, M; Kloczko, J; Konopka, L; Kowal, M; Kuliczkowski, K; Robak, T; Skotnicki, AB; Stella-Holowiecka, B; Sulek, K; Tomaszewska, A; Warzocha, K; Zawilska, K, 2006)
"Seventy adults with acute promyelocytic leukemia were studied to clarify the significance of the level and kinetics of minimal residual disease (MRD) over their entire treatment course by realtime quantitative polymerase chain reaction."2.72The significance of minimal residual disease kinetics in adults with newly diagnosed PML-RARalpha-positive acute promyelocytic leukemia: results of a prospective trial. ( Cho, SG; Eom, KS; Kim, CC; Kim, HJ; Kim, YJ; Lee, JW; Lee, S; Min, CK; Min, WS, 2006)
"In this series confined to patients with minimal residual disease after initial therapy subjected to second-line intraperitoneal treatment, it appears to identify a poor prognostic (positive) subset for survival."2.70Correlation of p53 immunostaining in primary and residual ovarian cancer at the time of positive second-look laparotomy and its prognostic role: a Southwest Oncology Group ancillary study. ( Alberts, DS; Belt, RJ; Cote, R; Felix, J; Hawes, D; Liu, PY; Muggia, FM; Terada, K; Wilczynski, S, 2002)
"Treatment results in childhood ALL continue to improve, and the expected current cure rates approach 75 to 80% of all children with ALL, including T-ALL and mature B-cell ALL, the two variants that, not too long ago, had a considerably poorer prognosis compared with the common form of BpALL."2.42Recent advances in pediatric acute lymphoblastic and myeloid leukemia. ( Ravindranath, Y, 2003)
"acute lymphoblastic leukemia-type chemotherapy that incorporated high-dose cytarabine was effective in achieving an minimal residual disease-negativity rate of 69% in evaluated patients, which was also predictive of better outcome."1.56Clinicoepidemiologic Profile and Outcome Predicted by Minimal Residual Disease in Children With Mixed-phenotype Acute Leukemia Treated on a Modified MCP-841 Protocol at a Tertiary Cancer Institute in India. ( Banavali, S; Gujral, S; Myint, HH; Narula, G; Patkar, N; Prasad, M; Subramanian, P; Tandon, S; Tembhare, P, 2020)
"Mortality of acute myeloid leukemia is still 60-70% in young (<60 years) adults and 90% in elderly (≥60 years) patients."1.40[Treatment of acute myeloid leukemia -- a single center experience (2007-2013)]. ( Batár, P; Bedekovics, J; Hevessy, Z; Illés, A; Kiss, A; Márton, A; Pinczés, L; Rejtő, L; Reményi, G; Selmeczi, A; Szász, R; Telek, B; Udvardy, M; Ujfalusi, A; Ujj, Z, 2014)
"Molecular relapse was detected in two patients by RQ-PCR four and six weeks, respectively before hematologic relapse occurred."1.33The prognostic value of MLL-AF9 detection in patients with t(9;11)(p22;q23)-positive acute myeloid leukemia. ( Döhner, H; Döhner, K; Eiwen, K; Fröhling, S; Schlenk, RF; Scholl, C, 2005)
"Minimal residual disease was monitored by qualitative and real-time quantitative PCR."1.33Rituximab induces effective clearance of minimal residual disease in molecular relapses of mantle cell lymphoma. ( Astolfi, M; Boccadoro, M; Bodoni, CL; De Marco, F; Drandi, D; Gianni, AM; Guidetti, A; Ladetto, M; Magni, M; Mantoan, B; Matteucci, P; Pagliano, G; Ricca, I; Tarella, C; Zanni, M, 2006)
"After each course, minimal residual disease was tested by specific reverse transcriptase-polymerase chain reaction (RT-PCR) (median sensitivity, 10(-5))."1.31Outcome of treatment in adults with Philadelphia chromosome-positive acute lymphoblastic leukemia--results of the prospective multicenter LALA-94 trial. ( Bilhou-Nabera, C; Blaise, D; Boiron, JM; Boucheix, C; Bourhis, JH; Buzyn, A; Cayuela, JM; Charrin, C; Delannoy, A; Dombret, H; Espérou, H; Fegueux, N; Fenaux, P; Fière, D; Gabert, J; Lhéritier, V; MacIntyre, E; Rigal-Huguet, F; Thomas, X; Vernant, JP, 2002)
"However, minimal residual disease (MRD) detected with DEK/CAN chimeric m-RNA by reverse transcription polymerase chain reaction (RT-PCR) was continuously observed, although decreased quantitatively, following several courses of consolidation and intensification chemotherapies."1.30[The detection of minimal residual disease by DEK/CAN chimeric m-RNA in a case of AML M2 with translocation t(6;9) (p23;q34) after chemotherapy and peripheral blood stem cell transplantation]. ( Ando, T; Ariyoshi, K; Hikiji, K; Kobayashi, M; Shinohara, K; Toyosawa, M, 1997)
"Mitomycin C was administered initially and mitoxantrone was administered following the same schedule if disease recurred during followup."1.29Up-front intravesical chemotherapy for low stage, low grade recurrent bladder cancer. ( Carmignani, G; Maffezzini, M; Raber, M; Simonato, A; Zanon, M, 1996)

Research

Studies (37)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (16.22)18.2507
2000's21 (56.76)29.6817
2010's8 (21.62)24.3611
2020's2 (5.41)2.80

Authors

AuthorsStudies
Bishton, MJ1
Rule, S1
Wilson, W1
Turner, D1
Patmore, R1
Clifton-Hadley, L1
McMillan, A1
Lush, R1
Haynes, A1
Myint, HH1
Tandon, S1
Narula, G1
Prasad, M1
Subramanian, P1
Patkar, N1
Tembhare, P1
Gujral, S1
Banavali, S1
Alexander, TB1
Wang, L1
Inaba, H1
Triplett, BM1
Pounds, S1
Ribeiro, RC1
Pui, CH1
Rubnitz, JE1
Yoon, S1
Kim, H1
Hur, M1
Han, SH1
Chung, HJ1
Moon, HW1
Yun, YM1
Lee, MH1
Guolo, F1
Minetto, P1
Clavio, M1
Miglino, M1
Colombo, N1
Cagnetta, A1
Cea, M1
Marcolin, R1
Todiere, A1
Ballerini, F1
Gobbi, M1
Lemoli, RM1
Shi, Y1
Su, Z1
Li, S1
Chen, Y1
Chen, X1
Xiao, Y1
Sun, M1
Ping, Q1
Zong, L1
Ferrero, D1
Crisà, E1
Marmont, F1
Audisio, E1
Frairia, C1
Giai, V1
Gatti, T1
Festuccia, M1
Bruno, B1
Riera, L1
Passera, R1
Boccadoro, M2
Selmeczi, A1
Udvardy, M1
Illés, A1
Telek, B1
Kiss, A1
Batár, P1
Reményi, G1
Szász, R1
Ujj, Z1
Márton, A1
Ujfalusi, A1
Hevessy, Z1
Pinczés, L1
Bedekovics, J1
Rejtő, L1
Munir, T1
Howard, DR1
McParland, L1
Pocock, C2
Rawstron, AC2
Hockaday, A1
Varghese, A1
Hamblin, M1
Bloor, A1
Pettitt, A2
Fegan, C2
Blundell, J1
Gribben, JG1
Phillips, D1
Hillmen, P2
Cohen, DR1
Cocks, K1
Sayala, HA1
Kennedy, DB1
Milligan, DW1
Radford, J1
Mercieca, J1
Dearden, C1
Ezekwisili, R1
Smith, AF1
Brown, J1
Booth, GA1
Varghese, AM1
Dombret, H2
Gabert, J1
Boiron, JM1
Rigal-Huguet, F1
Blaise, D1
Thomas, X2
Delannoy, A1
Buzyn, A2
Bilhou-Nabera, C1
Cayuela, JM2
Fenaux, P1
Bourhis, JH1
Fegueux, N1
Charrin, C1
Boucheix, C1
Lhéritier, V2
Espérou, H1
MacIntyre, E2
Vernant, JP2
Fière, D1
Hawes, D1
Liu, PY2
Muggia, FM2
Wilczynski, S1
Cote, R1
Felix, J1
Terada, K1
Belt, RJ1
Alberts, DS2
Wernstedt, P1
Brune, M1
Andersson, PO1
Gustavsson, B1
Stockelberg, D1
Wadenvik, H1
Ravindranath, Y1
Gianni, AM2
Magni, M2
Martelli, M1
Di Nicola, M1
Carlo-Stella, C1
Pilotti, S1
Rambaldi, A1
Cortelazzo, S1
Patti, C2
Parvis, G1
Benedetti, F1
Capria, S2
Corradini, P1
Tarella, C2
Barbui, T1
Venditti, A2
Maurillo, L2
Buccisano, F2
Del Poeta, G2
Mazzone, C2
Tamburini, A2
Del Principe, MI2
Consalvo, MI2
De Fabritiis, P2
Cudillo, L1
Picardi, A1
Franchi, A1
Lo-Coco, F1
Amadori, S2
Coco, FL1
Kern, W2
Voskova, D1
Schoch, C2
Schnittger, S1
Hiddemann, W2
Haferlach, T2
Santini, G1
Chisesi, T1
Nati, S1
Porcellini, A1
Zoli, V1
Rizzoli, V1
Zupo, S1
Marino, G1
Rubagotti, A1
Polacco, A1
Spriano, M1
Vimercati, R1
Congiu, AM1
Ravetti, JL1
Aversa, S1
Candela, M1
Wilda, M1
Perez, AV1
Bruch, J1
Woessmann, W1
Metzler, M1
Fuchs, U1
Borkhardt, A1
Scholl, C1
Schlenk, RF1
Eiwen, K1
Döhner, H1
Fröhling, S1
Döhner, K1
Robak, T1
Blonski, JZ1
Gora-Tybor, J1
Jamroziak, K1
Dwilewicz-Trojaczek, J1
Tomaszewska, A1
Konopka, L1
Ceglarek, B1
Dmoszynska, A1
Kowal, M1
Kloczko, J1
Stella-Holowiecka, B1
Sulek, K1
Calbecka, M1
Zawilska, K1
Kuliczkowski, K1
Skotnicki, AB1
Warzocha, K1
Kasznicki, M1
Lee, S1
Kim, YJ1
Eom, KS1
Min, CK1
Kim, HJ1
Cho, SG1
Lee, JW1
Min, WS1
Kim, CC1
de Labarthe, A1
Rousselot, P1
Huguet-Rigal, F1
Delabesse, E1
Witz, F1
Maury, S1
Réa, D1
Vekemans, MC1
Reman, O1
Pigneux, A1
Escoffre, M1
Chalandon, Y1
Ifrah, N1
Ladetto, M1
Pagliano, G1
De Marco, F1
Drandi, D1
Ricca, I1
Astolfi, M1
Matteucci, P1
Guidetti, A1
Mantoan, B1
Bodoni, CL1
Zanni, M1
Esteve, J1
Escoda, L2
Martín, G1
Rubio, V1
Díaz-Mediavilla, J1
González, M2
Rivas, C1
Alvarez, C1
González San Miguel, JD1
Brunet, S1
Tomás, JF1
Tormo, M1
Sayas, MJ2
Sánchez Godoy, P1
Colomer, D1
Bolufer, P1
Sanz, MA1
Spagnoli, A1
Panetta, P1
Neri, B1
Ottaviani, L1
Fraboni, D1
Sarlo, C1
Bosch, F1
Ferrer, A1
Villamor, N1
Briones, J1
González-Barca, E1
Abella, E1
Gardella, S1
Pérez-Ceballos, E1
Asensi, A1
Font, L1
Altés, A1
Muntañola, A1
Bertazzoni, P1
Rozman, M1
Aymerich, M1
Giné, E1
Montserrat, E1
Hirt, C1
Schüler, F1
Kiefer, T1
Schwenke, C1
Haas, A1
Niederwieser, D1
Neser, S1
Assmann, M1
Srock, S1
Rohrberg, R1
Dachselt, K1
Leithäuser, M1
Rabkin, CS1
Herold, M1
Dölken, G1
Narimatsu, H1
Yamamoto, F1
Kurahashi, S1
Sugimoto, T1
Sugiura, I1
Maffezzini, M1
Simonato, A1
Zanon, M1
Raber, M1
Carmignani, G1
Wallace, DL1
O'Toole, RV1
Terada, KY1
Franklin, EW1
Herrer, GW1
Goldberg, DA1
Hannigan, EV1
Toyosawa, M1
Shinohara, K1
Ariyoshi, K1
Ando, T1
Kobayashi, M1
Hikiji, K1
Topuz, E1
Aydiner, A1
Saip, P1
Bengisu, E1
Berkman, S1
Disci, R1
Meloni, G1
Diverio, D1
Vignetti, M1
Avvisati, G1
Petti, MC1
Mandelli, F1
Lo Coco, F1
Moos, M1
Schulz, R1
Martin, S1
Benner, A1
Haas, R1
Braess, J1
Unterhalt, M1
Wörmann, B1
Büchner, T1
Sarris, AH1
Jiang, Y1
Tsimberidou, AM1
Thomaides, A1
Rassidakis, GZ1
Ford, RJ1
Medeiros, LJ1
Cabanillas, F1
McLaughlin, P1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomized Phase II Trial of Fludarabine, Cyclophosphamide and Mitoxantrone (FCM) With or Without Rituximab in Previously Treated Chronic Lymphocytic Leukemia[NCT00337246]Phase 256 participants (Anticipated)Interventional2005-07-31Completed
A RANDOMIZED PHASE III TRIAL COMPARING DEXAMETHASONE WITH PREDNISONE IN INDUCTION TREATMENT AND BONE MARROW TRANSPLANTATION WITH INTENSIVE MAINTENANCE TREATMENT IN ADOLESCENT AND ADULT ACUTE LYMPHOBLASTIC LEUKEMIA (ALL-4)[NCT00002700]Phase 3392 participants (Anticipated)Interventional1995-08-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for mitoxantrone and Minimal Disease, Residual

ArticleYear
Recent advances in pediatric acute lymphoblastic and myeloid leukemia.
    Current opinion in oncology, 2003, Volume: 15, Issue:1

    Topics: Acute Disease; Antineoplastic Agents; Biomarkers, Tumor; Child; Chromosome Aberrations; Clinical Tri

2003

Trials

16 trials available for mitoxantrone and Minimal Disease, Residual

ArticleYear
The UK NCRI study of chlorambucil, mitoxantrone and dexamethasone (CMD) versus fludarabine, mitoxantrone and dexamethasone (FMD) for untreated advanced stage follicular lymphoma: molecular response strongly predicts prolonged overall survival.
    British journal of haematology, 2020, Volume: 190, Issue:4

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Dexamethasone

2020
Decreased relapsed rate and treatment-related mortality contribute to improved outcomes for pediatric acute myeloid leukemia in successive clinical trials.
    Cancer, 2017, Oct-01, Volume: 123, Issue:19

    Topics: Adolescent; Aminoglycosides; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplasti

2017
Survival improvement of poor-prognosis AML/MDS patients by maintenance treatment with low-dose chemotherapy and differentiating agents.
    Annals of hematology, 2014, Volume: 93, Issue:8

    Topics: Adult; Aged; Anthracyclines; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Thera

2014
Results of the randomized phase IIB ADMIRE trial of FCR with or without mitoxantrone in previously untreated CLL.
    Leukemia, 2017, Volume: 31, Issue:10

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Disease-Free Survival

2017
A randomized phase II trial of fludarabine, cyclophosphamide and mitoxantrone (FCM) with or without rituximab in previously treated chronic lymphocytic leukaemia.
    British journal of haematology, 2011, Volume: 152, Issue:5

    Topics: Adult; Aged; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols;

2011
Correlation of p53 immunostaining in primary and residual ovarian cancer at the time of positive second-look laparotomy and its prognostic role: a Southwest Oncology Group ancillary study.
    Gynecologic oncology, 2002, Volume: 87, Issue:1

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Cisplatin; Clinical Trials

2002
Pretransplant minimal residual disease level predicts clinical outcome in patients with acute myeloid leukemia receiving high-dose chemotherapy and autologous stem cell transplantation.
    Leukemia, 2003, Volume: 17, Issue:11

    Topics: Acute Disease; Adult; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Eto

2003
Cladribine alone and in combination with cyclophosphamide or cyclophosphamide plus mitoxantrone in the treatment of progressive chronic lymphocytic leukemia: report of a prospective, multicenter, randomized trial of the Polish Adult Leukemia Group (PALG C
    Blood, 2006, Jul-15, Volume: 108, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cladribine; Cyclopho

2006
The significance of minimal residual disease kinetics in adults with newly diagnosed PML-RARalpha-positive acute promyelocytic leukemia: results of a prospective trial.
    Haematologica, 2006, Volume: 91, Issue:5

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Disease Progression;

2006
Imatinib combined with induction or consolidation chemotherapy in patients with de novo Philadelphia chromosome-positive acute lymphoblastic leukemia: results of the GRAAPH-2003 study.
    Blood, 2007, Feb-15, Volume: 109, Issue:4

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Cytarabine; Female; H

2007
Outcome of patients with acute promyelocytic leukemia failing to front-line treatment with all-trans retinoic acid and anthracycline-based chemotherapy (PETHEMA protocols LPA96 and LPA99): benefit of an early intervention.
    Leukemia, 2007, Volume: 21, Issue:3

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Child; C

2007
Fludarabine, cyclophosphamide, and mitoxantrone as initial therapy of chronic lymphocytic leukemia: high response rate and disease eradication.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2008, Jan-01, Volume: 14, Issue:1

    Topics: ADP-ribosyl Cyclase 1; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Female; Hum

2008
Rapid and sustained clearance of circulating lymphoma cells after chemotherapy plus rituximab: clinical significance of quantitative t(14;18) PCR monitoring in advanced stage follicular lymphoma patients.
    British journal of haematology, 2008, Volume: 141, Issue:5

    Topics: Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined

2008
Intraperitoneal mitoxantrone or floxuridine: effects on time-to-failure and survival in patients with minimal residual ovarian cancer after second-look laparotomy--a randomized phase II study by theSouthwest Oncology Group.
    Gynecologic oncology, 1996, Volume: 61, Issue:3

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Female

1996
Intraperitoneal cisplatin--mitoxantrone in ovarian cancer patients with minimal residual disease.
    European journal of gynaecological oncology, 1997, Volume: 18, Issue:1

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Female; Humans; Middle Aged;

1997
Quantitative real-time polymerase chain reaction for monitoring minimal residual disease in patients with advanced indolent lymphomas treated with rituximab, fludarabine, mitoxantrone, and dexamethasone.
    Seminars in oncology, 2002, Volume: 29, Issue:1 Suppl 2

    Topics: Actins; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chem

2002

Other Studies

20 other studies available for mitoxantrone and Minimal Disease, Residual

ArticleYear
Clinicoepidemiologic Profile and Outcome Predicted by Minimal Residual Disease in Children With Mixed-phenotype Acute Leukemia Treated on a Modified MCP-841 Protocol at a Tertiary Cancer Institute in India.
    Journal of pediatric hematology/oncology, 2020, Volume: 42, Issue:7

    Topics: Acute Disease; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool;

2020
Do we still need morphologic evaluation in new era of advanced minimal residual disease analyses?
    International journal of laboratory hematology, 2019, Volume: 41, Issue:6

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Chromosomes, Human, Pair 21; Chromosomes, Hum

2019
Longitudinal minimal residual disease (MRD) evaluation in acute myeloid leukaemia with NPM1 mutation: from definition of molecular relapse to MRD-driven salvage approach.
    British journal of haematology, 2019, Volume: 186, Issue:6

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Disease-Free Survival; Etoposide;

2019
Multistep targeted nano drug delivery system aiming at leukemic stem cells and minimal residual disease.
    Molecular pharmaceutics, 2013, Jun-03, Volume: 10, Issue:6

    Topics: Animals; Antineoplastic Agents; Bone Marrow; Cell Line, Tumor; Drug Delivery Systems; Durapatite; Fo

2013
[Treatment of acute myeloid leukemia -- a single center experience (2007-2013)].
    Orvosi hetilap, 2014, Apr-27, Volume: 155, Issue:17

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Boronic

2014
Outcome of treatment in adults with Philadelphia chromosome-positive acute lymphoblastic leukemia--results of the prospective multicenter LALA-94 trial.
    Blood, 2002, Oct-01, Volume: 100, Issue:7

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Female; Follow-Up Stu

2002
Favorable outcome with STI571 (imatinib mesylate) and allogeneic stem cell transplantation in a case of Ph+ chemorefractory acute lymphocytic leukaemia.
    Bone marrow transplantation, 2002, Volume: 30, Issue:12

    Topics: Adult; Amsacrine; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Benzamides;

2002
Long-term remission in mantle cell lymphoma following high-dose sequential chemotherapy and in vivo rituximab-purged stem cell autografting (R-HDS regimen).
    Blood, 2003, Jul-15, Volume: 102, Issue:2

    Topics: Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemo

2003
Prognostic impact of early response to induction therapy as assessed by multiparameter flow cytometry in acute myeloid leukemia.
    Haematologica, 2004, Volume: 89, Issue:5

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Cells; Cytarabi

2004
Fludarabine, cyclophosphamide and mitoxantrone for untreated follicular lymphoma: a report from the non-Hodgkin's lymphoma co-operative study group.
    Leukemia & lymphoma, 2004, Volume: 45, Issue:6

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Cyclophosphamide; Disease-

2004
Use of MLL/GRAF fusion mRNA for measurement of minimal residual disease during chemotherapy in an infant with acute monoblastic leukemia (AML-M5).
    Genes, chromosomes & cancer, 2005, Volume: 43, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cytarabine; DNA-Binding Proteins; Etoposide; GTPase-

2005
The prognostic value of MLL-AF9 detection in patients with t(9;11)(p22;q23)-positive acute myeloid leukemia.
    Haematologica, 2005, Volume: 90, Issue:12

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Chromoso

2005
Rituximab induces effective clearance of minimal residual disease in molecular relapses of mantle cell lymphoma.
    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2006, Volume: 12, Issue:12

    Topics: Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemo

2006
Monitoring of minimal residual disease in adult acute myeloid leukemia using peripheral blood as an alternative source to bone marrow.
    Haematologica, 2007, Volume: 92, Issue:5

    Topics: Acute Disease; Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Blood Cells;

2007
Difficulty of peripheral blood stem cell collection after multiple consolidation therapy in acute myeloid leukemia.
    Journal of clinical and experimental hematopathology : JCEH, 2008, Volume: 48, Issue:1

    Topics: Antigens, CD34; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Daunorubicin; Female; Gr

2008
Up-front intravesical chemotherapy for low stage, low grade recurrent bladder cancer.
    The Journal of urology, 1996, Volume: 155, Issue:1

    Topics: Administration, Intravesical; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Trans

1996
[The detection of minimal residual disease by DEK/CAN chimeric m-RNA in a case of AML M2 with translocation t(6;9) (p23;q34) after chemotherapy and peripheral blood stem cell transplantation].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 1997, Volume: 38, Issue:1

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Chromosomes, Human, Pair 6; Chromosomes,

1997
Autologous bone marrow transplantation for acute promyelocytic leukemia in second remission: prognostic relevance of pretransplant minimal residual disease assessment by reverse-transcription polymerase chain reaction of the PML/RAR alpha fusion gene.
    Blood, 1997, Aug-01, Volume: 90, Issue:3

    Topics: Adolescent; Adult; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Biom

1997
The remission status before and the PCR status after high-dose therapy with peripheral blood stem cell support are prognostic factors for relapse-free survival in patients with follicular non-Hodgkin's lymphoma.
    Leukemia, 1998, Volume: 12, Issue:12

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Chromosomes, Human, Pair 14; Chromosomes, Hum

1998
Multivariate analysis of prognostic factors in patients with refractory and relapsed acute myeloid leukemia undergoing sequential high-dose cytosine arabinoside and mitoxantrone (S-HAM) salvage therapy: relevance of cytogenetic abnormalities.
    Leukemia, 2000, Volume: 14, Issue:2

    Topics: Adult; Aged; Analysis of Variance; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemothe

2000